{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:42:32Z","timestamp":1792802552109,"version":"4.5.0"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371833"],"award-info":[{"award-number":["81371833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical and health science and technology development plan of Shandong Province","award":["2013WS0211"],"award-info":[{"award-number":["2013WS0211"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hand, foot, and mouth disease (HFMD), which has led to millions of attacks and several outbreaks across the world and become more predominant in Asia-Pacific Region, especially in Mainland China, is caused by several Human Enteroviruses including new enterovirus, coxsakievirus and echovirus. In recent years, much research has focused on the epidemiological characteristics of HFMD. In this article, multiple characteristics of HFMD such as basic epidemiology, etiology and molecular epidemiology; influencing factors; detection; and surveillance are reviewed, as these can be help protect high risks groups, prevalence prediction and policy making for disease prevention.<\/jats:p>","DOI":"10.3390\/v7122947","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T07:06:30Z","timestamp":1449644790000},"page":"6400-6411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China"],"prefix":"10.3390","volume":"7","author":[{"given":"Zhi-Chao","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-Qiang","family":"Kou","sequence":"additional","affiliation":[{"name":"Shandong Center for Disease Control and Prevention, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Juan","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cong","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"},{"name":"Center for Biodefense and Emerging Infectious Diseases, Departments of Pathology and Microbiology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ling","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Virology, School of Public Health, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/314032","article-title":"Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: Clinical and pathological characteristics of the disease. 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