{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:34:51Z","timestamp":1760243691290,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Porton Down houses two separate sites capable of conducting high containment research on ACDP (Advisory Committee on Dangerous Pathogens) Hazard Group 4 agents: the Defence Science and Technology Laboratory (Dstl) and the Health Protection Agency (HPA), and filovirus research has been performed at Porton Down since the first Marburg virus disease outbreak in 1967. All work is conducted within primary containment either within cabinet lines (for in vitro work) or large rigid half-suit isolators (for in vivo work). There are extensive aerobiological facilities at high containment and the use of these facilities will be reported. Research at Dstl is primarily focused on assessing and quantifying the hazard, and testing the efficacy of medical countermeasures against filoviruses. Fundamental research directed to the study and understanding of the infectious and pathogenic nature of the filoviruses, particularly in aerosols, will be reported.<\/jats:p>","DOI":"10.3390\/v4081305","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T11:02:57Z","timestamp":1345201377000},"page":"1305-1317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Review of Filovirus Work and Facilities at The Defence Science and Technology Laboratory Porton Down"],"prefix":"10.3390","volume":"4","author":[{"given":"Sophie J.","family":"Smither","sequence":"first","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Lever","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire SP4 0JQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,8,17]]},"reference":[{"key":"ref_1","unstructured":"Carter, G. Personal communication."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0140-6736(68)90498-4","article-title":"Culture of vervet-monkey-disease agent","volume":"2","author":"Zlotnik","year":"1968","journal-title":"Lancet"},{"key":"ref_3","first-page":"458","article-title":"Vervet monkey disease. Experiment infection of guinea pigs and monkeys with the causative agent","volume":"49","author":"Simpson","year":"1968","journal-title":"Br. J. Exp. Pathol."},{"key":"ref_4","first-page":"400","article-title":"Vervet monkey disease: Studies on some physical and chemical properties of the causative agent","volume":"50","author":"Bowen","year":"1969","journal-title":"Br. J. Exp. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(77)92001-3","article-title":"Viral haemorrhagic fever in southern Sudan and northern Zaire. Preliminary studies on the aetiological agent","volume":"1","author":"Bowen","year":"1977","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0035-9203(78)90058-5","article-title":"Ebola haemorrhagic fever: Experimental infection of monkeys","volume":"72","author":"Bowen","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/bmj.2.6086.541","article-title":"A case of Ebola virus infection","volume":"2","author":"Emond","year":"1977","journal-title":"Br. Med. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/153567600801300204","article-title":"The microbiological validation of a new containment level 4 cabinet line","volume":"13","author":"Lever","year":"2008","journal-title":"J. Appl. Biosaf."},{"key":"ref_9","first-page":"1531","article-title":"The survival of filoviruses in liquids, on solid substrates and in a dynamic aerosol","volume":"109","author":"Piercy","year":"2010","journal-title":"J. Appl. Micobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jviromet.2011.06.021","article-title":"An alternative method of measuring aerosol survival using spiders\u2019 webs and its use for the filoviruses","volume":"177","author":"Smither","year":"2011","journal-title":"J. Virol. Methods"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1099\/jmm.0.036210-0","article-title":"Lethality and pathogenesis of airborne infection with filoviruses in A129 alpha\/beta -\/- interferon receptor-deficient mice","volume":"61","author":"Lever","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_12","unstructured":"O\u2019Brien, L. Personal communication."},{"key":"ref_13","unstructured":"Smither, S.J., Nelson, M., Eastaugh, L.E., Laws, T.R., Taylor, C., Smith, S.A., Salguero, F.J., and Lever, M.S. (2012). Establishment of lethal Marburg virus haemorrhagic fever by the aerosol route in the common marmoset (Callithrix jacchus). Int. J. Exp. Pathol., submitted."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/4\/8\/1305\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:51:51Z","timestamp":1760219511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/4\/8\/1305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,17]]},"references-count":13,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,8]]}},"alternative-id":["v4081305"],"URL":"https:\/\/doi.org\/10.3390\/v4081305","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2012,8,17]]}}}