{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:59Z","timestamp":1791332939281,"version":"4.3.1"},"reference-count":93,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia\/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease. This review will focus on the recent advances in the generation of immunodeficient and human hemato-lymphoid system mice with a particular emphasis on the development of mouse models for HTLV-1-mediated pathogenesis, their present limitations and the challenges yet to be addressed.<\/jats:p>","DOI":"10.3390\/v7122944","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T07:06:30Z","timestamp":1449644790000},"page":"6371-6386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis"],"prefix":"10.3390","volume":"7","author":[{"given":"El\u00e9onore","family":"P\u00e9r\u00e8s","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, Unit\u00e9 Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 7, France"},{"name":"SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e9nie","family":"Bagdassarian","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, Unit\u00e9 Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 7, France"},{"name":"SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France"},{"name":"Master BioSciences, D\u00e9partement de Biologie, ENS Lyon, 69366 Lyon Cedex 7, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"This","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, Unit\u00e9 Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 7, France"},{"name":"SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France"},{"name":"Master BioSciences, D\u00e9partement de Biologie, ENS Lyon, 69366 Lyon Cedex 7, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Villaudy","sequence":"additional","affiliation":[{"name":"AIMM Therapeutics, Meibergdreef 59, 1105 BA Amsterdam Zuidoost, The Netherlands"},{"name":"Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 BA Amsterdam Zuidoost, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Rigal","sequence":"additional","affiliation":[{"name":"Etablissement fran\u00e7ais du sang, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Gazzolo","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, Unit\u00e9 Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 7, France"},{"name":"SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Duc Dodon","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, Unit\u00e9 Mixte de Recherche 5239, Centre National de la Recherche Scientifique, Ecole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 7, France"},{"name":"SFR UMS3444 BioSciences Lyon-Gerland-Lyon Sud (UMS3444), 69366 Lyon Cedex 7, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/2261209a0","article-title":"RNA-dependent DNA polymerase in virions of RNA tumour viruses","volume":"226","author":"Baltimore","year":"1970","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/2261211a0","article-title":"RNA-dependent DNA polymerase in virions of Rous sarcoma virus","volume":"226","author":"Temin","year":"1970","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc. 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