{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:13:43Z","timestamp":1787030023177,"version":"build-2736575974"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:00:00Z","timestamp":1338336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The aim of this study was to evaluate the efficacy of the antiretrovirals: Zidovudine (ZDV) alone; ZDV + Recombinant Human Interferon-\u03b1 (rHuIFN-\u03b1); ZDV + Lamivudine (3TC) and ZDV + valproic acid (Valp) on naturally feline immunodeficiency virus (FIV)-infected cats, in the late phase of the asymptomatic stage of infection. The follow-up was performed over one year, through clinical evaluation and the determination of viral loads and CD4+\/CD8+ ratios. Neurological signs were studied by visual and auditory evoked potentials (VEP, AEP) and the responses were abnormal in 80% of the FIV-infected cats. After one year, an improvement in VEP and AEP was observed in the ZDV + Valp group and a worsening in the group receiving ZDV + rHuIFN-\u03b1. The CD4+\/CD8+ ratio showed a significant increase (both intra and inter-groups) only in ZDV and ZDV + 3TC, between their pre-treatment and one year values, as well as among the other groups. Viral load only showed a significant decrease in ZDV and ZDV + 3TC groups, when comparing the values at one year of treatment vs. pre-treatment values and when the different groups were compared. In addition, the viral load decrease was significantly more pronounced in the ZDV + 3TC vs. ZDV group. We conclude that ZDV and ZDV + 3TC produce significant reductions in viral load and stimulate a recovery of the CD4+\/CD8+ ratio, compared with the other protocols. It is clear that the addition of 3TC resulted in a greater reduction in viral load than use of ZDV as a single drug. Therefore, the combination ZDV + 3TC could be more effective than the sole use of ZDV.<\/jats:p>","DOI":"10.3390\/v4060924","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T11:08:12Z","timestamp":1338376092000},"page":"924-939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection"],"prefix":"10.3390","volume":"4","author":[{"given":"N\u00e9lida V.","family":"G\u00f3mez","sequence":"first","affiliation":[{"name":"Service of Electrophysiology, Veterinary Medicine Teaching Hospital of the University of Buenos Aires, San Mart\u00edn Av. 4453, CP 1427, Buenos Aires, Argentina"},{"name":"Department of Small Animals Medicine, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Fontanals","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina"},{"name":"Pablo Cassar\u00e1 Laboratory, Saladillo 2452, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Small Animals Medicine, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Department of Small Animals Medicine, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Suraniti","sequence":"additional","affiliation":[{"name":"Service of Electrophysiology, Veterinary Medicine Teaching Hospital of the University of Buenos Aires, San Mart\u00edn Av. 4453, CP 1427, Buenos Aires, Argentina"},{"name":"Department of Small Animals Medicine, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Mira","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology. School of Veterinary Sciences, University of Buenos Aires, Buenos Aires, 1427, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola B.","family":"Pisano","sequence":"additional","affiliation":[{"name":"Department of Small Animals Medicine, School of Veterinary Sciences, University of Buenos Aires, CP 1427, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0165-2427(01)00426-3","article-title":"Is AZT\/3TC therapy effective against FIV infection or immunopathogenesis?","volume":"85","author":"Arai","year":"2002","journal-title":"Vet. Immunol. 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