{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:50:38Z","timestamp":1763977838302,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Poxviruses are important pathogens of man and numerous domestic and wild animal species. Cross species (including zoonotic) poxvirus infections can have drastic consequences for the recipient host. Bats are a diverse order of mammals known to carry lethal viral zoonoses such as Rabies, Hendra, Nipah, and SARS. Consequent targeted  research is revealing bats to be infected with a rich diversity of novel viruses. Poxviruses were recently identified in bats and the settings in which they were found were  dramatically different. Here, we review the natural history of poxviruses in bats and  highlight the relationship of the viruses to each other and their context in the Poxviridae family. In addition to considering the zoonotic potential of these viruses, we reflect on the broader implications of these findings. Specifically, the potential to explore and exploit this newfound relationship to study coevolution and cross species transmission together with fundamental aspects of poxvirus host tropism as well as bat virology and immunology.<\/jats:p>","DOI":"10.3390\/v6041564","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T11:26:03Z","timestamp":1396524363000},"page":"1564-1577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Poxviruses in Bats \u2026 so What?"],"prefix":"10.3390","volume":"6","author":[{"given":"Kate","family":"Baker","sequence":"first","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Murcia","sequence":"additional","affiliation":[{"name":"University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G61 1QH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrmicro1099","article-title":"Poxvirus tropism","volume":"3","author":"McFadden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7589\/0090-3558-42.1.23","article-title":"Pathology and preliminary characterization of a parapoxvirus isolated from a California sea lion (Zalophus californianus)","volume":"42","author":"Nollens","year":"2006","journal-title":"J. Wildl. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.meegid.2012.12.002","article-title":"A survey of host range genes in poxvirus genomes","volume":"14","author":"Bratke","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00001432-200404000-00003","article-title":"Zoonotic poxvirus infections in humans","volume":"17","year":"2004","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1473-3099(03)00856-9","article-title":"Human monkeypox: An emerging zoonosis","volume":"4","author":"Eckburg","year":"2004","journal-title":"Lancet. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1017\/S0950268808000836","article-title":"Epidemics of squirrelpox virus disease in red squirrels (Sciurus vulgaris): Temporal and serological findings","volume":"137","author":"Carroll","year":"2009","journal-title":"Epidemiol. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e1003756","DOI":"10.1371\/journal.ppat.1003756","article-title":"An increasing danger of zoonotic orthopoxvirus infections","volume":"9","author":"Shchelkunov","year":"2013","journal-title":"PLoS Pathog."},{"key":"ref_8","first-page":"15","article-title":"Poxviruses and the evolution of host range and virulence","volume":"21C","author":"Haller","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.virol.2005.09.037","article-title":"Poxvirus entry and membrane fusion","volume":"344","author":"Moss","year":"2006","journal-title":"Virology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0065-3527(08)00003-1","article-title":"Poxvirus host range genes","volume":"71","author":"Werden","year":"2008","journal-title":"Adv. Virus Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1128\/jvi.62.4.1297-1304.1988","article-title":"A cowpox virus gene required for multiplication in Chinese hamster ovary cells","volume":"62","author":"Spehner","year":"1988","journal-title":"J. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1128\/JVI.01923-13","article-title":"Comparative analysis of the complete genome sequence of the California MSW strain of myxoma virus reveals potential host adaptations","volume":"87","author":"Kerr","year":"2013","journal-title":"J. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1369-5274(03)00083-3","article-title":"Parvovirus host range, cell tropism and evolution","volume":"6","author":"Hueffer","year":"2003","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature10831","article-title":"Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA\/H1N1 virus in ferrets","volume":"486","author":"Imai","year":"2012","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1128\/CMR.00017-06","article-title":"Bats: Important reservoir hosts of emerging viruses","volume":"19","author":"Calisher","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.1105113","article-title":"A molecular phylogeny for bats illuminates biogeography and the fossil record","volume":"307","author":"Teeling","year":"2005","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/genetics\/162.4.1811","article-title":"Likelihood and Bayes estimation of ancestral population sizes in hominoids using data from multiple loci","volume":"162","author":"Yang","year":"2002","journal-title":"Genetics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1073\/pnas.111551998","article-title":"Integrated fossil and molecular data reconstruct bat echolocation","volume":"98","author":"Springer","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1118391","article-title":"Bats are natural reservoirs of SARS-like coronaviruses","volume":"310","author":"Li","year":"2005","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nature12711","article-title":"Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor","volume":"503","author":"Ge","year":"2013","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1099\/0022-1317-81-8-1927","article-title":"Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus","volume":"81","author":"Halpin","year":"2000","journal-title":"J. Gen. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1286-4579(01)01522-2","article-title":"Isolation of Nipah virus from Malaysian Island flying-foxes","volume":"4","author":"Chua","year":"2002","journal-title":"Microbes Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e1000536","DOI":"10.1371\/journal.ppat.1000536","article-title":"Isolation of genetically diverse Marburg viruses from Egyptian fruit bats","volume":"5","author":"Towner","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/438575a","article-title":"Fruit bats as reservoirs of Ebola virus","volume":"438","author":"Leroy","year":"2005","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.coviro.2011.10.014","article-title":"A perspective on lyssavirus emergence and perpetuation","volume":"1","author":"Rupprecht","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"16151","DOI":"10.1073\/pnas.1308049110","article-title":"Bats carry pathogenic hepadnaviruses antigenically related to hepatitis B virus and capable of infecting human hepatocytes","volume":"110","author":"Drexler","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1073\/pnas.1116200109","article-title":"A distinct lineage of influenza A virus from bats","volume":"109","author":"Tong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.coviro.2011.10.013","article-title":"Mass extinctions, biodiversity and mitochondrial function: Are bats \u201cspecial\u201d as reservoirs for emerging viruses?","volume":"1","author":"Wang","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1863-2378.2012.01528.x","article-title":"Antiviral immune responses of bats: A review","volume":"60","author":"Baker","year":"2013","journal-title":"Zoonoses Public Health"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Luis, A.D., Hayman, D.T., O\u2019Shea, T.J., Cryan, P.M., Gilbert, A.T., Pulliam, J.R., Mills, J.N., Timonin, M.E., Willis, C.K., and Cunningham, A.A. (2013). A comparison of bats and rodents as reservoirs of zoonotic viruses: Are bats special?. Proc. Biol. Sci., 280.","DOI":"10.1098\/rspb.2012.2753"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e00598","DOI":"10.1128\/mBio.00598-13","article-title":"A strategy to estimate unknown viral diversity in mammals","volume":"4","author":"Anthony","year":"2013","journal-title":"mBio"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.virol.2013.03.014","article-title":"Metagenomic study of the viruses of African straw-coloured fruit bats: Detection of a chiropteran poxvirus and isolation of a novel adenovirus","volume":"441","author":"Baker","year":"2013","journal-title":"Virology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1128\/JVI.00501-10","article-title":"Bat guano virome: Predominance of dietary viruses from insects and plants plus novel mammalian viruses","volume":"84","author":"Li","year":"2010","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e61950","DOI":"10.1371\/journal.pone.0061950","article-title":"Virome profiling of bats from Myanmar by metagenomic analysis of tissue samples reveals more novel Mammalian viruses","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3201\/eid1906.121713","article-title":"Novel poxvirus in big brown bats, northwestern United States","volume":"19","author":"Emerson","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4269\/ajtmh.1965.14.156","article-title":"Cotia Virus: A New Agent Isolated from Sentinel Mice in S Ao Paulo, Brazil","volume":"14","author":"Lopesode","year":"1965","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1128\/JVI.07162-11","article-title":"Biological characterization and next-generation genome sequencing of the unclassified Cotia virus SPAn232 (Poxviridae)","volume":"86","author":"Afonso","year":"2012","journal-title":"J. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.7589\/2012-11-288","article-title":"Outbreak of Skin Nodules Associated with Riouxgolvania beveridgei (Nematoda: Muspiceida) in the Southern Bentwing Bat (Miniopterus schreibersii bassanii), South Australia","volume":"49","author":"McLelland","year":"2013","journal-title":"J. Wildl. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1751-0813.2011.00880.x","article-title":"Poxvirus infection outbreak in common ringtails (Pseudocheirus peregrinus)","volume":"90","author":"Vogelnest","year":"2012","journal-title":"Aust. Vet. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1128\/JVI.80.10.4978-4991.2006","article-title":"Genome of crocodilepox virus","volume":"80","author":"Afonso","year":"2006","journal-title":"J. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/vr.100721","article-title":"Molluscum contagiosum in two donkeys","volume":"170","author":"Fox","year":"2012","journal-title":"Vet. Rec."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0034-5288(98)90012-1","article-title":"Close relationship between equine and human molluscum contagiosum virus demonstrated by in situ hybridisation","volume":"64","author":"Thompson","year":"1998","journal-title":"Res. Vet. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1440-0960.1974.tb00545.x","article-title":"Molluscum contagiosum in a red kangaroo","volume":"15","author":"Bagnall","year":"1974","journal-title":"Australas. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e7666","DOI":"10.1371\/journal.pone.0007666","article-title":"The phylogenetics and ecology of the orthopoxviruses endemic to North America","volume":"4","author":"Emerson","year":"2009","journal-title":"PLoS One"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.7589\/0090-3558-8.2.119","article-title":"Survey of wild mammals in a Chesapeake Bay area for selected zoonoses","volume":"8","author":"Alexander","year":"1972","journal-title":"J. Wildl. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1134\/S0026893306010031","article-title":"The time scale in poxvirus evolution","volume":"40","author":"Babkin","year":"2006","journal-title":"Mol. Biol. (Mosk.)"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e1003657","DOI":"10.1371\/journal.ppat.1003657","article-title":"New world bats harbor diverse influenza A viruses","volume":"9","author":"Tong","year":"2013","journal-title":"PLoS Pathog."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9107","DOI":"10.1128\/JVI.00857-08","article-title":"Novel astroviruses in insectivorous bats","volume":"82","author":"Chu","year":"2008","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1099\/vir.0.034108-0","article-title":"Genetic diversity of novel circular ssDNA viruses in bats in China","volume":"92","author":"Ge","year":"2011","journal-title":"J. Gen. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1128\/JVI.02497-09","article-title":"Host range, prevalence, and genetic diversity of adenoviruses in bats","volume":"84","author":"Li","year":"2010","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e764","DOI":"10.1371\/journal.pone.0000764","article-title":"Marburg virus infection detected in a common African bat","volume":"2","author":"Towner","year":"2007","journal-title":"PLoS One"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1128\/JVI.02605-06","article-title":"Evolutionary insights into the ecology of coronaviruses","volume":"81","author":"Vijaykrishna","year":"2007","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/viro.1993.1236","article-title":"Molecular diversity of the Lyssavirus genus","volume":"194","author":"Bourhy","year":"1993","journal-title":"Virology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tree.2006.01.001","article-title":"The evolution of echolocation in bats","volume":"21","author":"Jones","year":"2006","journal-title":"Trends Ecol. Evol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.virusres.2006.01.009","article-title":"Evolutionary genomics of nucleo-cytoplasmic large DNA viruses","volume":"117","author":"Iyer","year":"2006","journal-title":"Virus Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ympev.2004.12.008","article-title":"Poxvirus genome evolution by gene gain and loss","volume":"35","author":"Hughes","year":"2005","journal-title":"Mol. Phylogenet. Evol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1574-6976.2000.tb00536.x","article-title":"Adventures with poxviruses of vertebrates","volume":"24","author":"Fenner","year":"2000","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1098\/rsbl.2010.0859","article-title":"Going, going, gone: The impact of white-nose syndrome on the summer activity of the little brown bat (Myotis lucifugus.)","volume":"7","author":"Dzal","year":"2011","journal-title":"Biol. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature10947","article-title":"Emerging fungal threats to animal, plant and ecosystem health","volume":"484","author":"Fisher","year":"2012","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1188836","article-title":"Host phylogeny constrains cross-species emergence and establishment of rabies virus in bats","volume":"329","author":"Streicker","year":"2010","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e1002720","DOI":"10.1371\/journal.ppat.1002720","article-title":"2012. Rates of viral evolution are linked to host geography in bat rabies","volume":"8","author":"Streicker","year":"2012","journal-title":"PLoS Pathog."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.virusres.2009.06.007","article-title":"Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara","volume":"145","author":"Jordan","year":"2009","journal-title":"Virus Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e8266","DOI":"10.1371\/journal.pone.0008266","article-title":"Establishment, immortalisation and characterisation of pteropid bat cell lines","volume":"4","author":"Crameri","year":"2009","journal-title":"PLoS One"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3390\/v4050889","article-title":"Authentication of the R06E fruit bat cell line","volume":"4","author":"Jordan","year":"2012","journal-title":"Viruses"},{"key":"ref_65","first-page":"224","article-title":"Establishment of cell line from embryonic tissue of Pipistrellus ceylonicus bat species from India & its susceptibility to different viruses","volume":"138","author":"Mourya","year":"2013","journal-title":"Indian J. Med. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e28131","DOI":"10.1371\/journal.pone.0028131","article-title":"Type I interferon reaction to viral infection in interferon-competent, immortalized cell lines from the African fruit bat Eidolon helvum","volume":"6","author":"Biesold","year":"2011","journal-title":"PLoS One"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11923","DOI":"10.1073\/pnas.1305559110","article-title":"Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter","volume":"110","author":"Sheppard","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1230835","article-title":"Comparative analysis of bat genomes provides insight into the evolution of flight and immunity","volume":"339","author":"Zhang","year":"2013","journal-title":"Science"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/6\/4\/1564\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:09:55Z","timestamp":1760216995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/6\/4\/1564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,3]]},"references-count":68,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4]]}},"alternative-id":["v6041564"],"URL":"https:\/\/doi.org\/10.3390\/v6041564","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2014,4,3]]}}}