{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:01:43Z","timestamp":1792440103889,"version":"4.5.0"},"reference-count":125,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:00:00Z","timestamp":1350604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Jun\u00edn virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Jun\u00edn virus. We will review the pathogenesis of Jun\u00edn virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Jun\u00edn virus in elucidating virus attenuation. We will also summarize current knowledge on Jun\u00edn virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.<\/jats:p>","DOI":"10.3390\/v4102317","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T05:32:03Z","timestamp":1350883923000},"page":"2317-2339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Jun\u00edn Virus Pathogenesis and Virus Replication"],"prefix":"10.3390","volume":"4","author":[{"given":"Ashley","family":"Grant","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Seregin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Kolokoltsova","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Brasier","sequence":"additional","affiliation":[{"name":"Institute for Translational Sciences, Department of Internal Medicine and Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarence","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Paessler","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4269\/ajtmh.1994.51.554","article-title":"Prevalence of infection with junin virus in rodent populations in the epidemic area of argentine hemorrhagic fever","volume":"51","author":"Mills","year":"1994","journal-title":"T. Am. J. Trop. Med. Hyg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF01250608","article-title":"Characteristics of junin virus. Etiological agent of argentine hemorrhagic fever","volume":"19","author":"Parodi","year":"1966","journal-title":"Archiv fur die gesamte Virusforschung"},{"key":"ref_3","unstructured":"Knipe, D.M.H.P. (2007). Fields virology, Wolter Kluwer Lippincott Williams & Wilkins."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-1702(00)00222-7","article-title":"Arenavirus nucleocapsid protein displays a transcriptional antitermination activity in vivo","volume":"73","author":"Tortorici","year":"2001","journal-title":"Vir. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7659","DOI":"10.1128\/jvi.68.11.7659-7664.1994","article-title":"Sequence heterogeneity in the termini of lymphocytic choriomeningitis virus genomic and antigenomic rnas","volume":"68","author":"Meyer","year":"1994","journal-title":"J. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1128\/JVI.77.5.2866-2872.2003","article-title":"Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase ski-1\/s1p","volume":"77","author":"Beyer","year":"2003","journal-title":"J. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"12701","DOI":"10.1073\/pnas.221447598","article-title":"The lassa virus glycoprotein precursor gp-c is proteolytically processed by subtilase ski-1\/s1p","volume":"98","author":"Lenz","year":"2001","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1073\/pnas.1332709100","article-title":"Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein","volume":"100","author":"Pinschewer","year":"2003","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1002\/j.1460-2075.1989.tb08565.x","article-title":"Identification of four conserved motifs among the rna-dependent polymerase encoding elements","volume":"8","author":"Poch","year":"1989","journal-title":"EMBO J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12978","DOI":"10.1073\/pnas.2133782100","article-title":"The small ring finger protein z drives arenavirus budding: Implications for antiviral strategies","volume":"100","author":"Perez","year":"2003","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10700","DOI":"10.1128\/JVI.77.19.10700-10705.2003","article-title":"Lassa virus z protein is a matrix protein and sufficient for the release of virus-like particles [corrected]","volume":"77","author":"Strecker","year":"2003","journal-title":"J. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1128\/JVI.80.8.4191-4195.2006","article-title":"Cellular factors required for lassa virus budding","volume":"80","author":"Urata","year":"2006","journal-title":"J. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1000455","DOI":"10.1371\/journal.ppat.1000455","article-title":"Genetic detection and characterization of lujo virus, a new hemorrhagic fever-associated arenavirus from southern africa","volume":"5","author":"Briese","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_14","first-page":"117","article-title":"Clinical manifestations of new world hantaviruses","volume":"256","author":"Enria","year":"2001","journal-title":"Curr. Top. Microbiol."