{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:03:14Z","timestamp":1789621394068,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The remarkable success of biomedical HIV prevention has transformed the global response to HIV through the widespread implementation of oral pre-exposure prophylaxis (PrEP), long-acting antiretroviral agents and HIV self-testing. However, ensuring equitable access to these interventions remains a major challenge. Although more than one billion people worldwide live with a disability, disability has received surprisingly little attention within contemporary HIV prevention research and implementation. This narrative review examines the intersection between disability and modern HIV prevention, integrating evidence on sexual and reproductive health, structural barriers to healthcare and the evolving landscape of biomedical prevention. The available literature suggests that people with disabilities experience persistent inequalities in access to sexuality education, HIV information, testing and preventive services, largely due to physical, communication and systemic barriers rather than biological vulnerability. Despite these well-documented disparities, disability is rarely incorporated into PrEP implementation studies, HIV prevention policies or differentiated service delivery models. We argue that disability should be considered an implementation and health equity challenge rather than a pharmacological one. The effectiveness of biomedical prevention ultimately depends on healthcare systems capable of delivering accessible, person-centred and inclusive services. Integrating disability into implementation science, clinical practice and public health policy represents an essential step toward achieving equitable HIV prevention. As HIV prevention continues to evolve, accessibility should be recognised not as an optional adaptation but as a fundamental component of high-quality prevention programmes.<\/jats:p>","DOI":"10.3390\/v18091017","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:15:04Z","timestamp":1789395304000},"page":"1017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disability and Biomedical HIV Prevention: The Missing Equity Dimension"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9687-4841","authenticated-orcid":false,"given":"Francesco","family":"De Maria","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3949-4293","authenticated-orcid":false,"given":"Paolo","family":"Fusco","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3846-4620","authenticated-orcid":false,"given":"Alessandro","family":"Russo","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach, World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240031593."},{"key":"ref_2","unstructured":"World Health Organization (2022). Global Report on Health Equity for Persons with Disabilities, World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240063600."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/09638288.2020.1762124","article-title":"Left behind: Persons with disabilities in HIV prevalence research and national strategic plans in east and Southern Africa","volume":"44","author":"Ward","year":"2022","journal-title":"Disabil. Rehabil."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.1016\/S2352-3018(21)00345-3","article-title":"A focus on disability is necessary to achieve HIV epidemic control","volume":"9","author":"Kuper","year":"2022","journal-title":"Lancet HIV"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.3109\/09638288.2012.672541","article-title":"Disability rights in the context of HIV and AIDS: A critical review of nineteen Eastern and Southern Africa (ESA) countries","volume":"34","author":"Grant","year":"2012","journal-title":"Disabil. Rehabil."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Curiel, P., Vicente, E., Mor\u00e1n, M.L., and G\u00f3mez, L.E. (2023). The Right to Sexuality, Reproductive Health, and Found a Family for People with Intellectual Disability: A Systematic Review. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20021587"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.socscimed.2012.10.024","article-title":"HIV issues and people with disabilities: A review and agenda for research","volume":"77","author":"Groce","year":"2013","journal-title":"Soc. Sci. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jackson-Best, F., and Edwards, N. (2018). Stigma and intersectionality: A systematic review of systematic reviews across HIV\/AIDS, mental illness, and physical disability. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-5861-3"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1177\/1524838021995975","article-title":"Sexual Violence Against Persons with Disabilities: A Meta-Analysis","volume":"23","author":"Joyal","year":"2022","journal-title":"Trauma Violence Abus."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1080\/09540121.2014.936820","article-title":"Disability and HIV: A systematic review and a meta-analysis of the risk of HIV infection among adults with disabilities in Sub-Saharan Africa","volume":"26","author":"Pasquier","year":"2014","journal-title":"AIDS Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e26239","DOI":"10.1002\/jia2.26239","article-title":"HIV knowledge and access to testing for people with and without disabilities in low- and middle-income countries: Evidence from 37 Multiple Indicator Cluster Surveys","volume":"27","author":"Rotenberg","year":"2024","journal-title":"J. Int. AIDS Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"102087","DOI":"10.1016\/j.dhjo.2026.102087","article-title":"Barriers and facilitators of sexual and reproductive health service utilization among young people with disabilities: A scoping review","volume":"19","author":"Abbasi","year":"2026","journal-title":"Disabil. Health J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13690-026-01987-z","article-title":"Sexual and reproductive health services for adolescents and young people with disabilities in Sub-Saharan Africa countries, 2013\u20132024: A scoping review","volume":"84","author":"Ojo","year":"2026","journal-title":"Arch. Public Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e002903","DOI":"10.1136\/bmjgh-2020-002903","article-title":"From words to actions: Systematic review of interventions to promote sexual and reproductive health of persons with disabilities in low- and middle-income countries","volume":"5","author":"Hameed","year":"2020","journal-title":"BMJ Glob. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/19317611.2024.2349615","article-title":"Disability Inclusion in the National Strategic Plan for HIV\/AIDS: A Review on the National Response of West African Countries","volume":"36","author":"Olufadewa","year":"2024","journal-title":"Int. J. Sex. Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/09540121.2022.2029341","article-title":"Accessibility and use of HIV prevention services among people with disabilities in Burkina Faso and Niger","volume":"34","author":"Samadoulougou","year":"2022","journal-title":"AIDS Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.whi.2025.10.008","article-title":"Patient Experiences in Accessing Reproductive Health Services for Women with Cognitive, Intellectual, and Developmental Disabilities: A Systematic Review","volume":"36","author":"Chang","year":"2026","journal-title":"Womens Health Issues"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Matin, B.K., Ballan, M., Darabi, F., Karyani, A.K., Soofi, M., and Soltani, S. (2021). Sexual health concerns in women with intellectual disabilities: A systematic review in qualitative studies. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-12027-6"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1177\/0956462419896705","article-title":"HIV-related risk behaviors and HIV testing among people with sensory disabilities in the United States","volume":"31","author":"Olakunde","year":"2020","journal-title":"Int. J. STD AIDS"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1080\/09638288.2022.2051079","article-title":"Lived experiences of persons with disabilities living with HIV in accessing HIV services in Africa: A qualitative systematic review","volume":"45","author":"Philip","year":"2023","journal-title":"Disabil. Rehabil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100131","DOI":"10.1016\/j.hpopen.2024.100131","article-title":"Closing the equity gap: A call for policy and programmatic reforms to ensure inclusive and effective HIV prevention, treatment and care for persons with disabilities in Eastern and Southern Africa","volume":"7","author":"Dzinamarira","year":"2024","journal-title":"Health Policy Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/sextrans-2024-056306","article-title":"Evaluating equity reporting within systematic reviews of pre-exposure prophylaxis (PrEP)","volume":"101","author":"Paris","year":"2025","journal-title":"Sex. Transm. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/09540121.2022.2049195","article-title":"Prevalence and factors associated with HIV infection among people with disabilities in Mali","volume":"34","author":"Cisse","year":"2022","journal-title":"AIDS Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/09540121.2022.2050177","article-title":"Low prevalence of HIV infection among persons with disabilities in Niger: Findings from a household-based cross-sectional study in 2018","volume":"34","author":"Ouedraogo","year":"2022","journal-title":"AIDS Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10461-011-9912-3","article-title":"Choice-disability and HIV infection: A cross sectional study of HIV status in Botswana, Namibia and Swaziland","volume":"16","author":"Andersson","year":"2012","journal-title":"AIDS Behav."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Tomsa, R., Gutu, S., Cojocaru, D., Guti\u00e9rrez-Bermejo, B., Flores, N., and Jenaro, C. (2021). Prevalence of Sexual Abuse in Adults with Intellectual Disability: Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041980"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"108132","DOI":"10.1016\/j.chiabu.2026.108132","article-title":"Prevalence, risk factors, and impact of sexual abuse among children with disabilities in Asian countries: A scoping review of three decades (1995\u20132025)","volume":"178","author":"Mansur","year":"2026","journal-title":"Child Abus. Negl."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1080\/09638280500164297","article-title":"HIV\/AIDS information and services: The situation experienced by adolescents with disabilities in Rwanda and Uganda","volume":"27","author":"Yousafzai","year":"2005","journal-title":"Disabil. Rehabil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2989\/17280583.2013.823867","article-title":"Sexual abstinence and HIV knowledge in school-going adolescents with intellectual disabilities and non-disabled adolescents in Nigeria","volume":"25","author":"Aderemi","year":"2013","journal-title":"J. Child Adolesc. Ment. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2226345","DOI":"10.1080\/26410397.2023.2226345","article-title":"Comprehensive sexuality education for out-of-school young people living with HIV and young people with disabilities: Findings from a formative research study in Malawi","volume":"31","author":"Malata","year":"2023","journal-title":"Sex. Reprod. Health Matters"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1352\/1944-7558-119.3.276","article-title":"An interactive multimedia program to prevent HIV transmission in men with intellectual disability","volume":"119","author":"Wells","year":"2014","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.3109\/09638288.2011.573055","article-title":"Inclusion of disability within national strategic responses to HIV and AIDS in Eastern and Southern Africa","volume":"33","author":"Strode","year":"2011","journal-title":"Disabil. Rehabil."