{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:45:50Z","timestamp":1792032350499,"version":"4.4.0"},"reference-count":136,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Bundibugyo virus disease, caused by Bundibugyo virus (Orthoebolavirus bundibugyoense), is a severe human Ebola disease with substantial mortality, unresolved reservoir ecology, limited diagnostic implementation, and no licensed vaccines or therapeutics specifically approved for this Orthoebolavirus species. The May 2026 public health emergency in the Democratic Republic of the Congo and Uganda renewed the need for a focused synthesis of Bundibugyo virus-specific diagnostics and medical countermeasures. This review synthesizes the peer-reviewed literature, preprints, and official public-health documents on diagnostics, antivirals, therapeutics, vaccines, and post-exposure prophylaxis. Comparative evidence from the Ebola virus, Sudan virus, Marburg virus, and pan-filovirus platforms is included only where it clarifies Bundibugyo virus-specific evidence, exposes unsupported extrapolation, or defines preparedness gaps. The 2007\u20132008 outbreak showed that assays optimized for known filoviruses can miss divergent ebolaviruses; the 2026 outbreak underscored the importance of diagnostic breadth, sequencing-based confirmation, decentralized laboratory capacity, and regional coordination. Clinical and immunological data indicate that Bundibugyo virus cannot be reduced to an Ebola virus-like model. Countermeasure evidence remains largely preclinical: recombinant vesicular stomatitis virus vaccines expressing Bundibugyo virus glycoprotein provide the strongest direct animal protection data, whereas antiviral and antibody-based evidence varies widely and requires careful separation of direct Bundibugyo virus data from platform-based extrapolation.<\/jats:p>","DOI":"10.3390\/v18070775","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:08:34Z","timestamp":1784189314000},"page":"775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bundibugyo Virus Disease: Diagnostics and Medical Countermeasures for a Neglected Ebolavirus"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7261-7470","authenticated-orcid":false,"given":"Katharina","family":"Kopp","sequence":"first","affiliation":[{"name":"One Health Pathogenomics Consulting, 80687 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"001955","DOI":"10.1099\/jgv.0.001955","article-title":"ICTV Virus Taxonomy Profile: Filoviridae 2024","volume":"105","author":"Biedenkopf","year":"2024","journal-title":"J. Gen. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41579-019-0187-4","article-title":"New filovirus disease classification and nomenclature","volume":"17","author":"Kuhn","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-020-0147-3","article-title":"Ebola virus disease","volume":"6","author":"Jacob","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Towner, J.S., Sealy, T.K., Khristova, M.L., Albari\u00f1o, C.G., Conlan, S., Reeder, S.A., Quan, P.L., Lipkin, W.I., Downing, R., and Tappero, J.W. (2008). Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000212"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3201\/eid1607.091525","article-title":"Ebola hemorrhagic fever associated with novel virus strain, Uganda, 2007\u20132008","volume":"16","author":"Wamala","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Roddy, P., Howard, N., Van Kerkhove, M.D., Lutwama, J., Wamala, J., Yoti, Z., Colebunders, R., Palma, P.P., Sterk, E., and Jeffs, B. (2012). Clinical manifestations and case management of Ebola haemorrhagic fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007\u20132008. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052986"},{"key":"ref_7","unstructured":"Centers for Disease Control and Prevention (2026, May 20). Outbreak History, Available online: https:\/\/www.cdc.gov\/ebola\/outbreaks\/index.html."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3201\/eid1612.100627","article-title":"Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda","volume":"16","author":"MacNeil","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.virol.2013.04.014","article-title":"Genomic analysis of filoviruses associated with four viral hemorrhagic fever outbreaks in Uganda and the Democratic Republic of the Congo in 2012","volume":"442","author":"Shoemaker","year":"2013","journal-title":"Virology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kratz, T., Roddy, P., Tshomba Oloma, A., Jeffs, B., Pou Ciruelo, D., de la Rosa, O., and Borchert, M. (2015). Ebola virus disease outbreak in Isiro, Democratic Republic of the Congo, 2012: Signs and symptoms, management and outcomes. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129333"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100351","DOI":"10.1016\/j.xcrm.2021.100351","article-title":"Molecular analysis of the 2012 Bundibugyo virus disease outbreak","volume":"2","author":"Hulseberg","year":"2021","journal-title":"Cell Rep. Med."