{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:56:39Z","timestamp":1791644199248,"version":"4.3.4"},"reference-count":115,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy, Industry and Competitiveness","award":["SAF2016-75169-R AEI\/FEDER, UE"],"award-info":[{"award-number":["SAF2016-75169-R AEI\/FEDER, UE"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hepatitis B virus (HBV) is a major etiologic agent of acute and chronic hepatitis, and end-stage liver disease. Establishment of HBV infection, progression to persistency and pathogenesis are determined by viral and cellular factors, some of which remain still undefined. Key steps of HBV life cycle e.g., transformation of genomic viral DNA into transcriptionally active episomal DNA (cccDNA) or transcription of viral mRNAs from cccDNA, take place in the nucleus of infected cells and strongly depend on enzymatic activities provided by cellular proteins. In this regard, DNA damage response (DDR) pathways and some DDR proteins are being recognized as important factors regulating the infection. On one hand, HBV highjacks specific DDR proteins to successfully complete some of the steps of its life cycle. On the other hand, HBV subverts DDR pathways to presumably create a cellular environment that favours its replication. Direct consequences of these interactions are: HBV DNA integration into host chromosomal DNA, and accumulation of mutations in host chromosomal DNA that could eventually trigger carcinogenic processes, which would explain in part the incidence of hepatocellular carcinoma in chronically infected patients. Unravelling the interactions that HBV establishes with DDR pathways might help identify new molecular targets for therapeutic intervention.<\/jats:p>","DOI":"10.3390\/v9100304","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T11:07:29Z","timestamp":1508411249000},"page":"304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Hepatitis B Virus and DNA Damage Response: Interactions and Consequences for the Infection"],"prefix":"10.3390","volume":"9","author":[{"given":"Andoni","family":"G\u00f3mez-Moreno","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Centro Nacional de Biotecnolog\u00eda\u2014Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Darwin 3, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-5725","authenticated-orcid":false,"given":"Urtzi","family":"Garaigorta","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Centro Nacional de Biotecnolog\u00eda\u2014Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Darwin 3, 28049 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.iy.13.040195.000333","article-title":"Hepatitis B virus immunopathogenesis","volume":"13","author":"Chisari","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2006.05.013","article-title":"The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide","volume":"45","author":"Perz","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/S0140-6736(15)61412-X","article-title":"Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013","volume":"386","author":"Schweitzer","year":"2015","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.3748\/wjg.v20.i20.6236","article-title":"Role of hepatitis B virus DNA integration in human hepatocarcinogenesis","volume":"20","author":"Hai","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Schreiner, S., and Nassal, M. (2017). A Role for the host DNA damage response in hepatitis B virus cccDNA formation-and beyond?. Viruses, 9.","DOI":"10.3390\/v9050125"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.virol.2015.02.031","article-title":"Molecular biology of hepatitis B virus infection","volume":"479\u2013480","author":"Seeger","year":"2015","journal-title":"Virology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/gast.1996.v110.pm8613059","article-title":"Effect of hepatocyte proliferation and cellular DNA synthesis on hepatitis B virus replication","volume":"110","author":"Ozer","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0092-8674(82)90157-X","article-title":"Replication of the genome of a hepatitis B\u2014Like virus by reverse transcription of an RNA intermediate","volume":"29","author":"Summers","year":"1982","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/hep.21896","article-title":"Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans","volume":"46","author":"Schulze","year":"2007","journal-title":"Hepatology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e00049","DOI":"10.7554\/eLife.00049","article-title":"Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus","volume":"1","author":"Yan","year":"2012","journal-title":"Elife Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1128\/JVI.00873-12","article-title":"Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis","volume":"86","author":"Huang","year":"2012","journal-title":"J. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9849","DOI":"10.1073\/pnas.1730940100","article-title":"Nuclear import of hepatitis B virus capsids and release of the viral genome","volume":"100","author":"Rabe","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1128\/jvi.69.6.3350-3357.1995","article-title":"The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes","volume":"69","author":"Newbold","year":"1995","journal-title":"J. Virol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1002\/j.1460-2075.1996.tb00614.x","article-title":"A splice hepadnavirus RNA that is essential for virus replication","volume":"15","author":"Obert","year":"1996","journal-title":"EMBO J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0168-8278(02)00422-1","article-title":"The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis","volume":"38","author":"Soussan","year":"2003","journal-title":"J. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1002\/j.1460-2075.1992.tb05420.x","article-title":"Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome","volume":"11","author":"Bartenschlager","year":"1992","journal-title":"EMBO J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1128\/jvi.65.3.1255-1262.1991","article-title":"Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA","volume":"65","author":"Staprans","year":"1991","journal-title":"J. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(86)90602-1","article-title":"Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells","volume":"47","author":"Tuttleman","year":"1986","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1073\/pnas.0704000104","article-title":"Involvement of host cellular multivesicular body functions in hepatitis B virus budding","volume":"104","author":"Watanabe","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14913","DOI":"10.1073\/pnas.0406282101","article-title":"A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen","volume":"101","author":"Chen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1471-4906(03)00026-7","article-title":"Viral apoptotic mimicry: An immune evasion strategy developed by the hepatitis B virus?","volume":"24","author":"Vanlandschoot","year":"2003","journal-title":"Trends Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.3390\/v7052542","article-title":"Modulation of DNA damage and repair pathways by human tumour viruses","volume":"7","author":"Hollingworth","year":"2015","journal-title":"Viruses"},{"key":"ref_23","first-page":"1","article-title":"DDRprot: A database of DNA damage response-related proteins","volume":"2016","author":"Cases","year":"2016","journal-title":"Database"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrclinonc.2012.3","article-title":"The potential of exploiting DNA-repair defects for optimizing lung cancer treatment","volume":"9","author":"Vanhecke","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: An essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.dnarep.2014.02.020","article-title":"DNA-PK: A dynamic enzyme in a versatile DSB repair pathway","volume":"17","author":"Davis","year":"2014","journal-title":"DNA Repair"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.dnarep.2006.10.006","article-title":"Mammalian single-strand break repair: Mechanisms and links with chromatin","volume":"6","author":"Caldecott","year":"2007","journal-title":"DNA Repair"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/BJ20090942","article-title":"Mechanisms of double-strand break repair in somatic mammalian cells","volume":"423","author":"Hartlerode","year":"2009","journal-title":"Biochem. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.dnarep.2014.03.030","article-title":"Base excision repair: A critical player in many games","volume":"19","author":"Wallace","year":"2014","journal-title":"DNA Repair"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrm3822","article-title":"Understanding nucleotide excision repair and its roles in cancer and ageing","volume":"15","author":"Marteijn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.dnarep.2014.03.027","article-title":"New insights and challenges in mismatch repair: Getting over the chromatin hurdle","volume":"19","author":"Li","year":"2014","journal-title":"DNA Repair"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1101\/gad.195248.112","article-title":"Regulation of DNA cross-link repair by the Fanconi anemia\/BRCA pathway","volume":"26","author":"Kim","year":"2012","journal-title":"Genes Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1038\/sj.onc.1207116","article-title":"Control of apoptosis by p53","volume":"22","author":"Fridman","year":"2003","journal-title":"Oncogene"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Qi, Y., Gao, Z., Xu, G., Peng, B., Liu, C., Yan, H., Yao, Q., Sun, G., Liu, Y., and Tang, D. (2016). DNA polymerase \u03ba is a key cellular factor for the formation of covalently closed circular DNA of hepatitis B virus. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005893"},{"key":"ref_37","first-page":"E4244","article-title":"Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses","volume":"111","author":"Wingert","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbrc.2016.11.085","article-title":"Host factor PRPF31 is involved in cccDNA production in HBV-replicating cells","volume":"482","author":"Kinoshita","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cui, X., McAllister, R., Boregowda, R., Sohn, J.A., Ledesma, F.C., Caldecott, K.W., Seeger, C., and Hu, J. (2015). Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128401"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"K\u00f6ck, J., R\u00f6sler, C., Zhang, J.-J., Blum, H.E., Nassal, M., and Thoma, C. (2010). Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1001082"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.molcel.2007.06.014","article-title":"Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III \u03b1 in a cell-cycle-specific manner","volume":"27","author":"Moser","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.molcel.2010.02.009","article-title":"Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells","volume":"37","author":"Ogi","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1128\/jvi.69.7.4029-4036.1995","article-title":"Illegitimate replication of linear hepadnavirus DNA through nonhomologous recombination","volume":"69","author":"Yang","year":"1995","journal-title":"J. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1128\/JVI.72.11.8710-8717.1998","article-title":"Infection of ducklings with virus particles containing linear double-stranded duck hepatitis B virus DNA: Illegitimate replication and reversion","volume":"72","author":"Yang","year":"1998","journal-title":"J. Virol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9710","DOI":"10.1128\/JVI.73.12.9710-9717.1999","article-title":"Integration of hepadnavirus DNA in infected liver: Evidence for a linear precursor","volume":"73","author":"Yang","year":"1999","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Guo, H., Xu, C., Zhou, T., Block, T.M., and Guo, J.-T. (2012). Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043270"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Niu, C., Livingston, C.M., Li, L., Beran, R.K., Daffis, S., Ramakrishnan, D., Burdette, D., Peiser, L., Salas, E., and Ramos, H. (2017). The Smc5\/6 complex restricts HBV when localized to ND10 without inducing an innate immune response and is counteracted by the HBV X protein shortly after infection. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169648"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/JVI.79.7.4238-4245.2005","article-title":"Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death","volume":"79","author":"Leupin","year":"2005","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jhep.2011.02.015","article-title":"Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection","volume":"55","author":"Lucifora","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nature05175","article-title":"Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery","volume":"443","author":"Angers","year":"2006","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nature17170","article-title":"Hepatitis B virus X protein identifies the Smc5\/6 complex as a host restriction factor","volume":"531","author":"Mueller","year":"2016","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1016\/j.celrep.2016.08.026","article-title":"Hepatitis B virus X protein promotes degradation of SMC5\/6 to enhance HBV replication","volume":"16","author":"Murphy","year":"2016","journal-title":"Cell Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1002\/hep.25928","article-title":"Hepatitis B virus X protein stimulates gene expression selectively from extrachromosomal DNA templates","volume":"56","author":"Robert","year":"2012","journal-title":"Hepatology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.284.5415.825","article-title":"Viral clearance without destruction of infected cells during acute HBV infection","volume":"284","author":"Guidotti","year":"1999","journal-title":"Science"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.1243462","article-title":"Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA","volume":"343","author":"Lucifora","year":"2014","journal-title":"Science"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/jvh.12689","article-title":"Hepatitis B virus covalently closed circular DNA homeostasis is independent of the lymphotoxin pathway during chronic HBV infection","volume":"24","author":"Meier","year":"2017","journal-title":"J. Viral. Hepat."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/mt.2016.94","article-title":"Complete spectrum of CRISPR\/Cas9-induced mutations on HBV cccDNA","volume":"24","author":"Seeger","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/hep.20801","article-title":"APOBEC-mediated interference with hepadnavirus production","volume":"42","author":"Kann","year":"2005","journal-title":"Hepatology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1073\/pnas.1221921110","article-title":"RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase","volume":"110","author":"Liang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/rmv.699","article-title":"The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection","volume":"21","year":"2011","journal-title":"Rev. Med. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/hep.510270428","article-title":"Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinomas","volume":"27","author":"Su","year":"1998","journal-title":"Hepatology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hep.1840130121","article-title":"Significance of anti-HBx antibodies in hepatitis B virus infection","volume":"13","author":"Levrero","year":"1991","journal-title":"Hepatology"},{"key":"ref_63","first-page":"467","article-title":"Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: A key to the cell cycle and apoptosis","volume":"26","author":"Peng","year":"2005","journal-title":"Int. J. