{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:56:58Z","timestamp":1791644218154,"version":"4.3.4"},"reference-count":126,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The Epstein\u2013Barr virus (EBV) is a ubiquitous virus that infects most of the human population. EBV infection is associated with multiple human cancers, including Burkitt\u2019s lymphoma, Hodgkin\u2019s lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal carcinoma. Intensive research has shown that EBV triggers a DNA damage response (DDR) during primary infection and lytic reactivation. The EBV-encoded viral proteins have been implicated in deregulating the DDR signaling pathways. The consequences of DDR inactivation lead to genomic instability and promote cellular transformation. This review summarizes the current understanding of the relationship between EBV infection and the DDR transducers, including ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3-related), and DNA-PK (DNA-dependent protein kinase), and discusses how EBV manipulates the DDR signaling pathways to complete the replication process of viral DNA during lytic reactivation.<\/jats:p>","DOI":"10.3390\/v9110341","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T11:10:02Z","timestamp":1510830602000},"page":"341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Epstein\u2013Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle"],"prefix":"10.3390","volume":"9","author":[{"given":"Pok","family":"Hau","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Tsao","sequence":"additional","affiliation":[{"name":"School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"ref_1","first-page":"3","article-title":"Why and how epstein-barr virus was discovered 50 years ago","volume":"390","author":"Epstein","year":"2015","journal-title":"Curr. 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