{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:40:46Z","timestamp":1791427246441,"version":"4.3.3"},"reference-count":152,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-38111"],"award-info":[{"award-number":["MOP-38111"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-56974"],"award-info":[{"award-number":["MOP-56974"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs.<\/jats:p>","DOI":"10.3390\/v8060152","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T21:53:40Z","timestamp":1464126820000},"page":"152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway"],"prefix":"10.3390","volume":"8","author":[{"given":"Valerie","family":"Le Sage","sequence":"first","affiliation":[{"name":"HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montr\u00e9al, QC H3T 1E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cinti","sequence":"additional","affiliation":[{"name":"HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montr\u00e9al, QC H3T 1E2, Canada"},{"name":"Department of Medicine, McGill University, Montr\u00e9al, QC H3A 0G4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Amorim","sequence":"additional","affiliation":[{"name":"HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montr\u00e9al, QC H3T 1E2, Canada"},{"name":"Department of Medicine, McGill University, Montr\u00e9al, QC H3A 0G4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Mouland","sequence":"additional","affiliation":[{"name":"HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montr\u00e9al, QC H3T 1E2, Canada"},{"name":"Department of Medicine, McGill University, Montr\u00e9al, QC H3A 0G4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14071","DOI":"10.1074\/jbc.R109.094003","article-title":"Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony","volume":"285","author":"Foster","year":"2010","journal-title":"J. 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