},{"key":"ref_12","unstructured":"World Health Organization (2026, May 19). Disease Outbreak News: Ebola Disease Caused by Bundibugyo Virus\u2014Democratic Republic of the Congo and Uganda. Available online: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2026-DON602."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/femsre\/fuw010","article-title":"Neglected filoviruses","volume":"40","author":"Burk","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41579-020-0354-7","article-title":"Viral genomics in Ebola virus research","volume":"18","author":"Zeng","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41541-024-00985-y","article-title":"Filovirus vaccines as a response paradigm for emerging infectious diseases","volume":"9","author":"Marzi","year":"2024","journal-title":"npj Vaccines"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/21505594.2021.1898169","article-title":"Pathogenicity and virulence of ebolaviruses with species- and variant-specificity","volume":"12","author":"Yamaoka","year":"2021","journal-title":"Virulence"},{"key":"ref_17","unstructured":"Minist\u00e8re de la Sant\u00e9 Publique, Hygi\u00e8ne et Pr\u00e9voyance Sociale, R\u00e9publique D\u00e9mocratique du Congo (2026, July 12). D\u00e9claration de la 17\u00e8me \u00c9pid\u00e9mie de la Maladie \u00e0 Virus Ebola dans les Zones de Sant\u00e9 de Rwampara, Mongbwalu et Bunia dans la Province d\u2019Ituri, Available online: https:\/\/administration.sante.gouv.cd\/wp-content\/uploads\/2026\/05\/Declaration-de-la-17e-Epidemie-de-la-maladie-a-virus-Ebola-dans-les-zones-de-sante-de-Rwampara-Mongwalu-et-Bunia-dans-la-province-dIturi.pdf."},{"key":"ref_18","unstructured":"World Health Organization (2026, May 19). Epidemic of Ebola Disease Caused by Bundibugyo Virus in the Democratic Republic of the Congo and Uganda Determined a Public Health Emergency of International Concern. Available online: https:\/\/www.who.int\/news\/item\/17-05-2026-epidemic-of-ebola-disease-in-the-democratic-republic-of-the-congo-and-uganda-determined-a-public-health-emergency-of-international-concern."},{"key":"ref_19","unstructured":"Centers for Disease Control and Prevention (2026, May 19). Ebola Disease: Current Situation, Available online: https:\/\/www.cdc.gov\/ebola\/situation-summary\/index.html."},{"key":"ref_20","unstructured":"Rigby, J., and Le Poidevin, O. (2026, May 20). Ebola Likely Circulating in Congo for Two Months, Outbreak to Grow, WHO Says. Reuters. Available online: https:\/\/www.reuters.com\/business\/healthcare-pharmaceuticals\/who-says-139-suspected-ebola-deaths-congo-outbreak-numbers-expected-rise."},{"key":"ref_21","unstructured":"Africa Centres for Disease Control and Prevention (2026, May 19). Africa CDC Calls Urgent Regional Coordination Meeting Following Ebola Outbreak in Ituri Province, DRC. Available online: https:\/\/africacdc.org\/news-item\/africa-cdc-calls-for-urgent-regional-coordination-meeting-following-ebola-virus-disease-outbreak-in-ituri-province-drc\/."},{"key":"ref_22","unstructured":"BEACON (2026, May 20). Bundibugyo Virus Disease Outbreak, DRC, Uganda, and South Sudan: Nearly 600 Suspected Cases Reported; Suspected Case Under Investigation in South Sudan; Investigational Vaccine and Therapeutic Discussions Ongoing. BEACON. Available online: https:\/\/beaconbio.org\/en\/report\/?reportid=0dcdca95-b232-4565-a660-f9a608581e5c&eventid=1a9a0ef4-262f-45a1-9018-aa8f99d93a7c."},{"key":"ref_23","unstructured":"World Health Organization (2026, June 07). Experts Convened by WHO Advise on Candidate Treatments and Vaccines for Ebola Disease Caused by Bundibugyo Virus. Available online: https:\/\/www.who.int\/news\/item\/28-05-2026-experts-convened-by-who-advise-on-candidate-treatments-and-vaccines-for-ebola-disease-caused-by-bundibugyo-virus."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pinsky, B.A., Sahoo, M.K., Sandlund, J., Kleman, M., Kulkarni, M., Grufman, P., Nygren, M., Kwiatkowski, R., Baron, E.J., and Tenover, F. (2015). Analytical performance characteristics of the Cepheid GeneXpert Ebola assay for the detection of Ebola virus. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142216"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Semper, A.E., Broadhurst, M.J., Richards, J., Foster, G.M., Simpson, A.J., Logue, C.H., Kelly, J.D., Miller, A., Brooks, T.J., and Murray, M. (2016). Performance of the GeneXpert Ebola assay for diagnosis of Ebola virus disease in Sierra Leone: A field evaluation study. PLoS Med., 13.","DOI":"10.1371\/journal.pmed.1001980"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S1473-3099(15)70152-0","article-title":"Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: A retrospective cohort study","volume":"15","author":"Clark","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101685","DOI":"10.1016\/j.nmni.2025.101685","article-title":"Resilience and residuals beyond containment\u2014The hidden burden of Bundibugyo Ebola virus survivorship sixteen years on: A cross-sectional observational study","volume":"69","author":"Kaweesa","year":"2025","journal-title":"New Microbes New Infect."