{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:38:41Z","timestamp":1767109121504,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Anti-SARS-CoV-2 vaccines are safe and effective, also in individuals with allergic and immune-mediated diseases (IMDs). There are reports suggesting that vaccines may be able to trigger de-novo or exacerbate pre-existing IMDs in predisposed individuals. Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel vasculitis characterized by asthma, eosinophilia, and eosinophil-rich granulomatous inflammation in various tissues. We describe the case of a 63-year-old man who experienced cardiac, pulmonary, and neurological involvement one day after the administration of the booster dose of anti-SARS-CoV-2 vaccine (mRNA-1273). A diagnosis of EGPA was made and the patient was treated with high-dose steroids and cyclophosphamide, with a good clinical response. Interestingly, our patient had experienced a significant worsening of his pre-existing asthma six months earlier, just after the first two vaccine shots with the ChAdOx1 anti-SARS-CoV-2 vaccine. It is impossible to know whether our patient would have had developed EGPA following natural SARS-CoV-2 infection or at some point in his life regardless of infectious stimuli. Nevertheless, our report may suggest that caution should be paid during the administration of additional vaccine doses in individuals who experienced an increase in IMD severity that persisted over time following previous vaccine shots.<\/jats:p>","DOI":"10.3390\/vaccines10050716","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T08:21:25Z","timestamp":1651652485000},"page":"716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["New Onset of Eosinophilic Granulomatosis with Polyangiitis Following mRNA-Based COVID-19 Vaccine"],"prefix":"10.3390","volume":"10","author":[{"given":"Emanuele","family":"Nappi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-1336","authenticated-orcid":false,"given":"Maria","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-9225","authenticated-orcid":false,"given":"Giovanni","family":"Paoletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-7367","authenticated-orcid":false,"given":"Corrado","family":"Pelaia","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizia","family":"Terenghi","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pini","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Ciccarelli","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-0376","authenticated-orcid":false,"given":"Carlo Francesco","family":"Selmi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Puggioni","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio Walter","family":"Canonica","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-5663","authenticated-orcid":false,"given":"Enrico","family":"Heffler","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa2101544","article-title":"Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19","volume":"384","author":"Sadoff","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and Safety of the MRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 MRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Watad, A., de Marco, G., Mahajna, H., Druyan, A., Eltity, M., Hijazi, N., Haddad, A., Elias, M., Zisman, D., and Naffaa, M.E. (2021). Immune-Mediated Disease Flares or New-Onset Disease in 27 Subjects Following MRNA\/DNA SARS-CoV-2 Vaccination. Vaccines, 9.","DOI":"10.3390\/vaccines9050435"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wu, H.H.L., Kalra, P.A., and Chinnadurai, R. (2021). New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review. Vaccines, 9.","DOI":"10.3390\/vaccines9111252"},{"key":"ref_6","first-page":"e19616","article-title":"De-Novo Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Following the MRNA-1273 (Moderna) Vaccine for COVID-19","volume":"13","author":"Feghali","year":"2021","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-021-03744-4","article-title":"Antibody Epitopes in Vaccine-Induced Immune Thrombotic Thrombocytopaenia","volume":"596","author":"Huynh","year":"2021","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s13167-017-0101-y","article-title":"Vaccination and Autoimmune Diseases: Is Prevention of Adverse Health Effects on the Horizon?","volume":"8","author":"Poddighe","year":"2017","journal-title":"EPMA J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2174\/1573397113666170517155443","article-title":"Vasculitis Following Influenza Vaccination: A Review of the Literature","volume":"13","author":"Watanabe","year":"2017","journal-title":"Curr. Rheumatol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"258430","DOI":"10.1155\/2015\/258430","article-title":"Possible