{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:09:47Z","timestamp":1791616187497,"version":"4.3.4"},"reference-count":201,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T00:00:00Z","timestamp":1280188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Influenza virus infection of humans results in a respiratory disease that ranges in severity from sub-clinical infection to primary viral pneumonia that can result in death. The clinical effects of infection vary with the exposure history, age and immune status of the host, and also the virulence of the influenza strain. In humans, the virus is transmitted through either aerosol or contact-based transfer of infectious respiratory secretions. As is evidenced by most zoonotic influenza virus infections, not all strains that can infect humans are able to transmit from person-to-person. Animal models of influenza are essential to research efforts aimed at understanding the viral and host factors that contribute to the disease and transmission outcomes of influenza virus infection in humans. These models furthermore allow the pre-clinical testing of antiviral drugs and vaccines aimed at reducing morbidity and mortality in the population through amelioration of the virulence or transmissibility of influenza viruses. Mice, ferrets, guinea pigs, cotton rats, hamsters and macaques have all been used to study influenza viruses and therapeutics targeting them. Each model presents unique advantages and disadvantages, which will be discussed herein.<\/jats:p>","DOI":"10.3390\/v20801530","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T20:09:50Z","timestamp":1280347790000},"page":"1530-1563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":354,"title":["Animal Models for Influenza Virus Pathogenesis and Transmission"],"prefix":"10.3390","volume":"2","author":[{"given":"Nicole M.","family":"Bouvier","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA"},{"name":"Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anice C.","family":"Lowen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,7,27]]},"reference":[{"key":"ref_1","unstructured":"Mandell G.L. Bennett, J.E., and Dolin, R. (2010). Mandell, Douglas, and Bennett's Principles and Practices of Infectious Diseases, Churchill Livingstone Elsevier. [7th]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/QCO.0b013e328336eaae","article-title":"Epidemic viral pneumonia","volume":"23","author":"Lapinsky","year":"2010","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1086\/512160","article-title":"Pulmonary complications of interpandemic influenza A in hospitalized adults","volume":"195","author":"Murata","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/aje\/kwm375","article-title":"Time lines of infection and disease in human influenza: a review of volunteer challenge studies","volume":"167","author":"Carrat","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1062","article-title":"Complement is activated in the upper respiratory tract during influenza virus infection","volume":"143","author":"Bjornson","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/infdis\/124.5.473","article-title":"Correlated studies of a recombinant influenza-virus vaccine. \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t3. Protection against experimental influenza in man","volume":"124","author":"Couch","year":"1971","journal-title":"J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/jcp.38.3.312","article-title":"Acute phase response of serum amyloid A protein and C reactive protein to the common cold and influenza","volume":"38","author":"Whicher","year":"1985","journal-title":"J. Clin. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMoa0905498","article-title":"Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States","volume":"361","author":"Cauchemez","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1086\/651145","article-title":"Household transmission of 2009 influenza A (H1N1) virus after a school-based outbreak in New York City, April-May 2009","volume":"201","author":"France","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3201\/eid1604.091658","article-title":"Household transmission of pandemic (H1N1) 2009, San Antonio, Texas, USA, April-May 2009","volume":"16","author":"Morgan","year":"2010","journal-title":"Emerg Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e2691","DOI":"10.1371\/journal.pone.0002691","article-title":"Influenza virus in human exhaled breath: an observational study","volume":"3","author":"Fabian","year":"2008","journal-title":"PLoS One"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/jmv.21556","article-title":"Exhalation of respiratory viruses by breathing, coughing, and talking","volume":"81","author":"Oliver","year":"2009","journal-title":"J. Med. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/infdis\/144.5.433","article-title":"Patterns of shedding of myxoviruses and paramyxoviruses in children","volume":"144","author":"Frank","year":"1981","journal-title":"J. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1056\/NEJMe068114","article-title":"Influenza control","volume":"355","author":"Glezen","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/0002-9343(81)90594-5","article-title":"Nosocomial viral respiratory infections: perennial weeds on pediatric wards","volume":"70","author":"Hall","year":"1981","journal-title":"Am. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/infdis\/140.4.610","article-title":"Viral shedding patterns of children with influenza B infection","volume":"140","author":"Hall","year":"1979","journal-title":"J. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/01.inf.0000180976.81055.ce","article-title":"Viral shedding in children with influenza virus infections treated with neuraminidase inhibitors","volume":"24","author":"Sato","year":"2005","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1056\/NEJM200302273480923","article-title":"Prolonged shedding of multidrug-resistant influenza A virus in an immunocompromised patient","volume":"348","author":"Weinstock","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1086\/378292","article-title":"Transmission of influenza: implications for control in health care settings","volume":"37","author":"Kuehnert","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3181\/00379727-122-31255","article-title":"Human influenza resulting from aerosol inhalation","volume":"122","author":"Alford","year":"1966","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1473-3099(07)70029-4","article-title":"Transmission of influenza A in human beings","volume":"7","author":"Brankston","year":"2007","journal-title":"Lancet. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.3201\/eid1211.060426","article-title":"Review of aerosol transmission of influenza A virus","volume":"12","author":"Tellier","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_23","first-page":"4518","article-title":"Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation","volume":"8","author":"Staeheli","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"ref_24","first-page":"25","article-title":"Inborn resistance of mice to orthomyxoviruses","volume":"92","author":"Haller","year":"1981","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.149.3.601","article-title":"Genetically determined, interferon-dependent resistance to influenza virus in mice","volume":"149","author":"Haller","year":"1979","journal-title":"J. Exp. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0092-8674(86)90493-9","article-title":"Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus","volume":"44","author":"Staeheli","year":"1986","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1073\/pnas.0701849104","article-title":"Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene","volume":"104","author":"Grimm","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10818","DOI":"10.1128\/JVI.01116-07","article-title":"The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses","volume":"81","author":"Tumpey","year":"2007","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.micinf.2010.01.008","article-title":"Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection","volume":"12","author":"Alberts","year":"2010","journal-title":"Microbes Infect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1128\/JVI.00514-09","article-title":"Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice","volume":"83","author":"Boon","year":"2009","journal-title":"J. Virol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e4857","DOI":"10.1371\/journal.pone.0004857","article-title":"Host genetic background strongly influences the response to influenza a virus infections","volume":"4","author":"Srivastava","year":"2009","journal-title":"PLoS One"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1099\/vir.0.020925-0","article-title":"Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus","volume":"91","author":"Hale","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7662","DOI":"10.1128\/JVI.02444-09","article-title":"Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA\/2 mouse influenza model","volume":"84","author":"Boon","year":"2010","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1128\/JVI.02717-09","article-title":"PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models","volume":"84","author":"Hai","year":"2010","journal-title":"J. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1128\/JVI.00101-10","article-title":"Alternative live-attenuated influenza vaccines based on modifications in the polymerase genes protect against epidemic and pandemic flu","volume":"84","author":"Solorzano","year":"2010","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1119392","article-title":"Characterization of the reconstructed 1918 Spanish influenza pandemic virus","volume":"310","author":"Tumpey","year":"2005","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virusres.2007.01.011","article-title":"Effective replication of human influenza viruses in mice lacking a major alpha2,6 sialyltransferase","volume":"126","author":"Glaser","year":"2007","journal-title":"Virus Res."},{"key":"ref_38","unstructured":"Gard, S., Hallauer, C., and Meyer, K.F. (1968). The Influenza Viruses, Springer."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nature08260","article-title":"In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses","volume":"460","author":"Itoh","year":"2009","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1016\/j.vaccine.2008.03.055","article-title":"A bivalent influenza VLP vaccine confers complete inhibition of virus replication in lungs","volume":"26","author":"Quan","year":"2008","journal-title":"Vaccine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0264-410X(94)90287-9","article-title":"Selective induction of protection against influenza virus infection in mice by a lipid-peptide conjugate delivered in liposomes","volume":"12","author":"Friede","year":"1994","journal-title":"Vaccine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0264-410X(02)00539-X","article-title":"Induction of heterosubtypic immunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins","volume":"21","author":"Mitchell","year":"2003","journal-title":"Vaccine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0264-410X(90)90086-2","article-title":"Antigenic properties and protective capacity of a cyclic peptide corresponding to site A of influenza virus haemagglutinin","volume":"8","author":"Muller","year":"1990","journal-title":"Vaccine"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1432-1327.1999.00150.x","article-title":"Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin","volume":"260","author":"Saelens","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0264-410X(95)00014-R","article-title":"Protection of mice against lethal viral infection by synthetic peptides corresponding to B- and T-cell recognition sites of influenza A hemagglutinin","volume":"13","author":"Yun","year":"1995","journal-title":"Vaccine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.4049\/jimmunol.157.7.3065","article-title":"Protection against lethal influenza virus encephalitis by intranasally primed CD8+ memory T cells","volume":"157","author":"Stevenson","year":"1996","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1099\/0022-1317-68-2-433","article-title":"Purified influenza virus nucleoprotein protects mice from lethal infection","volume":"68","author":"Wraith","year":"1987","journal-title":"J. Gen. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.1128\/JVI.73.7.5903-5911.1999","article-title":"A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans","volume":"73","author":"Lu","year":"1999","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10580","DOI":"10.1128\/JVI.01213-08","article-title":"Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach","volume":"82","author":"Hai","year":"2008","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1128\/JVI.73.4.3184-3189.1999","article-title":"Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong","volume":"73","author":"Gao","year":"1999","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1086\/314515","article-title":"Characterization of influenza A\/HongKong\/156\/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice","volume":"178","author":"Gubareva","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0065-3527(09)73002-7","article-title":"Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses","volume":"73","author":"Belser","year":"2009","journal-title":"Adv. Virus Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11139","DOI":"10.1128\/JVI.01235-07","article-title":"Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans","volume":"81","author":"Belser","year":"2007","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1086\/518792","article-title":"The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses","volume":"196","author":"Munster","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"10558","DOI":"10.1128\/JVI.00970-07","article-title":"Evaluation of replication and pathogenicity of avian influenza a H7 subtype viruses in a mouse model","volume":"81","author":"Joseph","year":"2007","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.virol.2010.01.005","article-title":"Avian influenza virus isolates from wild birds replicate and cause disease in a mouse model of infection","volume":"399","author":"Driskell","year":"2010","journal-title":"Virology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1128\/JVI.02742-09","article-title":"Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice","volume":"84","author":"Belser","year":"2010","journal-title":"J. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.1177238","article-title":"Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice","volume":"325","author":"Maines","year":"2009","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13849","DOI":"10.1073\/pnas.212519699","article-title":"Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus","volume":"99","author":"Tumpey","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/432008","article-title":"Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A\/Vietnam\/1203\/04 influenza virus in mice","volume":"192","author":"Yen","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.antiviral.2008.05.012","article-title":"Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice","volume":"80","author":"Boltz","year":"2008","journal-title":"Antiviral Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1128\/AAC.01667-08","article-title":"Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model","volume":"53","author":"Govorkova","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1128\/AAC.01579-07","article-title":"Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice","volume":"52","author":"Ilyushina","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/135965350701200302","article-title":"Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice","volume":"12","author":"Ilyushina","year":"2007","journal-title":"Antivir. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1128\/AAC.45.10.2723-2732.2001","article-title":"Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses","volume":"45","author":"Govorkova","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1128\/AAC.50.4.1470-1479.2006","article-title":"Sialidase Fusion Protein as a Novel Broad-Spectrum Inhibitor of Influenza Virus Infection","volume":"50","author":"Malakhov","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1128\/JVI.02165-08","article-title":"Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection","volume":"83","author":"Prabhu","year":"2009","journal-title":"J. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/135965350801300112","article-title":"In vitro and in vivo protection against the highly pathogenic H5N1 influenza virus by an antisense phosphorothioate oligonucleotide","volume":"13","author":"Duan","year":"2008","journal-title":"Antivir. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1086\/522609","article-title":"DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection","volume":"196","author":"Belser","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1073\/pnas.0909603107","article-title":"T-705 (favipiravir) activity against lethal H5N1 influenza A viruses","volume":"107","author":"Kiso","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1128\/AAC.00933-09","article-title":"Effects of the combination of favipiravir (T-705) and oseltamivir on influenza a virus infections in mice","volume":"54","author":"Smee","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1128\/AAC.01051-06","article-title":"Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice","volume":"51","author":"Sidwell","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e1000745","DOI":"10.1371\/journal.ppat.1000745","article-title":"Protection of mice against lethal challenge with 2009 H1N1 influenza A \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tvirus by 1918-like and classical swine H1N1 based vaccines","volume":"6","author":"Manicassamy","year":"2010","journal-title":"PLoS Pathog."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1128\/jvi.67.2.759-764.1993","article-title":"Biologic importance of neuraminidase stalk length in influenza A virus","volume":"67","author":"Castrucci","year":"1993","journal-title":"J. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nature02951","article-title":"Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus","volume":"431","author":"Kobasa","year":"2004","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1128\/JVI.79.18.11788-11800.2005","article-title":"Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals","volume":"79","author":"Maines","year":"2005","journal-title":"J. Virol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/viro.1994.1615","article-title":"Receptor Specificity in Human, Avian, and Equine H2 and H3 Influenza Virus Isolates","volume":"205","author":"Connor","year":"1994","journal-title":"Virology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0042-6822(89)90249-3","article-title":"Receptor binding properties of human and animal H1 influenza virus isolates","volume":"173","author":"Rogers","year":"1989","journal-title":"Virology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1128\/JVI.02677-05","article-title":"Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells","volume":"80","author":"Ibricevic","year":"2006","journal-title":"J. Virol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/440435a","article-title":"Avian flu: Influenza virus receptors in the human airway","volume":"440","author":"Shinya","year":"2006","journal-title":"Nature"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2353\/ajpath.2007.070248","article-title":"Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals","volume":"171","author":"Munster","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1128\/JVI.74.3.1443-1450.2000","article-title":"Distinct pathogenesis of hong kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses","volume":"74","author":"Dybing","year":"2000","journal-title":"J. Virol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3201\/eid1604.091061","article-title":"Influenza A strain-dependent pathogenesis in fatal H1N1 and H5N1 subtype infections of mice","volume":"16","author":"Garigliany","year":"2010","journal-title":"Emerg Infect. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e1000115","DOI":"10.1371\/journal.ppat.1000115","article-title":"H5N1 and 1918 pandemic influenza virus infection results in early and \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\texcessive infiltration of macrophages and neutrophils in the lungs of \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tmice","volume":"4","author":"Perrone","year":"2008","journal-title":"PLoS Pathog."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1164\/rccm.200803-455OC","article-title":"Influenza A virus inhibits alveolar fluid clearance in BALB\/c mice","volume":"178","author":"Wolk","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"14063","DOI":"10.1073\/pnas.0900096106","article-title":"Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration","volume":"106","author":"Jang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1637\/0005-2086-47.s3.1122","article-title":"Neurological manifestations of avian influenza viruses in mammals","volume":"47","author":"Rowe","year":"2003","journal-title":"Avian Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbi.2009.10.007","article-title":"The olfactory nerve has a role in the body temperature and brain cytokine responses to influenza virus","volume":"24","author":"Churchill","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/13550280701427069","article-title":"Detection of mouse-adapted human influenza virus in the olfactory bulbs of mice within hours after intranasal infection","volume":"13","author":"Majde","year":"2007","journal-title":"J. Neurovirol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3181\/00379727-108-27064","article-title":"Hypothermia in mice due to influenza virus infection","volume":"108","author":"Yang","year":"1961","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1371\/journal.ppat.0030133","article-title":"Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice","volume":"3","author":"Hatta","year":"2007","journal-title":"PLoS Pathog."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1056\/NEJMoa044307","article-title":"Fatal Avian Influenza A (H5N1) in a Child Presenting with Diarrhea Followed by Coma","volume":"352","author":"Cam","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1128\/AAC.36.2.473","article-title":"Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice","volume":"36","author":"Sidwell","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-3542(97)00065-X","article-title":"Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor","volume":"37","author":"Sidwell","year":"1998","journal-title":"Antiviral. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2007.04.001","article-title":"CYSTUS052, a polyphenol-rich plant extract, exerts anti-influenza virus activity in mice","volume":"76","author":"Droebner","year":"2007","journal-title":"Antiviral Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.144.3620.862","article-title":"Antiviral Activity of 1-Adamantanamine (Amantadine)","volume":"144","author":"Davies","year":"1964","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0042-6822(65)90273-4","article-title":"The in vivo Antiviral Activity of 1-Adamantanamine (Amantadine). I. Prophylactic and Therapeutic Activity against Influenza Viruses","volume":"26","author":"Grunert","year":"1965","journal-title":"Virology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1128\/AAC.1.5.408","article-title":"Rimantadine therapy of influenza A infection in mice","volume":"1","author":"Rabinovich","year":"1972","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1128\/AAC.8.2.154","article-title":"Treatment of influenza infection of mice by using rimantadine hydrochlorides by the aerosol and intraperitoneal routes","volume":"8","author":"Stephen","year":"1975","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1128\/AAC.42.3.640","article-title":"Oral administration of a prodrug of the influenza virus neuraminidase \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tinhibitor GS 4071 protects mice and ferrets against influenza infection","volume":"42","author":"Mendel","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/363418a0","article-title":"Rational design of potent sialidase-based inhibitors of influenza virus