{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:04:17Z","timestamp":1776222257450,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Viroporins are a group of low-molecular-weight proteins containing about  50\u2013120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly, as well as viral particle entry and release. Viroporins also play an important role in the regulation of antiviral innate immune responses, especially in inflammasome formation and activation,  to ensure the completion of the viral life cycle. By reviewing the research progress made in recent years on the regulation of the NLRP3 inflammasome by viroporins of animal viruses, we aim to understand the importance of viroporins in viral infection and to provide  a reference for further research and development of novel antiviral drugs.<\/jats:p>","DOI":"10.3390\/v7072777","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T11:05:12Z","timestamp":1435143912000},"page":"3380-3391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["NLRP3 Inflammasome Activation by Viroporins of  Animal Viruses"],"prefix":"10.3390","volume":"7","author":[{"given":"Hui-Chen","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, OIE\/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, OIE\/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yin","family":"Zhi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, OIE\/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, OIE\/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-739X","authenticated-orcid":false,"given":"Shi-Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, OIE\/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0014-5793(97)00198-1","article-title":"Ion channels formed by HIV-1 VPU: A modelling and simulation study","volume":"405","author":"Grice","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1128\/JVI.02848-13","article-title":"The human metapneumovirus small hydrophobic protein has properties consistent with those of a viroporin and can modulate viral fusogenic activity","volume":"88","author":"Masante","year":"2014","journal-title":"J. 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