{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:11:43Z","timestamp":1789132303174,"version":"build-2803163510"},"reference-count":143,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus pathogenesis. However, in comparison, the seven other known filovirus family members are significantly understudied. Many of these, including Marburgviruses and Ebolaviruses other than EBOV, are also highly virulent and fully capable of causing widespread epidemics. This review places the focus on these non-EBOV filoviruses, including known immunological and pathological data. The available animal models, research tools and currently available therapeutics will also be discussed along with an emphasis in the large number of current gaps in knowledge of these less highlighted filoviruses. It is evident that much research is yet to be done in order to bring the non-EBOV filovirus field to the forefront of current research and, importantly, to the development of more effective vaccines and therapeutics to combat potential future outbreaks.<\/jats:p>","DOI":"10.3390\/v7102867","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T11:05:55Z","timestamp":1443524755000},"page":"5172-5190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Filoviruses: One of These Things is (not) Like the Other"],"prefix":"10.3390","volume":"7","author":[{"given":"Scott","family":"Anthony","sequence":"first","affiliation":[{"name":"Immunology Graduate Program, The University of Texas Graduate School of Biomedical Sciences at  Houston, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston,  TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Bradfute","sequence":"additional","affiliation":[{"name":"University of New Mexico, Center for Global Health, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00705-010-0814-x","article-title":"Proposal for a revised taxonomy of the family filoviridae: Classification, names of taxa and viruses, and virus abbreviations","volume":"155","author":"Kuhn","year":"2010","journal-title":"Arch. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.3390\/v6114760","article-title":"Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014","volume":"6","author":"Kuhn","year":"2014","journal-title":"Viruses"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature14428","article-title":"Single-dose attenuated vesiculovax vaccines protect primates against Ebola Makona virus","volume":"520","author":"Mire","year":"2015","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp","volume":"514","author":"Qiu","year":"2014","journal-title":"Nature"},{"key":"ref_5","first-page":"457","article-title":"A hitherto unknown infectious disease contracted from monkeys. \u201cMarburg-virus\u201d disease","volume":"13","author":"Martini","year":"1968","journal-title":"Ger. Med. Mon."},{"key":"ref_6","first-page":"1","article-title":"The aetiology of an unknown human infection transmitted by monkeys (preliminary communication)","volume":"13","author":"Siegert","year":"1968","journal-title":"Ger. Med. Mon."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1056\/NEJMoa051465","article-title":"Marburg hemorrhagic fever associated with multiple genetic lineages of virus","volume":"355","author":"Bausch","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1128\/JVI.00069-06","article-title":"Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola","volume":"80","author":"Towner","year":"2006","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1000212","DOI":"10.1371\/journal.ppat.1000212","article-title":"Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda","volume":"4","author":"Towner","year":"2008","journal-title":"PLoS Pathog."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0140-6736(95)90925-7","article-title":"Isolation and partial characterisation of a new strain of Ebola virus","volume":"345","author":"Formenty","year":"1995","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S757","DOI":"10.1093\/infdis\/jir296","article-title":"Reston Ebolavirus in humans and animals in the Philippines: A review","volume":"204","author":"Miranda","year":"2011","journal-title":"J. Inf. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e1002304","DOI":"10.1371\/journal.ppat.1002304","article-title":"Discovery of an Ebolavirus-like filovirus in Europe","volume":"7","author":"Negredo","year":"2011","journal-title":"PLoS Pathog."},{"key":"ref_13","unstructured":"Kuhn, J.H., and Calisher, C.H. (2008). Filoviruses: A compendium of 40 years of epidemiological, clinical, and laboratory studies, Springer Science & Business Media."},{"key":"ref_14","first-page":"548","article-title":"Ebola viral disease outbreak\u2014West Africa, 2014","volume":"63","author":"Dixon","year":"2014","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"ref_15","unstructured":"World Health Organization (2012). Outbreak news. Ebola, Democratic Republic of the Congo. Wkly. Epidemiolog. Rec., 87, 421\u2013421."