{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:31:48Z","timestamp":1790285508816,"version":"4.1.0"},"reference-count":19,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China National Biotec Group Company Limited","award":["EV71-2017-03"],"award-info":[{"award-number":["EV71-2017-03"]}]},{"name":"China National Biotec Group Company Limited","award":["ts201511105"],"award-info":[{"award-number":["ts201511105"]}]},{"name":"Taishan Scholar Program of Shandong Province","award":["EV71-2017-03"],"award-info":[{"award-number":["EV71-2017-03"]}]},{"name":"Taishan Scholar Program of Shandong Province","award":["ts201511105"],"award-info":[{"award-number":["ts201511105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: The aim of this study was to investigate the immunogenicity and safety of the enterovirus 71 vaccine (EV71 vaccine) administered alone or simultaneously. Methods: A multi-center, open-label, randomized controlled trial was performed involving 1080 healthy infants aged 6 months or 8 months from Shandong, Shanxi, Shaanxi, and Hunan provinces. These infants were divided into four simultaneous administration groups and EV71 vaccine separate administration group. Blood samples were collected from the infants before the first vaccination and after the completion of the vaccination. This trial was registered in the Clinical Trials Registry (NCT03519568). Results: A total of 895 were included in the per-protocol analysis. The seroconversion rates of antibodies against EV71 in four simultaneous administration groups (98.44% (189\/192), 94.57% (122\/129), 99.47% (187\/188) and 98.45% (190\/193)) were non-inferior to EV71 vaccine separate administration group (97.93% [189\/193]) respectively. Fever was the most common adverse event, the pairwise comparison tests showed no difference in the incidence rate of solicited, systemic or local adverse events. Three serious adverse events related to the vaccination were reported. Conclusions: The evidence of immunogenicity and safety supports that the EV71 vaccine administered simultaneously with vaccines need to be administered during the same period of time recommended in China.<\/jats:p>","DOI":"10.3390\/vaccines10060895","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T08:01:18Z","timestamp":1654243278000},"page":"895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immunogenicity and Safety of an Inactivated Enterovirus 71 Vaccine Administered Simultaneously with Hepatitis B Virus Vaccine, Group A Meningococcal Polysaccharide Vaccine, Measles-Rubella Combined Vaccine and Japanese Encephalitis Vaccine: A Multi-Center, Randomized, Controlled Clinical Trial in China"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-765X","authenticated-orcid":false,"given":"Xiaodong","family":"Liu","sequence":"first","affiliation":[{"name":"Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China"},{"name":"Academy of Preventive Medicine, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoying","family":"Chang","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruize","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Center for Disease Control and Prevention, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Xiao","sequence":"additional","affiliation":[{"name":"China National Biotec Group Company Limited, Beijing 100024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjun","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China"},{"name":"Academy of Preventive Medicine, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Center for Disease Control and Prevention, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"China National Biotec Group Company Limited, Beijing 100024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan Institute of Biological Products Company Limited, Wuhan 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfan","family":"Cao","sequence":"additional","affiliation":[{"name":"Rushan City Center for Disease Control and Prevention, Rushan 264500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Center for Disease Control and Prevention, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daihong","family":"Zhan","sequence":"additional","affiliation":[{"name":"Shimen County Center for Disease Control and Prevention, Changde 415300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Chen","sequence":"additional","affiliation":[{"name":"China National Biotec Group Company Limited, Beijing 100024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuhan Institute of Biological Products Company Limited, Wuhan 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Haiyang City Center for Disease Control and Prevention, Haiyang 265199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6384-4516","authenticated-orcid":false,"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Center for Disease Control and Prevention, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"ref_1","first-page":"615","article-title":"Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; Isolation of group A Coxsackie virus","volume":"79","author":"Robinson","year":"1958","journal-title":"Can. 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