{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:42:42Z","timestamp":1790376162122,"version":"4.1.0"},"reference-count":82,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015550","name":"Ministry of Health Malaysia","doi-asserted-by":"publisher","award":["P42005001171004"],"award-info":[{"award-number":["P42005001171004"]}],"id":[{"id":"10.13039\/501100015550","id-type":"DOI","asserted-by":"publisher"}]},{"award":["P42005001171004"],"award-info":[{"award-number":["P42005001171004"]}],"id":[{"id":"https:\/\/ror.org\/05ddxe180","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue Virus (DENV) circulates as four antigenically distinct serotypes whose dominance fluctuates over time in many endemic regions, a phenomenon known as serotype shift that is frequently associated with large outbreaks and increased disease severity. This review, through a synthesis of epidemiological, virological, immunological, entomological, and environmental evidence, observes that serotype shift likely arises from the interaction of multiple determinants rather than solely from viral evolution, with population immunity playing a central role. The accumulation of serotype-specific herd immunity, together with short-lived cross-protection and Antibody-Dependent Enhancement (ADE), reshapes population susceptibility and creates ecological space for heterologous serotypes with higher transmission potential. The synthesis of global dengue studies indicates that these immune dynamics interact with viral genetic diversity, vector competence, climate variability, and human factors such as demography, socioeconomic status, population density and mobility to drive cyclical and sometimes abrupt changes in serotype dominance. Notably, the review indicates that serotype changes often precede or coincide with more clinical severity and patterns of outbreaks, with direct implications for the process of forecasting outbreaks, vaccine performance, and preparedness to respond with appropriate health measures. On the whole, this review confirms the opinion that the change of dengue serotype occurrence becomes a consequence of interconnected biological and ecological processes involved in the transmission of dengue serotype shifts in hyperendemic areas.<\/jats:p>","DOI":"10.3390\/v18060683","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:25:34Z","timestamp":1781778334000},"page":"683","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Determinants of Dengue Serotype Shifts: A Narrative Multifactorial Perspective"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-2149","authenticated-orcid":false,"given":"Jeyanthi","family":"Suppiah","sequence":"first","affiliation":[{"name":"Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-8821","authenticated-orcid":false,"given":"Sakshaleni","family":"Rajendiran","sequence":"additional","affiliation":[{"name":"Environmental Health Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-1529","authenticated-orcid":false,"given":"Siti Aishah","family":"Rashid","sequence":"additional","affiliation":[{"name":"Environmental Health Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-9720","authenticated-orcid":false,"given":"Nurulhusna","family":"Ab Hamid","sequence":"additional","affiliation":[{"name":"Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murni Maya Sari","family":"Zulkifli","sequence":"additional","affiliation":[{"name":"Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozainanee","family":"Mohd Zain","sequence":"additional","affiliation":[{"name":"Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam 40170, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20130414","DOI":"10.1098\/rsif.2013.0414","article-title":"Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity","volume":"10","author":"Reich","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e42496","DOI":"10.7554\/eLife.42496","article-title":"Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics","volume":"8","author":"Bell","year":"2019","journal-title":"Elife"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.meegid.2018.04.032","article-title":"Understanding dengue virus evolution to support epidemic surveillance and counter-measure development","volume":"2","author":"Pollett","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/j.ijid.2019.01.014","article-title":"Emergence of new genotypes and lineages of dengue viruses during the 2012-15 epidemics in southern India","volume":"84S","author":"Ahamed","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tim.2013.12.011","article-title":"Global spread of dengue virus types: Mapping the 70 year history","volume":"22","author":"Messina","year":"2014","journal-title":"Trends Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"22356","DOI":"10.1038\/srep22356","article-title":"Highly divergent dengue virus type 1 genotype sets a new distance record","volume":"6","author":"Pyke","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e2326","DOI":"10.7717\/peerj.2326","article-title":"Analysis of genotype diversity and evolution of Dengue virus