{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:33:03Z","timestamp":1778661183500,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:00:00Z","timestamp":1351036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>HRSV is one of the most important pathogens causing acute respiratory tract diseases as bronchiolitis and pneumonia among infants. HRSV was isolated from two distinct communities, a public day care center and a public hospital in S\u00e3o Jos\u00e9 do Rio Preto \u2013 SP, Brazil. We obtained partial sequences from G gene that were used on phylogenetic and selection pressure analysis. HRSV accounted for 29% of respiratory infections in hospitalized children and 7.7% in day care center children. On phylogenetic analysis of 60 HRSV strains, 48 (80%) clustered within or adjacent to the GA1 genotype; GA5, NA1, NA2, BA-IV and SAB1 were also observed. SJRP GA1 strains presented variations among deduced amino acids composition and lost the potential O-glycosilation site at amino acid position 295, nevertheless this resulted in an insertion of two potential O-glycosilation sites at positions 296 and 297. Furthermore, a potential O-glycosilation site insertion, at position 293, was only observed for hospital strains. Using SLAC and MEME methods, only amino acid 274 was identified to be under positive selection. This is the first report on HRSV circulation and genotypes classification derived from a day care center community in Brazil.<\/jats:p>","DOI":"10.3390\/v4112432","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T11:00:57Z","timestamp":1351076457000},"page":"2432-2447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diversity and Adaptation of Human Respiratory Syncytial Virus Genotypes Circulating in Two Distinct Communities: Public Hospital and Day Care Center"],"prefix":"10.3390","volume":"4","author":[{"given":"Luiz","family":"Gardinassi","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, SP. Departamento de Bioqu\u00edmica e Imunologia \u2013 Av. dos Bandeirantes, 3900 Monte Alegre \u2013 Cep: 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Simas","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas de S\u00e3o Jos\u00e9 do Rio Preto, SP. Departamento de Biologia - Rua Crist\u00f3v\u00e3o Colombo, 2265, Jardim Nazareth \u2013 Cep: 15054-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deriane","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas de S\u00e3o Jos\u00e9 do Rio Preto, SP. Departamento de F\u00edsica - Rua Crist\u00f3v\u00e3o Colombo, 2265, Jardim Nazareth \u2013 Cep: 15054-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Bonfim","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas de S\u00e3o Jos\u00e9 do Rio Preto, SP. Departamento de Biologia - Rua Crist\u00f3v\u00e3o Colombo, 2265, Jardim Nazareth \u2013 Cep: 15054-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas de S\u00e3o Jos\u00e9 do Rio Preto, SP. Departamento de Biologia - Rua Crist\u00f3v\u00e3o Colombo, 2265, Jardim Nazareth \u2013 Cep: 15054-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de Ribeir\u00e3o Preto, SP. Departamento de Bioqu\u00edmica e Imunologia \u2013 Av. dos Bandeirantes, 3900 Monte Alegre \u2013 Cep: 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Carareto","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas de S\u00e3o Jos\u00e9 do Rio Preto, SP. Departamento de Biologia - Rua Crist\u00f3v\u00e3o Colombo, 2265, Jardim Nazareth \u2013 Cep: 15054-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Rahal","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas de S\u00e3o Jos\u00e9 do Rio Preto, SP. Departamento de Biologia - Rua Crist\u00f3v\u00e3o Colombo, 2265, Jardim Nazareth \u2013 Cep: 15054-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas de S\u00e3o Jos\u00e9 do Rio Preto, SP. Departamento de F\u00edsica - Rua Crist\u00f3v\u00e3o Colombo, 2265, Jardim Nazareth \u2013 Cep: 15054-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1056\/NEJM197303082881005","article-title":"Epidemiology of acute lower respiratory disease in children","volume":"288","author":"Glezen","year":"1973","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children","volume":"360","author":"Hall","year":"2009","journal-title":"N. Engl. J. 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