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5350769","DOI":"10.1155\/2024\/5350769","article-title":"Experimental infection of Bundibugyo virus in domestic swine leads to viral shedding with evidence of intraspecies transmission","volume":"2024","author":"Lewis","year":"2024","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2011.11.027","article-title":"Serology and cytokine profiles in patients infected with the newly discovered Bundibugyo ebolavirus","volume":"423","author":"Gupta","year":"2012","journal-title":"Virology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e01517-21","DOI":"10.1128\/mBio.01517-21","article-title":"Bundibugyo ebolavirus survival is associated with early activation of adaptive immunity and reduced myeloid-derived suppressor cell signaling","volume":"12","author":"Woolsey","year":"2021","journal-title":"mBio"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1128\/JVI.01033-16","article-title":"Ferrets infected with Bundibugyo virus or Ebola virus recapitulate important aspects of human filovirus disease","volume":"90","author":"Kozak","year":"2016","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Marzi, A. (2025). One-for-one or one-for-all? Considerations for filovirus vaccine development. PLoS Biol., 23.","DOI":"10.1371\/journal.pbio.3003142"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jcv.2018.03.005","article-title":"The current landscape of nucleic acid tests for filovirus detection","volume":"103","author":"Clark","year":"2018","journal-title":"J. Clin. Virol."},{"key":"ref_34","unstructured":"World Health Organization (2024). Diagnostic Testing for Ebola and Marburg Virus Diseases: Interim Guidance, 20 December 2024, World Health Organization."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kopp, K., Smith, I., Klein, R., Todd, S., Marsh, G.A., and Ward, A.C. (2019). Pan-filovirus one-step reverse transcription-polymerase chain reaction screening assay. bioRxiv.","DOI":"10.1101\/579458"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.1086\/520600","article-title":"Diagnostic reverse-transcription polymerase chain reaction kit for filoviruses based on the strain collections of all European biosafety level 4 laboratories","volume":"196","author":"Panning","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jviromet.2010.11.010","article-title":"Detection of all known filovirus species by reverse transcription-polymerase chain reaction using a primer set specific for the viral nucleoprotein gene","volume":"171","author":"Ogawa","year":"2011","journal-title":"J. Virol. Methods"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1093\/infdis\/jiw246","article-title":"Evaluation of RealStar reverse transcription-polymerase chain reaction kits for filovirus detection in the laboratory and field","volume":"214","author":"Rieger","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Coertse, J., Mortlock, M., Grobbelaar, A., Moolla, N., Markotter, W., and Weyer, J. (2023). Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats. Viruses, 15.","DOI":"10.3390\/v15040987"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e0101024","DOI":"10.1128\/spectrum.01010-24","article-title":"A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses","volume":"12","author":"Cui","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"ref_41","unstructured":"altona Diagnostics GmbH (2021). RealStar\u00ae Filovirus Screen RT-PCR Kit 1.0 Instructions for Use (Version 08\/2021 EN), altona Diagnostics GmbH. Available online: https:\/\/altona-diagnostics.com\/wp-content\/uploads\/2023\/12\/RealStar-Filovirus-Screen-RT-PCR-Kit-1.0_WEB_CE_EN-S06.pdf."},{"key":"ref_42","unstructured":"World Health Organization (2026, July 08). WHO EUAL Public Report: EVD IVD Product RealStar\u00ae Filovirus Screen RT-PCR Kit 1.0, EAE 0425-153-00. Amended 31 January 2019. Available online: https:\/\/extranet.who.int\/prequal\/key-resources\/documents\/who-eual-public-report-evd-ivd-product-realstarr-filovirus-screen-rt-pcr."},{"key":"ref_43","unstructured":"World Health Organization (2026). Bundibugyo Virus (BDBV) Nucleic Acid Detection Tests: Ongoing EUL Applications, WHO. Available online: https:\/\/extranet.who.int\/prequal\/sites\/default\/files\/document_files\/EUL%20IVDs%20BDBV_status%20ongoing%20applications.pdf."},{"key":"ref_44","unstructured":"Amuri-Aziza, A., Adroba Tandele, P., Luakanda-Ndelemo, G., Kinganda-Lusamaki, E., Lola-Loway, M., Djemba-Fundji, B., Ola-Mpumbe, R., Cikaya-Kankolongo, F., Paku-Tshambu, P., and Muswamba-Kayembe, P.-C. (2026, May 31). Initial Genomes from May 2026 Bundibugyo Virus Disease Outbreak in the Democratic Republic of the Congo and Uganda Reveal a New Spillover Event. Virological.org 2026. Available online: https:\/\/virological.org\/t\/initial-genomes-from-may-2026-bundibugyo-virus-disease-outbreak-in-the-democratic-republic-of-the-congo-and-uganda\/1032."},{"key":"ref_45","unstructured":"altona Diagnostics GmbH (2026, July 08). RealStar\u00ae Ebolavirus RT-PCR Kit 1.0 Instructions for Use (Version 05\/2020), Available online: https:\/\/www.fda.gov\/media\/120430\/download."