serotype 2 using complete genomes","volume":"4","author":"Waman","year":"2016","journal-title":"PeerJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1099\/0022-1317-75-1-65","article-title":"Molecular evolution and epidemiology of dengue-3 viruses","volume":"75","author":"Lanciotti","year":"1994","journal-title":"J. Gen. Virol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Suppiah, J., Ali, E.Z., Mohd Khalid, M.K.N., Mohd Ghazali, S., Tee, K.K., Zulkifli, M.M.S., Ramli, N., Adiee, A.H., Ramly, M.N., and Robert, F. (2023). Resurgence of Dengue Virus Serotype 4 in Malaysia: A Comprehensive Clinicodemographic and Genomic Analysis. Trop. Med. Infect. Dis., 8.","DOI":"10.3390\/tropicalmed8080409"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2149\/tmh.2011-S02","article-title":"Quasispecies of dengue virus","volume":"39","author":"Kurosu","year":"2011","journal-title":"Trop. Med. Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100807","DOI":"10.1016\/j.ijmmb.2025.100807","article-title":"Serotype and genotype shift detection over two consecutive periods of dengue virus infection in a tertiary care hospital","volume":"54","author":"Bhat","year":"2025","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yadav, A.K., Chowdhary, R., Siddiqui, A., Malhotra, A.G., Kanwar, J.R., Kumar, A., Biswas, D., Khadanga, S., Joshi, R., and Pakhare, A. (2025). Emergence of a Novel Dengue Virus Serotype-2 Genotype IV Lineage III Strain and Displacement of Dengue Virus Serotype-1 in Central India (2019\u20132023). Viruses, 17.","DOI":"10.3390\/v17020144"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"de Alwis, R., Williams, K.L., Schmid, M.A., Lai, C.Y., Patel, B., Smith, S.A., Crowe, J.E., Wang, W.K., Harris, E., and de Silva, A.M. (2014). Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004386"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3201\/eid1605.091006","article-title":"Dengue virus surveillance for early warning, Singapore","volume":"16","author":"Lee","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22592","DOI":"10.1038\/srep22592","article-title":"Intra-epidemic evolutionary dynamics of a Dengue virus type 1 population reveal mutant spectra that correlate with disease transmission","volume":"6","author":"Hapuarachchi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1818","DOI":"10.1002\/hsr2.1818","article-title":"Predominant dengue virus serotype in Dhaka, Bangladesh: A research letter on samples from 2022 outbreak","volume":"7","author":"Nafisa","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Calvez, E., Pommelet, V., Somlor, S., Pompon, J., Viengphouthong, S., Bounmany, P., Chindavong, T.A., Xaybounsou, T., Prasayasith, P., and Keosenhom, S. (2020). Trends of the Dengue Serotype-4 Circulation with Epidemiological, Phylogenetic, and Entomological Insights in Lao PDR between 2015 and 2019. Pathogens, 9.","DOI":"10.3390\/pathogens9090728"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3329\/jhpn.v30i3.12300","article-title":"Changing pattern of dengue virus serotypes in Thailand between 2004 and 2010","volume":"30","author":"Pongsiri","year":"2012","journal-title":"J. Health Popul. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kelly, M.E., Msafiri, F., Affara, M., Gehre, F., Moremi, N., Mghamba, J., Misinzo, G., Thye, T., Gatei, W., and Whistler, T. (2023). Molecular Characterization and Phylogenetic Analysis of Dengue Fever Viruses in Three Outbreaks in Tanzania Between 2017 and 2019. PLoS Neglected Trop. Dis., 17.","DOI":"10.1371\/journal.pntd.0011289"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"veae116","DOI":"10.1093\/ve\/veae116","article-title":"Geographic origin and evolution of dengue virus serotypes 1 and 3 circulating in Africa","volume":"11","author":"Nyathi","year":"2024","journal-title":"Virus Evol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4269\/ajtmh.2010.09-0346","article-title":"The epidemiology of dengue in the Americas over the last three decades: A worrisome reality","volume":"82","author":"Brathwaite","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"584","DOI":"10.4269\/ajtmh.2012.11-0770","article-title":"The history of dengue outbreaks in the Americas","volume":"87","author":"Montoya","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11364","DOI":"10.1038\/s41467-025-66411-6","article-title":"Climate variation and serotype competition drive dengue outbreak dynamics in Singapore","volume":"16","author":"Finch","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.jiph.2023.10.014","article-title":"Changing pattern of circulating dengue serotypes in the endemic region: An alarming risk to the healthcare system during the pandemic","volume":"16","author":"Verma","year":"2023","journal-title":"J. Infect. Public Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijid.2013.10.012","article-title":"Evolution of dengue in Sri Lanka-changes in the virus, vector, and climate","volume":"19","author":"Sirisena","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1473-3099(25)00382-2","article-title":"Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in S\u00e3o Paulo, Brazil: A test-negative, case-control study","volume":"26","author":"Ranzani","year":"2026","journal-title":"Lancet Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mendoza-Cano, O., Danis-Lozano, R., Trujillo, X., Huerta, M., R\u00edos-Silva, M., Lugo-Radillo, A., Bricio-Barrios, J.A., Benites-God\u00ednez, V., Cuevas-Arellano, H.B., and Uribe-Ramos, J.M. (2025). Spatial patterns and clustering of dengue incidence in Mexico: Analysis of Moran\u2019s index across 2,471 municipalities from 2022 to 2024. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0324754"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1073\/pnas.0602768103","article-title":"Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok","volume":"103","author":"Adams","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"15259","DOI":"10.1073\/pnas.0507320102","article-title":"Dynamic effects of antibody-dependent enhancement on the fitness of viruses","volume":"102","author":"Cummings","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Cummings, D.A., Iamsirithaworn, S., Lessler, J.T., McDermott, A., Prasanthong, R., Nisalak, A., Jarman, R.G., Burke, D.S., and Gibbons, R.V. (2009). The impact of the demographic transition on dengue in Thailand: Insights from a statistical analysis and mathematical modeling. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000139"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4269\/ajtmh.1952.1.30","article-title":"Research on dengue during World War II","volume":"1","author":"Sabin","year":"1952","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1073\/pnas.1522136113","article-title":"Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort","volume":"113","author":"Katzelnick","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","first-page":"55","article-title":"Duration of short-lived cross-protective immunity against a clinical attack of dengue: A preliminary estimate","volume":"32","author":"Hiroshi","year":"2008","journal-title":"Dengue Bull."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.jiph.2023.10.006","article-title":"Impact of secondary infections on dengue presentation: A cross-sectional study in a tertiary care hospital in Uttar Pradesh, India","volume":"16","author":"Dinkar","year":"2023","journal-title":"J. Infect. Public Health"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Teo, A., Tan, H.D., Loy, T., Chia, P.Y., and Chua, C.L.L. (2023). Understanding antibody-dependent enhancement in dengue: Are afucosylated IgG1s a concern?. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011736"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"14688","DOI":"10.1073\/pnas.1508114112","article-title":"Asymptomatic humans transmit dengue virus to mosquitoes","volume":"112","author":"Duong","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e08347","DOI":"10.7554\/eLife.08347","article-title":"The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus","volume":"4","author":"Kraemer","year":"2015","journal-title":"Elife"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ekwudu, O., Marquart, L., Webb, L., Lowry, K.S., Devine, G.J., Hugo, L.E., and Frentiu, F.D. (2020). Effect of Serotype and Strain Diversity on Dengue Virus Replication in Australian Mosquito Vectors. Pathogens, 9.","DOI":"10.3390\/pathogens9080668"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4269\/ajtmh.1976.25.318","article-title":"Variation among geographic strains of Aedes albopictus in susceptibility to infection with dengue viruses","volume":"25","author":"Gubler","year":"1976","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"886","DOI":"10.4269\/ajtmh.2006.75.886","article-title":"Aedes aegypti vectorial capacity is determined by the infecting genotype of dengue virus","volume":"75","author":"Anderson","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Vazeille, M., Gaborit, P., Mousson, L., Girod, R., and Failloux, A.B. (2016). Competitive advantage of a dengue 4 virus when co-infecting the mosquito Aedes aegypti with a dengue 1 virus. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1666-0"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chaves, B.A., Godoy, R.S.M., Campolina, T.B., J\u00fanior, A.B.V., Paz, A.D.C., Vaz, E.B.D.C., Silva, B.M., Nascimento, R.M., Guerra, M.d.G.V.B., and Lacerda, M.V.G. (2021). Dengue Infection Susceptibility of Five Aedes aegypti Populations from Manaus (Brazil) after Challenge with Virus Serotypes 1-4. Viruses, 14.","DOI":"10.3390\/v14010020"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actatropica.2017.07.014","article-title":"Dengue serotype circulation in natural populations of Aedes aegypti","volume":"176","author":"Cruz","year":"2017","journal-title":"Acta Trop."