},{"key":"ref_15","unstructured":"Briggiler, A.M.L.S., Enriar, D.A., and Maiztegui, J.I. (1990). Argentine hemorrhagic fever in pregnant women. Medicina, 50."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jmv.1890220202","article-title":"Virus-specific factors in experimental argentine hemorrhagic fever in rhesus macaques","volume":"22","author":"McKee","year":"1987","journal-title":"J. Med. Virol."},{"key":"ref_17","first-page":"250","article-title":"Lymphatic tissue in argentine hemorrhagic fever. Pathologic features","volume":"104","author":"Gonzalez","year":"1980","journal-title":"Arch. Patho. l Lab. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1128\/JVI.76.3.1154-1162.2002","article-title":"Alterations in nf-kappab and rbp-jkappa by arenavirus infection of macrophages in vitro and in vivo","volume":"76","author":"Fennewald","year":"2002","journal-title":"J. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.4049\/jimmunol.172.5.2861","article-title":"Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells","volume":"172","author":"Baize","year":"2004","journal-title":"J. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1086\/320722","article-title":"Low levels of interleukin-8 and interferon-inducible protein-10 in serum are associated with fatal infections in acute lassa fever","volume":"183","author":"Mahanty","year":"2001","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S743","DOI":"10.1093\/clinids\/11.Supplement_4.S743","article-title":"Pathogenesis of viral hemorrhagic fevers: Rift valley fever and lassa fever contrasted","volume":"11","author":"Peters","year":"1989","journal-title":"Rev Infect Dis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1096-9071(199912)59:4<552::AID-JMV21>3.0.CO;2-A","article-title":"Lassa and mopeia virus replication in human monocytes\/macrophages and in endothelial cells: Different effects on il-8 and tnf-alpha gene expression","volume":"59","author":"Lukashevich","year":"1999","journal-title":"J. Med. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1073\/pnas.2232366100","article-title":"Targeting schwann cells by nonlytic arenaviral infection selectively inhibits myelination","volume":"100","author":"Rambukkana","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0140-6736(84)90299-X","article-title":"Importance of dose of neutralising antibodies in treatment of argentine haemorrhagic fever with immune plasma","volume":"2","author":"Enria","year":"1984","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S749","DOI":"10.1093\/clinids\/11.Supplement_4.S743","article-title":"Pathogenesis of viral hemorrhagic fevers","volume":"11","author":"Peters","year":"1989","journal-title":"Rev. Infect Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kolokoltsova, O.A., Yun, N.E., Poussard, A.L., Smith, J.K., Smith, J.N., Salazar, M., Walker, A., Tseng, C.T., Aronson, J.F., and Paessler, S. Mice lacking alpha\/beta and gamma interferon receptors are susceptible to junin virus infection. J. Virol., 84, 13063\u201313067.","DOI":"10.1128\/JVI.01389-10"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000149116","article-title":"Immunosuppression in experimental junin virus infection of mice","volume":"13","author":"Giovanniello","year":"1980","journal-title":"Intervirol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.micinf.2010.12.006","article-title":"Junin virus. A xxi century update","volume":"13","author":"Gomez","year":"2011","journal-title":"Microbes and infection \/ Institut Pasteur"},{"key":"ref_29","first-page":"507","article-title":"Experimental biology and pathogenesis of junin virus infection in animals and man","volume":"52","author":"Weissenbacher","year":"1975","journal-title":"B. World Health Organ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/jmv.1890260412","article-title":"Susceptible adult murine model for junin virus","volume":"26","author":"Campetella","year":"1988","journal-title":"J. Med. Virol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jmv.1890250213","article-title":"Junin virus-induced delayed-type hypersensitivity suppression in adult mice","volume":"25","author":"Campetella","year":"1988","journal-title":"J. Med. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000149330","article-title":"Junin virus infection in genetically athymic mice","volume":"19","author":"Weissenbacher","year":"1983","journal-title":"Intervirol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF01241176","article-title":"Junin virus multiplication in thymectomized mice. Effect of thymus and immunocompetent cells grafting","volume":"26","author":"Weissenbacher","year":"1969","journal-title":"Arch. Gesamte Virusforsch."