{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:42:14Z","timestamp":1761648134713,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hantaviruses are an established cause of haemorrhagic fever with renal syndrome (HFRS) in Europe. Following a confirmed case of HFRS in the UK, in an individual residing on a farm in North Yorkshire and the Humber, a tidal estuary on the east coast of Northern England, and the subsequent isolation of a Seoul hantavirus from rats trapped on the patient\u2019s farm, it was considered appropriate to further investigate the public health risk of this virus in the region. Of a total 119 individuals tested, nine (7.6%) were seropositive for hantavirus antibodies. Seven of the seropositive samples showed a stronger reaction to Seoul and Hantaan compared to other clinically relevant hantaviruses. Observation of rodents during the day, in particular mice, was associated with a reduced risk of seropositivity. In addition to one region known to be at risk following an acute case, five further potential risk areas have been identified. This study supports recently published evidence that hantaviruses are likely to be of public health interest in the region.<\/jats:p>","DOI":"10.3390\/v6020524","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T10:45:44Z","timestamp":1391597144000},"page":"524-534","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom"],"prefix":"10.3390","volume":"6","author":[{"given":"Lisa","family":"Jameson","sequence":"first","affiliation":[{"name":"Microbiology Services, Public Health England, Porton Down, Wiltshire, SP4 0JG, UK"},{"name":"Institute of Infection and Global Health, University of Liverpool, Liverpool, L69 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Autilia","family":"Newton","sequence":"additional","affiliation":[{"name":"Public Health England, Yorkshire and the Humber, York, YO41 1LZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Coole","sequence":"additional","affiliation":[{"name":"Field Epidemiology Services, Public Health England, Leeds, LS2 7UE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Newman","sequence":"additional","affiliation":[{"name":"Microbiology Services, Public Health England, Porton Down, Wiltshire, SP4 0JG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles","family":"Carroll","sequence":"additional","affiliation":[{"name":"Microbiology Services, Public Health England, Porton Down, Wiltshire, SP4 0JG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Beeching","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Hewson","sequence":"additional","affiliation":[{"name":"Microbiology Services, Public Health England, Porton Down, Wiltshire, SP4 0JG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9250-3032","authenticated-orcid":false,"given":"Robert","family":"Christley","sequence":"additional","affiliation":[{"name":"Institute of Infection and Global Health, University of Liverpool, Liverpool, L69 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vaheri, A., Henttonen, H., Voutilainen, L., Mustonen, J., Sironen, T., and Vapalahti, O. (2012). Hantavirus infections in Europe and their impact on public health. Rev. Med. Virol.","DOI":"10.1002\/rmv.1722"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/1040841X.2013.783555","article-title":"Epidemiology of hantavirus infections in humans: A comprehensive, global overview","volume":"40","author":"Watson","year":"2014","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_3","first-page":"62","article-title":"Hemorrhagic fever with renal syndrome","volume":"36","author":"Lee","year":"1989","journal-title":"Prog. Med. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.micinf.2008.12.016","article-title":"The hantaviral load in tissues of naturally infected rodents","volume":"11","author":"Korva","year":"2009","journal-title":"Microb. Infect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3855\/jidc.317","article-title":"Hantavirus infection: A review and global update","volume":"2","author":"Bi","year":"2008","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/rmv.581","article-title":"How to diagnose hantavirus infections and detect them in rodents and insectivores","volume":"18","author":"Vaheri","year":"2008","journal-title":"Rev. Med. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1017\/S0950268800048196","article-title":"Zoonotic infections in Northern Ireland farmers","volume":"105","author":"Stanford","year":"1990","journal-title":"Epidemiol. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.13031\/2013.5695","article-title":"Occupational exposure to animals and risk of zoonotic illness in a cohort of farmers, farmworkers and their families in England","volume":"5","author":"Thomas","year":"1999","journal-title":"J. Agric. Saf. Health."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2807\/ese.18.01.20344-en","article-title":"The continued emergence of hantaviruses: Isolation of a Seoul virus implicated in human disease, United Kingdom, October 2012","volume":"18","author":"Jameson","year":"2013","journal-title":"Euro Surveill."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cca.2007.04.011","article-title":"Saliva Specimen: A new laboratory tool for diagnostic and basic investigation","volume":"383","author":"Chiappin","year":"2007","journal-title":"Clin. Chim. Acta."},{"key":"ref_11","unstructured":"Mestecky, J., Ogra, P.L., Bienenstock, J., Lambrecht, B.N., Lamm, M.E., Strober, W., McGhee, J.R., and Mayer, L. (2005). Mucosal Immunology, Elsevier Academic Press. [3rd ed.]."},{"key":"ref_12","first-page":"R46","article-title":"Wild brown rats (Rattus norvegicus) as a zoonotic risk on farms in England and Wales","volume":"6","author":"Webster","year":"1996","journal-title":"CDR"},{"key":"ref_13","unstructured":"Brooks, T.J.G. (2010). Unpublished work."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5271\/sjweh.286","article-title":"Prevalence of antibodies specific to Puumala virus among farmers in Sweden","volume":"24","author":"Ahlm","year":"1998","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S095026880999029X","article-title":"Environmental and ecological potential for enzootic cycles of Puumala hantavirus in Great Britain","volume":"138","author":"Bennett","year":"2010","journal-title":"Epidemiol. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3201\/eid1904.121057","article-title":"Novel hantavirus in field vole, United Kingdom","volume":"19","author":"Pounder","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.trstmh.2010.07.002","article-title":"Climate change, flooding, urbanisation and leptospirosis: Fuelling the fire?","volume":"104","author":"Lau","year":"2010","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_18","first-page":"69","article-title":"Cell separation by gradient centrifugation","volume":"38","author":"Harwood","year":"1975","journal-title":"Int. Rev. Cytol."},{"key":"ref_19","first-page":"727","article-title":"The recovery of human saliva using the salivette system","volume":"32","author":"Lamey","year":"1994","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"key":"ref_20","unstructured":"Dohoo, I., Martin, W., and Stryhn, H. (2012). Methods in Epidemiologic Research, VER Inc."},{"key":"ref_21","unstructured":"R Core Team R: A language and environment for statistical computing. Available online:http:\/\/www.R-project.org\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1214\/ss\/1009213286","article-title":"Interval estimation for a binomial proportion","volume":"16","author":"Brown","year":"2001","journal-title":"Stat. Sci."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/6\/2\/524\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:07:57Z","timestamp":1760216877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/6\/2\/524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2]]}},"alternative-id":["v6020524"],"URL":"https:\/\/doi.org\/10.3390\/v6020524","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2014,2,5]]}}}