{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:22:43Z","timestamp":1771039363882,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Capital Health Research and Development of Special Projects","award":["No. SF-2018-2-1081"],"award-info":[{"award-number":["No. SF-2018-2-1081"]}]},{"name":"The Capital Health Research and Development of Special Projects","award":["trzdyxzy201801"],"award-info":[{"award-number":["trzdyxzy201801"]}]},{"name":"Capital Medical University Affiliated Beijing Tongren Hospital Key Medical Development Plan","award":["No. SF-2018-2-1081"],"award-info":[{"award-number":["No. SF-2018-2-1081"]}]},{"name":"Capital Medical University Affiliated Beijing Tongren Hospital Key Medical Development Plan","award":["trzdyxzy201801"],"award-info":[{"award-number":["trzdyxzy201801"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Purpose: To report the clinical characteristics of ocular adverse events that have occurred, in China, after vaccination with inactivated COVID-19 vaccines. Methods: A retrospective cross-sectional observational study was conducted of ocular disorders that occurred within 15 days from any dose of an inactivated COVID-19 vaccine. Information on gender, age, the interval between the vaccination and ocular symptoms, laterality, duration of the ocular symptoms, primary visual acuity, and clinical diagnosis were retrospectively collected. Results: Twenty-four patients were involved in the study, including 15 females and 9 males, with a mean age of 41 \u00b1 16 years (range of 8\u201371 years). The patients all denied a prior history of COVID-19 infection. Ocular adverse events occurred after the first dose of vaccine in 18 patients and, after the second or third doses, in six patients. The interval between vaccination with the inactivated COVID-19 vaccine and ocular symptoms was 6 \u00b1 5 days; six patients were bilaterally involved and 18 patients were unilaterally involved. Regarding the diagnosis, 10 patients were diagnosed with white dot syndrome (WDS), 9 patients were diagnosed with uveitis, and 5 patients were diagnosed with retinal vascular disorders. The ages of patients with WDS were younger than those with uveitis or retinal vascular disorders (32 \u00b1 10 vs. 48 \u00b1 18, p &lt; 0.05). For patients diagnosed with WDS, the best-corrected visual acuity (BCVA) was 0.74 \u00b1 0.73 LogMAR. For patients diagnosed with retinal vascular disorders or uveitis, the BCVA was 1.44 \u00b1 1.26 LogMAR. There was no significant difference (p &gt; 0.05). Conclusions: A relationship cannot be established between inactivated COVID-19 vaccines and ocular disorders; therefore, further investigation of the clinical spectrum of ocular adverse events after vaccination with an inactivated COVID-19 vaccine is necessary.<\/jats:p>","DOI":"10.3390\/vaccines10060918","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T06:31:59Z","timestamp":1655101919000},"page":"918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ocular Adverse Events after Inactivated COVID-19 Vaccination"],"prefix":"10.3390","volume":"10","author":[{"given":"Zhihua","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"},{"name":"Beijing Institute of Ophthalmology, Beijing 100005, China"},{"name":"Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Mao","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehui","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xusheng","family":"Cao","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4275-6856","authenticated-orcid":false,"given":"Xiaoyan","family":"Peng","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.abc0035","article-title":"The impact of COVID-19 and strategies for mitigation and suppression in low- and middle-income countries","volume":"369","author":"Walker","year":"2020","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/14760584.2021.1875824","article-title":"COVID-19 vaccine: Where are we now and where should we go?","volume":"20","author":"Soleimanpour","year":"2021","journal-title":"Expert Rev. 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