{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:15:39Z","timestamp":1791404139758,"version":"4.3.3"},"reference-count":192,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers. HTLV-1 is the etiological agent of an adult T-cell leukemia (ATL) and can lead to a variety of neurological pathologies, including HTLV-1-associated-myelopathy\/tropical spastic paraparesis (HAM\/TSP). The ability to treat the aggressive ATL subtypes remains inadequate. HTLV-1 replicates by (1) an infectious cycle involving virus budding and infection of new permissive target cells and (2) mitotic division of cells harboring an integrated provirus. Virus replication initiates host antiviral immunity and the checkpoint control of cell proliferation, but HTLV-1 has evolved elegant strategies to counteract these host defense mechanisms to allow for virus persistence. The study of the molecular biology of HTLV-1 replication has provided crucial information for understanding HTLV-1 replication as well as aspects of viral replication that are shared between HTLV-1 and human immunodeficiency virus type 1 (HIV-1). Here in this review, we discuss the various stages of the virus replication cycle\u2014both foundational knowledge as well as current updates of ongoing research that is important for understanding HTLV-1 molecular pathogenesis as well as in developing novel therapeutic strategies.<\/jats:p>","DOI":"10.3390\/v8020031","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T02:19:45Z","timestamp":1453947585000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Molecular Studies of HTLV-1 Replication: An Update"],"prefix":"10.3390","volume":"8","author":[{"given":"Jessica","family":"Martin","sequence":"first","affiliation":[{"name":"Institute for Molecular Virology, Pharmacoimmunology Training Program &amp; Pharmacology Graduate Program, University of Minnesota, 18-242 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-7119","authenticated-orcid":false,"given":"Jos\u00e9","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Institute for Molecular Virology &amp; DDS-PhD Dual Degree Program, University of Minnesota, 18-242 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Mueller","sequence":"additional","affiliation":[{"name":"Institute for Molecular Virology &amp; School of Physics and Astronomy, University of Minnesota, 18-242 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Molecular Virology, School of Dentistry &amp; Characterization Facility, University of Minnesota, 18-242 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Mansky","sequence":"additional","affiliation":[{"name":"Institute for Molecular Virology, School of Dentistry &amp; Pharmacology Graduate Program, University of Minnesota, 18-242 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","article-title":"Isolation and characterization of retrovirus from cell lines of human adult t-cell leukemia and its implication in the disease","volume":"79","author":"Yoshida","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1038\/sj.onc.1208980","article-title":"History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2","volume":"24","author":"Gallo","year":"2005","journal-title":"Oncogene"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.6981847","article-title":"A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia","volume":"218","author":"Kalyanaraman","year":"1982","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1002\/j.1460-2075.1993.tb06111.x","article-title":"Functional and biochemical interaction of the HTLV-I Tax1 transactivator with tbp","volume":"12","author":"Caron","year":"1993","journal-title":"EMBO J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1038\/sj.onc.1208968","article-title":"Global epidemiology of HTLV-I infection and associated diseases","volume":"24","author":"Proietti","year":"2005","journal-title":"Oncogene"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gessain, A., and Cassar, O. (2012). Epidemiological aspects and world distribution of HTLV-1 infection. Front. Microbiol., 3.","DOI":"10.3389\/fmicb.2012.00388"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Calattini, S., Chevalier, S.A., Duprez, R., Bassot, S., Froment, A., Mahieux, R., and Gessain, A. (2005). Discovery of a new human T-cell lymphotropic virus (HTLV-3) in central africa. Retrovirology, 2.","DOI":"10.1186\/1742-4690-2-30"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1073\/pnas.0501734102","article-title":"Emergence of unique primate T-lymphotropic viruses among central african bushmeat hunters","volume":"102","author":"Wolfe","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1073\/pnas.81.8.2534","article-title":"Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease","volume":"81","author":"Yoshida","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.7326\/0003-4819-111-7-555","article-title":"Sexual transmission of human T-lymphotropic virus type I (HTLV-I)","volume":"111","author":"Murphy","year":"1989","journal-title":"Ann. Int. Med."},{"key":"ref_12","first-page":"1096","article-title":"The risk of development of HTLV-I-associated myelopathy\/tropical spastic paraparesis among persons infected with HTLV-I","volume":"3","author":"Kaplan","year":"1990","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1086\/424598","article-title":"Persistent paradox of natural history of human T lymphotropic virus type I: Parallel analyses of Japanese and Jamaican carriers","volume":"190","author":"Hisada","year":"2004","journal-title":"J. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2008.18.2428","article-title":"Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: A proposal from an international consensus meeting","volume":"27","author":"Tsukasaki","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bbmt.2008.03.010","article-title":"Allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning for adult T cell leukemia\/lymphoma: Impact of antithymocyte globulin on clinical outcome","volume":"14","author":"Tanosaki","year":"2008","journal-title":"J. Am. Soc. Blood Marrow Transplant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1200\/JCO.2007.11.9958","article-title":"VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan clinical oncology group study JCOG9801","volume":"25","author":"Tsukasaki","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1200\/JCO.2009.25.3575","article-title":"Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma","volume":"28","author":"Yamamoto","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1200\/JCO.2010.28.0669","article-title":"Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia\/lymphoma showing improved survival in the leukemic subtypes","volume":"28","author":"Bazarbachi","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kinpara, S., Kijiyama, M., Takamori, A., Hasegawa, A., Sasada, A., Masuda, T., Tanaka, Y., Utsunomiya, A., and Kannagi, M. (2013). Interferon-\u03b1 (IFN-\u03b1) suppresses HTLV-1 gene expression and cell cycling, while IFN-\u03b1 combined with zidovudine induces p53 signaling and apoptosis in HTLV-1-infected cells. Retrovirology, 10.","DOI":"10.1186\/1742-4690-10-52"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Meekings, K.N., Leipzig, J., Bushman, F.D., Taylor, G.P., and Bangham, C.R. (2008). HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM\/TSP. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000027"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/13550289809114225","article-title":"Analysis of HTLV-I proviral load in 202 HAM\/TSP patients and 243 asymptomatic HTLV-I carriers: High proviral load strongly predisposes to HAM\/TSP","volume":"4","author":"Nagai","year":"1998","journal-title":"J. Neurovirol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.ncl.2008.03.008","article-title":"Treatment of HTLV-I-associated myelopathy\/tropical spastic paraparesis: Toward rational targeted therapy","volume":"26","author":"Oh","year":"2008","journal-title":"Neurol. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/299367a0","article-title":"Unique cell lines harbouring both epstein-barr virus and adult T-cel lleukaemia virus, established from leukaemia patients","volume":"299","author":"Yamamoto","year":"1982","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1073\/pnas.81.23.7588","article-title":"Infection of human endothelial cells by human T-lymphotropic virus type I","volume":"81","author":"Ho","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/310505a0","article-title":"Isolation of HTLV-transformed B-lymphocyte clone from a patient with HTLV-associated adult T-cell leukaemia","volume":"310","author":"Longo","year":"1984","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ijc.2910330606","article-title":"Isolation of HTLV derived from Japanese adult T-cell leukemia patients in human diploid fibroblast strain IMR90 and the biological characters of the infected cells","volume":"33","author":"Yoshikura","year":"1984","journal-title":"Int. J. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/viro.1993.1451","article-title":"In vivo infection of human T-cell leukemia virus type I in non-T cells","volume":"196","author":"Koyanagi","year":"1993","journal-title":"Virology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0092-8674(03)00881-X","article-title":"The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV","volume":"115","author":"Manel","year":"2003","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12692","DOI":"10.1128\/JVI.79.20.12692-12702.2005","article-title":"Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells","volume":"79","author":"Jones","year":"2005","journal-title":"J. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1128\/JVI.02719-05","article-title":"Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry","volume":"80","author":"Ghez","year":"2006","journal-title":"J. Virol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm1745","article-title":"Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells","volume":"14","author":"Jones","year":"2008","journal-title":"Nat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.virol.2006.01.045","article-title":"Infection of CD4+ T lymphocytes by the human T cell leukemia virus type 1 is mediated by the glucose transporter glut-1: Evidence using antibodies specific to the receptor\u2019s large extracellular domain","volume":"349","author":"Jin","year":"2006","journal-title":"Virology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0092-8674(94)90360-3","article-title":"Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain","volume":"76","author":"Aiken","year":"1994","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1097-2765(00)80056-8","article-title":"A novel human WD protein, H-\u03b2 TRCP, that interacts with HIV-1 VPU connects CD4 to the ER degradation pathway through an F-box motif","volume":"1","author":"Margottin","year":"1998","journal-title":"Mol. Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1128\/JVI.02686-14","article-title":"Separate cellular localizations of human T-lymphotropic virus 1 (HTLV-1) Env and glucose transporter type 1 (glut1) are required for HTLV-1 Env-mediated fusion and infection","volume":"89","author":"Maeda","year":"2015","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cmet.2014.05.004","article-title":"The glucose transporter glut1 is selectively essential for CD4 T cell activation and effector function","volume":"20","author":"Macintyre","year":"2014","journal-title":"Cell Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/2261211a0","article-title":"RNA-dependent DNA polymerase in virions of Rous sarcoma virus","volume":"226","author":"Temin","year":"1970","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/2261209a0","article-title":"RNA-dependent DNA polymerase in virions of RNA tumour viruses","volume":"226","author":"Baltimore","year":"1970","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1073\/pnas.1014522108","article-title":"Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription","volume":"108","author":"Hulme","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tekeste, S.S., Wilkinson, T.A., Weiner, E.M., Xu, X., Miller, J.T., Le Grice, S.F., Clubb, R.T., and Chow, S.A. (2015). Interaction between reverse transcriptase and integrase is required for reverse transcription during HIV-1 replication. J. Virol.","DOI":"10.1128\/JVI.01471-15"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1128\/JVI.01591-14","article-title":"Northern African strains of human T-lymphotropic virus type 1 arose from a recombination event","volume":"88","author":"Desrames","year":"2014","journal-title":"J. Virol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1128\/JVI.06570-11","article-title":"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1","volume":"86","author":"Ooms","year":"2012","journal-title":"J. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1128\/JVI.02239-09","article-title":"APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo","volume":"84","author":"Fan","year":"2010","journal-title":"J. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1073\/pnas.0609444104","article-title":"Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid","volume":"104","author":"Derse","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","unstructured":"Coffin, J.M., Hughes, S.H., and Varmus, H.E. (1997). Retroviruses, Cold Spring Harbor."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1073\/pnas.89.12.5532","article-title":"Nonrandom integration of retroviral DNA in vitro: Effect of CPG methylation","volume":"89","author":"Kitamura","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1182\/blood-2004-11-4350","article-title":"Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states","volume":"106","author":"Doi","year":"2005","journal-title":"Blood"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1073\/pnas.0501646102","article-title":"Symmetrical base preferences surrounding HIV-1, avian sarcoma\/leukosis virus, and murine leukemia virus integration sites","volume":"102","author":"Holman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8820","DOI":"10.1128\/JVI.00719-06","article-title":"Integration site choice of a feline immunodeficiency virus vector","volume":"80","author":"Kang","year":"2006","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1128\/JVI.02752-06","article-title":"Human T-cell leukemia virus type 1 integration target sites in the human genome: Comparison with those of other retroviruses","volume":"81","author":"Derse","year":"2007","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Gillet, N.A., Cook, L., Laydon, D.J., Hlela, C., Verdonck, K., Alvarez, C., Gotuzzo, E., Clark, D., Farre, L., and Bittencourt, A. (2013). Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003263"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1182\/blood-2014-02-553602","article-title":"The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia\/lymphoma","volume":"123","author":"Cook","year":"2014","journal-title":"Blood"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Niederer, H.A., Laydon, D.J., Melamed, A., Elemans, M., Asquith, B., Matsuoka, M., and Bangham, C.R. (2014). HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM\/TSP. J. Virol., 11.","DOI":"10.1186\/1743-422X-11-172"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1038\/sj.onc.1208973","article-title":"Transcriptional and post-transcriptional gene regulation of HTLV-1","volume":"24","author":"Kashanchi","year":"2005","journal-title":"Oncogene"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1128\/jvi.62.12.4499-4509.1988","article-title":"Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence","volume":"62","author":"Jeang","year":"1988","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/376606a0","article-title":"Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax","volume":"376","author":"Baranger","year":"1995","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1128\/jvi.69.3.1834-1841.1995","article-title":"Distinct regions in human T-cell lymphotropic virus type I Tax mediate interactions with activator protein CREB and basal transcription factors","volume":"69","author":"Adya","year":"1995","journal-title":"J. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1073\/pnas.91.12.5642","article-title":"Expansion of CREB\u2019S DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282\u2013284 near the conserved DNA-binding domain of CREB","volume":"91","author":"Adya","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1128\/jvi.69.9.5806-5811.1995","article-title":"The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein","volume":"69","author":"Goren","year":"1995","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1128\/jvi.70.12.8368-8374.1996","article-title":"Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat","volume":"70","author":"Tie","year":"1996","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1073\/pnas.89.15.7070","article-title":"Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction","volume":"89","author":"Zhao","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ching, Y.P., Chun, A.C., Chin, K.T., Zhang, Z.Q., Jeang, K.T., and Jin, D.Y. (2004). Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex. Retrovirology, 1.","DOI":"10.1186\/1742-4690-1-18"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/j.1460-2075.1986.tb04247.x","article-title":"Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator","volume":"5","author":"Seiki","year":"1986","journal-title":"EMBO J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1128\/MCB.17.9.5156","article-title":"Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of Tax transactivation","volume":"17","author":"Giebler","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/380642a0","article-title":"Control of CAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP","volume":"380","author":"Kwok","year":"1996","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.1128\/MCB.19.12.8136","article-title":"PCAF interacts with Tax and stimulates Tax transactivation in a histone acetyltransferase-independent manner","volume":"19","author":"Jiang","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11852","DOI":"10.1074\/jbc.275.16.11852","article-title":"P300 and p300\/CAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase\/activator-enhancer