{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:57Z","timestamp":1791332937119,"version":"4.3.1"},"reference-count":74,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T00:00:00Z","timestamp":1308614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Of the millions of HTLV-1 infected carriers worldwide, 3\u20135% will develop an aggressive T-cell neoplasm that is highly refractory to conventional therapy. The virus carries the Tax oncogene which constitutively activates the NF\u03baB pathway. This co-option of signaling through NF\u03baB provides for the HTLV-1 infected cell an escape from cell cycle arrest and apoptosis, a steady source of growth factors, and a mechanism by which the virus can activate its own target cell. Therapies that target the NF\u03baB pathway sensitize adult T-cell leukemia\/lymphoma (ATLL) cells to apoptosis. A focus on translational interrogation of NF\u03baB inhibitors in animal models and ATLL patients is needed to advance NF\u03baB-targeted ATLL therapies to the bedside.<\/jats:p>","DOI":"10.3390\/v3060886","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T11:26:00Z","timestamp":1308655560000},"page":"886-900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Targeting HTLV-1 Activation of NF\u03baB in Mouse Models and ATLL Patients"],"prefix":"10.3390","volume":"3","author":[{"given":"Daniel A.","family":"Rauch","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, Campus Box 8069, 660 S. Euclid Ave., St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Ratner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, Campus Box 8069, 660 S. Euclid Ave., St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/IR:34:1:1","article-title":"Modulation of nuclear factor-kB by human T-cell leukemia virus type 1 tax protein: Implications for oncogenesis and inflammation","volume":"34","author":"Peloponese","year":"2006","journal-title":"Immunol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/08830180701703364","article-title":"NF-kB in pathogenesis and treatment of adult T-cell leukemia\/lymphoma","volume":"26","author":"Horie","year":"2007","journal-title":"Int. Rev. Immunol."},{"key":"ref_3","first-page":"121","article-title":"An HTLV-I Transgenic Mouse Model: Role of the tax gene in pathogenesis in multiple organ systems","volume":"160","author":"Nerenberg","year":"1990","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.1887217","article-title":"Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I","volume":"253","author":"Iwakura","year":"1991","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.4049\/jimmunol.155.3.1588","article-title":"Autoimmunity induction by human T-cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans","volume":"155","author":"Iwakura","year":"1995","journal-title":"J. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/art.1780361117","article-title":"Inflammatory polyarthritis in mice transgenic for human T-cell leukemia virus type I","volume":"36","author":"Yamamoto","year":"1993","journal-title":"Arthritis Rheum."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI118789","article-title":"Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice","volume":"98","author":"Fujisawa","year":"1996","journal-title":"J. Clin. Invest."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1073\/pnas.92.4.1057","article-title":"Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I","volume":"92","author":"Grossman","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nm1389","article-title":"Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I","volume":"12","author":"Hasegawa","year":"2006","journal-title":"Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/aid.2009.0212","article-title":"Cytokine and growth factor expression by HTLV-1 Lck-tax transgenic cells in SCID mice","volume":"26","author":"Watters","year":"2010","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1006\/viro.1994.1581","article-title":"Construction and characterization of infectious human T-cell leukemia virus type 1 molecular clones","volume":"204","author":"Kimata","year":"1994","journal-title":"Virology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1128\/JVI.73.6.4856-4865.1999","article-title":"Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone","volume":"73","author":"Robek","year":"1999","journal-title":"J. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/cr.2010.161","article-title":"A single NF\u03baB system for both canonical and non-canonical signaling","volume":"21","author":"Shih","year":"2011","journal-title":"Cell Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.2741\/3456","article-title":"Control of cell death pathways by HTLV-1 proteins","volume":"14","author":"Saggioro","year":"2009","journal-title":"Front. Biosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1038\/sj.onc.1203220","article-title":"Persistent activation of NF\u03baB by the tax transforming protein of HTLV-1; hijacking cellular IkappaB kinases","volume":"18","author":"Sun","year":"1999","journal-title":"Oncogene"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1038\/sj.onc.1208825","article-title":"Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells","volume":"24","author":"Jeong","year":"2005","journal-title":"Oncogene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"40965","DOI":"10.1074\/jbc.M506235200","article-title":"3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling","volume":"280","author":"Tanaka","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"18137","DOI":"10.1074\/jbc.M401397200","article-title":"Human T-cell lymphotropic virus type 1 tax induction of biologically active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA\/p65","volume":"279","author":"Montano","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6805","DOI":"10.1093\/emboj\/20.23.6805","article-title":"Retroviral oncoprotein Tax induces processing of NF-kappaB2\/p100 in T cells: Evidence for the involvement of IKKalpha","volume":"20","author":"Xiao","year":"2001","journal-title":"EMBO J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.0507809103","article-title":"The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas","volume":"103","author":"Lovly","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1742-4690-6-83","article-title":"Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2","volume":"6","author":"Shoji","year":"2009","journal-title":"Retrovirology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1128\/JVI.75.5.2185-2193.2001","article-title":"Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model","volume":"75","author":"Portis","year":"2001","journal-title":"J. Virol."