},{"key":"ref_46","unstructured":"U.S. Food and Drug Administration (2026, July 08). RealStar Ebolavirus RT-PCR Kit 1.0 (altona Diagnostics GmbH), Emergency Use Authorization; Initial Issuance 10 November 2014, reissued 26 November 2014, Available online: https:\/\/www.fda.gov\/media\/123410\/download?attachment."},{"key":"ref_47","unstructured":"Africa Centres for Disease Control and Prevention (Africa CDC) (2026). Molecular Diagnostic Tests (RT-PCR) for Ebola Virus Bundibugyo Strain, Africa CDC. Available online: https:\/\/africacdc.org\/download\/molecular-diagnostic-tests-rt-pcr-for-ebola-virus-bundibugyo-strain\/."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4269\/ajtmh.2010.09-0636","article-title":"Comprehensive panel of real-time TaqMan polymerase chain reaction assays for detection and absolute quantification of filoviruses, arenaviruses, and New World hantaviruses","volume":"82","author":"Trombley","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lin, X., Jin, X., Xu, B., Wang, R., Fu, R., Su, Y., Jiang, K., Yang, H., Lu, Y., and Guo, Y. (2019). Fast and parallel detection of four Ebola virus species on a microfluidic-chip-based portable reverse transcription loop-mediated isothermal amplification system. Micromachines, 10.","DOI":"10.3390\/mi10110777"},{"key":"ref_50","unstructured":"altona Diagnostics GmbH (2021). RealStar\u00ae Filovirus Type RT-PCR Kit 2.0 Instructions for Use (Version 03\/2021 EN), altona Diagnostics GmbH. Available online: https:\/\/altona-diagnostics.com\/wp-content\/uploads\/2023\/12\/RealStar-Filovirus-Type-2.0_INS-452000-EN-S01_WEB.pdf."},{"key":"ref_51","unstructured":"altona Diagnostics GmbH (2026, July 08). altona Diagnostics Filovirus PCR Kits Detect Current Bundibugyo Ebolavirus Variant. Available online: https:\/\/altona-diagnostics.com\/altona-diagnostics-filovirus-pcr-kits-detect-current-bundibugyo-ebolavirus-variant\/."},{"key":"ref_52","unstructured":"International Pandemic Preparedness Secretariat (2026, July 09). Ebola (Bundibugyo) Day 15: The Status of Diagnostics, Investigational Therapeutics and Vaccines. Available online: https:\/\/ippsecretariat.org\/news\/day-15-ebola-bdbv-2026\/."},{"key":"ref_53","unstructured":"U.S. Food and Drug Administration (2026, July 08). BioFire Global Fever Special Pathogens Panel 510(k) Summary (K213362), Available online: https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf21\/K213362.pdf."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"ofad500.142","DOI":"10.1093\/ofid\/ofad500.142","article-title":"Clinical Evaluation of the BioFire\u00ae Global Fever Special Pathogens Panel","volume":"10","author":"Collins","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"ref_55","unstructured":"U.S. Food and Drug Administration (FDA) (2026, July 08). Xpert\u00ae Hemorrhagic Fever Test 510(k) Premarket Notification (Decision K253653), Available online: https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfPMN\/pmn.cfm?ID=K253653."},{"key":"ref_56","unstructured":"Cepheid Editorial Team (2026, July 08). Ebola Outbreak 2026: Closing Critical Diagnostic Gaps. Available online: https:\/\/www.cepheid.com\/en-US\/insights\/insight-hub\/community-and-global-health\/2026\/06\/ebola-outbreak-2026-closing-critical-diagnostic-gaps.html."},{"key":"ref_57","unstructured":"KH Medical Co., Ltd. (2024). RADIONE Ebola Detection Kit (Cat No. RP017) Product Manual, KH Medical Co., Ltd.. Available online: https:\/\/www.khmedical.co.kr\/eng\/products\/detail\/index.jsp?no=137."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Wawina-Bokalanga, T., Amuri-Aziza, A., Vercauteren, K., Mukadi-Bamuleka, D., Ngandu, C., Kindrachuk, J., Akilimali, P., Muyembe-Tamfum, J.J., Mbala-Kingebeni, P., and Ebola Research and Response Team (2026). Diagnostic performance of RADIONE for diagnosis of BDBV. Lancet Infect. Dis.","DOI":"10.1016\/S1473-3099(26)00321-X"},{"key":"ref_59","unstructured":"KH Medical Co., Ltd. (2024). RADIONE Pan-Ebola Genotyping & Marburg Multiplex Kit (Cat No. RP038) Product Manual, KH Medical Co., Ltd.. Available online: https:\/\/www.khmedical.co.kr\/eng\/products\/detail\/index.jsp?no=149."},{"key":"ref_60","unstructured":"Shanghai ZJ Bio-Tech Co., Ltd. (2025). Ebola Virus (EBOV) Real Time RT-PCR Kit Instructions for Use (Product Code: QR-0220-02), Rev. ZJ0003, Shanghai ZJ Bio-Tech Co., Ltd.. Available online: https:\/\/extranet.who.int\/prequal\/sites\/default\/files\/document_files\/IFU_Liferiver%20Ebola%20Kit%2C%20%28EUL%2014468-139-00%29.pdf."},{"key":"ref_61","unstructured":"World Health Organization (2026, July 07). WHO Lists the First BDBV Test Under Its EUL Procedure. Available online: https:\/\/extranet.who.int\/prequal\/news\/who-lists-first-bdbv-test-under-its-eul-procedure."},{"key":"ref_62","unstructured":"World Health Organization (2026). WHO Emergency Use List: Bundibugyo Virus (BDBV) Nucleic Acid Detection Tests, WHO. Available online: https:\/\/extranet.who.int\/prequal\/sites\/default\/files\/document_files\/EUL%20BDBV_List%20of%20BDBV%20IVDs.pdf."