{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:41:17Z","timestamp":1785426077844,"version":"3.56.0"},"reference-count":160,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000105","name":"York University","doi-asserted-by":"publisher","award":["Junior Faculty\/Minor Research Grant"],"award-info":[{"award-number":["Junior Faculty\/Minor Research Grant"]}],"id":[{"id":"10.13039\/501100000105","id-type":"DOI","asserted-by":"publisher"}]},{"award":["Junior Faculty\/Minor Research Grant"],"award-info":[{"award-number":["Junior Faculty\/Minor Research Grant"]}],"id":[{"id":"https:\/\/ror.org\/05fq50484","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Globally, cis and trans women face increasing rates of HIV, yet the uptake of existing HIV prevention medications often fails to meet their specific needs. This review examines HIV pre-exposure prophylaxis (PrEP) use among cis and trans women, including adolescent girls and young women; newcomers and migrants; sex workers; women who use drugs; and women who have been incarcerated, acknowledging intersectionality exists between these groups. A review of peer-reviewed published literature was conducted, and findings specifically on oral PrEP were synthesized. This review highlights several key themes shaping women\u2019s engagement with PrEP, including barriers to initiation and discontinuation; public health messaging and promotion; the role of women\u2019s networks; intimate partner violence; interpersonal trust in relationships; and \u201cseasons of risk,\u201d where temporary reductions in perceived risk may lead to discontinuation. Additional themes include preferred access points for PrEP, regional differences, and clinical implications for practice. Peer support and peer navigators emerge as important mechanisms for creating safe spaces that enhance trust and sustained PrEP use. Improving PrEP uptake and persistence among women requires a multifaceted, women-centred approach that addresses clinical, social, and structural barriers. Context-specific implementation remains critical to addressing diverse lived realities and strengthening HIV prevention outcomes globally.<\/jats:p>","DOI":"10.3390\/v18060636","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:17:31Z","timestamp":1780467451000},"page":"636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Update on HIV Pre-Exposure Prophylaxis (PrEP) Among Women"],"prefix":"10.3390","volume":"18","author":[{"given":"Tamara","family":"Barnett","sequence":"first","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cloutier","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafique","family":"Van Uum","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7130-0342","authenticated-orcid":false,"given":"Parsa","family":"Ebrahimpoor Mashhadi","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Crespi","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeeka","family":"Tahir","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajeela","family":"Rana","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlee","family":"Giffen","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2462-5120","authenticated-orcid":false,"given":"Roya","family":"Haghiri-Vijeh","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia J.","family":"Biondi","sequence":"additional","affiliation":[{"name":"School of Nursing, York University, 301A 4700 Keele Street, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"ref_1","unstructured":"UNAIDS (2025, March 06). 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