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pt.2010.12.001","article-title":"Quantitative genetics of Aedes aegypti vector competence for dengue viruses: Towards a new paradigm?","volume":"27","author":"Lambrechts","year":"2011","journal-title":"Trends Parasitol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1603\/ME11293","article-title":"Vector competence of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) for dengue virus in the Florida Keys","volume":"49","author":"Richards","year":"2012","journal-title":"J. Med. Entomol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1017\/S0950268816000753","article-title":"The effect of Wolbachia on dengue dynamics in the presence of two serotypes of dengue: Symmetric and asymmetric epidemiological characteristics","volume":"144","author":"Ndii","year":"2016","journal-title":"Epidemiol. Infect."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.meegid.2009.02.003","article-title":"Molecular evolution of dengue viruses: Contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease","volume":"9","author":"Weaver","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/viro.2002.1447","article-title":"Phylogenetic relationships and differential selection pressures among genotypes of dengue-2 virus","volume":"298","author":"Twiddy","year":"2002","journal-title":"Virology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/infdis\/jiv536","article-title":"Evolutionarily Successful Asian 1 Dengue Virus 2 Lineages Contain One Substitution in Envelope That Increases Sensitivity to Polyclonal Antibody Neutralization","volume":"213","author":"Wang","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Louren\u00e7o, J., and Recker, M. (2010). Viral and epidemiological determinants of the invasion dynamics of novel dengue genotypes. PLoS Neglected Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000894"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1017\/S0950268825100320","article-title":"Aedes aegypti and dengue: Insights into transmission dynamics and viral lifecycle","volume":"153","author":"Abbasi","year":"2025","journal-title":"Epidemiol. Infect."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s42003-025-07999-9","article-title":"Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand","volume":"8","author":"Perez","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Akorli, J., Oware, S.K.D., Sackitey, D.B., Pul, R.M., Akyea-Bobi, N.E., Akporh, S.S., Amlalo, G.K., Osei, J.H.N., Boakye, H.A., and Abudu, M. (2025). Climate-driven models reveal temporal trends in Aedes breeding: Implications for outbreak preparedness and control interventions. BMC Public Health, 25.","DOI":"10.1186\/s12889-025-24060-w"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"103977","DOI":"10.1016\/j.pdpdt.2024.103977","article-title":"Influence of temperature combined with photodynamic inactivation on the development of Aedes aegypti","volume":"45","author":"Garbuio","year":"2024","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Liu, Z., Zhang, Q., Li, L., He, J., Guo, J., Wang, Z., Huang, Y., Xi, Z., Yuan, F., and Li, Y. (2023). The effect of temperature on dengue virus transmission by Aedes mosquitoes. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1242173"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102841","DOI":"10.1016\/j.tmaid.2025.102841","article-title":"The impact of climate change on travel-related vector-borne diseases: A case study on dengue virus transmission","volume":"65","author":"Abbasi","year":"2025","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Benedum, C.M., Seidahmed, O.M.E., Eltahir, E.A.B., and Markuzon, N. (2018). Statistical modeling of the effect of rainfall flushing on dengue transmission in Singapore. PLoS Neglected Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006935"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S330","DOI":"10.1016\/j.gaceta.2021.07.020","article-title":"Analysis of temperature and humidity on dengue hemorrhagic fever in Manado Municipality","volume":"35","author":"Monintja","year":"2021","journal-title":"Gac. Sanit."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100452","DOI":"10.1016\/j.onehlt.2022.100452","article-title":"The association between dengue case and climate: A systematic review and meta-analysis","volume":"15","author":"Abdullah","year":"2022","journal-title":"One Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1038\/s41467-023-43954-0","article-title":"Interactions between climate change, urban infrastructure and mobility are driving dengue emergence in Vietnam","volume":"14","author":"Gibb","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13071-025-06764-5","article-title":"The effects of urbanization, temperature, and rainfall on Aedes aegypti and Aedes albopictus mosquito abundance across a broad latitudinal gradient in Central Africa","volume":"18","author":"Montgomery","year":"2025","journal-title":"Parasit. Vectors"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40249-025-01326-4","article-title":"The impact of hot nights on dengue incidence: A nationwide case crossover study in Brazil","volume":"14","author":"Su","year":"2025","journal-title":"Infect. Dis. Poverty"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kamal, A.S.M.M., Al-Montakim, M.N., Hasan, M.A., Mitu, M.M.P., Gazi, M.Y., Uddin, M.M., and Mia, M.B. (2023). Relationship between Urban Environmental Components and Dengue Prevalence in Dhaka City-An Approach of Spatial Analysis of Satellite Remote Sensing, Hydro-Climatic, and Census Dengue Data. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20053858"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1289\/ehp.1306556","article-title":"Climate and dengue transmission: Evidence and implications","volume":"121","author":"Morin","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Pirani, M., Lorenz, C., de Azevedo, T.S., Barbosa, G.L., Blangiardo, M., and Chiaravalloti-Neto, F. (2024). Effects of the El Ni\u00f1o-Southern Oscillation and seasonal weather conditions on Aedes aegypti infestation in the State of S\u00e3o Paulo (Brazil): A Bayesian spatio-temporal study. PLoS Neglected Trop. Dis., 18.","DOI":"10.1371\/journal.pntd.0012397"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Pramanik, M., Singh, P., Kumar, G., Ojha, V.P., and Dhiman, R.C. (2020). El Ni\u00f1o Southern Oscillation as an early warning tool for dengue outbreak in India. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-09609-1"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"de Almeida, M.T., Merighi, D.G.S., Visnardi, A.B., Boneto Gon\u00e7alves, C.A., Amorim, V.M.F., Ferrari, A.S.A., de Souza, A.S., and Guzzo, C.R. (2025). Latin America\u2019s Dengue Outbreak Poses a Global Health Threat. Viruses, 17.","DOI":"10.3390\/v17010057"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Chew, C.H., Woon, Y.L., Amin, F., Adnan, T.H., Abdul Wahab, A.H., Ahmad, Z.E., Bujang, M.A., Abdul Hamid, A.M., Jamal, R., and Chen, W.S. (2016). Rural-urban comparisons of dengue seroprevalence in Malaysia. BMC Public Health, 16.","DOI":"10.1186\/s12889-016-3496-9"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ganeshkumar, P., Murhekar, M.V., Poornima, V., Saravanakumar, V., Sukumaran, K., Anandaselvasankar, A., John, D., and Mehendale, S.M. (2018). Dengue infection in India: A systematic review and meta-analysis. PLoS Neglected Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006618"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2149\/tmh.2011-S05","article-title":"Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century","volume":"39","author":"Gubler","year":"2011","journal-title":"Trop. Med. Health"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Brady, O.J., Gething, P.W., Bhatt, S., Messina, J.P., Brownstein, J.S., Hoen, A.G., Moyes, C.L., Farlow, A.W., Scott, T.W., and Hay, S.I. (2012). Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Neglected Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001760"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/ijerph10041505","article-title":"Higher mosquito production in low-income neighborhoods of Baltimore and Washington, DC: Understanding ecological drivers and mosquito-borne disease risk in temperate cities","volume":"10","author":"LaDeau","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.micro.62.081307.163005","article-title":"Global spread and persistence of dengue","volume":"62","author":"Kyle","year":"2008","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Louren\u00e7o, J., and Recker, M. (2014). The 2012 Madeira dengue outbreak: Epidemiological determinants and future epidemic potential. PLoS Neglected Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003083"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Rahim, R., Hasan, A., Phadungsombat, J., Hasan, N., Ara, N., Biswas, S.M., Nakayama, E.E., Rahman, M., and Shioda, T. (2023). Genetic Analysis of Dengue Virus in Severe and Non-Severe Cases in Dhaka, Bangladesh, in 2018\u20132022. Viruses, 15.","DOI":"10.3390\/v15051144"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"114ra128","DOI":"10.1126\/scitranslmed.3003084","article-title":"Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity","volume":"3","author":"OhAinle","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Narvaez, F., Montenegro, C., Juarez, J.G., Zambrana, J.V., Gonzalez, K., Videa, E., Arguello, S., Barrios, F., Ojeda, S., and Plazaola, M. (2025). Dengue severity by serotype and immune status in 19 years of pediatric clinical studies in Nicaragua. PLoS Neglected Trop. Dis., 19.","DOI":"10.1371\/journal.pntd.0012811"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s40249-017-0328-9","article-title":"Dengue-specific serotype related to clinical severity during the 2012\/2013 epidemic in centre of Brazil","volume":"6","author":"Rocha","year":"2017","journal-title":"Infect. Dis. Poverty"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.virol.2013.01.018","article-title":"Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity","volume":"439","author":"Durbin","year":"2013","journal-title":"Virology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4269\/ajtmh.2008.79.128","article-title":"Antigenic relationships between sylvatic and endemic dengue viruses","volume":"79","author":"Vasilakis","year":"2008","journal-title":"Am. J. Trop. Med. 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