{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:08:58Z","timestamp":1791666538323,"version":"4.3.4"},"reference-count":89,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Indonesia Endowment Fund for Education (LPDP)","award":["20150822023688"],"award-info":[{"award-number":["20150822023688"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Measles virus is a highly contagious negative strand RNA virus that is transmitted via the respiratory route and causes systemic disease in previously unexposed humans and non-human primates. Measles is characterised by fever and skin rash and usually associated with cough, coryza and conjunctivitis. A hallmark of measles is the transient immune suppression, leading to increased susceptibility to opportunistic infections. At the same time, the disease is paradoxically associated with induction of a robust virus-specific immune response, resulting in lifelong immunity to measles. Identification of CD150 and nectin-4 as cellular receptors for measles virus has led to new perspectives on tropism and pathogenesis. In vivo studies in non-human primates have shown that the virus initially infects CD150+ lymphocytes and dendritic cells, both in circulation and in lymphoid tissues, followed by virus transmission to nectin-4 expressing epithelial cells. The abilities of the virus to cause systemic infection, to transmit to numerous new hosts via droplets or aerosols and to suppress the host immune response for several months or even years after infection make measles a remarkable disease. This review briefly highlights current topics in studies of measles virus host invasion and pathogenesis.<\/jats:p>","DOI":"10.3390\/v8080210","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T10:04:56Z","timestamp":1469700296000},"page":"210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":170,"title":["Measles Virus Host Invasion and Pathogenesis"],"prefix":"10.3390","volume":"8","author":[{"given":"Brigitta","family":"Laksono","sequence":"first","affiliation":[{"name":"Department of Viroscience, Erasmus MC, 3015CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-0127","authenticated-orcid":false,"given":"Rory","family":"De Vries","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, 3015CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McQuaid","sequence":"additional","affiliation":[{"name":"Centre for Cancer Research and Cell Biology, Queen\u2019s University of Belfast, BT7 1NN Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Duprex","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-8969","authenticated-orcid":false,"given":"Rik","family":"De Swart","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, 3015CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/v7020699","article-title":"Morbillivirus infections: An introduction","volume":"7","author":"Duprex","year":"2015","journal-title":"Viruses"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1099\/vir.0.82221-0","article-title":"Measles virus: Cellular receptors, tropism and pathogenesis","volume":"87","author":"Yanagi","year":"2006","journal-title":"J. Gen. Virol."},{"key":"ref_3","unstructured":"Griffin, D.E. (2013). Fields Virology, Lippincott Williams & Wilkins. [6th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1126\/science.aaa3662","article-title":"Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality","volume":"348","author":"Mina","year":"2015","journal-title":"Science"},{"key":"ref_5","first-page":"623","article-title":"Progress towards regional measles elimination, worldwide, 2000\u20132014","volume":"90","author":"Perry","year":"2015","journal-title":"Wkly. Epidemiol. Rec."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/35022579","article-title":"SLAM (CDw150) is a cellular receptor for measles virus","volume":"406","author":"Tatsuo","year":"2000","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nri2456","article-title":"SLAM receptors and SAP influence lymphocyte interactions, development and function","volume":"9","author":"Schwartzberg","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"De Swart, R.L., Ludlow, M., de Witte, L., Yanagi, Y., van Amerongen, G., McQuaid, S., Yuksel, S., Geijtenbeek, T.B., Duprex, W.P., and Osterhaus, A.D. (2007). Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030178"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Noyce, R.S., Bondre, D.G., Ha, M.N., Lin, L.T., Sisson, G., Tsao, M.S., and Richardson, C.D. (2011). Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002240"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature10639","article-title":"Adherens junction protein nectin-4 is the epithelial receptor for measles virus","volume":"480","author":"Muhlebach","year":"2011","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/exd.12593","article-title":"p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis","volume":"24","author":"Mollo","year":"2015","journal-title":"Exp. Dermatol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ajhg.2010.07.003","article-title":"Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome","volume":"87","author":"Brancati","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/NEN.0b013e31829a26b6","article-title":"Wild-type measles virus infection upregulates poliovirus receptor-related 4 and causes apoptosis in brain endothelial cells by induction of tumor necrosis factor-related apoptosis-inducing ligand","volume":"72","author":"Abdullah","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF01347970","article-title":"Measles rash. I. Light and electron microscopic study of skin eruptions","volume":"47","author":"Kimura","year":"1975","journal-title":"Arch. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/clinids\/22.1.36","article-title":"Detection and comparison of viral antigens in measles and rubella rashes","volume":"22","author":"Takahashi","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0092-8674(93)80071-L","article-title":"The human CD46 molecule is a receptor for measles virus (Edmonston strain)","volume":"75","author":"Marcil","year":"1993","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1702(96)01421-9","article-title":"Is CD46 the cellular receptor for measles virus?","volume":"48","author":"Buckland","year":"1997","journal-title":"Virus Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"De Witte, L., de Vries, R.D., van der Vlist, M., Yuksel, S., Litjens, M., de Swart, R.L., and Geijtenbeek, T.B. (2008). DC-SIGN and CD150 have distinct roles in transmission of measles virus from dendritic cells to T-lymphocytes. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000049"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/eji.201041305","article-title":"Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation","volume":"41","author":"Litjens","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"ref_20","first-page":"2448","article-title":"Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed","volume":"118","author":"Leonard","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1128\/JVI.02304-09","article-title":"Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys","volume":"84","author":"Leonard","year":"2010","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1128\/JVI.02633-09","article-title":"In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques","volume":"84","author":"Lemon","year":"2010","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Mesman, A.W., de Vries, R.D., McQuaid, S., Duprex, W.P., de Swart, R.L., and Geijtenbeek, T.B.H. (2012). A prominent role for DC-SIGN+ dendritic cells in initiation and dissemination of measles virus infection in non-human primates. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049573"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lemon, K., de Vries, R.D., Mesman, A.W., McQuaid, S., van Amerongen, G., Yuksel, S., Ludlow, M., Rennick, L.J., Kuiken, T., and Rima, B.K. (2011). Early target cells of measles virus after aerosol infection of non-human primates. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1001263"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/path.4457","article-title":"Pathological consequences of systemic measles virus infection","volume":"235","author":"Ludlow","year":"2015","journal-title":"J. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.coviro.2012.03.005","article-title":"The pathogenesis of measles","volume":"2","author":"Mesman","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"De Vries, R.D., McQuaid, S., van Amerongen, G., Yuksel, S., Verburgh, R.J., Osterhaus, A.D., Duprex, W.P., and de Swart, R.L. (2012). Measles immune suppression: Lessons from the macaque model. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002885"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.4049\/jimmunol.1000680","article-title":"Eye mucosa: An efficient vaccine delivery route for inducing protective immunity","volume":"185","author":"Seo","year":"2010","journal-title":"J. Immunol."},{"key":"ref_29","first-page":"380","article-title":"Contagion des virus a travers une conjonctive intacte; rougeole, oreillons, rub\u00e9ole","volume":"18","author":"Papp","year":"1954","journal-title":"Rev. Immunol. Ther. Antimicrob."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1099\/vir.0.016428-0","article-title":"Wild-type measles virus infection of primary epithelial cells occurs via the basolateral surface without syncytium formation or release of infectious virus","volume":"91","author":"Ludlow","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_31","first-page":"27","article-title":"Exp\u00e9riences prouvant que la voie d\u2019infection de la rougeole est la contamination de la muqueuse conjonctivale","volume":"20","author":"Papp","year":"1956","journal-title":"Rev. Immunol. Ther. Antimicrob."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1128\/JVI.00821-15","article-title":"The nectin-4\/afadin protein complex and intercellular membrane pores contribute to rapid spread of measles virus in primary human airway epithelia","volume":"89","author":"Singh","year":"2015","journal-title":"J. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1183\/09031936.01.00228701","article-title":"The immunology of virus infection in asthma","volume":"18","author":"Message","year":"2001","journal-title":"Eur. Respir. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1348-0421.1986.tb03036.x","article-title":"Growth of measles virus in epithelial and lymphoid tissues of cynomolgus monkeys","volume":"30","author":"Sakaguchi","year":"1986","journal-title":"Microb. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/030098587100800403","article-title":"Pathology of measles in rhesus monkeys","volume":"8","author":"Hall","year":"1971","journal-title":"Vet. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1006\/viro.1997.8576","article-title":"Experimental measles. I. Pathogenesis in the normal and the immunized host","volume":"233","author":"McChesney","year":"1997","journal-title":"Virology"},{"key":"ref_37","first-page":"343","article-title":"The effect of measles on the thymus and other lymphoid tissues","volume":"13","author":"White","year":"1973","journal-title":"Clin. Exp. Immunol."},{"key":"ref_38","first-page":"864","article-title":"Occurence of numerous large giant cells in the tonsils and pharyngeal mucosa in the prodormal stage of measles","volume":"11","author":"Warthin","year":"1931","journal-title":"Arch. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF01971157","article-title":"\u00dcber Riesenzellbefunde in den Gaumenmandeln, zugleich ein Beitrag zur Histopathologie der Mandelver\u00e4nderungen im Maserninkubationsstadium","volume":"281","author":"Finkeldey","year":"1931","journal-title":"Virchows Arch."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1001\/archpedi.1940.01990140011002","article-title":"Disseminated giant cell reaction: A possible prodrome of measles","volume":"59","author":"Stryker","year":"1940","journal-title":"Am. J. Dis. Child."