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1128\/iai.19.3.893-897.1978","article-title":"Enhanced resistance against junin virus infection induced by corynebacterium parvum","volume":"19","author":"Budzko","year":"1978","journal-title":"Infect. Immun."},{"key":"ref_35","first-page":"237","article-title":"Passive immunity against junin virus in mice","volume":"19","author":"Nejamkis","year":"1975","journal-title":"Acta Virol."},{"key":"ref_36","first-page":"61","article-title":"Further experiments on the action of antithymocyte serum in experimental junin virus infection","volume":"20","author":"Nota","year":"1976","journal-title":"Acta Virol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000150025","article-title":"Mouse splenocyte transfer effect depends on donor's junin virus infection stage","volume":"29","author":"Rabinovich","year":"1988","journal-title":"Intervirol."},{"key":"ref_38","first-page":"629","article-title":"Contrasuppressor cells induced by junin virus","volume":"69","author":"Campetella","year":"1990","journal-title":"Immunology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/jvi.53.1.75-80.1985","article-title":"Effect of immunosuppression on experimental argentine hemorrhagic fever in guinea pigs","volume":"53","author":"Kenyon","year":"1985","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/infdis\/143.1.7","article-title":"Junin virus infection of guinea pigs: Immunohistochemical and ultrastructural studies of hemopoietic tissue","volume":"143","author":"Carballal","year":"1981","journal-title":"J. Infect. Dis."},{"key":"ref_41","first-page":"197","article-title":"[experimental junin virus infection of guinea pigs. I. Pathological anatomy]","volume":"36","author":"Elsner","year":"1976","journal-title":"Medicina (B Aires)"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/infdis\/132.1.35","article-title":"Ultrastructural and immunohistochemical studies in five cases of argentine hemorrhagic fever","volume":"132","author":"Maiztegui","year":"1975","journal-title":"J. Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000150039","article-title":"Viral strain dependent differences in experimental argentine hemorrhagic fever (junin virus) infection of guinea pigs","volume":"29","author":"Kenyon","year":"1988","journal-title":"Intervirol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4269\/ajtmh.2008.79.275","article-title":"Pathogenesis of xj and romero strains of junin virus in two strains of guinea pigs","volume":"79","author":"Yun","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jmv.1890150208","article-title":"Neurotropism of a high-passage xj strain of junin virus","volume":"15","author":"Oubina","year":"1985","journal-title":"J. Med. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000149392","article-title":"Pathogenicity of an attenuated strain (xjcl3) of junin virus. Morphological and virological studies in experimentally infected guinea pigs","volume":"20","author":"Laguens","year":"1983","journal-title":"Intervirol."},{"key":"ref_47","first-page":"111","article-title":"[argentine hemorrhagic fever]","volume":"30","author":"Sabattini","year":"1970","journal-title":"Medicina (B Aires)"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4269\/ajtmh.1987.37.663","article-title":"Effect of persistent infection with junin virus on growth and reproduction of its natural reservoir, calomys musculinus","volume":"37","author":"Vitullo","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_49","first-page":"61","article-title":"[response of calomys musculinus to experimental infection with junin virus]","volume":"42","author":"Lampuri","year":"1982","journal-title":"Medicina"},{"key":"ref_50","first-page":"149","article-title":"Infeccion natural y experimental de roedores con virus junin","volume":"37","author":"Sabattini","year":"1977","journal-title":"Medicina (B Aires)"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/jhered\/esg095","article-title":"Restricted gene flow in calomys musculinus (rodentia, muridae), the natural reservoir of junin virus","volume":"94","author":"Chiappero","year":"2003","journal-title":"J. Hered."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000149059","article-title":"Argentine hemorrhagic fever: A primate model","volume":"11","author":"Weissenbacher","year":"1979","journal-title":"Intervirol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF02122446","article-title":"Effect of ribavirin and immune serum on junin virus-infected primates","volume":"175","author":"Weissenbacher","year":"1986","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/iai.35.2.425-430.1982","article-title":"Cross-protection in nonhuman primates against argentine hemorrhagic fever","volume":"35","author":"Weissenbacher","year":"1982","journal-title":"Infect. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jmv.1890240213","article-title":"Long-term protection against argentine hemorrhagic fever in tacaribe virus infected marmosets: Virologic and histopathologic findings","volume":"24","author":"Samoilovich","year":"1988","journal-title":"J. Med. Virol."},{"key":"ref_56","first-page":"277","article-title":"Nasal and intrathalamic inoculations of primates with tacaribe virus: Protection against argentine hemorrhagic fever and absence of neurovirulence","volume":"28","author":"Samoilovich","year":"1984","journal-title":"Acta Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4269\/ajtmh.1993.48.403","article-title":"Safety and immunogenicity of a live-attenuated junin (argentine hemorrhagic fever) vaccine in rhesus macaques","volume":"48","author":"McKee","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000150276","article-title":"Candid no. 1 argentine hemorrhagic fever vaccine protects against lethal junin virus challenge in rhesus macaques","volume":"34","author":"McKee","year":"1992","journal-title":"Intervirol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/infdis\/141.5.580","article-title":"Lassa virus infection of rhesus monkeys","volume":"141","author":"Jahrling","year":"1980","journal-title":"J. Infect. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jmv.1890270218","article-title":"Lymphocyte subsets alteration in patients with argentine hemorrhagic fever","volume":"27","author":"Vallejos","year":"1989","journal-title":"J. Med. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/jmv.1890370315","article-title":"Peripheral blood leukocytes of patients with argentine hemorrhagic fever as effectors of antibody-dependent cell-cytotoxicity","volume":"37","author":"Ambrosio","year":"1992","journal-title":"J. Med. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1128\/JVI.02102-10","article-title":"Rescue from cloned cdnas and in vivo characterization of recombinant pathogenic romero and live-attenuated candid #1 strains of junin virus, the causative agent of argentine hemorrhagic fever disease","volume":"85","author":"Emonet","year":"2011","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jmv.1890210109","article-title":"Protection of junin virus-infected marmosets by passive administration of immune serum: Association with late neurologic signs","volume":"21","author":"Avila","year":"1987","journal-title":"J. Med. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.antiviral.2007.10.010","article-title":"Treatment of argentine hemorrhagic fever","volume":"78","author":"Enria","year":"2008","journal-title":"Antivir. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1160\/TH09-06-0357","article-title":"The role of the vascular endothelium in arenavirus haemorrhagic fevers","volume":"102","author":"Kunz","year":"2009","journal-title":"Thromb. Haemostasis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/78654","article-title":"Identification of the ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury","volume":"6","author":"Yang","year":"2000","journal-title":"Nat. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1128\/iai.20.3.776-781.1978","article-title":"Replication of dengue and junin viruses in cultured rabbit and human endothelial cells","volume":"20","author":"Andrews","year":"1978","journal-title":"Infect. Immun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1160\/TH02-09-0043","article-title":"Endothelial cell function alteration after junin virus infection","volume":"90","author":"Gomez","year":"2003","journal-title":"Thromb. Haemostasis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4269\/ajtmh.1973.22.229","article-title":"Pathology of 12 fatal cases of argentine hemorrhagic fever","volume":"22","author":"Elsner","year":"1973","journal-title":"T. Am. J. Trop. Med. Hyg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature05539","article-title":"Transferrin receptor 1 is a cellular receptor for new world haemorrhagic fever arenaviruses","volume":"446","author":"Radoshitzky","year":"2007","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1073\/pnas.0709254105","article-title":"Receptor determinants of zoonotic transmission of new world hemorrhagic fever arenaviruses","volume":"105","author":"Radoshitzky","year":"2008","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nsmb.1772","article-title":"Structural basis for receptor recognition by new world hemorrhagic fever arenaviruses","volume":"17","author":"Abraham","year":"2010","journal-title":"Nat. Ctruct. Mol. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11058","DOI":"10.1128\/JVI.05304-11","article-title":"Junin virus infects mouse cells and induces innate immune responses","volume":"85","author":"Cuevas","year":"2011","journal-title":"J. Virol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"13457","DOI":"10.1128\/JVI.05616-11","article-title":"Substitutions in the glycoprotein (gp) of the candid#1 vaccine strain of junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of gp","volume":"85","author":"Reignier","year":"2011","journal-title":"J. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10404","DOI":"10.1128\/JVI.00856-11","article-title":"The major determinant of attenuation in mice of the candid1 vaccine for argentine hemorrhagic fever is located in the g2 glycoprotein transmembrane domain","volume":"85","author":"Albarino","year":"2011","journal-title":"J. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000149662","article-title":"Junin virus isolation from lympho-mononuclear cells of patients with argentine hemorrhagic fever","volume":"25","author":"Ambrosio","year":"1986","journal-title":"Intervirol."},{"key":"ref_77","first-page":"58","article-title":"Junin virus replication in peripheral blood mononuclear cells of patients with argentine haemorrhagic fever","volume":"34","author":"Ambrosio","year":"1990","journal-title":"Acta Virol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1128\/iai.41.3.1279-1283.1983","article-title":"In vivo replication of pathogenic and attenuated strains of junin virus in different cell populations of lymphatic tissue","volume":"41","author":"Laguens","year":"1983","journal-title":"Infect. Immun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02122447","article-title":"Splenic dendritic cells and junin virus","volume":"175","author":"Laguens","year":"1986","journal-title":"Med. Microbiol. Immun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/vim.1995.8.101","article-title":"The role of mononuclear blood cells in experimental junin virus spread to the central nervous system","volume":"8","author":"Medeot","year":"1995","journal-title":"Vir. Immun. y"},{"key":"ref_81","first-page":"177","article-title":"[isolation of junin virus from blood and peripheral lymphocytes of infected calomys musculinus]","volume":"17","author":"Alche","year":"1985","journal-title":"Rev. Argent. Microbiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e1137","DOI":"10.1371\/journal.pntd.0001137","article-title":"Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages","volume":"5","author":"Groseth","year":"2011","journal-title":"PLoS Neglect. Trop. Dis."},{"key":"ref_83","first-page":"229","article-title":"[role of macrophages in the dissemination of the junin virus in the rat]","volume":"17","author":"Blejer","year":"1985","journal-title":"Rev. Argent. Microbiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jmv.1890180311","article-title":"Role of calomys musculinus peritoneal macrophages in age-related resistance to junin virus infection","volume":"18","author":"Coulombie","year":"1986","journal-title":"J. Med. Virol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/infdis\/154.3.478","article-title":"Macrophage maturity and modulation of response to junin virus in infected rats","volume":"154","author":"Blejer","year":"1986","journal-title":"J. Infect. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/jir.1985.5.383","article-title":"Correlation between endogenous interferon and the clinical evolution of patients with argentine hemorrhagic fever","volume":"5","author":"Levis","year":"1985","journal-title":"J. Interfer. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/infdis\/149.3.428","article-title":"Endogenous interferon in argentine hemorrhagic fever","volume":"149","author":"Levis","year":"1984","journal-title":"J. Infect. Dis."},{"key":"ref_88","first-page":"377","article-title":"Activity of a platelet protein kinase that phosphorylates fibrinogen and histone in argentine hemorrhagic fever","volume":"41","author":"Lerer","year":"1991","journal-title":"Acta Physiol. Pharm. L."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e1000847","DOI":"10.1371\/journal.ppat.1000847","article-title":"Junin virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type i ifn signaling","volume":"6","author":"Pozner","year":"2010","journal-title":"PLoS Pathog."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jmv.1890230110","article-title":"Interferon response in the guinea pig infected with junin virus","volume":"23","author":"Dejean","year":"1987","journal-title":"J. Med. Virol."