},{"key":"ref_63","unstructured":"World Health Organization (2020). Amended Public Report for Liferiver\u2122\u2014Ebola Virus (EBOV) Real Time RT-PCR Kit (EAE 0432-139-00), WHO. Available online: https:\/\/cdn.who.int\/media\/docs\/default-source\/in-vitro-diagnostics\/ebola\/190122-eae-0432-139-00-pqpr-v2-incl-ifu.pdf?sfvrsn=6f7e5a21_2&download=true."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature16996","article-title":"Real-time, portable genome sequencing for Ebola surveillance","volume":"530","author":"Quick","year":"2016","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Kopp, K. (2026). Whole-Genome Sequencing for High-Consequence Emerging RNA Viruses: Strategy Selection for Bundibugyo Virus Disease Under 2026 Outbreak Constraints. Viruses, 18.","DOI":"10.20944\/preprints202606.0426.v1"},{"key":"ref_67","unstructured":"International Pandemic Preparedness Secretariat (2026, July 09). Ebola (Bundibugyo) Day 45: Tracking Progress on Medical Countermeasures. Available online: https:\/\/ippsecretariat.org\/news\/ebola-bundibugyo-day-45-tracking-progress-on-medical-countermeasures\/."},{"key":"ref_68","unstructured":"World Health Organization (2026, July 09). Bundibugyo Virus Disease PHEIC: Emergency Use Listing Procedure (EUL) for IVDs. Available online: https:\/\/extranet.who.int\/prequal\/vitro-diagnostics\/bundibugyo-virus-disease-pheic-emergency-use-listing-procedure-eul-ivds."},{"key":"ref_69","unstructured":"U.S. Food and Drug Administration (2026, July 09). Evaluation of Automatic Class III Designation for OraQuick Ebola Rapid Antigen Test: Decision Summary DEN190025, Available online: https:\/\/www.accessdata.fda.gov\/cdrh_docs\/reviews\/DEN190025.pdf."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wang, Z., Bennett, R.S., Roehler, M., Guillon, G., Fischl, M.J., Donadi, M.C., Makovetz, J., Holmes, N., Zaveri, T., and Toolan, E. (2023). Development and clinical evaluation of a rapid point-of-care test for Ebola virus infection in humans. Viruses, 15.","DOI":"10.3390\/v15020336"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"104568","DOI":"10.1016\/j.ebiom.2023.104568","article-title":"Head-to-head comparison of diagnostic accuracy of four Ebola virus disease rapid diagnostic tests versus GeneXpert\u00ae in eastern Democratic Republic of the Congo outbreaks: A prospective observational study","volume":"91","author":"Jacobs","year":"2023","journal-title":"eBioMedicine"},{"key":"ref_72","unstructured":"World Health Organization (2026, May 19). CORC Filovirus Research & Development Roadmap. Available online: https:\/\/cdn.who.int\/media\/docs\/default-source\/consultation-rdb\/corc-filovirus-roadmap.pdf?download=true&sfvrsn=7dd4fa_1."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e00643-21","DOI":"10.1128\/JVI.00643-21","article-title":"Comparison of Zaire and Bundibugyo ebolavirus polymerase complexes and susceptibility to antivirals through a newly developed Bundibugyo minigenome system","volume":"95","author":"Levine","year":"2021","journal-title":"J. Virol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature17180","article-title":"Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys","volume":"531","author":"Warren","year":"2016","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"26946","DOI":"10.1073\/pnas.2012294117","article-title":"Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases","volume":"117","author":"Lo","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"eadk6176","DOI":"10.1126\/science.adk6176","article-title":"Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus","volume":"383","author":"Cross","year":"2024","journal-title":"Science"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41591-025-03496-y","article-title":"Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates","volume":"31","author":"Cross","year":"2025","journal-title":"Nat. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"eadw0659","DOI":"10.1126\/sciadv.adw0659","article-title":"The oral drug obeldesivir protects nonhuman primates against lethal Ebola virus infection","volume":"11","author":"Woolsey","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_79","unstructured":"Island Pharmaceuticals Ltd (2026, July 09). Government Approvals Secured for the Use of Galidesivir as a Treatment for Bundibugyo Ebola Epidemic in Africa. ASX Announcement, 7 July 2026. Available online: https:\/\/announcements.asx.com.au\/asxpdf\/20260707\/pdf\/071g0w0swy8rq6.pdf."},{"key":"ref_80","unstructured":"BiotechDispatch (2026, July 09). Uganda Approves Galidesivir for Compassionate Use Amid Bundibugyo Ebola Outbreak. Available online: https:\/\/biotechdispatch.com.au\/news\/uganda-approves-galidesivir-for-compassionate-use-amid-bundibugyo-ebola-outbreak."