},{"key":"ref_23","first-page":"3377","article-title":"Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation","volume":"10","author":"Mahieux","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1182\/blood-2010-10-306571","article-title":"Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I-associated neurologic disease","volume":"117","author":"Oh","year":"2011","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrm2455","article-title":"Cancer as an overhealing wound: An old hypothesis revisited","volume":"9","author":"Werner","year":"2008","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1182\/blood-2005-04-1730","article-title":"HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition","volume":"106","author":"Gao","year":"2005","journal-title":"Blood"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V98.4.1200","article-title":"The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors","volume":"98","author":"Portis","year":"2001","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood.V90.2.783","article-title":"Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I","volume":"90","author":"Grossman","year":"1997","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nm.1886","article-title":"Bioluminescence imaging of myeloperoxidase activity in vivo","volume":"15","author":"Gross","year":"2009","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1182\/blood-2008-07-166462","article-title":"Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors","volume":"113","author":"Rauch","year":"2009","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1182\/blood-2004-01-0266","article-title":"Enhanced tumorigenesis in HTLV-1 tax-transgenic mice deficient in interferon-gamma","volume":"104","author":"Harding","year":"2004","journal-title":"Blood"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1182\/blood.V85.7.1865.bloodjournal8571865","article-title":"Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells","volume":"85","author":"Furukawa","year":"1995","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1038\/sj.onc.1208970","article-title":"Cellular immune response to HTLV-1","volume":"24","author":"Bangham","year":"2005","journal-title":"Oncogene"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1742-4690-6-116","article-title":"T-cell activation promotes tumorigenesis in inflammation-associated cancer","volume":"6","author":"Rauch","year":"2009","journal-title":"Retrovirology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1182\/blood-2003-11-3967","article-title":"Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants","volume":"104","author":"Harding","year":"2004","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1182\/blood-2002-01-0151","article-title":"Bay 11\u20137082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells","volume":"100","author":"Mori","year":"2002","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/08830180701703364","article-title":"NF-kappaB in pathogenesis and treatment of adult T-cell leukemia\/lymphoma","volume":"26","author":"Horie","year":"2007","journal-title":"Int. Rev. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1158\/1535-7163.MCT-04-0277","article-title":"Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways","volume":"4","author":"Ikezoe","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1158\/1535-7163.MCT-05-0434","article-title":"NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-kappaB signal pathway","volume":"5","author":"Okudaira","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ijc.21389","article-title":"Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells","volume":"118","author":"Tomita","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1207\/s15327914nc5202_9","article-title":"Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells","volume":"52","author":"Haneji","year":"2005","journal-title":"Nutr. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.leukres.2007.05.026","article-title":"Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB","volume":"32","author":"Nishioka","year":"2008","journal-title":"Leuk. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/carcin\/bgi095","article-title":"In vivo antitumor activity of the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia","volume":"26","author":"Ohsugi","year":"2005","journal-title":"Carcinogenesis"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","article-title":"Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984\u201387)","volume":"79","author":"Shimoyama","year":"1991","journal-title":"Br. J. Haematol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2008.18.2428","article-title":"Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: A proposal from an international consensus meeting","volume":"27","author":"Tsukasaki","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1128\/AAC.01413-10","article-title":"Integrase Inhibitors Effective Against Human T-Cell Leukemia Virus Type 1","volume":"55","author":"Seegulam","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ratner, L., Harrington, W., Feng, X., Grant, C., Jacobson, S., Noy, A., Sparano, J., Lee, J., Ambinder, R., and Campbell, N. (2009). AIDS Malignancy Consortium. Human