{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:28:50Z","timestamp":1760243330069,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>This British hantavirus IgG prevalence study, aimed at 119 asymptomatic farmers in England, and using indirect immunofluorescence assay (IFA) as screening technique, concluded that rat-transmitted Seoul virus (SEOV) might be the main suspect as hantaviral pathogen in the UK. Exactly the same conclusion, using the same IFA screening technique, resulted from a 1994 serosurvey in the same country, and in 627 clinical cases plus 100 healthy controls. SEOV-positive study subjects were also mainly farmers with heavy rat-exposure, but residing in Northern-Ireland, a region where all other known rodent reservoirs for pathogenic hantaviruses are known to be absent, except the wild rat. A rodent capture action in and around the farms of eight seropositives confirmed SEOV seropositivity in 21.6% of 51 rats. All SEOV seropositives were patients, hospitalized  with an acute feverish condition, a majority of which having the clinical picture of hantavirus-induced nephropathy, known as hemorrhagic fever with renal syndrome (HFRS). Leptospirosis, often mimicking perfectly HFRS, was serologically excluded. Thus, SEOV was established as a human hantaviral pathogen in the UK and in Europe  20 years ago.<\/jats:p>","DOI":"10.3390\/v6093415","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T10:25:43Z","timestamp":1410517543000},"page":"3415-3424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comment on Jameson et al.: Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom"],"prefix":"10.3390","volume":"6","author":[{"given":"Jan","family":"Clement","sequence":"first","affiliation":[{"name":"National Reference Centre for Hantavirus Infections, Laboratory of Clinical Virology, University Hospitals Gasthuisberg, Leuven, 3000, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"McKenna","sequence":"additional","affiliation":[{"name":"Janssen, Pharmaceutical Companies of Johnson & Johnson, Beerse, 2340, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentijn","family":"Vergote","sequence":"additional","affiliation":[{"name":"National Reference Centre for Hantavirus Infections, Laboratory of Clinical Virology, University Hospitals Gasthuisberg, Leuven, 3000, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Van Ranst","sequence":"additional","affiliation":[{"name":"National Reference Centre for Hantavirus Infections, Laboratory of Clinical Virology, University Hospitals Gasthuisberg, Leuven, 3000, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/v6020524","article-title":"Prevalence of antibodies against hantaviruses in serum and saliva of adults living or working on farms in Yorkshire, United Kingdom","volume":"6","author":"Jameson","year":"2014","journal-title":"Viruses"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/rmv.1722","article-title":"Hantavirus infections in Europe and their impact on public health","volume":"23","author":"Vaheri","year":"2013","journal-title":"Rev. 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