{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:48:17Z","timestamp":1791355697679,"version":"4.3.1"},"reference-count":79,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>While vaccines are the primary public health response to seasonal and pandemic flu, short of a universal vaccine there are inherent limitations to this approach. Antiviral drugs provide valuable alternative options for treatment and prophylaxis of influenza. Here, we will review drugs and drug candidates against influenza with an emphasis on the recent progress of a host-targeting entry-blocker drug candidate, DAS181, a sialidase fusion protein.<\/jats:p>","DOI":"10.3390\/v2081766","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T15:36:17Z","timestamp":1295019377000},"page":"1766-1781","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antiviral Strategies for Pandemic and Seasonal Influenza"],"prefix":"10.3390","volume":"2","author":[{"given":"Maria","family":"Hedlund","sequence":"first","affiliation":[{"name":"NexBio, Inc.\/10665 Sorrento Valley Rd, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Larson","sequence":"additional","affiliation":[{"name":"NexBio, Inc.\/10665 Sorrento Valley Rd, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"NexBio, Inc.\/10665 Sorrento Valley Rd, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Prevention and Control of Influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"55","author":"Smith","year":"2006","journal-title":"MMWR Recomm. 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