T-cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. Plos ONE, 4.","DOI":"10.1371\/journal.pone.0004420"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.2888190","article-title":"The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice","volume":"237","author":"Nerenberg","year":"1987","journal-title":"Science"},{"key":"ref_50","first-page":"5222","article-title":"Overexpression of transforming growth factor-beta in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene","volume":"11","author":"Kim","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1126\/science.1299224","article-title":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B","volume":"258","author":"Kitajima","year":"1992","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1126\/science.2888191","article-title":"A transgenic mouse model for human neurofibromatosis","volume":"237","author":"Hinrichs","year":"1987","journal-title":"Science"},{"key":"ref_53","first-page":"1401","article-title":"Adrenal medullary tumors and iris proliferation in a transgenic mouse model of neurofibromatosis","volume":"140","author":"Green","year":"1992","journal-title":"Am. J. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1128\/jvi.70.5.3280-3285.1996","article-title":"Repression of the NF1 gene by Tax may explain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice","volume":"70","author":"Feigenbaum","year":"1996","journal-title":"J. Virol."},{"key":"ref_55","first-page":"4635","article-title":"Trans activation of nerve growth factor in transgenic mice containing the human T-cell lymphotropic virus type I tax gene","volume":"11","author":"Green","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"ref_56","first-page":"1025","article-title":"Degeneration of oxidative muscle fibers in HTLV-1 tax transgenic mice","volume":"135","author":"Nerenberg","year":"1989","journal-title":"Am. J. Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/341072a0","article-title":"Exocrinopathy resembling Sjogren's syndrome in HTLV-1 tax transgenic mice","volume":"341","author":"Green","year":"1989","journal-title":"Nature"},{"key":"ref_58","first-page":"1045","article-title":"Abnormal B-cell function in HTLV-I-tax transgenic mice","volume":"10","author":"Peebles","year":"1995","journal-title":"Oncogene"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/viro.1993.1580","article-title":"Mice transgenic for HTLV-I LTR-tax exhibit tax expression in bone, skeletal alterations, and high bone turnover","volume":"197","author":"Ruddle","year":"1993","journal-title":"Virology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/viro.1993.1481","article-title":"A transgenic model of transactivation by the Tax protein of HTLV-I","volume":"196","author":"Bieberich","year":"1993","journal-title":"Virology"},{"key":"ref_61","first-page":"5371","article-title":"Transcriptional suppression of the human T-cell leukemia virus type I long terminal repeat occurs by an unconventional interaction of a CREB factor with the R region","volume":"14","author":"Xu","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1128\/jvi.63.7.3185-3189.1989","article-title":"Thymic atrophy characteristic in transgenic mice that harbor pX genes of human T-cell leukemia virus type I","volume":"63","author":"Furuta","year":"1989","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.4049\/jimmunol.162.5.2956","article-title":"The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice","volume":"162","author":"Habu","year":"1999","journal-title":"J. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1084\/jem.186.1.57","article-title":"Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-I) transgenic mice with autoimmune arthropathy","volume":"186","author":"Kishi","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1006\/viro.1998.9298","article-title":"Molecular mechanism of tumorigenesis in mice transgenic for the human T cell leukemia virus Tax gene","volume":"248","author":"Coscoy","year":"1998","journal-title":"Virology"},{"key":"ref_66","first-page":"2399","article-title":"Brain tumours and lymphomas in transgenic mice that carry HTLV-I LTR\/c-myc and Ig\/tax genes","volume":"7","author":"Benvenisty","year":"1992","journal-title":"Oncogene"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Rauch, D., Hurchla, M., Harding, J., Deng, H., Shea, L., Eagleton, M., Niewiesk, S., Lairmore, M., Piwnica-Worms, D., and Rosol, T. (2010). The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015755"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"35713","DOI":"10.1074\/jbc.M504848200","article-title":"Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax","volume":"280","author":"Kwon","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1084\/jem.20101095","article-title":"Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia","volume":"207","author":"Hasegawa","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1182\/blood-2008-11-189308","article-title":"Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice","volume":"114","author":"Kawaguchi","year":"2009","journal-title":"Blood"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1182\/blood-2008-08-174425","article-title":"Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia\/lymphoma","volume":"114","author":"Yamazaki","year":"2009","journal-title":"Blood"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nm0507-527","article-title":"The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells","volume":"13","author":"Ohsugi","year":"2007","journal-title":"Nat. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ohsugi, T., and Kumasaka, T. (2011). Low CD4\/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018518"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<209::AID-PATH162>3.0.CO;2-I","article-title":"Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression","volume":"186","author":"Hall","year":"1998","journal-title":"J. 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