},{"key":"ref_91","first-page":"23","article-title":"Aerosol infection of rhesus macaques with junin virus","volume":"33","author":"Kenyon","year":"1992","journal-title":"Intervirol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4269\/ajtmh.1999.60.85","article-title":"Proinflammatory cytokines and elastase-alpha-1-antitrypsin in argentine hemorrhagic fever","volume":"60","author":"Marta","year":"1999","journal-title":"T. Am. J. Trop. Med. Hyg."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Pythoud, C., Rodrigo, W.W., Pasqual, G., Rothenberger, S., Martinez-Sobrido, L., de la Torre, J.C., and Kunz, S. (2012). Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase ikk{varepsilon}. J. Virol.","DOI":"10.1128\/JVI.00187-12"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Rodrigo, W.W., Ortiz-Riano, E., Pythoud, C., Kunz, S., de la Torre, J.C., and Martinez-Sobrido, L. (2012). Arenavirus nucleoproteins prevent activation of nuclear factor kappa b. J. Virol.","DOI":"10.1128\/JVI.07240-11"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"13038","DOI":"10.1128\/JVI.05834-11","article-title":"The c-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in np-z interaction and counteraction of the type i interferon response","volume":"85","author":"Cheng","year":"2011","journal-title":"J. Virol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"12696","DOI":"10.1128\/JVI.00882-07","article-title":"Differential inhibition of type i interferon induction by arenavirus nucleoproteins","volume":"81","author":"Giannakas","year":"2007","journal-title":"J. Virol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1128\/JVI.00155-10","article-title":"Induction and inhibition of type i interferon responses by distinct components of lymphocytic choriomeningitis virus","volume":"84","author":"Zhou","year":"2010","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1128\/JVI.01362-09","article-title":"Z proteins of new world arenaviruses bind rig-i and interfere with type i interferon induction","volume":"84","author":"Fan","year":"2010","journal-title":"J. Virol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e1659","DOI":"10.1371\/journal.pntd.0001659","article-title":"Junin virus infection activates the type i interferon pathway in a rig-i-dependent manner","volume":"6","author":"Huang","year":"2012","journal-title":"PLoS Neglect. Trop. Dis."},{"key":"ref_100","first-page":"22","article-title":"[ini vitro interferon induction by junin virus; effect of pre-treatment with the inhibitor]","volume":"9","author":"Knecher","year":"1977","journal-title":"REv. Asoc. Argent. Microbiol."},{"key":"ref_101","first-page":"120","article-title":"[protection against encephalitis in rats caused by a pathogenic strain of the junin virus, using peripheral inoculation of an attenuated strain]","volume":"21","author":"Remesar","year":"1989","journal-title":"Rev. Argent. Microbiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"13063","DOI":"10.1128\/JVI.01389-10","article-title":"Mice lacking alpha\/beta and gamma interferon receptors are susceptible to junin virus infection","volume":"84","author":"Kolokoltsova","year":"2010","journal-title":"J. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000149452","article-title":"Cross-protection between tacaribe complex viruses. Presence of neutralizing antibodies against junin virus (argentine hemorrhagic fever) in guinea pigs infected with tacaribe virus","volume":"6","author":"Weissenbacher","year":"1975","journal-title":"Intervirol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jmv.1890230308","article-title":"Tacaribe virus: A new alternative for argentine hemorrhagic fever vaccine","volume":"23","author":"Carballal","year":"1987","journal-title":"J. Med. Virol."},{"key":"ref_105","first-page":"2300","article-title":"Sobre la etiologia del bute epidemico de junin","volume":"30","author":"Parodi","year":"1958","journal-title":"Dia Medico"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jmv.1890270215","article-title":"Antigenic relationships between attenuated and pathogenic strains of junin virus","volume":"27","author":"Candurra","year":"1989","journal-title":"J. Med. Virol."},{"key":"ref_107","first-page":"2239","article-title":"[treatment of argentine hemorrhagic fever with convalescent's plasma. 