{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:01:00Z","timestamp":1782216060578,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>We report a case of new-onset postural orthostatic tachycardia syndrome in a healthy 46-year-old female after a single dose of the BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine. There have been three prior reports of new-onset postural orthostatic tachycardia syndrome after COVID-19 vaccination. Predominant symptoms noted included fatigue, brain fog, headache, sinus tachycardia, and dizziness. Management includes noninvasive therapies, behavioral approaches, and pharmacologic regimens. Here, the patient presented with fatigue, palpitations, dizziness, and presyncope, with symptoms beginning 7 days after vaccination. Presenting vitals included temperature within normal limits, inappropriate tachycardia, up to 120 beats per minute, blood pressure of 128\/87 mm of mercury, and 100% saturation in room air. Her management included lifestyle changes, dietary supplements, and ivabradine. Further studies are needed to evaluate prevalence, etiology, and optimal management.<\/jats:p>","DOI":"10.3390\/vaccines10070991","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T01:59:47Z","timestamp":1655949587000},"page":"991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["COVID-19 Vaccination Might Induce Postural Orthostatic Tachycardia Syndrome: A Case Report"],"prefix":"10.3390","volume":"10","author":[{"given":"Melody","family":"Hermel","sequence":"first","affiliation":[{"name":"Scripps Clinic, Department of Cardiology, 9898 Genesee Avenue, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-9679","authenticated-orcid":false,"given":"Megan","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Scripps Center for Integrative Medicine, 10820 N. Torrey Pines Road, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-2018","authenticated-orcid":false,"given":"Edsel","family":"Abud","sequence":"additional","affiliation":[{"name":"Scripps Clinic, Department of Allergy & Immunology, 3811 Valley Centre Drive, San Diego, CA 92130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Luskin","sequence":"additional","affiliation":[{"name":"Scripps Clinic, Department of Allergy & Immunology, 3811 Valley Centre Drive, San Diego, CA 92130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose P.","family":"Criado","sequence":"additional","affiliation":[{"name":"Scripps Clinic, Department of Neurology, 9898 Genesee Avenue, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bonakdar","sequence":"additional","affiliation":[{"name":"Scripps Clinic, Department of Cardiology, 9898 Genesee Avenue, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gray","sequence":"additional","affiliation":[{"name":"Scripps Clinic, Department of Cardiology, 9898 Genesee Avenue, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ahern","sequence":"additional","affiliation":[{"name":"Scripps Clinic, Department of Cardiology, 9898 Genesee Avenue, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jacc.2018.11.059","article-title":"Postural Orthostatic Tachycardia Syndrome: JACC Focus Seminar","volume":"73","author":"Bryarly","year":"2019","journal-title":"J. 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