{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:35:23Z","timestamp":1760243723116,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non\u2011neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV.<\/jats:p>","DOI":"10.3390\/v4091509","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T21:03:04Z","timestamp":1347397384000},"page":"1509-1514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?"],"prefix":"10.3390","volume":"4","author":[{"given":"Stephanie F.","family":"James","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-3794","authenticated-orcid":false,"given":"Ravi","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Gilden","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA"},{"name":"Department of Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(94)90350-6","article-title":"An evolutionary perspective on apoptosis","volume":"76","author":"Vaux","year":"1994","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1099\/0022-1317-79-8-1833","article-title":"Viruses and apoptosis","volume":"79","year":"1998","journal-title":"J. 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