{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:43:02Z","timestamp":1790613782739,"version":"4.1.0"},"reference-count":108,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. Multiple roles have been now associated with autophagy, in particular a pro-survival role in nutrient starvation or in stressful environments, a role in life span extension, in development, or in innate and adaptive immunity. This cellular process can also take over microorganisms or viral proteins inside autophagosomes and degrade them directly in autolysosomes and is then called xenophagy and virophagy, respectively. Several Herpesviruses have developed strategies to escape this degradation, by expression of specific anti-autophagic proteins. However, we are increasingly discovering that Herpesviruses hijack autophagy, rather than just fight it. This beneficial effect is obvious since inhibition of autophagy will lead to decreased viral titers for human cytomegalovirus (HCMV), Epstein-Barr virus (EBV) or Varicella-Zoster virus (VZV), for example. Conversely, autophagy stimulation will improve viral multiplication. The autophagic machinery can be used in whole or in part, and can optimize viral propagation or persistence. Some viruses block maturation of autophagosomes to avoid the degradation step, then autophagosomal membranes are used to contribute to the envelopment and\/or the egress of viral particles. On the other hand, VZV stimulates the whole process of autophagy to subvert it in order to use vesicles containing ATG (autophagy-related) proteins and resembling amphisomes for their transport in the cytoplasm. During latency, autophagy can also be activated by latent proteins encoded by different oncogenic Herpesviruses to promote cell survival and achieve long term viral persistence in vivo. Finally, reactivation of gammaherpesvirus Murid Herpesvirus 68 (MHV68) in mice appears to be positively modulated by autophagy, in order to control the level of inflammation. Therefore, Herpesviruses appear to behave more like thieves than fugitives.<\/jats:p>","DOI":"10.3390\/v9120372","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T11:16:38Z","timestamp":1512386198000},"page":"372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Herpesvirus and Autophagy: \u201cAll Right, Everybody Be Cool, This Is a Robbery!\u201d"],"prefix":"10.3390","volume":"9","author":[{"given":"Marion","family":"Lussignol","sequence":"first","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University of Paris-Sud, Universit\u00e9 Paris-Saclay, 91198 Gif-sur-Yvette CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Esclatine","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, University of Paris-Sud, Universit\u00e9 Paris-Saclay, 91198 Gif-sur-Yvette CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00705-008-0278-4","article-title":"The order Herpesvirales","volume":"154","author":"Davison","year":"2009","journal-title":"Arch. Virol."},{"key":"ref_2","first-page":"1802","article-title":"Herpesviridae","volume":"Volume 2","author":"Knipe","year":"2013","journal-title":"Fields Virology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/rmv.1862","article-title":"Cytomegalovirus latency and reactivation: Recent insights into an age old problem","volume":"26","author":"Dupont","year":"2016","journal-title":"Rev. Med. Virol."},{"key":"ref_4","first-page":"297","article-title":"Aspects of human cytomegalovirus latency and reactivation","volume":"325","author":"Reeves","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.coviro.2013.03.004","article-title":"Epigenetic regulation of EBV and KSHV latency","volume":"3","author":"Chen","year":"2013","journal-title":"Curr. Opin. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrmicro1794","article-title":"Chromatin control of herpes simplex virus lytic and latent infection","volume":"6","author":"Knipe","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1038\/emm.2014.84","article-title":"Epstein-Barr virus latent genes","volume":"47","author":"Kang","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.3390\/v7092861","article-title":"Tegument Assembly and Secondary Envelopment of Alphaherpesviruses","volume":"7","author":"Owen","year":"2015","journal-title":"Viruses"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tim.2012.04.008","article-title":"Viral and host control of cytomegalovirus maturation","volume":"20","author":"Tandon","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1128\/jvi.69.12.7472-7482.1995","article-title":"Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis","volume":"69","author":"Avitabile","year":"1995","journal-title":"J. Virol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1073\/pnas.90.7.2798","article-title":"Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1","volume":"90","author":"Campadelli","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5864","DOI":"10.1128\/JVI.00155-11","article-title":"Spatial relationships between markers for secretory and endosomal machinery in human cytomegalovirus-infected cells versus those in uninfected cells","volume":"85","author":"Das","year":"2011","journal-title":"J. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nrmicro2559","article-title":"Herpesviruses remodel host membranes for virus egress","volume":"9","author":"Johnson","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ebiom.2014.11.007","article-title":"Macroautophagy proteins assist Epstein Barr virus production and get incorporated into the virus particles","volume":"1","author":"Nowag","year":"2014","journal-title":"EBioMedicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1128\/JVI.00915-16","article-title":"Exocytosis of varicella-zoster virions involves a convergence of endosomal and autophagy pathways","volume":"90","author":"Buckingham","year":"2016","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"740","DOI":"10.4161\/auto.6398","article-title":"Autophagy revisited: A conversation with Christian de Duve","volume":"4","author":"Klionsky","year":"2008","journal-title":"Autophagy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nature.2016.20721","article-title":"Medicine Nobel for research on how cells \u2018eat themselves\u2019","volume":"538","author":"Ledford","year":"2016","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbamcr.2012.11.018","article-title":"Maturation of autophagosomes and endosomes: A key role for Rab7","volume":"1833","author":"Hyttinen","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jmb.2016.12.013","article-title":"The journey of the autophagosome through mammalian cell organelles and membranes","volume":"429","author":"Molino","year":"2017","journal-title":"J. Mol. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.15252\/embj.201797006","article-title":"ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis","volume":"36","author":"Nascimbeni","year":"2017","journal-title":"EMBO J."},{"key":"ref_21","first-page":"2534","article-title":"Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae","volume":"126","author":"Suzuki","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_22","first-page":"3","article-title":"The LC3 interactome at a glance","volume":"127","author":"Wild","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/ncb0910-842","article-title":"Can autophagy promote longevity?","volume":"12","author":"Madeo","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI73946","article-title":"Essential role for autophagy in life span extension","volume":"125","author":"Madeo","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4161\/auto.19242","article-title":"Allophagy: A macroautophagic process degrading spermatozoid-inherited organelles","volume":"8","author":"Djeddi","year":"2012","journal-title":"Autophagy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1172\/JCI73941","article-title":"The role for autophagy in cancer","volume":"125","author":"White","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.semcancer.2013.06.007","article-title":"Autophagy regulation and its role in cancer","volume":"23","author":"Lorin","year":"2013","journal-title":"Semin. Cancer Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cell.2006.12.044","article-title":"Autophagy gene-dependent clearance of apoptotic cells during embryonic development","volume":"128","author":"Qu","year":"2007","journal-title":"Cell"},{"key":"ref_31","first-page":"54","article-title":"Autophagic clearance of bacterial pathogens: Molecular recognition of intracellular microorganisms","volume":"3","author":"Pareja","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/JVI.02174-14","article-title":"Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes","volume":"89","author":"Sagnier","year":"2015","journal-title":"J. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chom.2010.01.007","article-title":"Autophagy protects against Sindbis virus infection of the central nervous system","volume":"7","author":"Orvedahl","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/embor.2013.51","article-title":"Species-specific impact of the autophagy machinery on Chikungunya virus infection","volume":"14","author":"Judith","year":"2013","journal-title":"EMBO Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.it.2016.08.017","article-title":"Autophagy beyond intracellular MHC class II antigen presentation","volume":"37","author":"Munz","year":"2016","journal-title":"Trends Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1128\/JVI.02974-12","article-title":"Inhibition of the host translation shutoff response by herpes simplex virus 1 triggers nuclear envelope-derived autophagy","volume":"87","author":"Radtke","year":"2013","journal-title":"J. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/ni.1720","article-title":"Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection","volume":"10","author":"English","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.1104904","article-title":"Endogenous MHC class II processing of a viral nuclear antigen after autophagy","volume":"307","author":"Paludan","year":"2005","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hayat, M.A. (2015). Chapter 8: Modulation of autophagy by Herpesvirus proteins. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Elsevier.","DOI":"10.1016\/B978-0-12-801033-4.00001-1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1073\/pnas.012485299","article-title":"Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway","volume":"99","author":"Talloczy","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chom.2006.12.001","article-title":"HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein","volume":"1","author":"Orvedahl","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wilcox, D.R., Wadhwani, N.R., Longnecker, R., and Muller, W.J. (2015). Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004580"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.chom.2014.01.009","article-title":"Crosstalk between the cGAS DNA sensor and BECLIN-1 autophagy protein shapes innate antimicrobial immune responses","volume":"15","author":"Liang","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.4049\/jimmunol.1100949","article-title":"Activation of autophagy by alpha-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes","volume":"187","author":"Rasmussen","year":"2011","journal-title":"J. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"12128","DOI":"10.1128\/JVI.01356-07","article-title":"Analysis of the role of autophagy in replication of herpes simplex virus in cell culture","volume":"81","author":"Alexander","year":"2007","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chom.2012.07.013","article-title":"A neuron-specific role for autophagy in antiviral defense against herpes simplex virus","volume":"12","author":"Yordy","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gobeil, P.A., and Leib, D.A. (2012). Herpes simplex virus gamma34.5 interferes with autophagosome maturation and antigen presentation in dendritic cells. mBio, 3.","DOI":"10.1128\/mBio.00267-12"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/JVI.01158-12","article-title":"The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR","volume":"87","author":"Lussignol","year":"2013","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/15548627.2015.1125071","article-title":"Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1\/Beclin 1-binding proteins","volume":"12","author":"Mouna","year":"2016","journal-title":"Autophagy"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1128\/JVI.05746-11","article-title":"The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1","volume":"86","author":"Chaumorcel","year":"2012","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12499","DOI":"10.1128\/JVI.01898-13","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation","volume":"87","author":"Liang","year":"2013","journal-title":"J. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/ncb1980","article-title":"FLIP-mediated autophagy regulation in cell death control","volume":"11","author":"Lee","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1080\/15548627.2016.1235122","article-title":"KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST\/calpastatin and ATG5 expression","volume":"12","author":"Santarelli","year":"2016","journal-title":"Autophagy"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.imlet.2007.07.013","article-title":"Human herpesvirus 8 (HHV-8) inhibits monocyte differentiation into dendritic cells and impairs their immunostimulatory activity","volume":"113","author":"Cirone","year":"2007","journal-title":"Immunol. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1182\/blood-2011-08-372383","article-title":"Induction of autophagy is essential for monocyte-macrophage differentiation","volume":"119","author":"Zhang","year":"2012","journal-title":"Blood"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular biology of pseudorabies virus: Impact on neurovirology and veterinary medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"39964","DOI":"10.1038\/srep39964","article-title":"Pseudorabies virus infection inhibits autophagy in permissive cells in vitro","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1080\/15548627.2015.1017188","article-title":"Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections","volume":"11","author":"Moreau","year":"2015","journal-title":"Autophagy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.virusres.2010.07.011","article-title":"Detection and description of a particular Ostreid herpesvirus 1 genotype associated with massive mortality outbreaks of Pacific oysters, Crassostrea gigas, in France in 2008","volume":"153","author":"Segarra","year":"2010","journal-title":"Virus Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4161\/auto.2176","article-title":"PKR-dependent autophagic degradation of herpes simplex virus type 1","volume":"2","author":"Talloczy","year":"2006","journal-title":"Autophagy"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4161\/auto.5184","article-title":"Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism","volume":"4","author":"Chaumorcel","year":"2008","journal-title":"Autophagy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.virol.2015.11.032","article-title":"Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication","volume":"489","author":"Braggin","year":"2016","journal-title":"Virology"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Gallo, A., Lampe, M., Gunther, T., and Brune, W. (2017). The viral Bcl-2 homologs of Kaposi\u2019s sarcoma-associated herpesvirus and Rhesus Rhadinovirus share an essential role for viral replication. J. Virol., 91.","DOI":"10.1128\/JVI.01875-16"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1128\/JVI.00102-15","article-title":"Identification of the essential role of viral Bcl-2 for Kaposi\u2019s sarcoma-associated herpesvirus lytic replication","volume":"89","author":"Liang","year":"2015","journal-title":"J. Virol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1080\/15548627.2015.1115939","article-title":"Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations","volume":"11","author":"Pujals","year":"2015","journal-title":"Autophagy"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"31302","DOI":"10.1038\/srep31302","article-title":"Early activation of MyD88-mediated autophagy sustains HSV-1 replication in human monocytic THP-1 cells","volume":"6","author":"Siracusano","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cai, M., Li, M., Wang, K., Wang, S., Lu, Q., Yan, J., Mossman, K.L., Lin, R., and Zheng, C. (2013). The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-\u03baB through the Toll-like receptor 2 and MyD88\/TRAF6-dependent signaling pathway. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054586"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s12038-014-9443-y","article-title":"Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells","volume":"39","author":"Petrovski","year":"2014","journal-title":"J. Biosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"12985","DOI":"10.1038\/srep12985","article-title":"Basal autophagy is required for herpes simplex virus-2 infection","volume":"5","author":"Yakoub","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1128\/JVI.02670-08","article-title":"Varicella-zoster virus infection induces autophagy in both cultured cells and human skin vesicles","volume":"83","author":"Takahashi","year":"2009","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1099\/jgv.0.000696","article-title":"Autophagy activated by duck enteritis virus infection positively affects its replication","volume":"98","author":"Yin","year":"2017","journal-title":"J. Gen. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/01652176.2017.1298885","article-title":"Duck virus enteritis (duck plague)\u2014A comprehensive update","volume":"37","author":"Dhama","year":"2017","journal-title":"Vet. Q."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1128\/JVI.02435-10","article-title":"Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1","volume":"85","author":"McFarlane","year":"2011","journal-title":"J. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1128\/JVI.02651-15","article-title":"Trehalose, an mTOR-independent inducer of autophagy, inhibits human cytomegalovirus infection in multiple cell types","volume":"90","author":"Belzile","year":"2015","journal-title":"J. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.molcel.2016.09.037","article-title":"An autophagic flux probe that releases an internal control","volume":"64","author":"Kaizuka","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"12133","DOI":"10.1128\/JVI.02033-14","article-title":"Regulation of autophagic activation by Rta of Epstein-Barr virus via the extracellular signal-regulated kinase pathway","volume":"88","author":"Hung","year":"2014","journal-title":"J. Virol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"12715","DOI":"10.1128\/JVI.02199-14","article-title":"Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication","volume":"88","author":"Granato","year":"2014","journal-title":"J. Virol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e1876","DOI":"10.1038\/cddis.2015.156","article-title":"Inhibition of autophagy in EBV-positive Burkitt\u2019s lymphoma cells enhances EBV lytic genes expression and replication","volume":"6","author":"Colavita","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1080\/15548627.2015.1091911","article-title":"The activation of KSHV lytic cycle blocks autophagy in PEL cells","volume":"11","author":"Granato","year":"2015","journal-title":"Autophagy"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1128\/JVI.00024-10","article-title":"Enhancement of autophagy during lytic replication by the Kaposi\u2019s sarcoma-associated herpesvirus replication and transcription activator","volume":"84","author":"Wen","year":"2010","journal-title":"J. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.chom.2009.09.005","article-title":"Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes","volume":"6","author":"Gannage","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.chom.2014.04.004","article-title":"Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production","volume":"15","author":"Ding","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.chom.2014.01.006","article-title":"A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability","volume":"15","author":"Beale","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.chom.2014.04.014","article-title":"The p value of HPIV3-mediated autophagy inhibition","volume":"15","author":"Faure","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jviromet.2013.06.018","article-title":"Visualization and quantitation of abundant macroautophagy in virus-infected cells by confocal three-dimensional fluorescence imaging","volume":"193","author":"Jackson","year":"2013","journal-title":"J. Virol. Methods"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1073\/pnas.1417878112","article-title":"Autophagic flux without a block differentiates varicella-zoster virus infection from herpes simplex virus infection","volume":"112","author":"Buckingham","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1128\/JVI.00281-11","article-title":"Autophagosome formation during varicella-zoster virus infection following endoplasmic reticulum stress and the unfolded protein response","volume":"85","author":"Carpenter","year":"2011","journal-title":"J. Virol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1128\/JVI.02646-13","article-title":"Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity","volume":"88","author":"Buckingham","year":"2014","journal-title":"J. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"10850","DOI":"10.1074\/jbc.M109.080796","article-title":"Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase","volume":"285","author":"Wu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Fliss, P.M., Jowers, T.P., Brinkmann, M.M., Holstermann, B., Mack, C., Dickinson, P., Hohenberg, H., Ghazal, P., and Brune, W. (2012). Viral mediated redirection of NEMO\/IKK\u03b3 to autophagosomes curtails the inflammatory cascade. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002517"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1073\/pnas.0800168105","article-title":"Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein","volume":"105","author":"Mack","year":"2008","journal-title":"Proc. Natil. Acad. Sci. USA"},{"key":"ref_93","first-page":"1161","article-title":"Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells","volume":"20","author":"Mo","year":"2014","journal-title":"Mol. Vis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1073\/pnas.85.11.3678","article-title":"Complex transcription of the Epstein-Barr virus BamHI fragment H rightward open reading frame 1 (BHRF1) in latently and lytically infected B lymphocytes","volume":"85","author":"Austin","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1038\/sj.onc.1210946","article-title":"The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy","volume":"27","author":"Lee","year":"2008","journal-title":"Oncogene"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1128\/JVI.03371-14","article-title":"Epstein-Barr virus latent membrane protein 2 induces autophagy to promote abnormal acinus formation","volume":"89","author":"Fotheringham","year":"2015","journal-title":"J. Virol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1128\/JVI.01089-13","article-title":"Epstein-Barr virus latent membrane protein 2A contributes to anoikis resistance through ERK activation","volume":"87","author":"Iwakiri","year":"2013","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ritthipichai, K., Nan, Y., Bossis, I., and Zhang, Y. (2012). Viral FLICE inhibitory protein of rhesus monkey rhadinovirus inhibits apoptosis by enhancing autophagosome formation. PLoS ONE, 7.","DOI":"10.1186\/1750-9378-7-S1-P44"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.chom.2012.01.005","article-title":"Subversion of autophagy by Kaposi\u2019s sarcoma-associated herpesvirus impairs oncogene-induced senescence","volume":"11","author":"Leidal","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.chom.2015.12.010","article-title":"Autophagy genes enhance Murine Gammaherpesvirus 68 reactivation from latency by preventing virus-induced systemic inflammation","volume":"19","author":"Park","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/JVI.80.1.192-200.2006","article-title":"Gamma interferon blocks gammaherpesvirus reactivation from latency","volume":"80","author":"Steed","year":"2006","journal-title":"J. Virol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4161\/auto.6803","article-title":"Molecular basis of the regulation of Beclin 1-dependent autophagy by the \u03b3-herpesvirus 68 Bcl-2 homolog M11","volume":"4","author":"Sinha","year":"2008","journal-title":"Autophagy"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.1074\/jbc.M113.515361","article-title":"Targeting \u03b3-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy","volume":"289","author":"Su","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"E, X., Hwang, S., Oh, S., Lee, J.S., Jeong, J.H., Gwack, Y., Kowalik, T.F., Sun, R., Jung, J.U., and Liang, C. (2009). Viral Bcl-2-mediated evasion of autophagy aids chronic infection of \u03b3herpesvirus 68. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000609"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1128\/JVI.02908-15","article-title":"Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons","volume":"90","author":"Katzenell","year":"2016","journal-title":"J. Virol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"Rubinsztein","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"856","DOI":"10.15252\/embj.201490784","article-title":"Autophagy in malignant transformation and cancer progression","volume":"34","author":"Galluzzi","year":"2015","journal-title":"EMBO J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1182\/blood-2006-06-028092","article-title":"Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling","volume":"109","author":"Sin","year":"2007","journal-title":"Blood"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/9\/12\/372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:52:31Z","timestamp":1760208751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/9\/12\/372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":108,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["v9120372"],"URL":"https:\/\/doi.org\/10.3390\/v9120372","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]}}}