{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:18:51Z","timestamp":1783419531260,"version":"3.54.6"},"reference-count":136,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2024 Key Research and Development Program of Henan Province","award":["241112110600"],"award-info":[{"award-number":["241112110600"]}]},{"name":"the Foundation of Key Technology Research Project of Henan Province","award":["262102110042"],"award-info":[{"award-number":["262102110042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Feline panleukopenia is a highly contagious and often fatal disease in cats caused by the feline panleukopenia virus (FPV), a member of the Parvoviridae family. Despite the widespread use of vaccination, FPV remains a significant threat to both domestic and wild felid populations worldwide, particularly in young or unvaccinated animals. Effective vaccination strategies are therefore essential for controlling the disease and reducing mortality. Current vaccines, including modified live and inactivated vaccines, have demonstrated substantial efficacy in inducing protective immunity; however, several challenges remain, such as maternal antibody interference, vaccine failure, and safety concerns in certain animal populations. Recent advances in vaccine technology have spurred the development of next-generation FPV vaccines, including recombinant vectors, DNA vaccines, virus-like particle (VLP) vaccines, and novel delivery platforms. Among these, probiotic-based vaccine vectors have garnered growing interest due to their favorable safety profiles, mucosal immunogenicity, and suitability for oral administration. These systems may provide innovative approaches for inducing both systemic and mucosal immune responses against FPV. This review summarizes the current understanding of the immunological mechanisms underlying protection against FPV infection and discusses the progress made in FPV vaccine development. Furthermore, it highlights the major challenges associated with current vaccination strategies and explores emerging vaccine platforms, including probiotic vector-based vaccines, as promising tools for future disease control. Improved vaccine design and optimized immunization strategies will be crucial for enhancing the prevention of feline panleukopenia in the future.<\/jats:p>","DOI":"10.3390\/v18070750","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:53:46Z","timestamp":1783418026000},"page":"750","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Feline Panleukopenia Virus Vaccines: Immunological Mechanisms, Current Challenges, and Future Perspectives"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-0179","authenticated-orcid":false,"given":"Shiqiang","family":"Zhu","sequence":"first","affiliation":[{"name":"Food Laboratory of Zhongyuan, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-0825","authenticated-orcid":false,"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Food Laboratory of Zhongyuan, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-1453","authenticated-orcid":false,"given":"Huakai","family":"Wang","sequence":"additional","affiliation":[{"name":"Food Laboratory of Zhongyuan, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Food Laboratory of Zhongyuan, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-3121","authenticated-orcid":false,"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Food Laboratory of Zhongyuan, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China"},{"name":"Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Food Laboratory of Zhongyuan, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China"},{"name":"Department of Nutrition and Health, China Agricultural University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.14202\/vetworld.2018.578-584","article-title":"Epidemiology and diagnosis of feline panleukopenia virus in Egypt: Clinical and molecular diagnosis in cats","volume":"11","author":"Awad","year":"2018","journal-title":"Vet. World"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/vr.93.6.156","article-title":"Isolation of panleucopaenia virus from lions","volume":"93","author":"Studdert","year":"1973","journal-title":"Vet. Rec."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"106379","DOI":"10.1016\/j.antiviral.2026.106379","article-title":"Therapeutic efficacy of a chimeric neutralizing antibody targeting feline parvovirus","volume":"248","author":"Huang","year":"2026","journal-title":"Antivir. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tvjl.2014.05.027","article-title":"Feline parvovirus infection and associated diseases","volume":"201","author":"Stuetzer","year":"2014","journal-title":"Vet. J."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kabir, A., Habib, T., Chouhan, C.S., Hassan, J., Rahman, A., and Nazir, K. (2023). Epidemiology and molecular characterization of Feline panleukopenia virus from suspected domestic cats in selected Bangladesh regions. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0282559"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tang, A., Li, B., Zhu, M., Zhu, S., Zhang, D., Li, N., Zhang, M., Zhu, Y., Li, C., and Meng, C. (2025). A novel feline herpesvirus vector subunit FCV VP1 and FPV VP2 vaccine protects cats against FHV-1 and FPV challenge and induces serum neutralizing antibody responses against FCV. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1636514"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1177\/1098612X13497738","article-title":"Case series of feline panleukopenia virus in an animal shelter","volume":"16","author":"Litster","year":"2014","journal-title":"J. Feline Med. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/vr.142.14.353","article-title":"Detection of feline parvovirus in dying pedigree kittens","volume":"142","author":"Addie","year":"1998","journal-title":"Vet. Rec."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jfms.2009.05.002","article-title":"Feline panleukopenia. ABCD guidelines on prevention and management","volume":"11","author":"Truyen","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1098\/rspb.2000.1248","article-title":"Dynamics of a feline virus with two transmission modes within exponentially growing host populations","volume":"267","author":"Berthier","year":"2000","journal-title":"Proc. Biol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0950-3536(05)80232-X","article-title":"Pathogenesis of feline panleukopenia virus and canine parvovirus","volume":"8","author":"Parrish","year":"1995","journal-title":"Baillieres Clin. Haematol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wen, Y., Tang, Z., Wang, K., Geng, Z., Yang, S., Guo, J., Chen, Y., Wang, J., Fan, Z., and Chen, P. (2024). Epidemiological and Molecular Investigation of Feline Panleukopenia Virus Infection in China. Viruses, 16.","DOI":"10.3390\/v16121967"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1099\/vir.0.2008\/001503-0","article-title":"Genetic analysis of feline panleukopenia viruses from cats with gastroenteritis","volume":"89","author":"Decaro","year":"2008","journal-title":"J. Gen. Virol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/s41598-025-31671-1","article-title":"Evaluating triple inactivated vaccine-induced immunity from a large-scale study in feline population","volume":"16","author":"Wang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1006\/viro.1998.9335","article-title":"Differences in the evolutionary pattern of feline panleukopenia virus and canine parvovirus","volume":"249","author":"Horiuchi","year":"1998","journal-title":"Virology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/1098612X20941784","article-title":"2020 AAHA\/AAFP Feline Vaccination Guidelines","volume":"22","author":"Stone","year":"2020","journal-title":"J. Feline Med. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100067","DOI":"10.1016\/j.vetvac.2024.100067","article-title":"Assessing immune evasion potential and vaccine suitability of a feline panleukopenia virus strain","volume":"3","author":"Li","year":"2024","journal-title":"Vet. Vaccine"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jakel, V., Cussler, K., Hanschmann, K.M., Truyen, U., Konig, M., Kamphuis, E., and Duchow, K. (2012). Vaccination against Feline Panleukopenia: Implications from a field study in kittens. BMC Vet. Res., 8.","DOI":"10.1186\/1746-6148-8-62"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110257","DOI":"10.1016\/j.vetmic.2024.110257","article-title":"Development of a recombinant Lactobacillus plantarum oral vaccine expressing VP2 protein for preventing feline panleukopenia virus","volume":"298","author":"Li","year":"2024","journal-title":"Vet. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Meng, Z., Sun, Z., Li, J., Qiu, W., Wei, J., Zhang, R., Ji, X., Zhu, H., Yu, J., and Liu, Y. (2026). Donor Plasmid Optimization Enhances Expression of Feline Parvovirus VP2 Protein in the Baculovirus Expression Vector System. Vaccines, 14.","DOI":"10.3390\/vaccines14010077"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.vaccine.2007.11.073","article-title":"Complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing VP2 from FPV","volume":"26","author":"Yang","year":"2008","journal-title":"Vaccine"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Feng, E., Luo, G., Wang, C., Liu, W., Yan, R., Bai, X., and Cheng, Y. (2025). Generation and Immunogenicity of Virus-like Particles Based on the Capsid Protein of a Chinese Epidemic Strain of Feline Panleukopenia Virus. Vet. Sci., 12.","DOI":"10.20944\/preprints202503.1854.v1"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, T., Wu, H., Wang, Y., Guan, Y., Cao, Y., Wang, L., Wang, M., Tan, F., Pang, W., and Tian, K. (2025). Virus-like Particle Vaccine for Feline Panleukopenia: Immunogenicity and Protective Efficacy in Cats. Vaccines, 13.","DOI":"10.3390\/vaccines13070684"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11262-026-02222-1","article-title":"Establishment of a reverse genetics system for feline panleukopenia virus and feasibility study of a live vector vaccine","volume":"62","author":"Li","year":"2026","journal-title":"Virus