{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:05:09Z","timestamp":1778724309109,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009992","name":"Seattle Children's Hospital","doi-asserted-by":"publisher","award":["410311830101"],"award-info":[{"award-number":["410311830101"]}],"id":[{"id":"10.13039\/100009992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Multiple factors may be associated with immune responses to SARS-CoV-2 vaccines. Factors potentially related to magnitude and durability of response include age, time, and vaccine reactogenicity. This study analyzed SARS-CoV-2 IgG spike antibody responses following the second dose of vaccine in healthcare workers (HCWs). Data were collected from participants enrolled in a longitudinal SARS-CoV-2 serology study over a 12-month period. Participants completed a survey documenting symptoms post-vaccination. Serum specimens were tested for SARS-CoV-2 IgG antibodies using the Abbott Architect AdvisdeDx SARS-CoV-2 IgGII assay. Antibody levels were compared against time from second vaccine dose, and symptoms following vaccination. Altogether, 335 women (86.6%) and 52 men (13.4%) participated. Median age was 37 years (IQR 30-43). Overall median antibody level was 2150.80 [1246.12, 3556.98] AU\/mL (IQR). Age was not associated with antibody concentration (p-value = 0.10). Higher antibody responses (2253 AU\/mL vs. 1506 AU\/mL; p = 0.008) were found in HCWs with one or more symptoms after the second dose of the vaccine (n = 311). Antibody responses persisted throughout the study period post-vaccination; statistically significant decreases in antibody responses were observed over time (p &lt; 0.001). Higher antibody response was associated with reactogenicity post-vaccine. Age and sex were not associated with higher antibody responses.<\/jats:p>","DOI":"10.3390\/vaccines10040601","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T23:07:16Z","timestamp":1649891236000},"page":"601","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Higher Antibody Concentrations in U.S. Health Care Workers Associated with Greater Reactogenicity Post-Vaccination"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-2892","authenticated-orcid":false,"given":"Jane A.","family":"Dickerson","sequence":"first","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA 98145, USA"},{"name":"Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98145, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet A.","family":"Englund","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA 98145, USA"},{"name":"Division of Infectious Diseases, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98145, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA 98145, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Brown","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA 98145, USA"},{"name":"Division of Emergency Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98145, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle M.","family":"Zerr","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA 98145, USA"},{"name":"Division of Infectious Diseases, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98145, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Strelitz","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA 98145, USA"},{"name":"Division of Emergency Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98145, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA 98145, USA"},{"name":"Division of Emergency Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98145, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"ref_1","unstructured":"The New York Times (2022, March 30). 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