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9773","DOI":"10.1128\/JVI.00458-12","article-title":"Measles virus transmission from dendritic cells to T cells: Formation of synapse-like interfaces concentrating viral and cellular components","volume":"86","author":"Koethe","year":"2012","journal-title":"J. Virol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1242\/jcs.159400","article-title":"Connections matter\u2014How viruses use cell-cell adhesion components","volume":"128","author":"Mateo","year":"2015","journal-title":"J. Cell. Sci"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1128\/JVI.03258-12","article-title":"Measles virus infection of epithelial cells in the macaque upper respiratory tract is mediated by subepithelial immune cells","volume":"87","author":"Ludlow","year":"2013","journal-title":"J. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1128\/JVI.03037-12","article-title":"Nectin-4-dependent measles virus spread to the cynomolgus monkey tracheal epithelium: Role of infected immune cells infiltrating the lamina propria","volume":"87","author":"Frenzke","year":"2013","journal-title":"J. Virol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"14161","DOI":"10.1128\/JVI.02379-14","article-title":"Different roles of the three loops forming the adhesive interface of nectin-4 in measles virus binding and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1","volume":"88","author":"Mateo","year":"2014","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1160\/TH09-03-0202","article-title":"Systemic spread of measles virus: Overcoming the epithelial and endothelial barriers","volume":"102","author":"Ludlow","year":"2009","journal-title":"Thromb. Haemost"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11273","DOI":"10.1128\/JVI.00775-08","article-title":"Measles virus-induced block of transendothelial migration of T lymphocytes and infection-mediated virus spread across endothelial cell barriers","volume":"82","author":"Dittmar","year":"2008","journal-title":"J. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"S700","DOI":"10.1093\/clinids\/11.Supplement_4.S700","article-title":"Infection of endothelial cells by common human viruses","volume":"11","author":"Friedman","year":"1989","journal-title":"Rev. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/infdis\/158.2.433","article-title":"Acute measles in patients with and without neurological involvement: Distribution of measles virus antigen and RNA","volume":"158","author":"Moench","year":"1988","journal-title":"J. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1128\/JVI.76.13.6743-6749.2002","article-title":"SLAM (CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein","volume":"76","author":"Hashimoto","year":"2002","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/cr.2015.57","article-title":"In-cell infection: Bringing uninvited guests","volume":"25","author":"Lee","year":"2015","journal-title":"Cell. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJM197011192832105","article-title":"Role of measles virus in skin lesions and Koplik\u2018s spots","volume":"283","author":"Suringa","year":"1970","journal-title":"N. Engl. J. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(99)04652-8","article-title":"Measles in a Dutch hospital introduced by an immuno-compromised infant from Indonesia infected with a new virus genotype","volume":"355","author":"Muller","year":"2000","journal-title":"Lancet"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/B978-0-444-53488-0.00027-4","article-title":"Measles virus and the nervous system","volume":"123","author":"Griffin","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1073\/pnas.80.8.2346","article-title":"Molecular mimicry in virus infection: Crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments","volume":"80","author":"Fujinami","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.spen.2012.02.003","article-title":"Measles virus and associated central nervous system sequelae","volume":"19","author":"Buchanan","year":"2012","journal-title":"Semin. Pediatr. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e657","DOI":"10.1542\/peds.2004-0949","article-title":"A new complication of stem cell transplantation: Measles inclusion body encephalitis","volume":"114","author":"Freeman","year":"2004","journal-title":"Pediatrics"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1086\/520449","article-title":"Measles inclusion-body encephalitis caused by the vaccine strain of measles virus","volume":"29","author":"Bitnun","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1086\/377712","article-title":"The clinical significance of measles: A review","volume":"189","author":"Perry","year":"2004","journal-title":"J. Infect. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1128\/JVI.76.11.5720-5728.2002","article-title":"Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion","volume":"76","author":"Ehrengruber","year":"2002","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1128\/JVI.74.17.7972-7979.2000","article-title":"In vitro and in vivo infection of neural cells by a recombinant measles virus expressing enchanced green fluorescent protein","volume":"74","author":"Duprex","year":"2002","journal-title":"J. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1128\/JVI.74.4.1908-1918.2000","article-title":"Measles virus spread between neurons requires cell contact but not CD46 expression, syncytium formation, or extracellular virus production","volume":"74","author":"Lawrence","year":"2000","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.virol.2007.02.033","article-title":"Neurokinin-1 enables measles virus trans-synaptic spread in neurons","volume":"362","author":"Makhortova","year":"2007","journal-title":"Virology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1128\/JVI.02632-12","article-title":"Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters","volume":"87","author":"Watanabe","year":"2013","journal-title":"J. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2006.11.007","article-title":"What is the blood-brain barrier (not)?","volume":"28","author":"Bechmann","year":"2007","journal-title":"Trends Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nri3265","article-title":"The anatomical and cellular basis of immune surveillance in the central nervous system","volume":"12","author":"Ransohoff","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nrmicro1550","article-title":"Global measles elimination","volume":"4","author":"Moss","year":"2006","journal-title":"Nat. Rev. Microb."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1217378","article-title":"Virology. An exit strategy for measles virus","volume":"334","author":"Racaniello","year":"2011","journal-title":"Science"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.0954-6820.1953.tb15701.x","article-title":"An epidemic of measles in Southern Greenland, 1951. I. Measles in virgin soil","volume":"144","author":"Christensen","year":"1953","journal-title":"Acta Med. Scand."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature04153","article-title":"Superspreading and the effect of individual variation on disease emergence","volume":"438","author":"Schreiber","year":"2005","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1542\/peds.75.4.676","article-title":"Measles outbreak in a pediatric practice: Airborne transmission in an office setting","volume":"75","author":"Bloch","year":"1985","journal-title":"Pediatrics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/infdis\/171.3.679","article-title":"An outbreak of measles at an international sporting event with airborne transmission in a domed stadium","volume":"171","author":"Ehresmann","year":"1995","journal-title":"J. Infect. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/2011054a0","article-title":"Survival of measles virus in air","volume":"201","author":"Winkler","year":"1964","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/infdis\/170.2.443","article-title":"Viral replication and development of specific immunity in macaques after infection with different measles virus strains","volume":"170","author":"UytdeHaag","year":"1994","journal-title":"J. Infect. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/mi.2010.52","article-title":"Regulation of inducible BALT formation and contribution to immunity and pathology","volume":"3","author":"Foo","year":"2010","journal-title":"Mucosal Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1084\/jem.20090410","article-title":"Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice","volume":"206","author":"GeurtsvanKessel","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_78","first-page":"994","article-title":"Functional and phenotypic changes in circulating lymphocytes from hospitalized zambian children with measles","volume":"9","author":"Ryon","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/eji.200939949","article-title":"Specific CD8+ T-lymphocytes control dissemination of measles virus","volume":"40","author":"Yuksel","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJM198906223202506","article-title":"Immune activation in measles","volume":"320","author":"Griffin","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1600-065X.2010.00925.x","article-title":"Measles virus-induced suppression of immune responses","volume":"236","author":"Griffin","year":"2010","journal-title":"Immunol. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/clin.1993.1061","article-title":"Changes in cytokine production after measles virus vaccination: Predominant production of IL-4 suggests induction of a Th2 response","volume":"67","author":"Ward","year":"1993","journal-title":"Clin. Immunol. Immunopathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1086\/338009","article-title":"Altered synthesis of interleukin-12 and type 1 and type 2 cytokinesin rhesus macaques during measles and atypical measles","volume":"185","author":"Polack","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/321009","article-title":"Natural measles causes prolonged suppression of interleukin-12 production","volume":"184","author":"Atabani","year":"2001","journal-title":"J. Infect. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.273.5272.228","article-title":"Mechanism of suppression of cell-mediated immunity by measles virus","volume":"273","author":"Karp","year":"1996","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6636","DOI":"10.1128\/JVI.76.13.6636-6642.2002","article-title":"Targeting and hematopoietic suppression of human CD34+ cells by measles virus","volume":"76","author":"Manchester","year":"2002","journal-title":"J. Virol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1128\/JVI.00532-11","article-title":"Wild-type measles virus interferes with short-term engraftment of human CD34+ hematopoietic progenitor cells","volume":"85","author":"Boussaad","year":"2011","journal-title":"J. Virol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"De Vries, R.D., and de Swart, R.L. (2014). Measles immune suppression: Functional impairment or numbers game?. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004482"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.coviro.2016.01.019","article-title":"Mapping the evolutionary trajectories of morbilliviruses: What, where and whither","volume":"16","author":"Nambulli","year":"2016","journal-title":"Curr. Opin. Virol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/8\/8\/210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:27:15Z","timestamp":1760210835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/8\/8\/210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,28]]},"references-count":89,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8]]}},"alternative-id":["v8080210"],"URL":"https:\/\/doi.org\/10.3390\/v8080210","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,28]]}}}