{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:03:16Z","timestamp":1791234196440,"version":"4.1.0"},"reference-count":145,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI41599"],"award-info":[{"award-number":["R01AI41599"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI113565"],"award-info":[{"award-number":["R21AI113565"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2010- 16382"],"award-info":[{"award-number":["BFU2010- 16382"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2013-41249-P"],"award-info":[{"award-number":["BFU2013-41249-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["FIS2011-16090-E"],"award-info":[{"award-number":["FIS2011-16090-E"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Here we review the current knowledge on maturation of adenovirus, a  non-enveloped icosahedral eukaryotic virus. The adenovirus dsDNA genome fills the capsid in complex with a large amount of histone-like viral proteins, forming the core. Maturation involves proteolytic cleavage of several capsid and core precursor proteins by the viral protease (AVP). AVP uses a peptide cleaved from one of its targets as a \u201cmolecular sled\u201d to slide on the viral genome and reach its substrates, in a remarkable example of  one-dimensional chemistry. Immature adenovirus containing the precursor proteins lacks infectivity because of its inability to uncoat. The immature core is more compact and stable than the mature one, due to the condensing action of unprocessed core polypeptides; shell precursors underpin the vertex region and the connections between capsid and core. Maturation makes the virion metastable, priming it for stepwise uncoating by facilitating vertex release and loosening the condensed genome and its attachment to the icosahedral shell. The packaging scaffold protein L1 52\/55k is also a substrate for AVP. Proteolytic processing of L1 52\/55k disrupts its interactions with other virion components, providing a mechanism for its removal during maturation. Finally, possible roles for maturation of the terminal protein are discussed.<\/jats:p>","DOI":"10.3390\/v6114536","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T10:09:36Z","timestamp":1416564576000},"page":"4536-4570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Structure, Function and Dynamics in Adenovirus Maturation"],"prefix":"10.3390","volume":"6","author":[{"given":"Walter","family":"Mangel","sequence":"first","affiliation":[{"name":"Biological, Environmental and Climate Sciences Department, Brookhaven National Laboratory,  Upton, NY 11973, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-175X","authenticated-orcid":false,"given":"Carmen","family":"San Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Macromolecular Structure and NanoBiomedicine Initiative, Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), Darwin 3, Madrid 28049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"ref_1","unstructured":"Knipe, D.M., Howley, P.M., Griffin, D.E., Lamb, R.A., and Martin, M.A. (2007). 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