{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:23:08Z","timestamp":1791238988045,"version":"4.1.0"},"reference-count":115,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>There are no currently available specific antiviral therapies for non-polio Enterovirus infections. Although several vaccines have entered clinical trials, the efficacy requires further evaluation, particularly for cross-strain protective activity. Curing patients with viral infections is a public health problem due to antigen alterations and drug resistance caused by the high genomic mutation rate. To conquer these limits in the development of anti-Enterovirus treatments, a comprehensive understanding of the interactions between Enterovirus and host cells is urgently needed. MicroRNA (miRNA) constitutes the biggest family of gene regulators in mammalian cells and regulates almost a half of all human genes. The roles of miRNAs in Enterovirus pathogenesis have recently begun to be noted. In this review, we shed light on recent advances in the understanding of Enterovirus infection-modulated miRNAs. The impacts of altered host miRNAs on cellular processes, including immune escape, apoptosis, signal transduction, shutdown of host protein synthesis and viral replication, are discussed. Finally, miRNA-based medication provides a promising strategy for the development of antiviral therapy.<\/jats:p>","DOI":"10.3390\/v8010011","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T10:05:59Z","timestamp":1452074759000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["MicroRNA and Pathogenesis of Enterovirus Infection"],"prefix":"10.3390","volume":"8","author":[{"given":"Bing-Ching","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 10048, Taiwan"},{"name":"Center of Genomic Medicine, National Taiwan University, Taipei 10048, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan-Chyr","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Genomic Medicine, National Taiwan University, Taipei 10048, Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei 10048, Taiwan"},{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 10048, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Liang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 10048, Taiwan"},{"name":"Center of Genomic Medicine, National Taiwan University, Taipei 10048, Taiwan"},{"name":"Center for Optoelectronic Biomedicine, College of Medicine, National Taiwan University, Taipei 10048, Taiwan"},{"name":"Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan"},{"name":"Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 10048, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3109\/00365548.2011.577094","article-title":"Clinical and virological features of enterovirus 71 infections in Denmark, 2005 to 2008","volume":"43","author":"Badran","year":"2011","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1586\/14787210.2015.1058156","article-title":"Coxsackievirus A6: A new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide","volume":"13","author":"Bian","year":"2015","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12250-011-3195-8","article-title":"Hand foot and mouth disease due to enterovirus 71 in Malaysia","volume":"26","author":"Chua","year":"2011","journal-title":"Virol. Sin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1099\/vir.0.000062","article-title":"Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: A potential role of recombination in emergence and pathogenicity","volume":"96","author":"Gaunt","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Guan, H., Wang, J., Wang, C., Yang, M., Liu, L., Yang, G., and Ma, X. (2015). Etiology of multiple Non-EV71 and non-CVA16 enteroviruses associated with hand, foot and mouth disease in Jinan, China, 2009\u2014June 2013. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142733"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jcv.2012.11.018","article-title":"Human enterovirus 71 strains in the background population and in hospital patients in Finland","volume":"56","author":"Honkanen","year":"2013","journal-title":"J. Clin. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Huang, X., Wei, H., Wu, S., Du, Y., Liu, L., Su, J., Xu, Y., Wang, H., Li, X., and Wang, Y. (2015). Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008\u20132013. Sci. Rep., 5.","DOI":"10.1038\/srep08904"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/jmv.23763","article-title":"Clinical and enterovirus findings associated with acute flaccid paralysis in the Republic of Korea during the recent decade","volume":"86","author":"Kim","year":"2014","journal-title":"J. Med. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/INF.0b013e3181a41d63","article-title":"Diseases caused by enterovirus 71 infection","volume":"28","author":"Lee","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1186\/1423-0127-21-16","article-title":"Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations","volume":"21","author":"Linsuwanon","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1348-0421.2002.tb02767.x","article-title":"Complete sequence analyses of enterovirus 71 strains from fatal and non-fatal cases of the hand, foot and mouth disease outbreak in Singapore (2000)","volume":"46","author":"Singh","year":"2002","journal-title":"Microbiol. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jviromet.2013.07.051","article-title":"Patterns of polymorphism and divergence in the VP1 gene of enterovirus 71 circulating in the Asia-Pacific region between 1994 and 2013","volume":"193","author":"Wu","year":"2013","journal-title":"J. Virol. Methods"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wu, W.H., Kuo, T.C., Lin, Y.T., Huang, S.W., Liu, H.F., Wang, J., and Chen, Y.M. (2013). Molecular epidemiology of enterovirus 71 infection in the central region of Taiwan from 2002 to 2012. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083711"},{"key":"ref_14","unstructured":"Fields, B.N., Knipe, D.M., and Howley, P.M. (2007). Fields' Virology, Wolters Kluwer Health\/Lippincott Williams & Wilkins."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/rmv.538","article-title":"Genetic evolution of enterovirus 71: Epidemiological and pathological implications","volume":"17","author":"Bible","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7883\/yoken.52.12","article-title":"Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997\u20131998","volume":"52","author":"Shimizu","year":"1999","journal-title":"Jpn J. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1086\/318454","article-title":"Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia","volume":"32","author":"McMinn","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3201\/eid1611.100104","article-title":"Enterovirus 71 infection with central nervous system involvement, South Korea","volume":"16","author":"Ryu","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/QCO.0000000000000187","article-title":"The epidemiology of non-polio enteroviruses: Recent advances and outstanding questions","volume":"28","author":"Parker","year":"2015","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMoa065954","article-title":"Neurodevelopment and cognition in children after enterovirus 71 infection","volume":"356","author":"Chang","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1128\/JVI.78.15.7916-7924.2004","article-title":"A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection","volume":"78","author":"Wang","year":"2004","journal-title":"J. Virol."},{"key":"ref_23","first-page":"36736","article-title":"Fulminant neurogenic pulmonary oedema with hand, foot, and mouth disease","volume":"352","author":"Chang","year":"1998","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJM199909233411302","article-title":"Neurologic complications in children with enterovirus 71 infection","volume":"341","author":"Huang","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3181\/0903-RM-116","article-title":"Enterovirus 71 infection of human dendritic cells","volume":"234","author":"Lin","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nrmicro1284","article-title":"Host and virus determinants of picornavirus pathogenesis and tropism","volume":"3","author":"Whitton","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.gde.2005.12.005","article-title":"MicroRNAs as oncogenes","volume":"16","author":"Hammond","year":"2006","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.5483\/BMBRep.2014.47.8.109","article-title":"MicroRNA-directed cleavage of targets: Mechanism and experimental approaches","volume":"47","author":"Park","year":"2014","journal-title":"BMB Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","article-title":"An overview of microRNAs","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc3932","article-title":"MicroRNA biogenesis pathways in cancer","volume":"15","author":"Lin","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.molcel.2004.12.002","article-title":"Transcription and processing of human microRNA precursors","volume":"16","author":"Cullen","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nsmb1167","article-title":"RNA polymerase III transcribes human microRNAs","volume":"13","author":"Borchert","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1062961","article-title":"A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA","volume":"293","author":"Hutvagner","year":"2001","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","article-title":"Role for a bidentate ribonuclease in the initiation step of RNA interference","volume":"409","author":"Bernstein","year":"2001","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(01)00431-7","article-title":"Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing","volume":"106","author":"Grishok","year":"2001","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/35005107","article-title":"An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells","volume":"404","author":"Hammond","year":"2000","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1073\/pnas.0510928103","article-title":"MicroRNAs direct rapid deadenylation of mRNA","volume":"103","author":"Wu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1101\/gad.1591507","article-title":"MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation","volume":"21","author":"Standart","year":"2007","journal-title":"Genes Dev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1261\/rna.972008","article-title":"miR-148 targets human DNMT3b protein coding region","volume":"14","author":"Duursma","year":"2008","journal-title":"RNA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1158\/0008-5472.CAN-09-0352","article-title":"New tricks for animal microRNAS: Targeting of amino acid coding regions at conserved and nonconserved sites","volume":"69","author":"Rigoutsos","year":"2009","journal-title":"Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1101\/gr.089367.108","article-title":"New class of microRNA targets containing simultaneous 5\u2032-UTR and 3\u2032-UTR interaction sites","volume":"19","author":"Lee","year":"2009","journal-title":"Genom. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Grey, F., Tirabassi, R., Meyers, H., Wu, G., McWeeney, S., Hook, L., and Nelson, J.A. (2010). A viral microRNA down-regulates multiple cell cycle genes through mRNA 5\u2032AUTRs. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000967"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrg2634","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1101\/gad.1793309","article-title":"The role of RNAi and microRNAs in animal virus replication and antiviral immunity","volume":"23","author":"Umbach","year":"2009","journal-title":"Genes Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: MicroRNA biogenesis pathways and their regulation","volume":"11","author":"Winter","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature07103","article-title":"MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs","volume":"454","author":"Umbach","year":"2008","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1096781","article-title":"Identification of virus-encoded microRNAs","volume":"304","author":"Pfeffer","year":"2004","journal-title":"Science"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nature05992","article-title":"A viral microRNA functions as an orthologue of cellular miR-155","volume":"450","author":"Gottwein","year":"2007","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1126\/science.1136319","article-title":"Suppression of microRNA-silencing pathway by HIV-1 during virus replication","volume":"315","author":"Triboulet","year":"2007","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA","volume":"309","author":"Jopling","year":"2005","journal-title":"Science"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ye, X., Zhang, H.M., Qiu, Y., Hanson, P.J., Hemida, M.G., Wei, W., Hoodless, P.A., Chu, F., and Yang, D. (2014). Coxsackievirus-induced miR-21 disrupts cardiomyocyte interactions via the downregulation of intercalated disk components. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004070"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/cmi.12401","article-title":"miR-146a and miR-370 coordinate enterovirus 71-induced cell apoptosis through targeting SOS1 and GADD45\u03b2","volume":"17","author":"Chang","year":"2015","journal-title":"Cell Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1128\/JVI.02655-12","article-title":"Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome","volume":"87","author":"Zheng","year":"2013","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1093\/nar\/gkt058","article-title":"MiR-10a* up-regulates coxsackievirus B3 biosynthesis by targeting the 3D-coding sequence","volume":"41","author":"Tong","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Ho, B.C., Yu, I.S., Lu, L.F., Rudensky, A., Chen, H.Y., Tsai, C.W., Chang, Y.L., Wu, C.T., Chang, L.Y., and Shih, S.R. (2014). Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Nat. Commun., 5.","DOI":"10.1038\/ncomms4344"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chom.2010.12.001","article-title":"Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E","volume":"9","author":"Ho","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nri1860","article-title":"Defensins in innate antiviral immunity","volume":"6","author":"Klotman","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1016\/j.jmb.2013.09.038","article-title":"Antiviral mechanisms of human defensins","volume":"425","author":"Wilson","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ni1303","article-title":"Innate immune recognition of viral infection","volume":"7","author":"Kawai","year":"2006","journal-title":"Nat. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/v3060920","article-title":"Pattern recognition receptors and the innate immune response to viral infection","volume":"3","author":"Thompson","year":"2011","journal-title":"Viruses"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.immunol.17.1.189","article-title":"Natural killer cells in antiviral defense: Function and regulation by innate cytokines","volume":"17","author":"Biron","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1074-7613(01)00126-1","article-title":"Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo","volume":"14","author":"Schiavoni","year":"2001","journal-title":"Immunity"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1126\/science.1074900","article-title":"Critical role for STAT4 activation by type 1 interferons in the interferon-\u03b3 response to viral infection","volume":"297","author":"Nguyen","year":"2002","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-065X.1999.tb01327.x","article-title":"Stimulation of naive and memory T cells by cytokines","volume":"170","author":"Tough","year":"1999","journal-title":"Immunol. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jmv.1890150304","article-title":"Neutralizing antibody and interferon-\u03b1 in cerebrospinal fluids and sera of acute aseptic meningitis","volume":"15","author":"Ichimura","year":"1985","journal-title":"J. Med. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1099\/vir.0.81195-0","article-title":"Type I interferons protect mice against enterovirus 71 infection","volume":"86Pt 12","author":"Liu","year":"2005","journal-title":"J. Gen. Virol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1128\/JVI.01400-14","article-title":"Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response","volume":"88","author":"Xu","year":"2014","journal-title":"J. Virol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000343750","article-title":"MicroRNAs regulate the pathogenesis of CVB3-induced viral myocarditis","volume":"56","author":"Zhang","year":"2013","journal-title":"Intervirology"},{"key":"ref_72","first-page":"2349","article-title":"MiR-155 and miR-148a reduce cardiac injury by inhibiting NF-\u03baB pathway during acute viral myocarditis","volume":"18","author":"Bao","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s13238-012-2081-y","article-title":"MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-lambda1","volume":"4","author":"Li","year":"2013","journal-title":"Protein Cell"},{"key":"ref_74","first-page":"180","article-title":"Acute viral myocarditis: Current concepts in diagnosis and treatment","volume":"15","author":"Shauer","year":"2013","journal-title":"Isr. Med. Assoc. J. IMAJ"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1128\/JVI.01779-10","article-title":"Sustained high levels of interleukin-6 contribute to the pathogenesis of enterovirus 71 in a neonate mouse model","volume":"85","author":"Khong","year":"2011","journal-title":"J. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/jmv.22198","article-title":"Partial protection against enterovirus 71 (EV71) infection in a mouse model immunized with recombinant Newcastle disease virus capsids displaying the EV71 VP1 fragment","volume":"83","author":"Stanbridge","year":"2011","journal-title":"J. Med. Virol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/08830180305213","article-title":"Apoptosis prevention as a mechanism of immune evasion","volume":"22","author":"Aubert","year":"2003","journal-title":"Int. Rev. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.25011\/cim.v36i2.19573","article-title":"MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis","volume":"36","author":"He","year":"2013","journal-title":"Clin. Investig. Med. Med. Clin. Exp."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3892\/mmr.2015.3482","article-title":"Enterovirus 71 induces apoptosis of SHSY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression","volume":"12","author":"Du","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.yjmcc.2009.01.008","article-title":"MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4","volume":"47","author":"Cheng","year":"2009","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.2119\/molmed.2012.00055","article-title":"Isocorydine targets the drug-resistant cellular side population through PDCD4-related apoptosis in hepatocellular carcinoma","volume":"18","author":"Lu","year":"2012","journal-title":"Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1074\/jbc.M707224200","article-title":"Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells","volume":"283","author":"Frankel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1128\/JVI.03138-13","article-title":"Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by Toll-like receptor 3","volume":"88","author":"Xiang","year":"2014","journal-title":"J. Virol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9830","DOI":"10.1128\/JVI.01425-14","article-title":"Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1\/TAB1\/TAB2\/TAB3 complex","volume":"88","author":"Lei","year":"2014","journal-title":"J. Virol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1128\/MCB.24.4.1779-1790.2004","article-title":"Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: A novel mechanism for host translation shutoff","volume":"24","author":"Younan","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1099\/0022-1317-83-6-1367","article-title":"Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death","volume":"83","author":"Kuo","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1128\/JVI.78.12.6313-6321.2004","article-title":"Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection","volume":"78","author":"Graham","year":"2004","journal-title":"J. Virol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/JVI.02712-13","article-title":"Enterovirus 2Apro targets MDA5 and MAVS in infected cells","volume":"88","author":"Feng","year":"2014","journal-title":"J. Virol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Barnabei, M.S., Sjaastad, F.V., Townsend, D., Bedada, F.B., and Metzger, J.M. (2015). Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment. Sci. Transl. Med., 7.","DOI":"10.1126\/scitranslmed.aaa4804"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/MCB.20.4.1271-1277.2000","article-title":"Poliovirus 2A protease induces apoptotic cell death","volume":"20","author":"Goldstaub","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/CIRCRESAHA.112.267443","article-title":"MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis","volume":"111","author":"Corsten","year":"2012","journal-title":"Circ. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.febslet.2014.12.006","article-title":"miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor","volume":"589","author":"Lam","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11010-011-1136-3","article-title":"MicroRNA-1 represses Cx43 expression in viral myocarditis","volume":"362","author":"Xu","year":"2012","journal-title":"Mol. Cell Biochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3892\/mmr.2014.2205","article-title":"MicroRNA21 regulation of the progression of viral myocarditis to dilated cardiomyopathy","volume":"10","author":"Xu","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Xu, L.J., Jiang, T., Zhao, W., Han, J.F., Liu, J., Deng, Y.Q., Zhu, S.Y., Li, Y.X., Nian, Q.G., and Zhang, Y. (2014). Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095272"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1007\/s00018-013-1411-4","article-title":"MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1\/2 and Wnt\/\u03b2-catenin signal pathways","volume":"70","author":"Ye","year":"2013","journal-title":"Cell Mol. Life Sci. CMLS"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11262-014-1114-4","article-title":"miR-27a suppresses EV71 replication by directly targeting EGFR","volume":"49","author":"Zhang","year":"2014","journal-title":"Virus Genes"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000348504","article-title":"MicroRNA-23b inhibits enterovirus 71 replication through downregulation of EV71 VPl protein","volume":"56","author":"Wen","year":"2013","journal-title":"Intervirology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.antiviral.2011.12.004","article-title":"MiR-342-5p suppresses coxsackievirus B3 biosynthesis by targeting the 2C-coding region","volume":"93","author":"Wang","year":"2012","journal-title":"Antivir. Res."},{"key":"ref_100","first-page":"943","article-title":"MiR373 and miR542-5p regulate the replication of enterovirus 71 in rhabdomyosarcoma cells","volume":"30","author":"Yang","year":"2014","journal-title":"Chin. J. Biotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/S0378-3782(14)70023-4","article-title":"Human enterovirus and parechovirus infections in newborns with sepsis-like illness and neurological disorders","volume":"90","author":"Piralla","year":"2014","journal-title":"Early Hum. Dev."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Britton, P.N., Khandaker, G., Booy, R., and Jones, C.A. (2014). The causes and consequences of childhood encephalitis in Asia. Infect. Disord. Drug Targets, 14.","DOI":"10.2174\/1871526514666141021113317"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1002\/jcp.22677","article-title":"Enterovirus 71 induces integrin \u03b21\/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: Role of HO-1\/CO in viral replication","volume":"226","author":"Tung","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/jcb.22946","article-title":"Enterovirus 71 modulates a COX-2\/PGE2\/cAMP-dependent viral replication in human neuroblastoma cells: Role of the c-Src\/EGFR\/p42\/p44 MAPK\/CREB signaling pathway","volume":"112","author":"Tung","year":"2011","journal-title":"J. Cell Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cellsig.2009.09.018","article-title":"Enterovirus 71 induces COX-2 expression via MAPKs, NF-\u03baB, and AP-1 in SK-N-SH cells: Role of PGE(2) in viral replication","volume":"22","author":"Tung","year":"2010","journal-title":"Cell Signal."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0966-842X(00)01788-1","article-title":"Picornavirus RNA translation: Roles for cellular proteins","volume":"8","author":"Belsham","year":"2000","journal-title":"Trends Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0968-0004(03)00029-X","article-title":"Translation initiation and viral tricks","volume":"28","author":"Schneider","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00018-012-1104-4","article-title":"MicroRNA-203 enhances coxsackievirus B3 replication through targeting zinc finger protein-148","volume":"70","author":"Hemida","year":"2013","journal-title":"Cell Mol. Life Sci. CMLS"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.chom.2011.01.004","article-title":"RNA virus harnesses microRNAs to seize host translation control","volume":"9","author":"Abraham","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molcel.2008.05.001","article-title":"MicroRNA-10a binds the 5\u2032MUTR of ribosomal protein mRNAs and enhances their translation","volume":"30","author":"Orom","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1093\/nar\/gkr426","article-title":"miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components","volume":"39","author":"Roberts","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1303224","article-title":"An inactivated enterovirus 71 vaccine in healthy children","volume":"370","author":"Li","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1304923","article-title":"Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China","volume":"370","author":"Zhu","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Farooqi, A.A., Fayyaz, S., Shatynska-Mytsyk, I., Javed, Z., Jabeen, S., Yaylim, I., Gasparri, M.L., and Panici, P.B. (2015). Is miR-34a a well equipped swordsman to conquer temple of molecular oncology?. Chem. Biol. Drug Des., 86.","DOI":"10.1111\/cbdd.12634"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N. Engl. J. Med."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/8\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:17:19Z","timestamp":1760210239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/8\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,6]]},"references-count":115,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1]]}},"alternative-id":["v8010011"],"URL":"https:\/\/doi.org\/10.3390\/v8010011","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,6]]}}}