{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:57:58Z","timestamp":1785412678641,"version":"3.56.0"},"reference-count":66,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","award":["PICT 2016-2117"],"award-info":[{"award-number":["PICT 2016-2117"]}]},{"name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","award":["PICT 2019-2611"],"award-info":[{"award-number":["PICT 2019-2611"]}]},{"award":["PICT 2016-2117"],"award-info":[{"award-number":["PICT 2016-2117"]}],"id":[{"id":"https:\/\/ror.org\/03stxzb56","id-type":"ROR","asserted-by":"publisher"}]},{"award":["PICT 2019-2611"],"award-info":[{"award-number":["PICT 2019-2611"]}],"id":[{"id":"https:\/\/ror.org\/03stxzb56","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n Argentina de Infectolog\u00eda Pedi\u00e1trica"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Secondary dengue infections are often linked to more severe clinical outcomes, yet pre-existing antibodies may exert either protective or pathogenic effects. To evaluate the role of acute-phase dengue antibodies in pediatric dengue, we analyzed clinical and laboratory features, viremia, and antibody profiles in children infected with DENV-1. We conducted a retrospective study of patients under 18 years diagnosed with DENV-1 in Salta, Argentina. Viremia was quantified by real-time RT-PCR; acute-phase IgG antibodies (within 7 days from symptom onset) against DENV, DENV-1, and DENV-NS1 were measured by immunoassays, and neutralizing antibodies by plaque reduction neutralization tests. Among 151 patients (median age 12 years), 62% presented dengue with warning signs and one case progressed to severe dengue. Viremia was higher in probable primary infections than in probable secondary infections and did not correlate with disease severity. Probable secondary infections were characterized by acute-phase antibody profiles that did not associate with DENV viremia. Age-stratified analyses revealed that adolescents exhibited higher viremia levels than younger children in probable primary infections, while viremia levels were comparable across age groups in probable secondary infections. Furthermore, children younger than 10 years displayed acute-phase antibody levels similar to those of adolescents. In adolescents with probable secondary infections, anti-DENV and anti-DENV-1 IgG were inversely correlated with platelet counts, whereas neutralizing and anti-DENV-NS1 antibodies showed no association. Collectively, these findings indicate that probable secondary DENV infections in our pediatric cohort were characterized by acute-phase antibodies that were not associated with viremia control, and that in adolescents, anti-DENV and anti-DENV-1 IgG antibodies likely associated with platelet depletion. These results highlight important implications for vaccine design, underscoring the need for vaccines that elicit strong neutralizing responses while minimizing cross-reactivity and the risk of antibody dependent enhancement.<\/jats:p>","DOI":"10.3390\/v18070741","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:15:53Z","timestamp":1783095353000},"page":"741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute-Phase Dengue Antibody Profiles in Pediatric Patients: Influence on Viremia and Disease Manifestations"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-8672","authenticated-orcid":false,"given":"Florencia A.","family":"Bonnin","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular (LIIBM), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"},{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires 1428, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostina","family":"Bruno","sequence":"additional","affiliation":[{"name":"Hospital San Vicente de Paul, San Ram\u00f3n de la Nueva Or\u00e1n 4530, Salta, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Manuela","family":"Bono","sequence":"additional","affiliation":[{"name":"Hospital San Vicente de Paul, San Ram\u00f3n de la Nueva Or\u00e1n 4530, Salta, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina A.","family":"Lucero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBIO), Universidad Nacional de San Mart\u00edn (UNSAM)-CONICET, San Mart\u00edn 1650, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Ni\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBIO), Universidad Nacional de San Mart\u00edn (UNSAM)-CONICET, San Mart\u00edn 1650, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBIO), Universidad Nacional de San Mart\u00edn (UNSAM)-CONICET, San Mart\u00edn 1650, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-9670","authenticated-orcid":false,"given":"Diego E.","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBIO), Universidad Nacional de San Mart\u00edn (UNSAM)-CONICET, San Mart\u00edn 1650, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular (LIIBM), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"},{"name":"Departamento de Medicina, Programa de Enfermedades Infecciosas, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Universidad de Buenos Aires, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-7176","authenticated-orcid":false,"given":"Cybele C.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), UBA-CONICET, Ciudad Aut\u00f3noma de Buenos Aires 1428, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo O.","family":"Quipildor","sequence":"additional","affiliation":[{"name":"Hospital San Vicente de Paul, San Ram\u00f3n de la Nueva Or\u00e1n 4530, Salta, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Talarico","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Infectol\u00f3gicas y Biolog\u00eda Molecular (LIIBM), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Ciudad Aut\u00f3noma de Buenos Aires 1425, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global 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