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In the course of examining mutations in the glycoprotein gene associated with 2014 Ebola virus (EBOV) sequences, a differential level of conservation was noted between the soluble form of glycoprotein (sGP) and the full length glycoprotein (GP), which are both encoded by the GP gene via RNA editing. In the region of the proteins encoded after the RNA editing site sGP was more conserved than the overlapping region of GP when compared to a distant outlier species, Tai Forest ebolavirus. Half of the amino acids comprising the \u201cdelta peptide\u201d, a 40 amino acid carboxy-terminal fragment of sGP, were identical between otherwise widely divergent species. A lysine-rich amphipathic peptide motif was noted at the carboxyl terminus of delta peptide with high structural relatedness to the cytolytic peptide of the non-structural protein 4 (NSP4) of rotavirus. EBOV delta peptide is a candidate viroporin, a cationic pore-forming peptide, and may contribute to EBOV pathogenesis.<\/jats:p>","DOI":"10.3390\/v7010285","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T12:36:22Z","timestamp":1421757382000},"page":"285-305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif"],"prefix":"10.3390","volume":"7","author":[{"given":"William","family":"Gallaher","sequence":"first","affiliation":[{"name":"Mockingbird Nature Research Group, PO Box 568, Pearl River, LA 70452, USA"},{"name":"Department of Microbiology, Immunology & Parasitology, Louisiana State University  Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5683-3250","authenticated-orcid":false,"given":"Robert","family":"Garry","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Tulane University Medical Center,  1430 Tulane Avenue, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/S0140-6736(68)92023-0","article-title":"Human disease from monkeys (Marburg virus)","volume":"1","author":"Malherbe","year":"1968","journal-title":"Lancet"},{"key":"ref_2","unstructured":"World Health Organization (1978). 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