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1086\/514285","article-title":"Human infection due to Ebola virus, subtype C\u00f4te d'Ivoire: Clinical and biologic presentation","volume":"179","author":"Formenty","year":"1999","journal-title":"J. Infect Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/jcp.43.10.813","article-title":"Use of immunoelectron microscopy to show Ebola virus during the 1989 United States epizootic","volume":"43","author":"Geisbert","year":"1990","journal-title":"J. Clin. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00705-012-1477-6","article-title":"Reston virus in domestic pigs in China","volume":"159","author":"Pan","year":"2014","journal-title":"Arch. Virol."},{"key":"ref_19","first-page":"10","article-title":"The neuropathology of an infectious disease transmitted by African green monkeys (cercopithecus aethiops)","volume":"14","author":"Bechtelsheimer","year":"1969","journal-title":"Ger. Med. Mon."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1055\/s-0028-1105101","article-title":"Pathological anatomy of the \u201cMarburg virus\u201d disease (the so-called \u201cMarburg monkey disease\u201d)","volume":"93","author":"Gedigk","year":"1968","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1055\/s-0028-1105099","article-title":"On an infectious disease transmitted by cercopithecus aethiops. (\u201cgreen monkey disease\u201d)","volume":"93","author":"Stille","year":"1968","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1473-3099(12)70018-X","article-title":"Acute liver failure, multiorgan failure, cerebral oedema, and activation of proangiogenic and antiangiogenic factors in a case of Marburg haemorrhagic fever","volume":"12","author":"Bauer","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"ref_23","first-page":"1377","article-title":"Imported case of Marburg hemorrhagic fever-Colorado, 2008","volume":"58","author":"Fujita","year":"2009","journal-title":"MMWR. Morb. Mortal. Wkly Rep."},{"key":"ref_24","first-page":"101","article-title":"Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya","volume":"11","author":"Johnson","year":"1996","journal-title":"Arch. Virol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1056\/NEJMoa1500306","article-title":"Persistence of Ebola virus in ocular fluid during convalescence","volume":"372","author":"Varkey","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1473-3099(14)71033-3","article-title":"Ebola virus in the semen of convalescent men","volume":"15","author":"Mackay","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1086\/520545","article-title":"Assessment of the risk of Ebola virus transmission from bodily fluids and fomites","volume":"196","author":"Bausch","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/BF01734141","article-title":"Spermatogenic transmission of the \u201cMarburg virus\u201d. (Causes of \u201cMarburg simian disease\u201d)","volume":"46","author":"Martini","year":"1968","journal-title":"Klin. Wochenschr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/bjo.61.4.265","article-title":"Uveal involvement in Marburg virus disease","volume":"61","author":"Kuming","year":"1977","journal-title":"Brit. J. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/7422","article-title":"Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in ebola virus-infected patients","volume":"5","author":"Baize","year":"1999","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-2249.2002.01800.x","article-title":"Inflammatory responses in ebola virus-infected patients","volume":"128","author":"Baize","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1371\/journal.pntd.0000837","article-title":"Human fatal zaire Ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis","volume":"4","author":"Wauquier","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S188","DOI":"10.1086\/514283","article-title":"Markedly elevated levels of interferon (IFN)-\u03b3, IFN-\u03b1, interleukin (IL)-2, IL-10, and tumor necrosis factor-\u03b1 associated with fatal Ebola virus infection","volume":"179","author":"Villinger","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2249.2001.01517.x","article-title":"Early immune responses accompanying human asymptomatic Ebola infections","volume":"124","author":"Leroy","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/S0140-6736(00)02405-3","article-title":"Human asymptomatic Ebola infection and strong inflammatory response","volume":"355","author":"Leroy","year":"2000","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S357","DOI":"10.1086\/520611","article-title":"Cytokine and chemokine expression in humans infected with sudan Ebola virus","volume":"196","author":"Hutchinson","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/infdis\/jiu088","article-title":"Ebola hemorrhagic fever: Novel biomarker correlates of clinical outcome","volume":"210","author":"McElroy","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2011.11.027","article-title":"Serology and cytokine profiles in patients infected with the newly discovered bundibugyo Ebolavirus","volume":"423","author":"Gupta","year":"2012","journal-title":"Virology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e0118434","DOI":"10.1371\/journal.pone.0118434","article-title":"Mechanisms of immunity in post-exposure vaccination against Ebola virus infection","volume":"10","author":"Bradfute","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e0118345","DOI":"10.1371\/journal.pone.0118345","article-title":"Virus-like particles activate type I interferon pathways to facilitate post-exposure protection against Ebola virus infection","volume":"10","author":"Ayithan","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_41","first-page":"35","article-title":"Effects of tumor necrosis factor antiserum of the course of Marburg hemorrhagic fever","volume":"3","author":"Kashentseva","year":"1998","journal-title":"Vestn. Ross. Akad. Med. Nauk."