{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:10:19Z","timestamp":1781280619887,"version":"3.54.1"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T00:00:00Z","timestamp":1292803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>An ideal animal model for the study of a human disease is one which utilizes a route of infection that mimics the natural transmission of the pathogen; the ability to obtain disease with an infectious dose equivalent to that causing disease in humans; as well having a disease course, morbidity and mortality similar to that seen with human disease. Additionally, the animal model should have a mode(s) of transmission that mimics human cases. The development of small animal models for the study of monkeypox virus (MPXV) has been quite extensive for the relatively short period of time this pathogen has been known, although only a few of these models have been used to study anti-poxvirus agents. We will review those MPXV small animal models that have been developed thus far for the study of therapeutic agents.<\/jats:p>","DOI":"10.3390\/v2122763","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T12:05:18Z","timestamp":1292846718000},"page":"2763-2776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Monkeypox Virus Infections in Small Animal Models for Evaluation of Anti-Poxvirus Agents"],"prefix":"10.3390","volume":"2","author":[{"given":"Christina L.","family":"Hutson","sequence":"first","affiliation":[{"name":"Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd. MS-G06 Atlanta, GA 30029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger K.","family":"Damon","sequence":"additional","affiliation":[{"name":"Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd. MS-G06 Atlanta, GA 30029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,12,20]]},"reference":[{"key":"ref_1","unstructured":"Jezek, Z., and Fenner, F. (1988). Human Monkeypox, Karger AG. Monographs in Virology."},{"key":"ref_2","first-page":"13","article-title":"Susceptibility of some rodent species to monkeypox virus, and course of the infection","volume":"53","author":"Marennikova","year":"1976","journal-title":"Bull. WHO"},{"key":"ref_3","first-page":"703","article-title":"Generalized monkeypox in orally infected rabbits and white mice","volume":"Nov\u2013Dec","author":"Shchelukhina","year":"1975","journal-title":"Vopr. Virusol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"von Magnus, P., Andersen, E.K., Petersen, K.P., and Birch-Andersen, A. (1959). A Pox-like disease in Cynomolgus monkeys. Strasb. Med., 156\u2013176.","DOI":"10.1111\/j.1699-0463.1959.tb00328.x"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF01241445","article-title":"Histopathological and virological studies on monkeypox","volume":"21","author":"Gispen","year":"1967","journal-title":"Arch. Gesamte Virusforsch."},{"key":"ref_6","first-page":"368","article-title":"Possible mechanism of orthopoxvirus preservation in nature","volume":"Jul\u2013Aug","author":"Shelukhina","year":"1979","journal-title":"Vopr. Virusol."},{"key":"ref_7","unstructured":"Marennikova, S.S., and Shchelkunov, S.N. (2005). Orthopoxviruses Pathogenic for Humans, Springer."},{"key":"ref_8","unstructured":"Kitamura, T. (2005). Orthopoxviruses Pathogenic for Humans, Springer."},{"key":"ref_9","first-page":"399","article-title":"Experimental infection of squirrels Sciurus vulgaris by monkeypox virus","volume":"33","author":"Marennikova","year":"1989","journal-title":"Acta Virol."},{"key":"ref_10","unstructured":"Shelukhina, E.M., Khodakevich, D., Messinger, S.B., Pole, B., Hussar, M., and Szeniovskii, M. (1989). Experimental infection of tropical squirrels with monkeypox virus, Unpublished work."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3201\/eid1009.040310","article-title":"Experimental infection of ground squirrels (Spermophilus tridecemlineatus) with monkeypox virus","volume":"10","author":"Tesh","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4269\/ajtmh.2007.76.155","article-title":"Comparative pathology of North American and central African strains of monkeypox virus in a ground squirrel model of the disease","volume":"76","author":"Sbrana","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3201\/eid1104.040907","article-title":"Experimental infection of prairie dogs with monkeypox virus","volume":"11","author":"Xiao","year":"2005","journal-title":"Emerg. Infect. Dis"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1099\/vir.0.005108-0","article-title":"A prairie dog animal model of systemic orthopoxvirus disease using West African and Congo Basin strains of monkeypox virus","volume":"90","author":"Hutson","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.virol.2010.03.012","article-title":"Dosage comparison of Congo Basin and West African strains of monkeypox virus using a prairie dog animal model of systemic orthopoxvirus disease","volume":"402","author":"Hutson","year":"2010","journal-title":"Virology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.virol.2008.09.025","article-title":"Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus","volume":"383","author":"Schultz","year":"2009","journal-title":"Virology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hutson, C.L., Abel, J.A., Carroll, D.S., Olson, V.A., Braden, Z.H., Hughes, C.M., Dillon, M., Hopkins, C., Karem, K.L., Damon, I.K., and Osorio, J.E. (2010). Comparison of West African and Congo Basin monkeypox viruses in BALB\/c and C57BL\/6 mice. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008912"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Osorio, J.E., Iams, K.P., Meteyer, C.U., and Rocke, T.E. (2009). Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006592"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1128\/JVI.02012-09","article-title":"A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus","volume":"84","author":"Stabenow","year":"2010","journal-title":"J. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1128\/JVI.00621-10","article-title":"Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models","volume":"84","author":"Americo","year":"2010","journal-title":"J. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"768","DOI":"10.4269\/ajtmh.2007.76.768","article-title":"Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection","volume":"76","author":"Sbrana","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11416","DOI":"10.1128\/JVI.78.20.11416-11421.2004","article-title":"Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1","volume":"78","author":"Hogan","year":"2004","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/JVI.02096-06","article-title":"Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses","volume":"81","author":"Mumphrey","year":"2007","journal-title":"J. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.4049\/jimmunol.180.5.3319","article-title":"Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection","volume":"180","author":"Shornick","year":"2008","journal-title":"J. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.4049\/jimmunol.175.6.3946","article-title":"Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice","volume":"175","author":"Shresta","year":"2005","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Smith, S.K., Self, J., Weiss, S., Carroll, D., Braden, Z., Russell, R.L., Davidson, W., Jordan, R., Hruby, D.E., and Damon, I.K. (2010). Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox. J. 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