complex","volume":"275","author":"Harrod","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1128\/MCB.18.4.2392","article-title":"Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300","volume":"18","author":"Bex","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1073\/pnas.1419198112","article-title":"Tcf1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax","volume":"112","author":"Ma","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zou, T., Yang, Y., Xia, F., Huang, A., Gao, X., Fang, D., Xiong, S., and Zhang, J. (2013). Resveratrol inhibits CD4+ T cell activation by enhancing the expression and activity of Sirt1. PloS ONE, 8.","DOI":"10.1371\/journal.pone.0075139"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.1128\/JVI.01229-15","article-title":"Sirt1 suppresses human T-cell leukemia virus type 1 transcription","volume":"89","author":"Tang","year":"2015","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Huang, H., Santoso, N., Power, D., Simpson, S., Dieringer, M., Miao, H., Gurova, K., Giam, C.Z., Elledge, S., and Zhu, J. (2015). Fact proteins, SUPT16H and SSRP1, are transcriptional suppressors of HIV-1 and HTLV-1 that facilitate viral latency. J. Biol. Chem.","DOI":"10.1074\/jbc.M115.652339"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1096\/fasebj.4.2.2404818","article-title":"Regulation of human T cell leukemia virus expression","volume":"4","author":"Green","year":"1990","journal-title":"FASEB J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/j.1460-2075.1988.tb02840.x","article-title":"Post-transcriptional regulator (Rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins","volume":"7","author":"Hidaka","year":"1988","journal-title":"EMBO J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5704","DOI":"10.1073\/pnas.88.13.5704","article-title":"The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements","volume":"88","author":"Bogerd","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9798","DOI":"10.1073\/pnas.86.24.9798","article-title":"Nucleolar targeting signal of human T-cell leukemia virus type I Rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mrna","volume":"86","author":"Nosaka","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/excr.1997.3562","article-title":"The activation domain of a hormone inducible HTLV-1 Rex protein determines colocalization with the nuclear pore","volume":"233","author":"Rehberger","year":"1997","journal-title":"Exp. Cell Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1128\/jvi.70.9.6442-6445.1996","article-title":"The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal","volume":"70","author":"Palmeri","year":"1996","journal-title":"J. Virol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1128\/JVI.06361-11","article-title":"Nuclear export and expression of human T-cell leukemia virus type 1 Tax\/Rex mRNA are Rxre\/Rex dependent","volume":"86","author":"Bai","year":"2012","journal-title":"J. Virol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12977-015-0184-2","article-title":"Identification of novel monocistronic HTLV-1 mrnas encoding functional Rex isoforms","volume":"12","author":"Rende","year":"2015","journal-title":"Retrovirology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1128\/JVI.76.7.3089-3094.2002","article-title":"Destiny of unspliced retroviral RNA: Ribosome and\/or virion?","volume":"76","author":"Butsch","year":"2002","journal-title":"J. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1101\/gad.891101","article-title":"Internal ribosome entry sites in eukaryotic mRNA molecules","volume":"15","author":"Hellen","year":"2001","journal-title":"Genes Dev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1042\/BST0331479","article-title":"Takeover of host ribosomes by divergent IRES elements","volume":"33","author":"Sarnow","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1042\/BST0331231","article-title":"Alternative mechanisms of initiating translation of mammalian mrnas","volume":"33","author":"Jackson","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0014-5793(96)00815-0","article-title":"The RU5 (\u201cR\u201d) region from human leukaemia viruses (HTLV-1) contains an internal ribosome entry site (IRES)-like sequence","volume":"392","author":"Attal","year":"1996","journal-title":"FEBS Let."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1093\/nar\/gkm124","article-title":"RNA helicase a interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1","volume":"35","author":"Bolinger","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1128\/JVI.00279-14","article-title":"The 5\u2019 untranslated region of the human T-cell lymphotropic virus type 1 mRNA enables cap-independent translation initiation","volume":"88","author":"Olivares","year":"2014","journal-title":"J. Virol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bpj.2011.02.008","article-title":"Characterization of cytoplasmic Gag-gag interactions by dual-color z-scan fluorescence fluctuation spectroscopy","volume":"100","author":"Fogarty","year":"2011","journal-title":"Biophys. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1128\/JVI.03584-14","article-title":"Analysis of HIV-1 Gag protein interactions via biotin ligase tagging","volume":"89","author":"Ritchie","year":"2015","journal-title":"J. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1182\/blood-2004-07-2850","article-title":"Engagement of specific T-cellsurface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes","volume":"106","author":"Barnard","year":"2005","journal-title":"Blood"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1074\/jbc.M109.051334","article-title":"C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism","volume":"285","author":"Qualley","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/JVI.02151-13","article-title":"Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: Implications for genomic RNA packaging","volume":"88","author":"Sun","year":"2014","journal-title":"J. Virol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"E5205","DOI":"10.1073\/pnas.1413169111","article-title":"Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of gag protein","volume":"111","author":"Chen","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3934\/biophy.2015.3.343","article-title":"Morphology and ultrastructure of retrovirus particles","volume":"2","author":"Zhang","year":"2015","journal-title":"AIMS Biophys."