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/jmv.2073","article-title":"Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (reston serotype)","volume":"65","author":"Hutchinson","year":"2001","journal-title":"J. Med. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0002-9440(10)63591-2","article-title":"Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: Evidence that dendritic cells are early and sustained targets of infection","volume":"163","author":"Geisbert","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-2478(01)00327-3","article-title":"Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily","volume":"80","author":"Hensley","year":"2002","journal-title":"Immunol. Lett."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Rubins, K.H., Hensley, L.E., Wahl-Jensen, V., Daddario DiCaprio, K.M., Young, H.A., Reed, D.S., Jahrling, P.B., Brown, P.O., Relman, D.A., and Geisbert, T.W. (2007). The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Genome Biol., 8.","DOI":"10.1186\/gb-2007-8-8-r174"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/vim.2008.0023","article-title":"Cellular immune response to Marburg virus infection in cynomolgus macaques","volume":"21","author":"Fritz","year":"2008","journal-title":"Viral Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0168-1656(95)00104-2","article-title":"Inactivated Marburg virus elicits a nonprotective immune response in rhesus monkeys","volume":"44","author":"Ignatyev","year":"1996","journal-title":"J. Biotechnol."},{"key":"ref_48","first-page":"206","article-title":"Experimental study of possible treatment of Marburg hemorrhagic fever with desferal, ribavirin, and homologous interferon","volume":"41","author":"Agafonov","year":"1996","journal-title":"Vopr. Virusol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6404","DOI":"10.1128\/JVI.00126-09","article-title":"Development and characterization of a mouse model for Marburg hemorrhagic fever","volume":"83","author":"Warfield","year":"2009","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"12703","DOI":"10.1128\/JVI.01643-14","article-title":"Establishment and characterization of a lethal mouse model for the angola strain of Marburg virus","volume":"88","author":"Qiu","year":"2014","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S329","DOI":"10.1086\/520588","article-title":"Sequence-based human leukocyte antigen-b typing of patients infected with Ebola virus in Uganda in 2000: Identification of alleles associated with fatal and nonfatal disease outcomes","volume":"196","author":"Sanchez","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1099\/0022-1317-82-6-1365","article-title":"The role of the type I interferon response in the resistance of mice to filovirus infection","volume":"82","author":"Bray","year":"2001","journal-title":"J. Gen. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S986","DOI":"10.1093\/infdis\/jir335","article-title":"Filovirus infection of STAT-1 knockout mice","volume":"204","author":"Raymond","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"O'Brien, L.M., Stokes, M.G., Lonsdale, S.G., Maslowski, D.R., Smither, S.J., Lever, M.S., Laws, T.R., and Perkins, S.D. (2014). Vaccination with recombinant adenoviruses expressing Ebola virus glycoprotein elicits protection in the interferon \u03b1\/\u03b2 receptor knock-out mouse. Virology, 324\u2013333.","DOI":"10.1016\/j.virol.2013.03.028"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1099\/jmm.0.036210-0","article-title":"Lethality and pathogenesis of airborne infection with filoviruses in a129 \u03b1\/\u03b2 -\/-interferon receptor-deficient mice","volume":"61","author":"Lever","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1371\/journal.ppat.0020073","article-title":"Molecular determinants of Ebola virus virulence in mice","volume":"2","author":"Ebihara","year":"2006","journal-title":"PLoS Pathog."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1128\/JVI.80.6.3009-3020.2006","article-title":"Global suppression of the host antiviral response by Ebola- and Marburgviruses: Increased antagonism of the type I interferon response is associated with enhanced virulence","volume":"80","author":"Kash","year":"2006","journal-title":"J. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13469","DOI":"10.1128\/JVI.01097-07","article-title":"Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin \u03b1 proteins with activated STAT1","volume":"81","author":"Reid","year":"2007","journal-title":"J. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1128\/JVI.02349-05","article-title":"Ebola virus VP24 binds karyopherin \u03b11 and blocks STAT1 nuclear accumulation","volume":"80","author":"Reid","year":"2006","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7945","DOI":"10.1128\/JVI.77.14.7945-7956.2003","article-title":"The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3","volume":"77","author":"Basler","year":"2003","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12289","DOI":"10.1073\/pnas.220398297","article-title":"The Ebola virus VP35 protein functions as a type I IFN antagonist","volume":"97","author":"Basler","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e1000493","DOI":"10.1371\/journal.ppat.1000493","article-title":"Ebola zaire virus blocks type I interferon production by exploiting the host sumo modification machinery","volume":"5","author":"Chang","year":"2009","journal-title":"PLoS Pathog."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e1000721","DOI":"10.1371\/journal.ppat.1000721","article-title":"Marburg virus evades interferon responses by a mechanism distinct from Ebola virus","volume":"6","author":"Valmas","year":"2010","journal-title":"PLoS Pathog."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e1002916","DOI":"10.1371\/journal.ppat.1002916","article-title":"Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism","volume":"8","author":"Bale","year":"2012","journal-title":"PLoS Pathog."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1128\/JVI.02575-10","article-title":"Marburg virus VP40 antagonizes interferon signaling in a species-specific manner","volume":"85","author":"Valmas","year":"2011","journal-title":"J. Virol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/infdis\/jis921","article-title":"Interferon-\u03b2 therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever","volume":"208","author":"Smith","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1086\/514310","article-title":"Evaluation of immune globulin and recombinant interferon-\u03b12b for treatment of experimental Ebola virus infections","volume":"179","author":"Jahrling","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Qiu, X., Wong, G., Fernando, L., Audet, J., Bello, A., Strong, J., Alimonti, J.B., and Kobinger, G.P. (2013). Mabs and ad-vectored IFN-\u03b1 therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms. Sci. Tran. Med., 5.","DOI":"10.1126\/scitranslmed.3006605"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1128\/JVI.00561-09","article-title":"Single-injection vaccine protects nonhuman primates against infection with Marburg virus and three species of Ebola virus","volume":"83","author":"Geisbert","year":"2009","journal-title":"J. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e1000904","DOI":"10.1371\/journal.ppat.1000904","article-title":"Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus species","volume":"6","author":"Hensley","year":"2010","journal-title":"PLoS Pathog."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.1711250303","article-title":"The pathology of experimental Ebola virus infection in monkeys","volume":"125","author":"Baskerville","year":"1978","journal-title":"J. Pathol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0035-9203(78)90058-5","article-title":"Ebola haemorrhagic fever: Experimental infection of monkeys","volume":"72","author":"Bowen","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/infdis\/166.4.753","article-title":"Pathogenic potential of filoviruses: Role of geographic origin of primate host and virus strain","volume":"166","author":"Brammer","year":"1992","journal-title":"J. Infect. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.virol.2011.08.022","article-title":"A small nonhuman primate model for filovirus-induced disease","volume":"420","author":"Carrion","year":"2011","journal-title":"Virology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/BF02445023","article-title":"Experimental study of Ebola hemorrhagic fever in baboon models","volume":"120","author":"Luchko","year":"1995","journal-title":"Biull. Eksp. Biol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.1086\/514293","article-title":"An analysis of features of pathogenesis in two animal models of Ebola virus infection","volume":"179","author":"Ryabchikova","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jmv.1890060205","article-title":"A comparative study of strains of Ebola virus isolated from southern sudan and northern zaire in 1976","volume":"6","author":"Bowen","year":"1980","journal-title":"J. Med. Virol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1086\/514305","article-title":"Pathogenesis of experimental Ebola virus infection in guinea pigs","volume":"179","author":"Connolly","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/infdis\/jis626","article-title":"A syrian golden hamster model recapitulating Ebola hemorrhagic fever","volume":"207","author":"Ebihara","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/515386","article-title":"A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever","volume":"178","author":"Bray","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1128\/JVI.00456-08","article-title":"Recombinant vesicular stomatitis virus vector mediates postexposure protection against sudan Ebola hemorrhagic fever in nonhuman primates","volume":"82","author":"Geisbert","year":"2008","journal-title":"J. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1086\/514313","article-title":"ELISA for the detection of antibodies to Ebola viruses","volume":"179","author":"Ksiazek","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_83","first-page":"115","article-title":"Experimental infection of cynomolgus macaques with Ebola-reston filoviruses from the 1989\u20131990 U.S. Epizootic","volume":"11","author":"Jahrling","year":"1996","journal-title":"Arch. Virol.."},{"key":"ref_84","first-page":"458","article-title":"Vervet monkey disease. Experiment infection of guinea pigs and monkeys with the causative agent","volume":"49","author":"Simpson","year":"1968","journal-title":"Br. J. Exp. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/viro.1998.9367","article-title":"Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates","volume":"251","author":"Hevey","year":"1998","journal-title":"Virology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1006\/viro.1997.8883","article-title":"Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinants","volume":"239","author":"Hevey","year":"1997","journal-title":"Virology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1128\/JVI.02372-10","article-title":"Key genomic changes necessary for an in vivo lethal mouse Marburgvirus variant selection process","volume":"85","author":"Lofts","year":"2011","journal-title":"J. Virol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"9659","DOI":"10.1128\/JVI.00959-06","article-title":"Cross-protection against Marburg virus strains by using a live, attenuated recombinant vaccine","volume":"80","author":"Geisbert","year":"2006","journal-title":"J. Virol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1126\/science.1172705","article-title":"Discovery of swine as a host for the reston Ebolavirus","volume":"325","author":"Barrette","year":"2009","journal-title":"Science"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"S804","DOI":"10.1093\/infdis\/jir300","article-title":"Ebola reston virus infection of pigs: Clinical significance and transmission potential","volume":"204","author":"Marsh","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/infdis\/jir077","article-title":"Replication, pathogenicity, shedding, and transmission of Zaire Ebolavirus in pigs","volume":"204","author":"Kobinger","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e61904","DOI":"10.1371\/journal.pone.0061904","article-title":"Immunopathogenesis of severe acute respiratory disease in Zaire Ebolavirus-infected pigs","volume":"8","author":"Nfon","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Weingartl, H.M., Embury-Hyatt, C., Nfon, C., Leung, A., Smith, G., and Kobinger, G. (2012). Transmission of Ebola virus from pigs to non-human primates. Sci. Rep., 2.","DOI":"10.1038\/srep00811"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.1259595","article-title":"Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance","volume":"346","author":"Rasmussen","year":"2014","journal-title":"Science"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.3390\/v4091477","article-title":"Mouse models for filovirus infections","volume":"4","author":"Bradfute","year":"2012","journal-title":"Viruses"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature10348","article-title":"Ebola virus entry requires the cholesterol transporter niemann-pick C1","volume":"477","author":"Carette","year":"2011","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature10380","article-title":"Small molecule inhibitors reveal niemann-pick C1 is essential for Ebola virus infection","volume":"477","author":"Cote","year":"2011","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ng, M., Ndungo, E., Jangra, R.K., Cai, Y., Postnikova, E., Radoshitzky, S.R., Dye, J.M., Ramirez de Arellano, E., Negredo, A., and Palacios, G. (2014). Cell entry by a novel european filovirus requires host endosomal cysteine proteases and niemann-pick C1. Virology, 637\u2013646.","DOI":"10.1016\/j.virol.2014.08.019"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/JVI.02265-13","article-title":"Characterization of the envelope glycoprotein of a novel filovirus, Lloviu virus","volume":"88","author":"Maruyama","year":"2014","journal-title":"J. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1128\/JVI.02190-10","article-title":"A new Ebola virus nonstructural glycoprotein expressed through RNA editing","volume":"85","author":"Mehedi","year":"2011","journal-title":"J. Virol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1128\/JVI.02600-10","article-title":"Ebolavirus \u03b4-peptide immunoadhesins inhibit Marburgvirus and Ebolavirus cell entry","volume":"85","author":"Radoshitzky","year":"2011","journal-title":"J. Virol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e1003065","DOI":"10.1371\/journal.ppat.1003065","article-title":"Antigenic subversion: A novel mechanism of host immune evasion by Ebola virus","volume":"8","author":"Mohan","year":"2012","journal-title":"PLoS Pathog."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e1004509","DOI":"10.1371\/journal.ppat.1004509","article-title":"Shed GP of Ebola virus triggers immune activation and increased vascular permeability","volume":"10","author":"Volchkova","year":"2014","journal-title":"PLoS Pathog."