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jiph.2016.04.002","article-title":"BCX4430: A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease","volume":"9","author":"Taylor","year":"2016","journal-title":"J. Infect. Public Health"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"S302","DOI":"10.1093\/ofid\/ofx163.697","article-title":"Efficacy of galidesivir against Ebola virus disease in rhesus monkeys","volume":"4","author":"Warren","year":"2017","journal-title":"Open Forum Infect. Dis."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Comer, J.E., Escaffre, O., Neef, N., Brasel, T., Juelich, T.L., Smith, J.K., Smith, J., Kalveram, B., Perez, D.D., and Massey, S. (2019). Filovirus virulence in interferon \u03b1\/\u03b2 and \u03b3 double knockout mice, and treatment with favipiravir. Viruses, 11.","DOI":"10.3390\/v11020137"},{"key":"ref_84","unstructured":"U.S. Food and Drug Administration (2026, June 08). VEKLURY (Remdesivir) for Injection, for Intravenous Use: Prescribing Information, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/214787s030lbl.pdf."},{"key":"ref_85","unstructured":"European Medicines Agency (2026, June 08). Veklury. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/veklury."},{"key":"ref_86","unstructured":"Pharmaceuticals and Medical Devices Agency (2026, June 08). Avigan Tablet 200 mg: Report on the Deliberation Results. Available online: https:\/\/www.pmda.go.jp\/files\/000210319.pdf."},{"key":"ref_87","unstructured":"Central Drugs Standard Control Organisation (2026, June 08). List of New Drugs Approved in the Year 2020 till Date, Available online: https:\/\/cdsco.gov.in\/opencms\/resources\/UploadCDSCOWeb\/2018\/UploadApprovalNewDrugs\/newdrugs%20approval%20july2020.pdf."},{"key":"ref_88","unstructured":"Gilead Sciences (2026, July 09). Neglected and Emerging Viruses and Pandemic Preparedness. Available online: https:\/\/www.gilead.com\/science\/therapeutic-areas\/virology\/neglected-and-emerging-viruses-and-pandemic-preparedness."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1038\/s41467-025-59168-5","article-title":"Remdesivir, mAb114, REGN-EB3, and ZMapp partially rescue nonhuman primates infected with a low-passage Kikwit variant of Ebola virus","volume":"16","author":"Prasad","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cell.2015.12.022","article-title":"Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection","volume":"164","author":"Flyak","year":"2016","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1038\/s41467-019-09732-7","article-title":"Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk","volume":"10","author":"King","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"113254","DOI":"10.1016\/j.celrep.2023.113254","article-title":"Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2\/tetherin","volume":"42","author":"Santos","year":"2023","journal-title":"Cell Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"S565","DOI":"10.1093\/infdis\/jiy295","article-title":"Efficacy of human monoclonal antibody monotherapy against Bundibugyo virus infection in nonhuman primates","volume":"218","author":"Gilchuk","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_94","first-page":"S418","article-title":"Ebolavirus chimerization for the development of a mouse model for screening of Bundibugyo-specific antibodies","volume":"218","author":"Ilinykh","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_95","first-page":"1003","article-title":"Lethal VSV-based surrogate mouse models for Sudan and Bundibugyo ebolaviruses enable antibody evaluation under BSL-2 conditions","volume":"47","author":"Zhang","year":"2026","journal-title":"Zool. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.chom.2018.12.005","article-title":"A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates","volume":"25","author":"Bornholdt","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1056\/NEJMoa1910993","article-title":"A randomized, controlled trial of Ebola virus disease therapeutics","volume":"381","author":"Mulangu","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_98","unstructured":"U.S. Food and Drug Administration (2026, June 07). INMAZEB (Atoltivimab, Maftivimab, and Odesivimab-Ebgn) Injection, for Intravenous Use: Prescribing Information, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/761169s011lbl.pdf."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.chom.2023.01.002","article-title":"Structure of the Inmazeb cocktail and resistance to Ebola virus escape","volume":"31","author":"Rayaprolu","year":"2023","journal-title":"Cell Host Microbe"},{"key":"ref_100","unstructured":"World Health Organization (2026, June 07). Sudan Ebolavirus\u2014Experts Deliberations: Candidate Treatments Prioritization and Trial Design Discussions, October & November 2022. Available online: https:\/\/cdn.who.int\/media\/docs\/default-source\/blue-print\/sudan-therapeutics-prioritization-and-trial-design-committee-summary-nov-15-2022_final-web.pdf?download=true&sfvrsn=3d04f6b6_4."