{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:57:27Z","timestamp":1777100247794,"version":"3.51.4"},"reference-count":10,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: A shoulder injury related to vaccine administration (SIRVA) is a vaccination complication that can affect daily life activities. To date, there have been no case series of patients diagnosed as SIRVA following a COVID-19 vaccination. We offer a series of seven SIRVA cases including clinical presentations, investigations and treatment outcomes. Methods: A retrospective chart review was performed for seven patients who developed SIRVA following a COVID-19 vaccination between April 2021 and October 2021. All patients had no prior shoulder pain before their vaccination and then developed shoulder pain within a few days following the vaccination, which did not spontaneously improve within 1 week. Results: Four of the seven patients were male, and the average age was 62.29 \u00b1 7.76 years. The average body mass index was 25.1 \u00b1 2.2 kg\/m2. In all cases, the cause of the SIRVA was from an incorrect COVID-19 vaccine administration technique. Two patients developed shoulder pain immediately following the injection, one patient about 3 h after the injection, and the other four patients within the next few days. Two of the seven patients visited the orthopedic clinic after the persistent shoulder pain for 3 and 4 days and the other five patients 1\u20139 weeks following their injections. One of the seven patients was treated with combined intravenous antibiotic and oral non-steroidal anti-inflammatory drug (NSAID) because septic arthritis of the shoulder could not initially be ruled out, and recovered within 2 weeks. The other six patients had shoulder pain without acute fever, and five of them were treated with only oral prednisolone 30 mg\/day for 5\u201310 days, following which the pain improved and they all could return to normal activities within 14 days, with no side effects from the prednisolone such as stomachache, nausea, vomiting, headache, or dizziness. Discussion and conclusion: In our series, the most common cause of SIRVA was an incorrect vaccination technique. Most patients responded well to oral NSAIDs or oral prednisolone. Clinical relevance: All SIRVAs were from an incorrect injection technique and not actually the vaccination, so our series highlights the importance of ensuring all vaccinators understand the importance of taking proper care with the injection technique. Additionally, most of our patients with SIRVA from a COVID-19 injection responded well to oral prednisolone (30 mg\/day). If there are no contraindications, we suggest this as the first line treatment for COVID-19-related SIRVA.<\/jats:p>","DOI":"10.3390\/vaccines10040588","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:48:45Z","timestamp":1649803725000},"page":"588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Shoulder Injury Related to COVID-19 Vaccine Administration: A Case Series"],"prefix":"10.3390","volume":"10","author":[{"given":"Korakot","family":"Maliwankul","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine, Prince of Songkla University, 15 Karnjanavanich Road, Hat Yai, Songkhla 90110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattira","family":"Boonsri","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Prince of Songkla University, 15 Karnjanavanich Road, Hat Yai, Songkhla 90110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapakorn","family":"Klabklay","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine, Prince of Songkla University, 15 Karnjanavanich Road, Hat Yai, Songkhla 90110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-1306","authenticated-orcid":false,"given":"Chaiwat","family":"Chuaychoosakoon","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine, Prince of Songkla University, 15 Karnjanavanich Road, Hat Yai, Songkhla 90110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref_1","first-page":"E298","article-title":"Treating SIRVA Early with Corticosteroid Injections: A Case Series","volume":"185","author":"MacOmb","year":"2020","journal-title":"Mil. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1016\/j.vaccine.2010.10.005","article-title":"Shoulder Injury Related to Vaccine Administration (SIRVA)","volume":"28","author":"Atanasoff","year":"2010","journal-title":"Vaccine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.vaccine.2019.11.032","article-title":"Shoulder Injury Related to Vaccine Administration (SIRVA): Petitioner Claims to the National Vaccine Injury Compensation Program, 2010\u20132016","volume":"38","author":"Hesse","year":"2020","journal-title":"Vaccine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102819","DOI":"10.1016\/j.amsu.2021.102819","article-title":"Combined Subacromial-Subdeltoid Bursitis and Supraspinatus Tear Following a COVID-19 Vaccination: A Case Report","volume":"69","author":"Boonsri","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102622","DOI":"10.1016\/j.amsu.2021.102622","article-title":"Shoulder Injury Related to Sinovac COVID-19 Vaccine: A Case Report","volume":"68","author":"Chuaychoosakoon","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.vaccine.2019.11.023","article-title":"Reports of Atypical Shoulder Pain and Dysfunction Following Inactivated Influenza Vaccine, Vaccine Adverse Event Reporting System (VAERS), 2010\u20132017","volume":"38","author":"Hibbs","year":"2020","journal-title":"Vaccine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"232596712110088","DOI":"10.1177\/23259671211008834","article-title":"The Relationship Between Arm Abduction Position and the Risk of Iatrogenic Anterior Branch of the Axillary Nerve Injuries: A Cadaveric Study","volume":"9","author":"Chuaychoosakoon","year":"2021","journal-title":"Orthop. J. Sport. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4161\/hv.27232","article-title":"Subdeltoid\/Subacromial Bursitis Associated with Influenza Vaccination","volume":"10","author":"Cook","year":"2014","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1308\/003588406X94968","article-title":"Dead Men and Radiologists Don\u2019t Lie: A Review of Cadaveric and Radiological Studies of Rotator Cuff Tear Prevalence","volume":"88","author":"Reilly","year":"2006","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_10","first-page":"CD006189","article-title":"Oral Steroids for Adhesive Capsulitis","volume":"4","author":"Buchbinder","year":"2006","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/4\/588\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:52:09Z","timestamp":1760136729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/4\/588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["vaccines10040588"],"URL":"https:\/\/doi.org\/10.3390\/vaccines10040588","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]}}}