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1038\/sj.onc.1209559","article-title":"Hepatitis B virus-related hepatocellular carcinoma: Paradigms for viral-related human carcinogenesis","volume":"25","author":"Kremsdorf","year":"2006","journal-title":"Oncogene"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1128\/jvi.69.2.1107-1114.1995","article-title":"Hepatitis B virus X protein interacts with a probable cellular DNA repair protein","volume":"69","author":"Lee","year":"1995","journal-title":"J. Virol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/bbrc.1997.6269","article-title":"Hepatitis B virus X-protein binds damaged DNA and sensitizes liver cells to ultraviolet irradiation","volume":"232","author":"Capovilla","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/hep.22542","article-title":"Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1","volume":"48","author":"Schaeffer","year":"2008","journal-title":"Hepatology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrm.2016.30","article-title":"SMC complexes: From DNA to chromosomes","volume":"17","author":"Uhlmann","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Chang, H.R., Munkhjargal, A., Kim, M.-J., Park, S.Y., Jung, E., Ryu, J.-H., Yang, Y., Lim, J.-S., and Kim, Y. (2017). The functional roles of PML nuclear bodies in genome maintenance. Mutat. Res.","DOI":"10.1016\/j.mrfmmm.2017.05.002"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.bbrc.2014.07.019","article-title":"HBx affects CUL4-DDB1 function in both positive and negative manners","volume":"450","author":"Guo","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1128\/JVI.02574-12","article-title":"Methyltransferase PRMT1 is a binding partner of HBx and a negative regulator of hepatitis B virus transcription","volume":"87","author":"Benhenda","year":"2013","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.3390\/v6114683","article-title":"Hepatitis B Virus HBx protein interactions with the ubiquitin proteasome system","volume":"6","author":"Minor","year":"2014","journal-title":"Viruses"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1073\/pnas.91.9.4053","article-title":"Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein","volume":"91","author":"Keeney","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"21293","DOI":"10.1016\/S0021-9258(19)36923-6","article-title":"Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E","volume":"268","author":"Keeney","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1128\/JVI.72.1.266-272.1998","article-title":"Hepatitis B virus X protein interferes with cellular DNA repair","volume":"72","author":"Becker","year":"1998","journal-title":"J. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<875::AID-IJC13>3.0.CO;2-Z","article-title":"Hepatitis B virus X protein inhibits nucleotide excision repair","volume":"80","author":"Jia","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"14124","DOI":"10.1074\/jbc.M010852200","article-title":"Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue","volume":"276","author":"Benlimame","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/sj.onc.1201369","article-title":"Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells","volume":"15","author":"Takada","year":"1997","journal-title":"Oncogene"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bbrc.2003.10.194","article-title":"Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts","volume":"312","author":"Capovilla","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/(SICI)1097-4652(199808)176:2<314::AID-JCP9>3.0.CO;2-R","article-title":"Characterization of gene-specific DNA repair by primary cultures of rat hepatocytes","volume":"176","author":"Guo","year":"1998","journal-title":"J. Cell Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hep.1840090515","article-title":"Biologic significance of the detection of HBsAg and HBcAg in liver and tumor from 204 HBsAg-positive patients with primary hepatocellular carcinoma","volume":"9","author":"Hsu","year":"1989","journal-title":"Hepatology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/jhep.2001.21163","article-title":"Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection","volume":"33","author":"Fan","year":"2001","journal-title":"Hepatology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/carcin\/bgh207","article-title":"Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage","volume":"25","author":"Hsieh","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/path.4531","article-title":"Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis","volume":"236","author":"Hsieh","year":"2015","journal-title":"J. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1158\/1541-7786.MCR-07-0098","article-title":"Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1","volume":"5","author":"Hsieh","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1136\/gut.2008.174029","article-title":"Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT","volume":"58","author":"Luan","year":"2009","journal-title":"Gut"},{"key":"ref_87","first-page":"2028","article-title":"The correlation of hepatitis B virus pre-S mutation with cellular oxidative DNA damage in hepatocellular carcinoma","volume":"55","author":"Gwak","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Tu, T., Budzinska, M.A., Shackel, N.A., and Urban, S. (2017). HBV DNA integration: Molecular mechanisms and clinical implications. Viruses, 9.","DOI":"10.3390\/v9040075"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1053\/jhep.2002.30203","article-title":"Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly(ADP-ribosyl)ation","volume":"35","author":"Dandri","year":"2002","journal-title":"Hepatology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrm.2017.53","article-title":"The multifaceted roles of PARP1 in DNA repair and chromatin