Genes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jfms.2008.05.004","article-title":"Feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus antibody responses in seronegative specific pathogen-free cats after a single administration of two different modified live FVRCP vaccines","volume":"11","author":"Lappin","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9642624","DOI":"10.1155\/tbed\/9642624","article-title":"Novel Strain-Based Triple Inactivated Vaccine Confers Rapid Neutralizing Immunity to Feline Multisystemic Pathogens with Two-Dose Regimen","volume":"2025","author":"Wu","year":"2025","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1098612X11432239","article-title":"Effects of maternally-derived antibodies on serologic responses to vaccination in kittens","volume":"14","author":"Digangi","year":"2012","journal-title":"J. Feline Med. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"109978","DOI":"10.1016\/j.vetmic.2023.109978","article-title":"A potential dual protection vaccine: Recombinant feline herpesvirus-1 expressing feline parvovirus VP2 antigen","volume":"290","author":"Yang","year":"2024","journal-title":"Vet. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Chen, C., Li, Y.L., Lv, F.L., Xu, L.D., and Huang, Y.W. (2022). Surface Display of Peptides Corresponding to the Heptad Repeat 2 Domain of the Feline Enteric Coronavirus Spike Protein on Bacillus subtilis Spores Elicits Protective Immune Responses Against Homologous Infection in a Feline Aminopeptidase-N-Transduced Mouse Model. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.925922"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.rvsc.2010.03.001","article-title":"Characterisation of canine parvovirus strains isolated from cats with feline panleukopenia","volume":"89","author":"Decaro","year":"2010","journal-title":"Res. Vet. Sci."},{"key":"ref_31","first-page":"585","article-title":"Molecular detection and phylogenetic analysis of feline panleukopenia virus in domestic cat population of Mizoram state, India","volume":"16","author":"Zochampuii","year":"2025","journal-title":"Vet. Res. Forum"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.vetmic.2013.02.005","article-title":"Feline panleukopenia virus: Its interesting evolution and current problems in immunoprophylaxis against a serious pathogen","volume":"165","author":"Truyen","year":"2013","journal-title":"Vet. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00705-013-1914-1","article-title":"The family Parvoviridae","volume":"159","author":"Cotmore","year":"2014","journal-title":"Arch. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yeo, Y.G., Kim, H.R., Park, J., Kim, J.M., Shin, Y.K., Lee, K.K., Kwon, O.K., Jeoung, H.Y., Kang, H.E., and Ku, B.K. (2023). Epidemiological and Molecular Approaches for a Fatal Feline Panleukopenia Virus Infection of Captive Siberian Tigers (Panthera tigris altaica) in the Republic of Korea. Animals, 13.","DOI":"10.3390\/ani13182991"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, S., Chen, X., Hao, Y., Zhang, G., Lyu, Y., Wang, J., Liu, W., and Qin, T. (2022). Characterization of the VP2 and NS1 genes from canine parvovirus type 2 (CPV-2) and feline panleukopenia virus (FPV) in Northern China. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.934849"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1534-5807(01)00031-4","article-title":"A viral phospholipase A2 is required for parvovirus infectivity","volume":"1","author":"Zadori","year":"2001","journal-title":"Dev. Cell"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Pan, S., Jiao, R., Xu, X., Ji, J., Guo, G., Yao, L., Kan, Y., Xie, Q., and Bi, Y. (2023). Molecular characterization and genetic diversity of parvoviruses prevalent in cats in Central and Eastern China from 2018 to 2022. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1218810"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/tbed.12483","article-title":"Genetic Analysis of Feline Panleukopenia Virus Full-Length VP2 Gene in Domestic Cats Between 2006\u20132008 and 2012\u20132014, Portugal","volume":"64","author":"Miranda","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s11259-025-10877-8","article-title":"Engineering a recombinant VP2-Based neutralizing epitope vaccine candidate against canine parvovirus: A preliminary immunogenicity assessment","volume":"49","author":"Wu","year":"2025","journal-title":"Vet. Res. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-1702(97)00145-7","article-title":"Mapping the antigenic structure of porcine parvovirus at the level of peptides","volume":"53","author":"Kamstrup","year":"1998","journal-title":"Virus Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Xie, Q., Sun, Z., Xue, X., Pan, Y., Zhen, S., Liu, Y., Zhan, J., Jiang, L., Zhang, J., and Zhu, H. (2024). China-origin G1 group isolate FPV072 exhibits higher infectivity and pathogenicity than G2 group isolate FPV027. Front. Vet. Sci., 11.","DOI":"10.3389\/fvets.2024.1328244"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.3390\/cimb45040236","article-title":"Identification and Genome Characterization of Novel Feline Parvovirus Strains Isolated in Shanghai, China","volume":"45","author":"Liu","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/1098612X13489210","article-title":"Prevention of infectious diseases in cat shelters: ABCD guidelines","volume":"15","author":"Mostl","year":"2013","journal-title":"J. Feline Med. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2011.09.007","article-title":"Canine parvovirus\u2014A review of epidemiological and diagnostic aspects, with emphasis on type 2c","volume":"155","author":"Decaro","year":"2012","journal-title":"Vet. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-virology-031413-085444","article-title":"Parvoviruses: Small Does Not Mean Simple","volume":"1","author":"Cotmore","year":"2014","journal-title":"Annu. Rev. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e01871-16","DOI":"10.1128\/JVI.01871-16","article-title":"Parvovirus Capsid Structures Required for Infection: Mutations Controlling Receptor Recognition and Protease Cleavages","volume":"91","author":"Callaway","year":"2017","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1128\/JVI.78.11.5601-5611.2004","article-title":"Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains","volume":"78","author":"Hueffer","year":"2004","journal-title":"J. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1128\/JVI.75.8.3896-3902.2001","article-title":"Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells","volume":"75","author":"Parker","year":"2001","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1128\/JVI.02623-09","article-title":"Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection","volume":"84","author":"Goodman","year":"2010","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1099\/vir.0.19490-0","article-title":"Parvovirus LuIII transducing vectors packaged by LuIII versus FPV capsid proteins: The VP1 N-terminal region is not a major determinant of human cell permissiveness","volume":"85","author":"Maxwell","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/viro.1994.1020","article-title":"Two dominant neutralizing antigenic determinants of canine parvovirus are found on the threefold spike of the virus capsid","volume":"198","author":"Strassheim","year":"1994","journal-title":"Virology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1128\/jvi.69.8.4702-4710.1995","article-title":"Evolution of the feline-subgroup parvoviruses and the control of canine host range in vivo","volume":"69","author":"Truyen","year":"1995","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/38.6.2186090","article-title":"Immunolocalization of transferrin and transferrin receptor in mouse small intestinal absorptive cells","volume":"38","author":"Levine","year":"1990","journal-title":"J. Histochem. Cytochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e0009324","DOI":"10.1128\/jvi.00093-24","article-title":"Novel mutation N588 residue in the NS1 protein of feline parvovirus greatly augments viral replication","volume":"98","author":"Li","year":"2024","journal-title":"J. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13015","DOI":"10.1128\/JVI.01703-07","article-title":"Replication initiator protein NS1 of the parvovirus minute virus of mice binds to modular divergent sites distributed throughout duplex viral DNA","volume":"81","author":"Cotmore","year":"2007","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Garigliany, M., Gilliaux, G., Jolly, S., Casanova, T., Bayrou, C., Gommeren, K., Fett, T., Mauroy, A., Levy, E., and Cassart, D. (2016). Feline panleukopenia virus in cerebral neurons of young and adult cats. BMC Vet. Res., 12.","DOI":"10.1186\/s12917-016-0657-0"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.anireprosci.2019.06.012","article-title":"Passive immune transfer in puppies","volume":"207","author":"Chastant","year":"2019","journal-title":"Anim. Reprod. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/viro.1996.0186","article-title":"Raccoon poxvirus feline panleukopenia virus VP2 recombinant protects cats against FPV challenge","volume":"218","author":"Hu","year":"1996","journal-title":"Virology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/S0264-410X(97)00062-5","article-title":"Raccoon poxvirus live recombinant feline panleukopenia virus VP2 and rabies virus glycoprotein bivalent vaccine","volume":"15","author":"Hu","year":"1997","journal-title":"Vaccine"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1128\/JVI.76.4.1884-1891.2002","article-title":"The VP1 N-terminal sequence of canine parvovirus affects nuclear transport of capsids and efficient cell infection","volume":"76","author":"Wang","year":"2002","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1128\/JVI.73.3.1974-1979.1999","article-title":"Generation of neutralizing human monoclonal antibodies against parvovirus B19 proteins","volume":"73","author":"Gigler","year":"1999","journal-title":"J. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF01315223","article-title":"Antigenic relationships between canine parvovirus type 2, feline panleukopenia virus and mink enteritis virus using conventional antisera and monoclonal antibodies","volume":"72","author":"Parrish","year":"1982","journal-title":"Arch. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/jsap.13718","article-title":"2024 guidelines for the vaccination of dogs and cats\u2014Compiled by the Vaccination Guidelines Group (VGG) of the World Small Animal Veterinary Association (WSAVA)","volume":"65","author":"Squires","year":"2024","journal-title":"J. Small Anim. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Vaccination Guidelines Group, Day, M.J., Horzinek, M.C., and Schultz, R.D. (2010). WSAVA guidelines for the vaccination of dogs and cats. J. Small Anim. Pract., 51, e1\u2013e32.","DOI":"10.1111\/j.1748-5827.2010.00959a.x"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Nakarin, F., and Sprenger, K.G. (2025). A paradigm shift in simulating affinity maturation to elicit broadly neutralizing antibodies. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1627674"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Saha, A., Ghosh Roy, S., Dwivedi, R., Tripathi, P., Kumar, K., Nambiar, S.M., and Pathak, R. (2025). Beyond the Pandemic Era: Recent Advances and Efficacy of SARS-CoV-2 Vaccines Against Emerging Variants of Concern. Vaccines, 13.","DOI":"10.3390\/vaccines13040424"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1089\/08828240260066297","article-title":"A longitudinal study of cell-mediated immunity in pigs infected with porcine parvovirus","volume":"15","author":"Nielsen","year":"2002","journal-title":"Viral Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Feng, H., Hu, G.Q., Wang, H.L., Liang, M., Liang, H., Guo, H., Zhao, P., Yang, Y.J., Zheng, X.X., and Zhang, Z.F. (2014). Canine parvovirus VP2 protein expressed in silkworm pupae self-assembles into virus-like particles with high immunogenicity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0079575"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri3152","article-title":"Expanding roles for CD4(+) T cells in immunity to viruses","volume":"12","author":"Swain","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"eadl2016","DOI":"10.1126\/science.adl2016","article-title":"Interferon-gamma and infectious diseases: Lessons and prospects","volume":"384","author":"Casanova","year":"2024","journal-title":"Science"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41392-024-02005-w","article-title":"Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_72","first-page":"324","article-title":"Effect of feline panleukopenia virus infection on development of humoral and cellular immunity","volume":"66","author":"Schultz","year":"1976","journal-title":"Cornell Vet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/iai.7.4.547-549.1973","article-title":"Absence of an immune response after oral administration of attenuated feline panleukopenia virus","volume":"7","author":"Schultz","year":"1973","journal-title":"Infect. Immun."},{"key":"ref_74","first-page":"643","article-title":"Preparation of the vaccine with inactivated Feline Panleukopenia Virus isolated from tiger and the preliminary application","volume":"49","author":"Yu","year":"2009","journal-title":"Wei Sheng Wu Xue Bao"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri2368","article-title":"The known unknowns of antigen processing and presentation","volume":"8","author":"Vyas","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/(SICI)1521-4141(199804)28:04<1401::AID-IMMU1401>3.0.CO;2-M","article-title":"A recombinant virus-like particle system derived from parvovirus as an efficient antigen carrier to elicit a polarized Th1 immune response without adjuvant","volume":"28","author":"Rueda","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.chom.2025.03.004","article-title":"Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis","volume":"33","author":"Lisicka","year":"2025","journal-title":"Cell Host Microbe"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/CVI.05204-11","article-title":"Immunogenicity of recombinant classic swine fever virus CD8(+) T lymphocyte epitope and porcine parvovirus VP2 antigen coexpressed by Lactobacillus casei in swine via oral vaccination","volume":"18","author":"Xu","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.4049\/jimmunol.179.11.7751","article-title":"Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer\u2019s patches with restriction to mucosal compartment","volume":"179","author":"Kadaoui","year":"2007","journal-title":"J. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.4049\/jimmunol.172.5.3026","article-title":"Targeting of secretory IgA to Peyer\u2019s patch dendritic and T cells after transport by intestinal M cells","volume":"172","author":"Rey","year":"2004","journal-title":"J. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1016\/S0264-410X(03)00342-6","article-title":"Mechanisms by which maternal antibodies influence infant vaccine responses: Review of hypotheses and definition of main determinants","volume":"21","author":"Siegrist","year":"2003","journal-title":"Vaccine"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wu, H., Qiao, P., Chen, Y., Liu, C., Huo, N., Ding, H., Wang, X., Wang, L., Xi, X., and Liu, Y. (2024). Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine. Front. Vet. Sci., 11.","DOI":"10.3389\/fvets.2024.1516850"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Spiri, A.M., Novacco, M., Meli, M.L., Stirn, M., Riond, B., Fogle, J.E., Boretti, F.S., Herbert, I., Hosie, M.J., and Hofmann-Lehmann, R. (2021). Modified-Live Feline Calicivirus Vaccination Elicits Cellular Immunity against a Current Feline Calicivirus Field Strain in an Experimental Feline Challenge Study. Viruses, 13.","DOI":"10.3390\/v13091736"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1177\/1098612X18816463","article-title":"Antibody response to feline panleukopenia virus vaccination in cats with asymptomatic retrovirus infections: A pilot study","volume":"21","author":"Bergmann","year":"2019","journal-title":"J. Feline Med. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2460\/javma.1999.214.01.67","article-title":"Outbreak of fatal salmonellosis in cats following use of a high-titer modified-live panleukopenia virus vaccine","volume":"214","author":"Foley","year":"1999","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jsap.12431","article-title":"Vaccination Guidelines Group (VGG) of the World Small Animal Veterinary Association (WSAVA). WSAVA Guidelines for the vaccination of dogs and cats","volume":"57","author":"Day","year":"2016","journal-title":"J. Small Anim. Pract."},{"key":"ref_87","first-page":"701","article-title":"Antibody and cell mediated immune responses to an inactivated feline panleukopenia virus vaccine","volume":"34","author":"Tham","year":"1987","journal-title":"Zentralbl. Vet. B"},{"key":"ref_88","first-page":"16","article-title":"Dog response to inactivated canine parvovirus and feline panleukopenia virus vaccines","volume":"72","author":"Pollock","year":"1982","journal-title":"Cornell Vet."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Hartmann, K., Mostl, K., Lloret, A., Thiry, E., Addie, D.D., Belak, S., Boucraut-Baralon, C., Egberink, H., Frymus, T., and Hofmann-Lehmann, R. (2022). Vaccination of Immunocompromised Cats. Viruses, 14.","DOI":"10.3390\/v14050923"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2460\/ajvr.1999.60.05.652","article-title":"Long-term immunity in cats vaccinated with an inactivated trivalent vaccine","volume":"60","author":"Scott","year":"1999","journal-title":"Am. J. Vet. Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Egberink, H., Frymus, T., Hartmann, K., Mostl, K., Addie, D.D., Belak, S., Boucraut-Baralon, C., Hofmann-Lehmann, R., Lloret, A., and Marsilio, F. (2022). Vaccination and Antibody Testing in Cats. Viruses, 14.","DOI":"10.3390\/v14081602"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1024\/0036-7281\/a000032","article-title":"Feline vaccination protocols: Is a consensus emerging?","volume":"152","author":"Sparkes","year":"2010","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.rvsc.2012.01.017","article-title":"Immunogenicity of a DNA-launched replicon-based canine parvovirus DNA vaccine expressing VP2 antigen in dogs","volume":"93","author":"Dahiya","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Zhao, C., Ao, Z., and Yao, X. (2016). Current Advances in Virus-like Particles as a Vaccination Approach against HIV Infection. Vaccines, 4.","DOI":"10.3390\/vaccines4010002"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-065X.2010.00980.x","article-title":"DNA vaccines: An historical perspective and view to the future","volume":"239","author":"Liu","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1126\/science.1690918","article-title":"Direct gene transfer into mouse muscle in vivo","volume":"247","author":"Wolff","year":"1990","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"102628","DOI":"10.1016\/j.omtn.2025.102628","article-title":"Thermostable unit solid dose formulations for subcutaneous administration of DNA vaccines","volume":"36","author":"Yeow","year":"2025","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"40039","DOI":"10.1038\/s41598-025-23919-7","article-title":"Bivalent SARS-CoV-2 spike immunization with non-replicative antibiotic resistance-free DNA vaccine induces immunity to multiple virus variants","volume":"15","author":"Larraga","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.0105-2896.2004.00141.x","article-title":"The processing of antigens delivered as DNA vaccines","volume":"199","author":"Howarth","year":"2004","journal-title":"Immunol. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1146\/annurev.immunol.18.1.927","article-title":"DNA vaccines: Immunology, application, and optimization","volume":"18","author":"Gurunathan","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1189\/jlb.68.6.793","article-title":"DNA vaccination: Antigen presentation and the induction of immunity","volume":"68","author":"Shedlock","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1016\/j.vaccine.2005.02.026","article-title":"A vector expressing feline mature IL-18 fused to IL-1beta antagonist protein signal sequence is an effective adjuvant to a DNA vaccine for feline leukaemia virus","volume":"23","author":"McMonagle","year":"2005","journal-title":"Vaccine"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Flingai, S., Czerwonko, M., Goodman, J., Kudchodkar, S.B., Muthumani, K., and Weiner, D.B. (2013). Synthetic DNA vaccines: Improved vaccine potency by electroporation and co-delivered genetic adjuvants. Front. Immunol., 4.","DOI":"10.3389\/fimmu.2013.00354"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S0264-410X(01)00507-2","article-title":"Protection against feline immunodeficiency virus using replication defective proviral DNA vaccines with feline interleukin-12 and -18","volume":"20","author":"Dunham","year":"2002","journal-title":"Vaccine"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Jiao, C., Zhang, H., Liu, W., Jin, H., Liu, D., Zhao, J., Feng, N., Zhang, C., and Shi, J. (2020). Construction and Immunogenicity of Virus-Like Particles of Feline Parvovirus from the Tiger. Viruses, 12.","DOI":"10.3390\/v12030315"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Ahmadivand, S., and Gomez-Casado, E. (2026). Advances in Nanoparticles as Vaccine Adjuvants. Vaccines, 14.","DOI":"10.3390\/vaccines14020159"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"121844","DOI":"10.1016\/j.carbpol.2024.121844","article-title":"The immunogenicity of p24 protein from HIV-1 virus is strongly supported and modulated by coupling with liposomes and mannan","volume":"332","author":"Zachova","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13567-025-01695-6","article-title":"Intestinal mucosal immune responses induced by oral administration of chitosan nanoparticles encapsulating the PEDV S1 protein","volume":"57","author":"Su","year":"2025","journal-title":"Vet. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ijpharm.2016.10.065","article-title":"Induction of a balanced Th1\/Th2 immune responses by co-delivery of PLGA\/ovalbumin nanospheres and CpG ODNs\/PEI-SWCNT nanoparticles as TLR9 agonist in BALB\/c mice","volume":"515","author":"Ebrahimian","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"109898","DOI":"10.1016\/j.vetmic.2023.109898","article-title":"A bacterium-like particle vaccine displaying protective feline herpesvirus 1 antigens can induce an immune response in mice and cats","volume":"287","author":"Jiao","year":"2023","journal-title":"Vet. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/jpp\/rgad089","article-title":"Engineering carrier nanoparticles with biomimetic moieties for improved intracellular targeted delivery of mRNA therapeutics and vaccines","volume":"76","author":"Puccetti","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Xu, C., Aqib, A.I., Fatima, M., Muneer, S., Zaheer, T., Peng, S., Ibrahim, E.H., and Li, K. (2024). Deciphering the Potential of Probiotics in Vaccines. Vaccines, 12.","DOI":"10.3390\/vaccines12070711"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1007\/s12602-025-10667-3","article-title":"Genetically Modified Lactic Acid Bacteria: A Promising Mucosal Delivery Vector for Vaccines","volume":"18","author":"Chowdhury","year":"2026","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1007\/s00253-016-7557-x","article-title":"Lactic acid bacteria as mucosal delivery vehicles: A realistic therapeutic option","volume":"100","author":"Wang","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.addr.2011.07.003","article-title":"Gut-associated lymphoid tissues for the development of oral vaccines","volume":"64","author":"Kunisawa","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Wang, X., Wang, L., Huang, X., Ma, S., Yu, M., Shi, W., Qiao, X., Tang, L., Xu, Y., and Li, Y. (2017). Oral Delivery of Probiotics Expressing Dendritic Cell-Targeting Peptide Fused with Porcine Epidemic Diarrhea Virus COE Antigen: A Promising Vaccine Strategy against PEDV. Viruses, 9.","DOI":"10.3390\/v9110312"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.jcpa.2007.04.019","article-title":"Vaccine safety in the neonatal period","volume":"137","author":"Day","year":"2007","journal-title":"J. Comp. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00705-012-1589-z","article-title":"Oral immunization of mice using Bifidobacterium longum expressing VP1 protein from enterovirus 71","volume":"158","author":"Yu","year":"2013","journal-title":"Arch. Virol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12934-018-0861-7","article-title":"Oral recombinant Lactobacillus vaccine targeting the intestinal microfold cells and dendritic cells for delivering the core neutralizing epitope of porcine epidemic diarrhea virus","volume":"17","author":"Ma","year":"2018","journal-title":"Microb. Cell Fact."