{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:41:14Z","timestamp":1760236874389,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"Colciencias","doi-asserted-by":"publisher","award":["699-2018"],"award-info":[{"award-number":["699-2018"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>We estimate the seroprevalence of IgG antibodies to varicella zoster virus (VZV) based on the first serological study in a cohort of pregnant women and newborns from the Aburr\u00e1 Valley (Antioquia-Colombia) who attended delivery in eight randomly chosen hospitals. An indirect enzyme immunoassay was used to determine anti-VZV IgG antibodies. Generalized linear models were constructed to identify variables that modify seropositivity. In pregnant women, seropositivity was 85.8% (95% CI: 83.4\u201385.9), seronegativity was 12.6% (95% CI: 10.8\u201314.6), and concordance with umbilical cord titers was 90.0% (95% CI: 89\u201391). The seropositivity of pregnant women was lower in those who lived in rural areas (IRR: 0.4, 95% CI: 0.2\u20130.7), belonged to the high socioeconomic status (IRR: 0.4, 95% CI: 0.2\u20130.7), and had studied 11 years or more (IRR: 0.6, 95% CI: 0.4\u20130.8). Among newborns, seropositivity was lower in those who weighed less than 3000 g (IRR: 0.8, 95% CI: 0.6\u20131.0). The high seropositivity and seronegativity pattern indicates the urgent need to design preconception consultation and vaccination reinforcement for women of childbearing age according to their sociodemographic conditions, to prevent infection and complications in the mother and newborn.<\/jats:p>","DOI":"10.3390\/vaccines10010052","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T23:29:07Z","timestamp":1640906947000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Seroprevalence of Varicella in Pregnant Women and Newborns in a Region of Colombia"],"prefix":"10.3390","volume":"10","author":[{"given":"Viviana","family":"Lenis-Ballesteros","sequence":"first","affiliation":[{"name":"Hector Abad G\u00f3mez National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Hector Abad G\u00f3mez National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doracelly","family":"Hincapi\u00e9-Palacio","sequence":"additional","affiliation":[{"name":"Hector Abad G\u00f3mez National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-2330","authenticated-orcid":false,"given":"Alba","family":"Le\u00f3n-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Hector Abad G\u00f3mez National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4371-2257","authenticated-orcid":false,"given":"Felipe","family":"Vargas-Restrepo","sequence":"additional","affiliation":[{"name":"Hector Abad G\u00f3mez National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta C.","family":"Ospina","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health of the Regional Secretariat of Health and Social Protection of Antioquia, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seti","family":"Buitrago-Giraldo","sequence":"additional","affiliation":[{"name":"Laboratory of Public Health of the Regional Secretariat of Health and Social Protection of Antioquia, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad de Antioquia UdeA, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Gonzalez-Ort\u00edz","sequence":"additional","affiliation":[{"name":"Secretariat of Health of Medellin, Medellin 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ncl.2008.03.011","article-title":"Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis of Disease, and Latency","volume":"26","author":"Mueller","year":"2008","journal-title":"Neurol. 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