{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:01:31Z","timestamp":1785420091667,"version":"3.56.0"},"reference-count":58,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI155275"],"award-info":[{"award-number":["AI155275"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"award":["AI155275"],"award-info":[{"award-number":["AI155275"]}],"id":[{"id":"https:\/\/ror.org\/043z4tv69","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIH","award":["P51OD011106"],"award-info":[{"award-number":["P51OD011106"]}]},{"award":["P51OD011106"],"award-info":[{"award-number":["P51OD011106"]}],"id":[{"id":"https:\/\/ror.org\/044zkrt47","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Henipaviruses (HNVs), including Nipah virus (NiV) and Hendra virus (HeV), are highly pathogenic and often lethal zoonotic viruses with broad species tropism and no approved human vaccines. The emergence of genetically divergent HNVs\u2014including Ghana virus (GhV), Langya virus (LayV), and Mojiang virus (MojV)\u2014emphasizes the need for broadly protective countermeasures. Here, we evaluated the antibody (Ab) responses to sequential mRNA vaccines encoding the membrane-bound attachment glycoprotein (gG) from NiV, GhV, and\/or LayV in a pilot study with Indian rhesus macaques. Serum binding Ab responses were quantified by ELISA against five soluble gG antigens (NiV, HeV, GhV, LayV, MojV). Functional activity was assessed by neutralization assays using NiV, HeV, and GhV pseudoviruses, and by receptor-blocking ELISA. Sequential vaccination induced high-titer IgG binding against all five HNV gGs with increasing breadth after each dose. Pan-genus regimens elicited moderate neutralizing Ab titers against NiV, HeV, and GhV, whereas the NiV-only regimen elicited potent but narrow neutralization against NiV and HeV. Conversely, the GhV-LayV-GhV regimen elicited strong binding to GhV, LayV, and MojV gG and robust neutralization of GhV pseudovirus, but limited cross-reactivity to NiV and HeV. In this pilot study, we demonstrated that mRNA vaccination can elicit broadly reactive binding and neutralizing Ab responses across phylogenetically distant HNVs. Additionally, we show GhV pseudovirus neutralization for the first time. Collectively, these data provide a foundation for the development of next-generation pan-genus HNV vaccines capable of mitigating future HNV outbreaks.<\/jats:p>","DOI":"10.3390\/v18050487","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:11:14Z","timestamp":1776931874000},"page":"487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterologous Sequential mRNA Vaccination of Indian Rhesus Macaques Elicits Broad Binding and Neutralizing Antibody Responses Against Diverse Henipaviruses"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-897X","authenticated-orcid":false,"given":"Thomas B.","family":"Voigt","sequence":"first","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"},{"name":"Mabloc LLC, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon C.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"},{"name":"Medical Scientist Training Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7503-4267","authenticated-orcid":false,"given":"Taylor","family":"Newbolt","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan J.","family":"Louw","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Yrizarry-Medina","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christakis","family":"Panayiotou","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack T.","family":"Mauter","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana","family":"de Figueiredo Godoy","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Terao","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-5309","authenticated-orcid":false,"given":"Eva G.","family":"Rakasz","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1484-6408","authenticated-orcid":false,"given":"Matthew R.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"},{"name":"Mabloc LLC, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8098-8666","authenticated-orcid":false,"given":"Michael J.","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA"},{"name":"Mabloc LLC, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105693","DOI":"10.1016\/j.micpath.2022.105693","article-title":"The pathogenesis of Nipah virus: A review","volume":"170","author":"Devnath","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.7861\/clinmed.2022-0166","article-title":"Nipah virus, an emerging zoonotic disease causing fatal encephalitis","volume":"22","author":"Alam","year":"2022","journal-title":"Clin. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1007\/s11357-022-00670-9","article-title":"Henipaviruses: An expanding global public health concern?","volume":"44","author":"Quarleri","year":"2022","journal-title":"Geroscience"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.cell.2020.11.023","article-title":"Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein","volume":"183","author":"Dong","year":"2020","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"s200","DOI":"10.1136\/bmj.s200","article-title":"Nipah: Two health workers infected, sparking quarantine of 200 and widespread airport screening","volume":"392","author":"Ahmad","year":"2026","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ana.21178","article-title":"Long-term neurological and functional outcome in Nipah virus infection","volume":"62","author":"Sejvar","year":"2007","journal-title":"Ann. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kummer, S., and Kranz, D.C. (2022). Henipaviruses-A constant threat to livestock and humans. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010157"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Liew, Y.J.M., Ibrahim, P.A.S., Ong, H.M., Chong, C.N., Tan, C.T., Schee, J.P., Roman, R.G., Cherian, N.G., Wong, W.F., and Chang, L.Y. (2022). The Immunobiology of Nipah Virus. Microorganisms, 10.","DOI":"10.3390\/microorganisms10061162"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110969","DOI":"10.1016\/j.celrep.2022.110969","article-title":"Emerging viruses: Cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats","volume":"39","author":"Tian","year":"2022","journal-title":"Cell Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100080","DOI":"10.1016\/j.onehlt.2018.100080","article-title":"Infectious disease and economics: The case for considering multi-sectoral impacts","volume":"7","author":"Smith","year":"2019","journal-title":"One Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106882","DOI":"10.1016\/j.ijsu.2022.106882","article-title":"Langya virus, a newly identified Henipavirus in China-Zoonotic pathogen causing febrile illness in humans, and its health concerns: Current knowledge and counteracting strategies\u2014Correspondence","volume":"105","author":"Chakraborty","year":"2022","journal-title":"Int. J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3201\/eid2006.131022","article-title":"Novel Henipa-like virus, Mojiang Paramyxovirus, in rats, China, 2012","volume":"20","author":"Wu","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/vbz.2018.2365","article-title":"Henipaviruses at the Interface Between Bats, Livestock and Human Population in Africa","volume":"19","author":"Mbacham","year":"2019","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Marsh, G.A., de Jong, C., Barr, J.A., Tachedjian, M., Smith, C., Middleton, D., Yu, M., Todd, S., Foord, A.J., and Haring, V. (2012). Cedar virus: A novel Henipavirus isolated from Australian bats. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002836"},{"key":"ref_15","first-page":"1","article-title":"Beyond the Headlines: Why Henipaviruses Warrant Our Attention","volume":"68","author":"Adhikari","year":"2025","journal-title":"Acta Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3201\/eid3108.250401","article-title":"Henipavirus in Northern Short-Tailed Shrew, Alabama, USA","volume":"31","author":"Haring","year":"2025","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2154188","DOI":"10.1080\/21505594.2022.2154188","article-title":"Langya henipavirus: Is it a potential cause for public health concern?","volume":"14","author":"Sanchez","year":"2023","journal-title":"Virulence"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"03034","DOI":"10.7189\/jogh-13-03034","article-title":"Global emergence of Langya virus: A serious public health concern","volume":"13","author":"Piracha","year":"2023","journal-title":"J. Glob. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1473-3099(19)30634-6","article-title":"Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: A first-in-human, randomised, controlled, phase 1 study","volume":"20","author":"Playford","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_20","unstructured":"NIAID (2026, April 19). VRC 322\/DMID 21-0016: A Phase I, Dose Escalation, Open-Label Clinical Trial to Evaluate Safety, Tolerability and Immunogenicity of a Nipah Virus (NiV) mRNA Vaccine, mRNA-1215, in Healthy Adults, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05398796."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/S1473-3099(21)00400-X","article-title":"Medical countermeasures against henipaviruses: A review and public health perspective","volume":"22","author":"Roman","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_22","unstructured":"(2026, April 19). ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/search?cond=henipavirus."},{"key":"ref_23","unstructured":"(2026, April 19). Auro Vaccines, LLC A Phase 1 Randomized, Placebo-controlled, Observer-blind Trial to Assess the Safety and Immunogenicity of a Nipah Vaccine, HeV-sG-V (Hendra Virus Soluble Glycoprotein Vaccine), in Healthy Adults, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04199169."},{"key":"ref_24","unstructured":"(2026, April 19). Public Health Vaccines, LLC A Phase 1 Randomized, Single Center, Double-Blind, Placebo-Controlled, Dose-Response Study to Evaluate the Safety and Immunogenicity of rVSV-Nipah Virus Vaccine Candidate PHV02 in Healthy Adult Subjects, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05178901."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/nyas.14898","article-title":"Lessons from the pandemic: Responding to emerging zoonotic viral diseases\u2014A Keystone Symposia report","volume":"1518","author":"Cable","year":"2022","journal-title":"Ann. Acad. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.chom.2023.05.017","article-title":"Broad-spectrum pan-genus and pan-family virus vaccines","volume":"31","author":"Tan","year":"2023","journal-title":"Cell Host Microbe"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.virs.2025.08.005","article-title":"Antigenic and structural insights into Langya henipavirus attachment glycoprotein","volume":"40","author":"Li","year":"2025","journal-title":"Virol. Sin."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.str.2024.05.003","article-title":"Structural insights into the Langya virus attachment glycoprotein","volume":"32","author":"Wang","year":"2024","journal-title":"Structure"},{"key":"ref_29","unstructured":"Weatherall, D.J. (2006). The Use of Non-Human Primates in Research, Medical Research Council (MRC)."},{"key":"ref_30","unstructured":"National Research Council of the National Academies (2011). Guide for the Care and Use of Laboratory Animals, The National Academies Press."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10802","DOI":"10.1128\/JVI.01440-15","article-title":"Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection","volume":"89","author":"Martins","year":"2015","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e00690-18","DOI":"10.1128\/JVI.00690-18","article-title":"Mamu-B*17+ Rhesus Macaques Vaccinated with env, vif, and nef Manifest Early Control of SIVmac239 Replication","volume":"92","author":"Martins","year":"2018","journal-title":"J. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JVI.01626-18","article-title":"The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques","volume":"93","author":"Martins","year":"2019","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1743-422X-7-312","article-title":"A functional henipavirus envelope glycoprotein pseudotyped lentivirus assay system","volume":"7","author":"Khetawat","year":"2010","journal-title":"Virol. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1128\/JVI.03655-13","article-title":"Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a)","volume":"88","author":"Pernet","year":"2014","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"116407","DOI":"10.1016\/j.celrep.2025.116407","article-title":"Structure and function of a pair of non-competing monoclonal antibodies against Langya henipavirus attachment glycoprotein","volume":"44","author":"Li","year":"2025","journal-title":"Cell Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2314990121","DOI":"10.1073\/pnas.2314990121","article-title":"Structure and design of Langya virus glycoprotein antigens","volume":"121","author":"Wang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Rosen, B.C., Sawatzki, K., Ricciardi, M.J., Smith, E., Golez, I., Mauter, J.T., Pedre\u00f1o-L\u00f3pez, N., Yrizarry-Medina, A., Weisgrau, K.L., and Vosler, L.J. (2024). Acute-phase innate immune responses in SIVmac239-infected Mamu-B*08+ Indian rhesus macaques may contribute to the establishment of elite control. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1478063"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8827","DOI":"10.1128\/JVI.00895-07","article-title":"Mamu-B*08-positive macaques control simian immunodeficiency virus replication","volume":"81","author":"Loffredo","year":"2007","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1086\/528801","article-title":"Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody","volume":"197","author":"Zhu","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1056\/NEJMoa2024671","article-title":"Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates","volume":"383","author":"Corbett","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bezeljak, U., Jerman, A., Kobal, T., Lokar Kosmac, M., Birsa, E., Kolenc, M., Deri, D., Palyi, B., Kis, Z., and Peterka, M. (2025). Purification and immunogenicity of Nipah virus-like particles from insect cells. BMC Biotechnol., 26.","DOI":"10.1186\/s12896-025-01095-w"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lv, C., He, J., Zhang, Q., and Wang, T. (2025). Vaccines and Animal Models of Nipah Virus: Current Situation and Future Prospects. Vaccines, 13.","DOI":"10.3390\/vaccines13060608"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.1038\/ncomms6342","article-title":"Evidence for henipavirus spillover into human populations in Africa","volume":"5","author":"Pernet","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Agrawal, B. (2019). Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02631"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/jimmun\/vkae067","article-title":"Modulation of germinal center and antibody dynamics via ipsilateral versus contralateral immunization against SARS-CoV-2","volume":"214","author":"Burmas","year":"2025","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rizvi, N.B., Bibi, M., Rana, M.Z., Zaffar, S., and Farooq, H. (2024). Comparison of antibody responses of heterologous and homologous Covid-19 booster vaccination: An observational study. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1448408"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1073\/pnas.0903181106","article-title":"Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine","volume":"106","author":"Galli","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e29245","DOI":"10.1002\/jmv.29245","article-title":"Effect of previous heterologous flavivirus vaccinations on human antibody responses in tick-borne encephalitis and dengue virus infections","volume":"95","author":"Rossbacher","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_50","first-page":"E2156","article-title":"Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus","volume":"112","author":"Lee","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, R., Wang, M., Liu, Y., Yin, Y., Zai, X., Song, X., Chen, Y., Xu, J., and Chen, W. (2020). Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice. Viruses, 12.","DOI":"10.3390\/v12040480"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e0062123","DOI":"10.1128\/jvi.00621-23","article-title":"Sequence basis for selectivity of ephrin-B2 ligand for Eph receptors and pathogenic henipavirus G glycoproteins","volume":"97","author":"Narayanan","year":"2023","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/bs.apha.2025.01.015","article-title":"Innovations in vaccine design: Computational tools and techniques","volume":"103","author":"Nag","year":"2025","journal-title":"Adv. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00705-024-06143-y","article-title":"Changes to virus taxonomy and the ICTV Statutes ratified by the International Committee on Taxonomy of Viruses (2024)","volume":"169","author":"Simmonds","year":"2024","journal-title":"Arch. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.cell.2019.11.003","article-title":"High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity","volume":"179","author":"Setliff","year":"2019","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s40259-024-00667-0","article-title":"Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases","volume":"38","author":"Schardt","year":"2024","journal-title":"BioDrugs"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Dhawan, M., Rabaan, A.A., Fawarah, M.M.A., Almuthree, S.A., Alsubki, R.A., Alfaraj, A.H., Mashraqi, M.M., Alshamrani, S.A., Abduljabbar, W.A., and Alwashmi, A.S.S. (2023). Updated Insights into the T Cell-Mediated Immune Response against SARS-CoV-2: A Step Towards Efficient and Reliable Vaccines. Vaccines, 11.","DOI":"10.3390\/vaccines11010101"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ura, T., Takeuchi, M., Kawagoe, T., Mizuki, N., Okuda, K., and Shimada, M. (2022). Current Vaccine Platforms in Enhancing T-Cell Response. Vaccines, 10.","DOI":"10.3390\/vaccines10081367"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/5\/487\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:24:29Z","timestamp":1777091069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/5\/487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":58,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["v18050487"],"URL":"https:\/\/doi.org\/10.3390\/v18050487","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}