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Vilander, A.C., Shelton, K., LaVoy, A., and Dean, G.A. (2023). Expression of E. coli FimH Enhances Trafficking of an Orally Delivered Lactobacillus acidophilus Vaccine to Immune Inductive Sites via Antigen-Presenting Cells. Vaccines, 11.","DOI":"10.3390\/vaccines11071162"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Leontieva, G., Kramskaya, T., Gupalova, T., Bormotova, E., Desheva, Y., Korzhevsky, D., Kirik, O., Koroleva, I., Borisevitch, S., and Suvorov, A. (2024). Comparative Efficacy of Parenteral and Mucosal Recombinant Probiotic Vaccines Against SARS-CoV-2 and S. pneumoniae Infections in Animal Models. Vaccines, 12.","DOI":"10.3390\/vaccines12101195"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Lin, J., Mou, C., Zhang, S., Zhu, L., Li, Y., and Yang, Q. (2022). Immune Responses Induced by Recombinant Bacillus subtilis Expressing the PEDV Spike Protein Targeted at Microfold Cells. Vet. Sci., 9.","DOI":"10.3390\/vetsci9050211"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Liu, Y., Cao, X., Liu, H., and Zhang, W. (2025). The crosstalk between probiotics and T cell immunity. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1695840"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41586-024-08033-4","article-title":"Probiotic neoantigen delivery vectors for precision cancer immunotherapy","volume":"635","author":"Redenti","year":"2024","journal-title":"Nature"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.12938\/bmfh.2024-006","article-title":"Action and immunomodulatory mechanisms, formulations, and safety concerns of probiotics","volume":"44","author":"Ashaolu","year":"2025","journal-title":"Biosci. Microbiota Food Health"},{"key":"ref_126","first-page":"101189","article-title":"Boosting vaccine effectiveness: The groundbreaking role of probiotics","volume":"16","author":"Abavisani","year":"2024","journal-title":"J. Agric. Food Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s12602-021-09773-9","article-title":"The Role of Mucosal Immunity and Recombinant Probiotics in SARS-CoV2 Vaccine Development","volume":"13","author":"Abdolvahab","year":"2021","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Xu, R., Hong, H.A., Khandaker, S., Baltazar, M., Allehyani, N., Beentjes, D., Prince, T., Ho, Y.L., Nguyen, L.H., and Hynes, D. (2025). Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1501907"},{"key":"ref_129","first-page":"3","article-title":"Development of a recombinant Lactobacillus casei strain expressing Bovine rotavirus VP4 and VP7 proteins as an oral vaccine candidate against calf enteritis","volume":"61","author":"Atalay","year":"2026","journal-title":"Vet. Ital."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Chen, M., Cao, Z., Chen, Y., Ren, Z., Lu, S., Pu, D., Zhang, S., Zhang, G., Yang, J., and Pu, J. (2025). Immunomodulatory effects of probiotic Lactobacillus brevis ZG2488 on SARS-CoV-2 vaccine responses in mice. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1655383"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Liu, F., Chang, J., Huang, J., Liao, Y., Deng, X., Guo, T., Kong, J., and Kong, W. (2025). Surface Display of Avian H5 and H9 Hemagglutinin Antigens on Non-Genetically Modified Lactobacillus Cells for Bivalent Oral AIV Vaccine Development. Microorganisms, 13.","DOI":"10.3390\/microorganisms13071649"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Guo, T., Gao, C., Hao, J., Lu, X., Xie, K., Wang, X., Li, J., Zhou, H., Cui, W., and Shan, Z. (2022). Strategy of Developing Oral Vaccine Candidates Against Co-Infection of Porcine Diarrhea Viruses Based on a Lactobacillus Delivery System. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.872550"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Niewiesk, S. (2014). Maternal antibodies: Clinical significance, mechanism of interference with immune responses, and possible vaccination strategies. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00446"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Jenkins, E., Davis, C., Carrai, M., Ward, M.P., O\u2019Keeffe, S., van Boeijen, M., Beveridge, L., Desario, C., Buonavoglia, C., and Beatty, J.A. (2020). Feline Parvovirus Seroprevalence Is High in Domestic Cats from Disease Outbreak and Non-Outbreak Regions in Australia. Viruses, 12.","DOI":"10.3390\/v12030320"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Su, X., Zhou, H., Jiang, W., Xu, F., Xiao, B., Zhang, J., Qi, Q., and Yang, B. (2026). Isolation and evolutionary analysis of feline panleukopenia virus strains FPV-BJ-J2 and FPV-BJ-J3 (T440A, N564S, A568G) in Beijing, China. Front. Vet. Sci., 13.","DOI":"10.3389\/fvets.2026.1745551"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Safwat, M.S., Xi, C., El-Sayed M, S., Anwer, A.Z., Ali, M.E., Abdallah, E.S.A., Amer, H.M., Saeed, O.S., Khalil, G.M., and Abdelhaleem, S.W. (2025). Emergence, surge, and fading of the novel feline parvovirus Thr390Ala mutant in Egyptian cats during 2023: Insights from a comprehensive full-length VP2 genetic analysis. BMC Vet. Res., 21.","DOI":"10.1186\/s12917-025-05004-3"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/7\/750\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:10:35Z","timestamp":1783419035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/7\/750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":136,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["v18070750"],"URL":"https:\/\/doi.org\/10.3390\/v18070750","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]}}}