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Irungu, A.S.W., Kerochi, A., and Odongo, A.O. (2026). Access to sexual and reproductive health and rights services among women with disabilities: A cross-sectional study from Murang\u2019a South, Central Kenya. BMC Public Health, 26.","DOI":"10.1186\/s12889-026-27874-4"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ojo, L., Ginindza, T.G., Ansu-Mensah, M., and Kuupiel, D. (2026). Accessibility and predictors of sexual and reproductive health services utilisation among adolescents and youth people with disabilities in Bono Region, Ghana: A cross-sectional survey. BMC Public Health, Epub ahead of print.","DOI":"10.1186\/s12889-026-28323-y"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jadohealth.2025.07.014","article-title":"Sexual and Reproductive Health Care Receipt Among Female Adolescents and Young Adults with Disability in the United States, 2011\u20132019","volume":"77","author":"Hoyle","year":"2025","journal-title":"J. Adolesc. Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12978-023-01625-9","article-title":"Knowledge level and access barriers related to sexual and reproductive health information among youth with disabilities in China: A cross-sectional study","volume":"20","author":"Qi","year":"2023","journal-title":"Reprod. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e70032","DOI":"10.1111\/jar.70032","article-title":"Fostering Healthy Relationships in Special Olympic Athletes: Supporting the Intersection of Intellectual Disability and Sexual Health","volume":"38","author":"Andreasen","year":"2025","journal-title":"J. Appl. Res. Intellect. Disabil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MRR.0b013e328010c68f","article-title":"HIV\/AIDS and disability: A pilot survey of HIV\/AIDS knowledge among a deaf population in Swaziland","volume":"29","author":"Groce","year":"2006","journal-title":"Int. J. Rehabil. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1363\/psrh.12221","article-title":"Sexual and reproductive health services for autistic young people in the United States: A conceptual model of utilization","volume":"55","author":"Holmes","year":"2023","journal-title":"Perspect. Sex. Reprod. Health"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.dhjo.2017.02.008","article-title":"Sexual health in the community: Services for people with intellectual and developmental disabilities","volume":"10","author":"Friedman","year":"2017","journal-title":"Disabil. Health J."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"de Oliveira, K.H., de Oliveira Ferreira, B., da Silva Junior, F.J., Barp, L.F.G., de Menezes Guerra, C.B., da Silva C\u00e2mara, F.D., de Almeida Soares, M.A., Bercht, G., Honorato, I.B., and Gagliolo, A.A. (2025). PrEP public policies for HIV prevention in South America: An intersectional analysis. BMC Public Health, 26.","DOI":"10.1186\/s12889-025-25211-9"},{"key":"ref_42","unstructured":"Centers for Disease Control and Prevention (2026, September 06). Clinical Guidance for PrEP, Available online: https:\/\/www.cdc.gov\/hivnexus\/hcp\/prep\/index.html."},{"key":"ref_43","unstructured":"Brady, M., Clutterbuck, D., Rodger, A., Medland, N., Sullivan, A., Apea, V., Coukan, F., Estcourt, C., Fidler, S., and Field, N. (2025). BASHH\/BHIVA Guidelines on the Use of HIV Pre-Exposure Prophylaxis (PrEP) 2025, British HIV Association. Available online: https:\/\/bhiva.org\/clinical-guideline\/prep-guidelines\/."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jama.2024.24543","article-title":"Antiretroviral drugs for treatment and prevention of HIV in adults: 2024 recommendations of the International Antiviral Society-USA Panel","volume":"333","author":"Gandhi","year":"2025","journal-title":"JAMA"},{"key":"ref_45","unstructured":"World Health Organization (2025). Guidelines on Lenacapavir for HIV Prevention and Testing Strategies for Long-acting Injectable Pre-exposure Prophylaxis (PrEP), World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240111608."},{"key":"ref_46","unstructured":"World Health Organization (2026). Consolidated HIV Guidelines: Service Delivery, World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240124233."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/hiv.70120","article-title":"Major revision version 13.0 of the European AIDS Clinical Society guidelines 2025","volume":"27","author":"Ambrosioni","year":"2026","journal-title":"HIV Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ji, J., Zhang, Y., Zhang, X., Liu, J., and Xu, J. (2026). Digital health interventions for HIV-related sexual risk behaviors: A systematic review and network meta-analysis. npj Digit Med., Epub ahead of print.","DOI":"10.1038\/s41746-026-02966-y"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ssemata, J.L.N., King, R., Ssesaazi, P., Naggirinya, A.B., Beinomugisha, J., and Parkes-Ratanshi, R. (2024). Perceptions and attitudes towards unmanned aerial vehicles (drones) use for delivery of HIV medication among fisher folk communities on the Islands of Kalangala, Uganda. PLoS Glob. Public Health, 4.","DOI":"10.1371\/journal.pgph.0003468"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/9\/1017\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:10:38Z","timestamp":1789618238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/18\/9\/1017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["v18091017"],"URL":"https:\/\/doi.org\/10.3390\/v18091017","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}