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1128\/JVI.79.16.10442-10450.2005","article-title":"Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function","volume":"79","author":"Afanasieva","year":"2005","journal-title":"J. Virol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Hoenen, T., Marzi, A., Scott, D.P., Feldmann, F., Callison, J., Safronetz, D., Ebihara, H., and Feldmann, H. (2015). Soluble glycoprotein is not required for Ebola virus virulence in guinea pigs. J. Infect. Dis., 7.","DOI":"10.1093\/infdis\/jiv111"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Volchkova, V.A., Dolnik, O., Martinez, M.J., Reynard, O., and Volchkov, V.E. (2015). RNA editing of the GP gene of Ebola virus is an important pathogenicity factor. J. Infect. Dis., 7.","DOI":"10.1093\/infdis\/jiv309"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1126\/science.1057269","article-title":"Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity","volume":"291","author":"Volchkov","year":"2001","journal-title":"Science"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.coviro.2012.04.003","article-title":"Ebolavirus vaccines for humans and Apes","volume":"2","author":"Mulangu","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4161\/hv.7.6.15398","article-title":"Filovirus vaccines","volume":"7","author":"Bradfute","year":"2011","journal-title":"Hum. Vaccin."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Pyankov, O.V., Bodnev, S.A., Pyankova, O.G., Solodkyi, V.V., Pyankov, S.A., Setoh, Y.X., Volchkova, V.A., Suhrbier, A., Volchkov, V.V., and Agafonov, A.A. (2015). A kunjin replicon virus-like particle vaccine provides protection against Ebola virus infection in nonhuman primates. J. Infect. Dis., 7.","DOI":"10.1093\/infdis\/jiv019"},{"key":"ref_111","unstructured":"Ledgerwood, J.E., DeZure, A.D., Stanley, D.A., Novik, L., Enama, M.E., Berkowitz, N.M., Hu, Z., Joshi, G., Ploquin, A., and Sitar, S. (2014). Chimpanzee adenovirus vector Ebola vaccine\u2014preliminary report. N. Engl. J. Med."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Agnandji, S.T., Huttner, A., Zinser, M.E., Njuguna, P., Dahlke, C., Fernandes, J.F., Yerly, S., Dayer, J.A., Kraehling, V., and Kasonta, R. (2015). Phase 1 trials of RVSV Ebola vaccine in Africa and Europe\u2014Preliminary report. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa1502924"},{"key":"ref_113","unstructured":"Regules, J.A., Beigel, J.H., Paolino, K.M., Voell, J., Castellano, A.R., Munoz, P., Moon, J.E., Ruck, R.C., Bennett, J.W., and Twomey, P.S. (2015). A recombinant vesicular stomatitis virus Ebola vaccine\u2014Preliminary report. N. Engl. J. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/S0140-6736(15)60553-0","article-title":"Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: Preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial","volume":"385","author":"Zhu","year":"2015","journal-title":"Lancet"},{"key":"ref_115","unstructured":"Rampling, T., Ewer, K., Bowyer, G., Wright, D., Imoukhuede, E.B., Payne, R., Hartnell, F., Gibani, M., Bliss, C., and Minhinnick, A. (2015). A monovalent chimpanzee adenovirus Ebola vaccine \u2014Preliminary report. N. Engl. J. Med."},{"key":"ref_116","first-page":"270","article-title":"Development and study of the properties of immunoglobulin against Ebola fever","volume":"40","author":"Borisevich","year":"1995","journal-title":"Vopr. Virusol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1086\/514294","article-title":"Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections","volume":"179","author":"Sergeyev","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1371\/journal.ppat.0030009","article-title":"Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys","volume":"3","author":"Oswald","year":"2007","journal-title":"PLoS Pathog."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.1200409109","article-title":"Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease","volume":"109","author":"Dye","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e36192","DOI":"10.1371\/journal.pone.0036192","article-title":"Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever","volume":"7","author":"Marzi","year":"2012","journal-title":"PLoS ONE"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"18030","DOI":"10.1073\/pnas.1213709109","article-title":"Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques","volume":"109","author":"Olinger","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_122","first-page":"138ra81","article-title":"Successful treatment of Ebola virus-infected cynomolgus macaques with monoclonal antibodies","volume":"4","author":"Qiu","year":"2012","journal-title":"Sci. Tran. Med."