{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:52:31Z","timestamp":1760151151935,"version":"build-2065373602"},"reference-count":15,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIHGM103424","NIHGM110760"],"award-info":[{"award-number":["NIHGM103424","NIHGM110760"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["119Z409"],"award-info":[{"award-number":["119Z409"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans.<\/jats:p>","DOI":"10.3390\/vaccines10020300","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T20:28:59Z","timestamp":1645043339000},"page":"300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge"],"prefix":"10.3390","volume":"10","author":[{"given":"Paul J. F.","family":"Rider","sequence":"first","affiliation":[{"name":"Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, LA 70803, USA"},{"name":"Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd","family":"Kamil","sequence":"additional","affiliation":[{"name":"Aly Lab, Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul 34820, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilknur","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Aly Lab, Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul 34820, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habibe N.","family":"Atmaca","sequence":"additional","affiliation":[{"name":"Aly Lab, Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul 34820, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Kalkan-Yazici","sequence":"additional","affiliation":[{"name":"Microbiology Lab, Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul 34820, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Ziya Doymaz","sequence":"additional","affiliation":[{"name":"Microbiology Lab, Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul 34820, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin G.","family":"Kousoulas","sequence":"additional","affiliation":[{"name":"Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, LA 70803, USA"},{"name":"Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed S. 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