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1126\/science.278.5339.849","article-title":"Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein","volume":"278","author":"Gamble","year":"1997","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1128\/JVI.75.11.5277-5287.2001","article-title":"The NH2-terminal domain of the human T-cell leukemia virus type 1 capsid protein is involved in particle formation","volume":"75","author":"Rayne","year":"2001","journal-title":"J. Virol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1128\/JVI.78.5.2545-2552.2004","article-title":"Assembly properties of the human immunodeficiency virus type 1 CA protein","volume":"78","author":"Stray","year":"2004","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"13463","DOI":"10.1128\/JVI.79.21.13463-13472.2005","article-title":"The retroviral capsid domain dictates virion size, morphology, and coassembly of gag into virus-like particles","volume":"79","author":"Johnson","year":"2005","journal-title":"J. Virol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1128\/JVI.02545-08","article-title":"Quantitative fluorescence resonance energy transfer microscopy analysis of the human immunodeficiency virus type 1 Gag-gag interaction: Relative contributions of the CA and NC domains and membrane binding","volume":"83","author":"Hogue","year":"2009","journal-title":"J. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.virusres.2014.07.001","article-title":"How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle","volume":"193","author":"Lingappa","year":"2014","journal-title":"Virus research"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Maldonado, J.O., Martin, J.L., Mueller, J.D., Zhang, W., and Mansky, L.M. (2014). New insights into retroviral Gag-gag and Gag-membrane interactions. Frontiers Microbiol., 5.","DOI":"10.3389\/fmicb.2014.00302"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1042\/BST0370955","article-title":"Lipid rafts as functional heterogeneity in cell membranes","volume":"37","author":"Lingwood","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2217\/fvl.09.4","article-title":"HIV-1 assembly at the plasma membrane: Gag trafficking and localization","volume":"4","author":"Ono","year":"2009","journal-title":"Futur. Virol."},{"key":"ref_104","first-page":"4","article-title":"Membrane domains and the \u201clipid raft\u201d concept","volume":"20","author":"Sonnino","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Inlora, J., Collins, D.R., Trubin, M.E., Chung, J.Y., and Ono, A. (2014). Membrane binding and subcellular localization of retroviral Gag proteins are differentially regulated by MA interactions with phosphatidylinositol-(4,5)-bisphosphate and RNA. mBio, 5.","DOI":"10.1128\/mBio.02202-14"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.virusres.2004.08.007","article-title":"Retrovirus budding","volume":"106","author":"Demirov","year":"2004","journal-title":"Virus Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.cellbio.20.010403.102350","article-title":"Retrovirus budding","volume":"20","author":"Morita","year":"2004","journal-title":"Ann. Rev. Cell Dev. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0168-1702(01)00278-7","article-title":"HTLV-1 structural proteins","volume":"78","author":"Grange","year":"2001","journal-title":"Virus Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.virol.2015.03.021","article-title":"Retroviral proteases and their roles in virion maturation","volume":"479\u2013480","author":"Konvalinka","year":"2015","journal-title":"Virology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1128\/CMR.00063-09","article-title":"Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1-associated diseases","volume":"23","author":"Goncalves","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_111","first-page":"1162","article-title":"Mother-to-child transmission of human T-cell lymphotropic virus type I (HTLV-I) in Jamaica: Association with antibodies to envelope glycoprotein (gp46) epitopes","volume":"6","author":"Wiktor","year":"1993","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/ijc.2910490508","article-title":"Inhibitory effect of maternal antibody on mother-to-child transmission of human T-lymphotropic virus type I. The mother-to-child transmission study group","volume":"49","author":"Takahashi","year":"1991","journal-title":"Int. J. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00042560-199606010-00013","article-title":"Mother-to-child transmission of human T-cell lymphotropic virus types I and II (HTLV-I\/II) in Gabon: A prospective follow-up of 4 years","volume":"12","author":"Nyambi","year":"1996","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1086\/423941","article-title":"Provirus load in breast milk and risk of mother-to-child transmission of human T lymphotropic virus type I","volume":"190","author":"Li","year":"2004","journal-title":"J. Infec. Dis."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1182\/blood-2011-08-374637","article-title":"Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells","volume":"120","author":"Gnadig","year":"2012","journal-title":"Blood"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Kinlock, B.L., Wang, Y., Turner, T.M., Wang, C., and Liu, B. (2014). Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway. PloS ONE, 9.","DOI":"10.1371\/journal.pone.0096760"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1091\/mbc.e05-03-0192","article-title":"HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer","volume":"16","author":"Alfsen","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/cid\/civ145","article-title":"A severe bite from a nonhuman primate is a major risk factor for HTLV-1 infection in hunters from central Africa","volume":"60","author":"Filippone","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/infdis\/jiu464","article-title":"Origin of HTLV-1 in hunters of nonhuman primates in central Africa","volume":"211","author":"Kazanji","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"LeBreton, M., Switzer, W.M., Djoko, C.F., Gillis, A., Jia, H., Sturgeon, M.M., Shankar, A., Zheng, H., Nkeunen, G., and Tamoufe, U. (2014). A gorilla reservoir for human T-lymphotropic virus type 4. Emerg. Microbes  Infect., 3.","DOI":"10.1038\/emi.2014.7"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Miura, M., Yasunaga, J., Tanabe, J., Sugata, K., Zhao, T., Ma, G., Miyazato, P., Ohshima, K., Kaneko, A., and Watanabe, A. (2013). Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology, 10.","DOI":"10.1186\/1742-4690-10-118"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/viro.1994.1097","article-title":"Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: Evidence for independent virus evolution in Asia and Africa","volume":"199","author":"Song","year":"1994","journal-title":"Virology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1128\/jcm.30.4.905-910.1992","article-title":"Infection of peripheral blood mononuclear cells and cell lines by cell-free human T-cell lymphoma\/leukemia virus type I","volume":"30","author":"Fan","year":"1992","journal-title":"J. Clin. Microbiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1080115","article-title":"Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton","volume":"299","author":"Igakura","year":"2003","journal-title":"Science"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Majorovits, E., Nejmeddine, M., Tanaka, Y., Taylor, G.P., Fuller, S.D., and Bangham, C.R. (2008). Human T-lymphotropic virus-1 visualized at the virological synapse by electron tomography. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002251"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1182\/blood-2008-03-136770","article-title":"HTLV-1-Tax and ICAM-1 act on T-cellsignal pathways to polarize the microtubule-organizing center at the virological synapse","volume":"114","author":"Nejmeddine","year":"2009","journal-title":"Blood"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"29653","DOI":"10.1074\/jbc.M502639200","article-title":"Human T-lymphotropic virus, type 1, Tax protein triggers microtubule reorientation in the virological synapse","volume":"280","author":"Nejmeddine","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Chevalier, S.A., Turpin, J., Cachat, A., Afonso, P.V., Gessain, A., Brady, J.N., Pise-Masison, C.A., and Mahieux, R. (2014). Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cellconjugates and viral transmission. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003917"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ijc.2910520316","article-title":"Strong induction of ICAM-1 in human T cells transformed by human T-cell-leukemia virus type 1 and depression of ICAM-1 or LFA-1 in adult T-cell-leukemia-derived cell lines","volume":"52","author":"Fukudome","year":"1992","journal-title":"Int. J. Cancer."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1128\/jvi.67.4.2182-2190.1993","article-title":"Quantitation of human immunodeficiency virus type 1 infection kinetics","volume":"67","author":"Dimitrov","year":"1993","journal-title":"J. Virol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Mazurov, D., Ilinskaya, A., Heidecker, G., Lloyd, P., and Derse, D. (2010). Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000788"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1128\/JVI.01021-15","article-title":"Human blood-circulating basophils capture HIV-1 and mediate viral trans-infection of CD4+ T cells","volume":"89","author":"Jiang","year":"2015","journal-title":"J. Virol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm.2065","article-title":"Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses","volume":"16","author":"Sachse","year":"2010","journal-title":"Nat. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4149\/av_2015_03_247","article-title":"Monoclonal antibody profiling of cell surface proteins associated with the viral biofilms on HTLV-1 transformed cells","volume":"59","author":"Tarasevich","year":"2015","journal-title":"Acta Virol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"10580","DOI":"10.1128\/JVI.01799-15","article-title":"Viral source-independent high susceptibility of dendritic cells to human T-cell leukemia virus type 1 infection compared to that of T lymphocytes","volume":"89","author":"Alais","year":"2015","journal-title":"J. Virol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1128\/jvi.66.4.2288-2295.1992","article-title":"Low degree of human T-cell leukemia\/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations","volume":"66","author":"Gessain","year":"1992","journal-title":"J. Virol."},{"key":"ref_137","first-page":"603","article-title":"The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains","volume":"21","author":"Pybus","year":"2004","journal-title":"Mol. Biol. Evolut."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1128\/JVI.74.20.9525-9531.2000","article-title":"In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy","volume":"74","author":"Mansky","year":"2000","journal-title":"J. Virol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1128\/jvi.69.8.5087-5094.1995","article-title":"Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase","volume":"69","author":"Mansky","year":"1995","journal-title":"J. Virol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1742-4690-3-63","article-title":"Zidovudine plus lamivudine in human T-lymphotropic virus type-I-associated myelopathy: A randomised trial","volume":"3","author":"Taylor","year":"2006","journal-title":"Retrovirology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"10683","DOI":"10.1128\/JVI.01009-06","article-title":"De novo human T-cell leukemia virus type 1 infection of human lymphocytes in NOD-SCID, common \u03b3-chain knockout mice","volume":"80","author":"Miyazato","year":"2006","journal-title":"J. Virol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/309640a0","article-title":"Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells","volume":"309","author":"Seiki","year":"1984","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0304-3835(98)00188-8","article-title":"Random integration of HTLV-1 provirus: Increasing chromosomal instability","volume":"132","author":"Ohshima","year":"1998","journal-title":"Cancer Lett."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1128\/jvi.69.5.2863-2868.1995","article-title":"Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy","volume":"69","author":"Wattel","year":"1995","journal-title":"J. Virol."