Triggering Effect of Influenza Vaccination on Psoriasis","volume":"2015","author":"Gunes","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/art.41982","article-title":"2022 American College of Rheumatology\/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis","volume":"74","author":"Grayson","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MD.0b013e318205a4c6","article-title":"The Five-Factor Score Revisited","volume":"90","author":"Guillevin","year":"2011","journal-title":"Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ki.2009.210","article-title":"Churg\u2013Strauss Syndrome","volume":"76","author":"Vaglio","year":"2009","journal-title":"Kidney Int."},{"key":"ref_15","first-page":"S57","article-title":"Expression of NKG2D and CD107 in CD8(+) Effector Memory Lymphocytes in Churg-Strauss Syndrome","volume":"30","author":"Boita","year":"2012","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.clim.2008.03.505","article-title":"Clonal CD8+ TCR-V\u03b2 Expanded Populations with Effector Memory Phenotype in Churg Strauss Syndrome","volume":"128","author":"Guida","year":"2008","journal-title":"Clin. Immunol."},{"key":"ref_17","first-page":"e21176","article-title":"Eosinophilic Granulomatosis With Polyangiitis Diagnosed in an Elderly Female After the Second Dose of MRNA Vaccine Against COVID-19","volume":"14","author":"Ibrahim","year":"2022","journal-title":"Cureus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/qjmed\/hcab273","article-title":"Eosinophilic Granulomatosis with Polyangiitis after COVID-19 Vaccination","volume":"114","author":"Ong","year":"2022","journal-title":"QJM Int. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Costanzo, G., Ledda, A.G., Ghisu, A., Vacca, M., Firinu, D., and del Giacco, S. (2021). Eosinophilic Granulomatosis with Polyangiitis Relapse after COVID-19 Vaccination: A Case Report. Vaccines, 10.","DOI":"10.3390\/vaccines10010013"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00296-021-05069-x","article-title":"ANCA-Associated Vasculitis Following ChAdOx1 NCoV19 Vaccination: Case-Based Review","volume":"42","author":"Prabhahar","year":"2022","journal-title":"Rheumatol. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10067-015-3073-0","article-title":"Viral RNA in the Influenza Vaccine May Have Contributed to the Development of ANCA-Associated Vasculitis in a Patient Following Immunisation","volume":"35","author":"Jeffs","year":"2016","journal-title":"Clin. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102592","DOI":"10.1016\/j.jaut.2020.102592","article-title":"The JANUS of Chronic Inflammatory and Autoimmune Diseases Onset during COVID-19\u2014A Systematic Review of the Literature","volume":"117","author":"Novelli","year":"2021","journal-title":"J. Autoimmun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1440-1797.2010.01375.x","article-title":"Influenza A H1N1, Microscopic Polyangiitis and Pulmonary Haemorrhage","volume":"15","author":"Jolly","year":"2010","journal-title":"Nephrology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/0267659120927210","article-title":"Life-Threatening Antineutrophil Cytoplasmic Antibody-Associated Vasculitis after Influenza A H1N1 Infection Requiring Veno-Venous Extracorporeal Membrane Oxygenation","volume":"35","author":"Frantzeskaki","year":"2020","journal-title":"Perfusion"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s12539-021-00438-3","article-title":"Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights","volume":"13","author":"Selvaraj","year":"2021","journal-title":"Interdiscip. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"102986","DOI":"10.1016\/j.autrev.2021.102986","article-title":"The COVID-19 Pandemic and ANCA-Associated Vasculitis\u2014Reports from the EUVAS Meeting and EUVAS Education Forum","volume":"20","author":"Kronbichler","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/all.14532","article-title":"COVID-19 in Severe Asthma Network in Italy (SANI) Patients: Clinical Features, Impact of Comorbidities and Treatments","volume":"76","author":"Heffler","year":"2021","journal-title":"Allergy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40733-021-00075-z","article-title":"Asthma and COVID-19: A Dangerous Liaison?","volume":"7","author":"Lombardi","year":"2021","journal-title":"Asthma Res. Pract."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Dolby, T., Nafilyan, V., Morgan, A., Kallis, C., Sheikh, A., and Quint, J.K. (2022). Relationship between Asthma and Severe COVID-19: A National Cohort Study. 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