remodelling","volume":"18","author":"Nussenzweig","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11135","DOI":"10.1073\/pnas.0403925101","article-title":"Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration","volume":"101","author":"Bill","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"12992","DOI":"10.1038\/ncomms12992","article-title":"Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma","volume":"7","author":"Zhao","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ng.3178","article-title":"Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism","volume":"47","author":"Hu","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_94","first-page":"543","article-title":"Effects of cell cycle on telomerase activity and on hepatitis B virus replication in HepG2 2.2.15 cells","volume":"3","author":"Huang","year":"2004","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000050074","article-title":"Optimised conditions for the production of hepatitis B virus from cell culture","volume":"44","author":"Glebe","year":"2001","journal-title":"Intervirology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/hep.23519","article-title":"Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene","volume":"51","author":"Cohen","year":"2010","journal-title":"Hepatology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jhep.2015.05.017","article-title":"Hepatitis B virus induces RNR-R2 expression via DNA damage response activation","volume":"63","author":"Ramanan","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"10665","DOI":"10.1128\/MCB.25.23.10665-10673.2005","article-title":"Autorepression of RFX1 gene expression: Functional conservation from yeast to humans in response to DNA replication arrest","volume":"25","author":"Lubelsky","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1101\/gad.1221004","article-title":"p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2","volume":"18","author":"Urist","year":"2004","journal-title":"Genes Dev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/jcb.10678","article-title":"Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM)","volume":"90","year":"2003","journal-title":"J. Cell Biochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"25455","DOI":"10.1074\/jbc.M801934200","article-title":"Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/hep.24163","article-title":"Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication","volume":"53","author":"Wang","year":"2011","journal-title":"Hepatology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1074\/jbc.M710608200","article-title":"Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation","volume":"283","author":"Koida","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Diab, A.M., Foca, A., Fusil, F., Lahlali, T., Jalaguier, P., Amirache, F., N\u2019Guyen, L., Isorce, N., Cosset, F.-L., and Zoulim, F. (2017). Polo-like-kinase 1 is a proviral host-factor for hepatitis B virus replication. Hepatology.","DOI":"10.1002\/hep.29236"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_106","first-page":"4","article-title":"Hepatocarcinogenesis: A dynamic cellular perspective","volume":"56","author":"Farber","year":"1987","journal-title":"Lab. Investig."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1084\/jem.188.2.341","article-title":"Immune pathogenesis of hepatocellular carcinoma","volume":"188","author":"Nakamoto","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1349-7006.2006.00235.x","article-title":"Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis","volume":"97","author":"Wang","year":"2006","journal-title":"Cancer Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"11652","DOI":"10.1073\/pnas.1635109100","article-title":"Hepatocyte turnover during resolution of a transient hepadnaviral infection","volume":"100","author":"Summers","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ng.2295","article-title":"Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma","volume":"44","author":"Sung","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.1128\/JVI.00700-09","article-title":"Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection","volume":"83","author":"Mason","year":"2009","journal-title":"J. Virol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1038\/sj.onc.1206492","article-title":"Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene","volume":"22","author":"Saigo","year":"2003","journal-title":"Oncogene"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cgh.2013.01.026","article-title":"Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleos(t)ide analogues of different potency","volume":"11","author":"Wong","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1053\/j.gastro.2004.03.018","article-title":"Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy","volume":"126","author":"Bowden","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/liv.13001","article-title":"Clinical relevance of the study of hepatitis B virus covalently closed circular DNA","volume":"36","author":"Kumar","year":"2016","journal-title":"Liver Int."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/9\/10\/304\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:47:49Z","timestamp":1760208469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/9\/10\/304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,19]]},"references-count":115,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10]]}},"alternative-id":["v9100304"],"URL":"https:\/\/doi.org\/10.3390\/v9100304","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,19]]}}}