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"van Griensven, J., De Weiggheleire, A., Delamou, A., Smith, P.G., Edwards, T., Vandekerckhove, P., Bah, E.I., Colebunders, R., Herve, I., and Lazaygues, C. (2015). The use of Ebola convalescent plasma to treat Ebola virus disease in resource-constrained settings: A perspective from the field. Clin. Infect. Dis., 7.","DOI":"10.1093\/cid\/civ680"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1056\/NEJMoa1409838","article-title":"Clinical care of two patients with Ebola virus disease in the united states","volume":"371","author":"Lyon","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature13027","article-title":"Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430","volume":"508","author":"Warren","year":"2014","journal-title":"Nature"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.antiviral.2011.10.011","article-title":"Identification of an antioxidant small-molecule with broad-spectrum antiviral activity","volume":"93","author":"Panchal","year":"2012","journal-title":"Antiviral Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1128\/AAC.01315-09","article-title":"Antiviral activity of a small-molecule inhibitor of filovirus infection","volume":"54","author":"Warren","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.antiviral.2009.06.001","article-title":"Development of a broad-spectrum antiviral with activity against Ebola virus","volume":"83","author":"Aman","year":"2009","journal-title":"Antiviral Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0166-3542(00)00066-8","article-title":"Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor","volume":"45","author":"Bray","year":"2000","journal-title":"Antiviral Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0166-3542(02)00018-9","article-title":"3-deazaneplanocin a induces massively increased interferon-\u03b1 production in Ebola virus-infected mice","volume":"55","author":"Bray","year":"2002","journal-title":"Antiviral Res."},{"key":"ref_131","first-page":"250ra116","article-title":"Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA","volume":"6","author":"Thi","year":"2014","journal-title":"Sci. Tran. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/infdis\/jit465","article-title":"Protection against lethal Marburg virus infection mediated by lipid encapsulated small interfering RNA","volume":"209","author":"Mire","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/S0140-6736(10)60357-1","article-title":"Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: A proof-of-concept study","volume":"375","author":"Geisbert","year":"2010","journal-title":"Lancet"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.3390\/v4112806","article-title":"Discovery and early development of Avi-7537 and Avi-7288 for the treatment of Ebola virus and Marburg virus infections","volume":"4","author":"Iversen","year":"2012","journal-title":"Viruses"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nm.2202","article-title":"Advanced antisense therapies for postexposure protection against lethal filovirus infections","volume":"16","author":"Warren","year":"2010","journal-title":"Nat. Med."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Warren, T.K., Whitehouse, C.A., Wells, J., Welch, L., Heald, A.E., Charleston, J.S., Sazani, P., Reid, S.P., Iversen, P.L., and Bavari, S. (2015). A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection. mBio, 6.","DOI":"10.1128\/mBio.02344-14"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMoa1410345","article-title":"Avi-7288 for Marburg virus in nonhuman primates and humans","volume":"373","author":"Heald","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.antiviral.2014.07.004","article-title":"Hspa5 is an essential host factor for Ebola virus infection","volume":"109","author":"Reid","year":"2014","journal-title":"Antiviral Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"S372","DOI":"10.1086\/520608","article-title":"Marburg virus Angola infection of rhesus macaques: Pathogenesis and treatment with recombinant nematode anticoagulant protein C2","volume":"196","author":"Geisbert","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(03)15012-X","article-title":"Treatment of Ebola virus infection with a recombinant inhibitor of factor viia\/tissue factor: A study in rhesus monkeys","volume":"362","author":"Geisbert","year":"2003","journal-title":"Lancet"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"S390","DOI":"10.1086\/520598","article-title":"Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever","volume":"196","author":"Hensley","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1128\/JVI.76.1.406-410.2002","article-title":"Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture","volume":"76","author":"Neumann","year":"2002","journal-title":"J. Virol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1128\/JVI.80.2.1038-1043.2006","article-title":"Rescue of recombinant Marburg virus from cDNA is dependent on nucleocapsid protein VP30","volume":"80","author":"Enterlein","year":"2006","journal-title":"J. Virol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/7\/10\/2867\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:49:27Z","timestamp":1760215767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/7\/10\/2867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,29]]},"references-count":143,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10]]}},"alternative-id":["v7102867"],"URL":"https:\/\/doi.org\/10.3390\/v7102867","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,29]]}}}