},{"key":"ref_145","first-page":"4862","article-title":"Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo","volume":"57","author":"Etoh","year":"1997","journal-title":"Cancer Res."},{"key":"ref_146","first-page":"2419","article-title":"Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP\/HAM","volume":"12","author":"Cavrois","year":"1996","journal-title":"Oncogene"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00705-014-2099-y","article-title":"Development of t cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice","volume":"159","author":"Zhao","year":"2014","journal-title":"Archives Virol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","article-title":"Crosstalk in NF-\u03baB signaling pathways","volume":"12","author":"Oeckinghaus","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.1074\/jbc.M510598200","article-title":"Role for Akt\/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 Tax oncoprotein","volume":"281","author":"Peloponese","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/sj.embor.7400931","article-title":"Retroviral oncoprotein Tax deregulates NF-\u03baB by activating Tak1 and mediating the physical association of tak1-IKK","volume":"8","author":"Wu","year":"2007","journal-title":"EMBO Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.virol.2010.08.023","article-title":"Association of HTLV Tax proteins with Tak1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-\u03baB activation","volume":"408","author":"Avesani","year":"2010","journal-title":"Virology"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Choi, Y.B., and Harhaj, E.W. (2014). HTLV-1 Tax stabilizes mcl-1 via traf6-dependent k63-linked polyubiquitination to promote cell survival and transformation. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004458"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0092-8674(00)81447-6","article-title":"HTLV-I Tax protein binds to mekk1 to stimulate I\u03baB kinase activity and NF-\u03baB activation","volume":"93","author":"Yin","year":"1998","journal-title":"Cell"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"22911","DOI":"10.1074\/jbc.274.33.22911","article-title":"Ikk\u03b3 serves as a docking subunit of the I\u03baB kinase (Ikk) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein","volume":"274","author":"Harhaj","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"13735","DOI":"10.1128\/JVI.01790-07","article-title":"The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme UBC13 for NF-\u03baB activation","volume":"81","author":"Shembade","year":"2007","journal-title":"J. Virol."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Israel, A. (2010). The IKK complex, a central regulator of NF-\u03baB activation. Cold Spring Harb. Perspect. Biol., 2.","DOI":"10.1101\/cshperspect.a000158"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"35974","DOI":"10.1074\/jbc.M506093200","article-title":"Positive regulation of I\u03baB kinase signaling by protein serine\/threonine phosphatase 2A","volume":"280","author":"Kray","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1074\/jbc.M210631200","article-title":"Human T-lymphotropic virus type I Tax activates I-\u03baB kinase by inhibiting I-\u03baB kinase-associated serine\/threonine protein phosphatase 2A","volume":"278","author":"Fu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"12119","DOI":"10.1074\/jbc.M610392200","article-title":"Heptad repeats regulate protein phosphatase 2A recruitment to I-\u03baB kinase \u03b3\/NF-\u03baB essential modulator and are targeted by human T-lymphotropic virus type 1 Tax","volume":"282","author":"Hong","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1038\/sj.onc.1208645","article-title":"High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-\u03baB-CBP ternary complex in the cytoplasm","volume":"24","author":"Azran","year":"2005","journal-title":"Oncogene"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"10391","DOI":"10.1128\/MCB.25.23.10391-10406.2005","article-title":"Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-\u03baB activation by the human T-cell leukemia virus Tax oncoprotein","volume":"25","author":"Lamsoul","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/viro.1996.0574","article-title":"Human T cell leukemia virus type 1 Tax protein increases NF-\u03baB dimer formation and antagonizes the inhibitory activity of the I\u03baB\u03b1 regulatory protein","volume":"225","author":"Petropoulos","year":"1996","journal-title":"Virology"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/ni1563","article-title":"The E3 ligase ITCH negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20","volume":"9","author":"Shembade","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Pujari, R., Hunte, R., Thomas, R., van der Weyden, L., Rauch, D., Ratner, L., Nyborg, J.K., Ramos, J.C., Takai, Y., and Shembade, N. (2015). Human T-cell leukemia virus type 1 (HTLV-1) Tax requires CADM1\/TSLC1 for inactivation of the NF-\u03baB inhibitor A20 and constitutive NF-\u03baB signaling. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004721"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1182\/blood-2010-08-303073","article-title":"The tumor suppressor gene WWOX links the canonical and noncanonical NF-\u03baB pathways in HTLV-I Tax-mediated tumorigenesis","volume":"117","author":"Fu","year":"2011","journal-title":"Blood"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"11900","DOI":"10.1128\/JVI.00532-07","article-title":"Cooperation of NF-\u03baB2\/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line","volume":"81","author":"Higuchi","year":"2007","journal-title":"J. Virol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"6805","DOI":"10.1093\/emboj\/20.23.6805","article-title":"Retroviral oncoprotein Tax induces processing of NF-\u03baB2\/p100 in T cells: Evidence for the involvement of IKK\u03b1","volume":"20","author":"Xiao","year":"2001","journal-title":"EMBO J."