{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:10:39Z","timestamp":1762866639221,"version":"build-2065373602"},"reference-count":110,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T00:00:00Z","timestamp":1436745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["WINGS project, GA n. 261426"],"award-info":[{"award-number":["WINGS project, GA n. 261426"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Padova, Padova, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate patient-specific models for the investigation of host\u2013pathogen interactions and to develop new antimicrobial and antiviral therapies. Applications of iPSC technology to the study of viral infections in humans have included in vitro modeling of viral infections of neural, liver, and cardiac cells; modeling of human genetic susceptibility to severe viral infectious diseases, such as encephalitis and severe influenza; genetic engineering and genome editing of patient-specific iPSC-derived cells to confer antiviral resistance.<\/jats:p>","DOI":"10.3390\/v7072800","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T10:38:10Z","timestamp":1436783890000},"page":"3835-3856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems"],"prefix":"10.3390","volume":"7","author":[{"given":"Marta","family":"Trevisan","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sinigaglia","sequence":"additional","affiliation":[{"name":"Veneto Institute of Oncology IOV IRCCS, via Gattamelata 64, Padova 35128, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Desole","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Padova, via A. Gabelli 63, Padova 35121, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Berto","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Padova, via A. 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