4433 cases]","volume":"15","author":"Ruggiero","year":"1986","journal-title":"Presse Med"},{"key":"ref_108","first-page":"334","article-title":"Early protection to junin virus of guinea pig with an attenuated junin virus strain","volume":"29","author":"Boxaca","year":"1985","journal-title":"Acta Virol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"694","DOI":"10.4161\/hv.7.6.15198","article-title":"Argentine hemorrhagic fever vaccines","volume":"7","author":"Ambrosio","year":"2011","journal-title":"Hum. Vaccines"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1099\/0022-1317-78-7-1605","article-title":"Molecular characterization of attenuated junin virus strains","volume":"78 ( Pt 7)","author":"Albarino","year":"1997","journal-title":"J. Gen. Virol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jmv.1890320308","article-title":"Neurovirulence of wild and laboratory junin virus strains in animal hosts","volume":"32","author":"Medeot","year":"1990","journal-title":"J. Med. Virol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1086\/514211","article-title":"Protective efficacy of a live attenuated vaccine against argentine hemorrhagic fever. Ahf study group","volume":"177","author":"Maiztegui","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000149136","article-title":"Biological properties of junin virus proteins. I. Identification of the immunogenic glycoprotein","volume":"13","author":"Cresta","year":"1980","journal-title":"Intervirol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jmv.1890290312","article-title":"Formalin inactivated junin virus: Immunogenicity and protection assays","volume":"29","author":"Videla","year":"1989","journal-title":"J. Med. Virol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1016\/j.vaccine.2010.04.077","article-title":"Tc83 replicon vectored vaccine provides protection against junin virus in guinea pigs","volume":"28","author":"Seregin","year":"2010","journal-title":"Vaccine"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0140-6736(79)92335-3","article-title":"Efficacy of immune plasma in treatment of argentine haemorrhagic fever and association between treatment and a late neurological syndrome","volume":"2","author":"Maiztegui","year":"1979","journal-title":"Lancet"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0882-4010(90)90010-N","article-title":"Protection of guinea pigs against experimental argentine hemorrhagic fever by purified human igg: Importance of elimination of infected cells","volume":"9","author":"Kenyon","year":"1990","journal-title":"Microbiol. Pathogen."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.virusres.2004.11.006","article-title":"Metabolism and antiviral activity of ribavirin","volume":"107","author":"Parker","year":"2005","journal-title":"Vir. Res."},{"key":"ref_119","unstructured":"Stephen, E.L., Jones, D.E., Peters, C.J., Eddy, G.A., Loizeaux, P.S., and Jahrling, P.B. (1980). Ribavirin treatment of toga-, areana- and bunyavirus infections in subhuman primates and other laboratory animals species, Academic Press."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/AAC.32.9.1304","article-title":"Ribavirin prophylaxis and therapy for experimental argentine hemorrhagic fever","volume":"32","author":"McKee","year":"1988","journal-title":"Antimicrob. Agents Ch."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1056\/NEJM199508033330505","article-title":"Brief report: Treatment of a laboratory-acquired sabia virus infection","volume":"333","author":"Barry","year":"1995","journal-title":"New Engl. J. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/clind\/24.4.718","article-title":"Treatment of bolivian hemorrhagic fever with intravenous ribavirin","volume":"24","author":"Kilgore","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"ref_123","first-page":"79","article-title":"Argentine hemorrhagic fever","volume":"134","author":"Weissenbacher","year":"1987","journal-title":"Curr. Top. Microbiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/AAC.29.3.521","article-title":"Effect of ribavirin and tributylribavirin on argentine hemorrhagic fever (junin virus) in guinea pigs","volume":"29","author":"Kenyon","year":"1986","journal-title":"Antimicrob. Agents Ch."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1863-2378.2011.01447.x","article-title":"Effect of ribavirin on junin virus infection in guinea pigs","volume":"59","author":"Salazar","year":"2012","journal-title":"Zoonoses Public Hlth."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/4\/10\/2317\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:52:59Z","timestamp":1760219579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/4\/10\/2317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,19]]},"references-count":125,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10]]}},"alternative-id":["v4102317"],"URL":"https:\/\/doi.org\/10.3390\/v4102317","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,19]]}}}