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1742-4690-2-54","article-title":"The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory pstaire helix","volume":"2","author":"Fraedrich","year":"2005","journal-title":"Retrovirology"},{"key":"ref_169","first-page":"14","article-title":"HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity to CDK4","volume":"11","author":"Suzuki","year":"1997","journal-title":"Leukemia"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1038\/sj.onc.1204364","article-title":"Phosphoinositide-3 kinase-PKB\/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I Tax","volume":"20","author":"Liu","year":"2001","journal-title":"Oncogene"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1084\/jem.172.1.121","article-title":"Transactivation of the transforming growth factor \u03b2 1 (TGF-\u03b21) gene by human T lymphotropic virus type 1 Tax: A potential mechanism for the increased production of TGF-\u03b2 1 in adult T cell leukemia","volume":"172","author":"Kim","year":"1990","journal-title":"J. Exp. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jmv.10074","article-title":"Transforming growth factor-\u03b2 enhances human T-cell leukemia virus type I infection","volume":"67","author":"Moriuchi","year":"2002","journal-title":"J. Med. Virol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/sj.onc.1203450","article-title":"HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration","volume":"19","author":"Ariumi","year":"2000","journal-title":"Oncogene"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1038\/sj.onc.1202766","article-title":"Tax protein of HTLV-1 inhibits CBP\/p300-mediated transcription by interfering with recruitment of CBP\/p300 onto DNA element of E-box or p53 binding site","volume":"18","author":"Suzuki","year":"1999","journal-title":"Oncogene"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1742-4690-9-114","article-title":"WIP1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis","volume":"9","author":"Zane","year":"2012","journal-title":"Retrovirology"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1158\/0008-5472.CAN-03-1452","article-title":"Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation","volume":"64","author":"Harashima","year":"2004","journal-title":"Cancer Res."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Rowan, A.G., Suemori, K., Fujiwara, H., Yasukawa, M., Tanaka, Y., Taylor, G.P., and Bangham, C.R. (2014). Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression. Retrovirology, 11.","DOI":"10.1186\/s12977-014-0116-6"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ijc.20007","article-title":"Genetic and epigenetic inactivation of Tax gene in adult T-cell leukemia cells","volume":"109","author":"Takeda","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1182\/blood.V97.4.987","article-title":"Existence of escape mutant in HTLV-I Tax during the development of adult T-cell leukemia","volume":"97","author":"Furukawa","year":"2001","journal-title":"Blood"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065","article-title":"Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia","volume":"88","author":"Tamiya","year":"1996","journal-title":"Blood"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"9389","DOI":"10.1128\/JVI.76.18.9389-9397.2002","article-title":"5\u2019-long terminal repeat-selective CPG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo","volume":"76","author":"Koiwa","year":"2002","journal-title":"J. Virol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"12813","DOI":"10.1128\/JVI.76.24.12813-12822.2002","article-title":"The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription","volume":"76","author":"Gaudray","year":"2002","journal-title":"J. Virol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.0507631103","article-title":"HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells","volume":"103","author":"Satou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1158\/0008-5472.CAN-15-0942","article-title":"HTLV-1 bZIP factor rna and protein impart distinct functions on T-cellproliferation and survival","volume":"75","author":"Mitobe","year":"2015","journal-title":"Cancer Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1128\/JVI.00480-06","article-title":"Human T-cell leukemia virus type 1 (HTLV-1) bZIP protein interacts with the cellular transcription factor CREB to inhibit HTLV-1 transcription","volume":"81","author":"Lemasson","year":"2007","journal-title":"J. Virol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1742-4690-8-19","article-title":"ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells","volume":"8","author":"Hagiya","year":"2011","journal-title":"Retrovirology"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1007\/s11033-013-2706-0","article-title":"The HTLV-1 HBZ protein inhibits cyclin D1 expression through interacting with the cellular transcription factor CREB","volume":"40","author":"Ma","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1093\/nar\/gks244","article-title":"The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300\/CBP","volume":"40","author":"Wurm","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1093\/carcin\/bgt221","article-title":"HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the Htert gene","volume":"34","author":"Borowiak","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-4690-4-14","article-title":"The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies","volume":"4","author":"Hivin","year":"2007","journal-title":"Retrovirology"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-5793(04)00225-X","article-title":"HBZ interacts with JunD and stimulates its transcriptional activity","volume":"562","author":"Thebault","year":"2004","journal-title":"FEBS Lett."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2015-04-641118","article-title":"Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor","volume":"126","author":"Sugata","year":"2015","journal-title":"Blood"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/8\/2\/31\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:18:22Z","timestamp":1760210302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/8\/2\/31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,27]]},"references-count":192,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2]]}},"alternative-id":["v8020031"],"URL":"https:\/\/doi.org\/10.3390\/v8020031","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,27]]}}}