replication","volume":"363","author":"Wu","year":"1993","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1021\/jm0002679","article-title":"BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tactive, and selective influenza neuraminidase inhibitor through \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tstructure-based drug design","volume":"43","author":"Babu","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1128\/AAC.45.4.1162-1167.2001","article-title":"Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir","volume":"45","author":"Bantia","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1128\/AAC.45.3.749-757.2001","article-title":"In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201","volume":"45","author":"Sidwell","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_105","first-page":"128","article-title":"Effects of immunity on transmission of influenza: experimental studies","volume":"12","author":"Schulman","year":"1970","journal-title":"Prog. Med. Virol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1084\/jem.125.3.467","article-title":"Experimental transmission of influenza virus infection in mice. \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t3. Differing effects of immunity induced by infection and by inactivated influenza virus vaccine on transmission of infection","volume":"125","author":"Schulman","year":"1967","journal-title":"J. Exp. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1084\/jem.125.3.479","article-title":"Experimental transmission of influenza virus infection in mice: IV. Relationship of transmissibility of different strains of virus and recovery of airborne virus in the environment of infector mice","volume":"125","author":"Schulman","year":"1967","journal-title":"J. Exp. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.2105\/AJPH.58.11.2092","article-title":"The use of an animal model to study transmission of influenza virus infection","volume":"58","author":"Schulman","year":"1968","journal-title":"Am. J. Public Health Nations Health"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/1951129a0","article-title":"Airborne transmission of influenza virus infection in mice","volume":"195","author":"Schulman","year":"1962","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1084\/jem.118.2.267","article-title":"Experimental Transmission of Influenza Virus Infection in Mice. \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tII. Some Factors Affecting the Incidence of Transmitted Infection","volume":"118","author":"Schulman","year":"1963","journal-title":"J. Exp. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1084\/jem.118.2.257","article-title":"Experimental transmission of influenza virus infection in mice: I. The period of transmissibility","volume":"118","author":"Schulman","year":"1963","journal-title":"J. Exp. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9988","DOI":"10.1073\/pnas.0604157103","article-title":"The guinea pig as a transmission model for human influenza viruses","volume":"103","author":"Lowen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1084\/jem.62.4.505","article-title":"Immunological Studies with the Virus of Influenza","volume":"62","author":"Francis","year":"1935","journal-title":"J. Exp. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1084\/jem.68.6.813","article-title":"Studies on the Nasal Histology of Epidemic Influenza Virus Infection in the Ferret : Iii. Histological and Serological Observations on Ferrets Receiving Repeated Inoculations of Epidemic Infuenza Virus","volume":"68","author":"Francis","year":"1938","journal-title":"J. Exp. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.68.6.789","article-title":"Studies on the Nasal Histology of Epidemic Influenza Virus Infection in the Ferret : I. The Development and Repair of the Nasal Lesion","volume":"68","author":"Francis","year":"1938","journal-title":"J. Exp. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1084\/jem.60.1.49","article-title":"The Infection of Ferrets with Swine Influenza Virus","volume":"60","author":"Shope","year":"1934","journal-title":"J. Exp. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.59.2.201","article-title":"Swine Influenza : V. Studies on Contagion","volume":"59","author":"Shope","year":"1934","journal-title":"J. Exp. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.62.4.561","article-title":"The Infection of Mice with Swine Influenza Virus","volume":"62","author":"Shope","year":"1935","journal-title":"J. Exp. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0140-6736(00)78541-2","article-title":"A virus obtained from influenza patients","volume":"2","author":"Smith","year":"1933","journal-title":"Lancet"},{"key":"ref_120","first-page":"572","article-title":"Otologic and systemic manifestations of experimental influenza A virus infection in the ferret","volume":"112","author":"Buchman","year":"1995","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1086\/597073","article-title":"Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model","volume":"199","author":"Mubareka","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF01314239","article-title":"Recent H1N1 viruses (A\/USSR\/90\/77, A\/Fiji\/15899\/83, A\/Firenze\/13\/83) replicate poorly in ferret bronchial epithelium. Brief report","volume":"85","author":"Sweet","year":"1985","journal-title":"Arch. Virol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1086\/650464","article-title":"Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses","volume":"201","author":"Baz","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1177127","article-title":"Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets","volume":"325","author":"Munster","year":"2009","journal-title":"Science"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1086\/322801","article-title":"Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virus","volume":"184","author":"Herlocher","year":"2001","journal-title":"J. Infect. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1128\/JVI.00534-09","article-title":"Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessment","volume":"83","author":"Jackson","year":"2009","journal-title":"J. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0166-3542(81)90014-0","article-title":"Antiviral effects of single-stranded polynucleotide inhibitors of the influenza virion-associated transcriptase against influenza virus infection of hamsters and ferrets","volume":"1","author":"Round","year":"1981","journal-title":"Antiviral. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/infdis\/164.5.969","article-title":"Virulence of rimantadine-resistant human influenza A (H3N2) viruses in ferrets","volume":"164","author":"Sweet","year":"1991","journal-title":"J Infect Dis"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1086\/586711","article-title":"Oseltamivir prophylactic regimens prevent H5N1 influenza morbidity and mortality in a ferret model","volume":"197","author":"Boltz","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"11308","DOI":"10.1128\/JVI.00691-08","article-title":"Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets","volume":"82","author":"Cameron","year":"2008","journal-title":"J. Virol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1128\/JVI.76.9.4420-4429.2002","article-title":"Pathogenesis of avian influenza A (H5N1) viruses in ferrets","volume":"76","author":"Zitzow","year":"2002","journal-title":"J. Virol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1128\/AAC.38.8.1864","article-title":"Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets","volume":"38","author":"Jakeman","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/vim.2009.0045","article-title":"Influenza B virus causes milder pathogenesis and weaker inflammatory responses in ferrets than influenza A virus","volume":"22","author":"Kim","year":"2009","journal-title":"Viral Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1128\/AAC.49.11.4515-4520.2005","article-title":"Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors","volume":"49","author":"Mishin","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1073\/pnas.0801259105","article-title":"Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility","volume":"105","author":"Belser","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e2923","DOI":"10.1371\/journal.pone.0002923","article-title":"Replication and transmission of H9N2 influenza viruses in ferrets: evaluation of pandemic potential","volume":"3","author":"Wan","year":"2008","journal-title":"PLoS One"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.80.2081.457.b","article-title":"Transmission of Influenza by a Filterable Virus","volume":"80","year":"1934","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1001\/jama.293.8.987","article-title":"Does this patient have influenza?","volume":"293","author":"Call","year":"2005","journal-title":"JAMA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/00016480252814207","article-title":"An explanation for the seasonality of acute upper respiratory tract viral infections","volume":"122","author":"Eccles","year":"2002","journal-title":"Acta Otolaryngol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1056\/NEJM200011023431801","article-title":"Inhaled zanamivir for the prevention of influenza in families. Zanamivir Family Study Group","volume":"343","author":"Hayden","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_141","first-page":"15G.2.1","article-title":"The ferret model for influenza","volume":"13","author":"Matsuoka","year":"2009","journal-title":"Curr. Protoc. Microbiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/laban1004-50","article-title":"The ferret: an animal model to study influenza virus","volume":"33","author":"Maher","year":"2004","journal-title":"Lab Anim. (NY)"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1128\/jvi.62.5.1508-1512.1988","article-title":"Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection","volume":"62","author":"Belshe","year":"1988","journal-title":"J. Virol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.1136212","article-title":"A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission","volume":"315","author":"Tumpey","year":"2007","journal-title":"Science"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.1125548","article-title":"H5N1 Virus Attachment to Lower Respiratory Tract","volume":"312","author":"Munster","year":"2006","journal-title":"Science"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2353\/ajpath.2007.070248","article-title":"Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals","volume":"171","author":"Munster","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1128\/AAC.01312-06","article-title":"Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus","volume":"51","author":"Govorkova","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.virol.2007.12.029","article-title":"Injectable peramivir mitigates disease and promotes survival in ferrets \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tand mice infected with the highly virulent influenza virus, \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tA\/Vietnam\/1203\/04 (H5N1)","volume":"374","author":"Yun","year":"2008","journal-title":"Virology"},{"key":"ref_149","unstructured":"Tamiflu (Oseltamivir Phosphate) Capsules and for Oral Suspension, 2008 \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t. Available online: http:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/InformationbyDrugClass\/UCM147992.pdf."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1128\/AAC.42.3.647","article-title":"Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071","volume":"42","author":"Li","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1749-6632.1965.tb12579.x","article-title":"Studies on the antiviral activity of amantadine hydrochloride","volume":"130","author":"Cochran","year":"1965","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1749-6632.1970.tb53414.x","article-title":"The evaluation of compounds against influenza viruses","volume":"173","author":"Squires","year":"1970","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/jac\/3.5.463","article-title":"The effects of peroral or local aerosol administration of 1-aminoadamantane hydrochloride (amantadine hydrochloride) on influenza infections of the ferret","volume":"3","author":"Fenton","year":"1977","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1086\/379049","article-title":"Assessment of development of resistance to antivirals in the ferret model of influenza virus infection","volume":"188","author":"Herlocher","year":"2003","journal-title":"J. Infect. Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/01.inf.0000143643.44463.b1","article-title":"Live attenuated influenza vaccine induces cross-reactive antibody \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tresponses in children against an A\/Fujian\/411\/2002-like H3N2 antigenic \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tvariant strain","volume":"23","author":"Mendelman","year":"2004","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"12121","DOI":"10.1073\/pnas.0605134103","article-title":"Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model","volume":"103","author":"Maines","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.1073\/pnas.0900877106","article-title":"Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus","volume":"106","author":"Sorrell","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1128\/AAC.49.10.4075-4084.2005","article-title":"Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility","volume":"49","author":"Yen","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1371\/journal.ppat.0030151","article-title":"Influenza virus transmission is dependent on relative humidity and temperature","volume":"3","author":"Lowen","year":"2007","journal-title":"PLoS Pathog."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1128\/JVI.02424-08","article-title":"Blocking inter-host transmission of influenza virus by vaccination in the guinea pig model","volume":"83","author":"Lowen","year":"2009","journal-title":"J. Virol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1128\/JVI.00325-08","article-title":"High temperature (30\u00b0C) blocks aerosol but not contact transmission of influenza virus","volume":"82","author":"Lowen","year":"2008","journal-title":"J. Virol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF02152923","article-title":"Influenza virus infection of the guinea pig: immune response and resistance","volume":"165","author":"Phair","year":"1979","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1099\/vir.0.007054-0","article-title":"Histopathology and growth kinetics of influenza viruses (H1N1 and H3N2) in the upper and lower airways of guinea pigs","volume":"90","author":"Tang","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1128\/JVI.02174-08","article-title":"Pathogenesis of the 1918 pandemic and H5N1 influenza virus infection in a guinea pig model: The antiviral potential of exogenous alpha-interferon to reduce virus shedding","volume":"83","author":"Belser","year":"2009","journal-title":"J. Virol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/JVI.01732-09","article-title":"Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment","volume":"84","author":"Steel","year":"2010","journal-title":"J. Virol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1354\/vp.46-1-138","article-title":"Bronchointerstitial Pneumonia in Guinea Pigs Following Inoculation with H5N1 High Pathogenicity Avian Influenza Virus","volume":"46","author":"Kwon","year":"2009","journal-title":"Vet. Pathol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e1000252","DOI":"10.1371\/journal.ppat.1000252","article-title":"Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E\/701N","volume":"5","author":"Steel","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e1000709","DOI":"10.1371\/journal.ppat.1000709","article-title":"Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host","volume":"5","author":"Gao","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1128\/JVI.01226-08","article-title":"Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol","volume":"82","author":"Bouvier","year":"2008","journal-title":"J. Virol."},{"key":"ref_170","unstructured":"Lowen, A.C., and Palese, P. (2008). Unpublished work \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0021-9975(84)90046-X","article-title":"Lung alterations in guinea-pigs infected with influenza virus","volume":"94","author":"Lambre","year":"1984","journal-title":"J. Comp. Path."},{"key":"ref_172","unstructured":"Steel, J., Lowen, A.C., and Palese, P. (2009). Unpublished work \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1099\/vir.0.81145-0","article-title":"The cotton rat provides a useful small-animal model for the study of influenza virus pathogenesis","volume":"86","author":"Ottolini","year":"2005","journal-title":"J. Gen. Virol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.virol.2004.01.032","article-title":"Influenza-induced tachypnea is prevented in immune cotton rats, but cannot be treated with an anti-inflammatory steroid or a neuraminidase inhibitor","volume":"322","author":"Eichelberger","year":"2004","journal-title":"Virology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ppul.10320","article-title":"Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model","volume":"36","author":"Ottolini","year":"2003","journal-title":"Pediatr. Pulmonol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1743-422X-5-44","article-title":"Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats","volume":"5","author":"Straight","year":"2008","journal-title":"Virol. J."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1016\/j.vaccine.2006.05.092","article-title":"Evidence of a cross-protective immune response to influenza A in the cotton rat model","volume":"24","author":"Straight","year":"2006","journal-title":"Vaccine"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3181\/00379727-49-13480","article-title":"Use of hamster (Cricetus auratus) for the detection of influenza virus in throat washings","volume":"49","author":"Taylor","year":"1942","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF01348964","article-title":"Transmissibility of influenza viruses in hamsters","volume":"72","author":"Ali","year":"1982","journal-title":"Arch. Virol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.4049\/jimmunol.113.6.1834","article-title":"Effect of preinfection and preimmunization on the serum antibody response to subsequent immunization with heterotypic influenza vaccines","volume":"113","author":"Jennings","year":"1974","journal-title":"J. Immunol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/pgmj.52.608.345","article-title":"The hamster as a model system for the study of influenza vaccines","volume":"52","author":"Potter","year":"1976","journal-title":"Postgrad. Med. J."