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.immuni.2018.06.018","article-title":"Multifunctional pan-ebolavirus antibody recognizes a site of broad vulnerability on the ebolavirus glycoprotein","volume":"49","author":"Gilchuk","year":"2018","journal-title":"Immunity"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1016\/j.cell.2021.09.035","article-title":"Pan-ebolavirus protective therapy by two multifunctional human antibodies","volume":"184","author":"Gilchuk","year":"2021","journal-title":"Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.cell.2022.02.023","article-title":"Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses","volume":"185","author":"Milligan","year":"2022","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/JVI.02172-15","article-title":"Macaque monoclonal antibodies targeting novel conserved epitopes within filovirus glycoprotein","volume":"90","author":"Keck","year":"2016","journal-title":"J. Virol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-018-08040-w","article-title":"Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates","volume":"10","author":"Brannan","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"19193","DOI":"10.1038\/srep19193","article-title":"Bispecific antibody affords complete post-exposure protection of mice from both Ebola (Zaire) and Sudan viruses","volume":"6","author":"Frei","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"S691","DOI":"10.1093\/infdis\/jiad205","article-title":"A pan-ebolavirus monoclonal antibody cocktail provides protection against Ebola and Sudan viruses","volume":"228","author":"Liu","year":"2023","journal-title":"J. Infect. Dis."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Wirchnianski, A.S., Nyakatura, E.K., Herbert, A.S., Kuehne, A.I., Abbasi, S.A., Florez, C., Storm, N., McKay, L.G.A., Dailey, L., and Kuang, E. (2024). Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies. PLoS Pathog., 20.","DOI":"10.1371\/journal.ppat.1012134"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2668755","DOI":"10.1080\/22221751.2026.2668755","article-title":"Engineered bispecific antibodies achieve broad and potent protection against multiple ebolavirus species","volume":"15","author":"Zhou","year":"2026","journal-title":"Emerg. Microbes Infect."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2432366","DOI":"10.1080\/22221751.2024.2432366","article-title":"A pan-orthoebolavirus neutralizing antibody encoded by mRNA effectively prevents virus infection","volume":"13","author":"Fan","year":"2024","journal-title":"Emerg. Microbes Infect."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.34133\/research.1211","article-title":"Computational design of broad-spectrum Ebola antibodies through framework and complementarity-determining region synergistic optimization","volume":"9","author":"Zhang","year":"2026","journal-title":"Research"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.virs.2026.03.018","article-title":"Nanobody targeting glycan cap confers broad orthoebolavirus neutralization","volume":"41","author":"Zhang","year":"2026","journal-title":"Virol. Sin."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1038\/s41467-026-70464-6","article-title":"A highly potent nanobody-based bispecific therapeutic provides broad-spectrum protection against ebolavirus","volume":"17","author":"Wang","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41564-018-0157-z","article-title":"Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region","volume":"3","author":"Flyak","year":"2018","journal-title":"Nat. Microbiol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Murin, C.D., Gilchuk, P., Crowe, J.E., and Ward, A.B. (2022). Structural biology illuminates molecular determinants of broad ebolavirus neutralization by human antibodies for pan-ebolavirus therapeutic development. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.808047"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e01674-18","DOI":"10.1128\/mBio.01674-18","article-title":"Structural basis of pan-ebolavirus neutralization by a human antibody against a conserved, yet cryptic epitope","volume":"9","author":"West","year":"2018","journal-title":"mBio"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Schoeder, C.T., Gilchuk, P., Sangha, A.K., Ledwitch, K.V., Malherbe, D.C., Zhang, X., Binshtein, E., Williamson, L.E., Martina, C.E., and Dong, J. (2022). Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1010518"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Mire, C.E., Geisbert, J.B., Marzi, A., Agans, K.N., Feldmann, H., and Geisbert, T.W. (2013). Vesicular stomatitis virus-based vaccines protect nonhuman primates against Bundibugyo ebolavirus. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002600"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"S1082","DOI":"10.1093\/infdis\/jir350","article-title":"Single immunization with a monovalent vesicular stomatitis virus-based vaccine protects nonhuman primates against heterologous challenge with Bundibugyo ebolavirus","volume":"204","author":"Falzarano","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"S660","DOI":"10.1093\/infdis\/jiad157","article-title":"A highly attenuated panfilovirus VesiculoVax vaccine rapidly protects nonhuman primates against Marburg virus and 3 species of Ebola virus","volume":"228","author":"Woolsey","year":"2023","journal-title":"J. Infect. Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e01845-18","DOI":"10.1128\/JVI.01845-18","article-title":"Antibody-mediated protective mechanisms induced by a trivalent parainfluenza virus-vectored ebolavirus vaccine","volume":"93","author":"Kimble","year":"2019","journal-title":"J. Virol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"S648","DOI":"10.1093\/infdis\/jiad266","article-title":"A single-dose intranasal combination panebolavirus vaccine","volume":"228","author":"Malherbe","year":"2023","journal-title":"J. Infect. Dis."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"105851","DOI":"10.1016\/j.antiviral.2024.105851","article-title":"Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- and multi-valent adjuvanted glycoprotein vaccines","volume":"225","author":"Felgner","year":"2024","journal-title":"Antivir. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1038\/s41467-025-66367-7","article-title":"Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification","volume":"16","author":"Lee","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e01884-19","DOI":"10.1128\/JVI.01884-19","article-title":"A bivalent, spherical virus-like particle vaccine enhances breadth of immune responses against pathogenic Ebola viruses in rhesus macaques","volume":"94","author":"Singh","year":"2020","journal-title":"J. Virol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e2316960121","DOI":"10.1073\/pnas.2316960121","article-title":"Design of universal Ebola virus vaccine candidates via immunofocusing","volume":"121","author":"Xu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e2517814123","DOI":"10.1073\/pnas.2517814123","article-title":"Multivalent mRNA vaccine platform with compatible antigens conferred broad-spectrum protection against orthoebolaviruses\u2019 exposure","volume":"123","author":"Zhang","year":"2026","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_128","unstructured":"CEPI (2026, June 07). CEPI Fast-Tracks Three Bundibugyo Ebolavirus Vaccine Candidates. Available online: https:\/\/cepi.net\/cepi-fast-tracks-three-bundibugyo-ebolavirus-vaccine-candidates."},{"key":"ref_129","unstructured":"University of Oxford (2026, June 07). Oxford Bundibugyo Ebolavirus Vaccine Candidate Receives CEPI Backing. Available online: https:\/\/www.ox.ac.uk\/news\/2026-06-01-oxford-bundibugyo-ebolavirus-vaccine-candidate-receives-cepi-backing."},{"key":"ref_130","unstructured":"CEPI (2026, May 19). Ambitious Research to Develop Multivalent Vaccines Against Multiple Deadly Filoviruses. Available online: https:\/\/cepi.net\/ambitious-research-develop-multivalent-vaccines-against-deadly-filoviruses."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"S712","DOI":"10.1093\/infdis\/jiad207","article-title":"A recombinant vesicular stomatitis virus-based vaccine provides postexposure protection against Bundibugyo ebolavirus infection","volume":"228","author":"Woolsey","year":"2023","journal-title":"J. Infect. Dis."},{"key":"ref_132","unstructured":"Regeneron Pharmaceuticals (2026, June 07). Regeneron\u2019s Ebola Antibody Recommended by World Health Organization for Investigational Use in Response to Current Bundibugyo Ebolavirus Outbreak. Available online: https:\/\/investor.regeneron.com\/news-releases\/news-release-details\/regenerons-ebola-antibody-recommended-world-health-organization."},{"key":"ref_133","unstructured":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin (2026, June 07). Patient Discharged from Charit\u00e9\u2019s Specialized Isolation Unit. Available online: https:\/\/www.charite.de\/en\/service\/press_reports\/artikel\/detail\/patient_discharged_from_charites_special_isolation_unit."},{"key":"ref_134","unstructured":"European Medicines Agency (2026, June 07). EMA, AMA and African Regulatory Authorities Join Forces on Ebola Outbreak Response. Available online: https:\/\/www.ema.europa.eu\/en\/news\/ema-ama-african-regulatory-authorities-join-forces-ebola-outbreak-response."},{"key":"ref_135","unstructured":"WHO Regional Office for Africa (2026, May 19). Democratic Republic of the Congo Confirms New Ebola Outbreak, WHO Scales up Support. Available online: https:\/\/www.afro.who.int\/countries\/democratic-republic-of-congo\/news\/democratic-republic-congo-confirms-new-ebola-outbreak-who-scales-upsupport."},{"key":"ref_136","unstructured":"U.S. Food and Drug Administration (2026, May 19). ERVEBO (Ebola Zaire Vaccine, Live): Package Insert, Available online: https:\/\/www.fda.gov\/media\/133748\/download?attachment=."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/7\/775\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:12:28Z","timestamp":1784189548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/7\/775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":136,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["v18070775"],"URL":"https:\/\/doi.org\/10.3390\/v18070775","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]}}}