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/infdis\/123.2.145","article-title":"Temperature-sensitive mutants of influenza virus. \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tI. Behavior in tissue culture and in experimental animals","volume":"123","author":"Mills","year":"1971","journal-title":"J. Infect. Dis."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF01317321","article-title":"Growth of influenza A viruses in hamsters","volume":"65","author":"Jennings","year":"1980","journal-title":"Arch. Virol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0166-3542(83)90003-7","article-title":"In vivo and in vitro hamster models in the assessment of virulence of recombinant influenza viruses","volume":"3","author":"Heath","year":"1983","journal-title":"Antiviral Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02121142","article-title":"Growth of some attenuated influenza A viruses in hamsters","volume":"166","author":"Reeve","year":"1978","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF02123591","article-title":"Studies with some influenza B viruses in cell cultures, hamsters and hamster tracheal organ cultures","volume":"169","author":"Reeve","year":"1981","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"10813","DOI":"10.1128\/JVI.00851-06","article-title":"Integrated molecular signature of disease: analysis of influenza \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tvirus-infected macaques through functional genomics and proteomics","volume":"80","author":"Baas","year":"2006","journal-title":"J. Virol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"11817","DOI":"10.1128\/JVI.00590-07","article-title":"Functional genomic and serological analysis of the protective immune \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tresponse resulting from vaccination of macaques with an NS1-truncated \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tinfluenza virus","volume":"81","author":"Baskin","year":"2007","journal-title":"J. Virol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.4049\/jimmunol.180.4.2385","article-title":"Interferon-induced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication","volume":"180","author":"Carroll","year":"2008","journal-title":"J. Immunol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1016\/j.vaccine.2004.02.021","article-title":"Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys","volume":"22","author":"Fan","year":"2004","journal-title":"Vaccine"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature05495","article-title":"Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus","volume":"445","author":"Kobasa","year":"2007","journal-title":"Nature"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1084\/jem.84.2.113","article-title":"Reactions of Monkeys to Experimentally Induced Influenza Virus a Infection : An Analysis of the Relative Roles of Humoral and Cellular Immunity under Conditions of Optimal or Deficient Nutrition","volume":"84","author":"Saslaw","year":"1946","journal-title":"J. Exp. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"e1000604","DOI":"10.1371\/journal.ppat.1000604","article-title":"Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes","volume":"5","author":"Cilloniz","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0264-410X(01)00262-6","article-title":"A single dose of an ISCOM influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect Cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses","volume":"20","author":"Rimmelzwaan","year":"2002","journal-title":"Vaccine"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e1000409","DOI":"10.1371\/journal.ppat.1000409","article-title":"Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates","volume":"5","author":"Fan","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.vaccine.2006.08.036","article-title":"Primary influenza A virus infection induces cross-protective immunity against a lethal infection with a heterosubtypic virus strain in mice","volume":"25","author":"Kreijtz","year":"2007","journal-title":"Vaccine"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1128\/JVI.02335-08","article-title":"Electroporation of synthetic DNA antigens offers protection in nonhuman \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tprimates challenged with highly pathogenic avian influenza virus","volume":"83","author":"Laddy","year":"2009","journal-title":"J. Virol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1128\/JVI.75.14.6687-6691.2001","article-title":"Pathogenesis of influenza A (H5N1) virus infection in a primate model","volume":"75","author":"Rimmelzwaan","year":"2001","journal-title":"J. Virol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1637\/0005-2086-47.s3.931","article-title":"A primate model to study the pathogenesis of influenza A (H5N1) virus infection","volume":"47","author":"Rimmelzwaan","year":"2003","journal-title":"Avian Dis."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.antiviral.2008.06.014","article-title":"Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques","volume":"80","author":"Stittelaar","year":"2008","journal-title":"Antiviral Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1128\/JVI.78.23.13037-13045.2004","article-title":"Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes","volume":"78","author":"Ferko","year":"2004","journal-title":"J. Virol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/2\/8\/1530\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:03:00Z","timestamp":1760220180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/2\/8\/1530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,27]]},"references-count":201,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8]]}},"alternative-id":["v20801530"],"URL":"https:\/\/doi.org\/10.3390\/v20801530","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,27]]}}}