{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:55:30Z","timestamp":1775015730067,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Mumps and rubella are vaccine-preventable viral diseases through the measles-mumps-rubella-varicella (MMRV) vaccine, administered at 12 months and again at 6 years. We assessed the sero-prevalence of mumps and rubella, identified factors associated with sero-negativity, and evaluated concordance between mumps and rubella sero-positivity. A national cross-sectional sero-survey was conducted on samples collected in 2015 by the Israel National Sera Bank. Samples were tested for mumps and rubella IgG antibodies using an enzyme-linked immunosorbent assay. Of 3131 samples tested for mumps IgG, 84.8% (95%CI: 83.5\u201386.0%) were sero-positive. Sero-negativity for mumps was significantly associated with age (high odds ratios observed in infants younger than 4 years and 20\u201329 years old subjects). Of 3169 samples tested for rubella IgG antibodies, 95.2% (95%CI: 94.4\u201395.9%) were sero-positive. Rubella sero-negativity was significantly associated with age (high odds ratios observed in children younger than 4 years old and adults older than 30 years), males, Jews, and others. Concordant sero-positivity for both mumps and rubella viruses was observed in 83.9% of the tested samples. The Israeli population was sufficiently protected against rubella but not against mumps. Since both components are administered in the MMRV vaccine simultaneously, the mumps component has a lower uptake than rubella and quicker waning.<\/jats:p>","DOI":"10.3390\/vaccines10070996","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T01:59:47Z","timestamp":1655949587000},"page":"996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Concordance between Mumps and Rubella Sero-Positivity among the Israeli Population in 2015"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-2968","authenticated-orcid":false,"given":"Ravit","family":"Bassal","sequence":"first","affiliation":[{"name":"Israel Center for Disease Control, Ministry of Health, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"},{"name":"Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamy","family":"Shohat","sequence":"additional","affiliation":[{"name":"Israel Center for Disease Control, Ministry of Health, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"},{"name":"Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Levin","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakefet","family":"Pando","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eilat","family":"Shinar","sequence":"additional","affiliation":[{"name":"Magen David Adom (MDA) National Blood Services, Tel Hashomer 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Amichay","sequence":"additional","affiliation":[{"name":"Soroka University Medical Center, Clalit Health Services, Beer Sheva 84101, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Barak","sequence":"additional","affiliation":[{"name":"Haifa and Western Galilee Laboratories, Clalit Health Services, Nesher 20300, Israel"},{"name":"Zefat Academic College, Safed 13206, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Ben-Dor","sequence":"additional","affiliation":[{"name":"Schneider Children Medical Center, Clalit Health Services, Petah-Tiqwa 49504, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina","family":"Bar-Haim","sequence":"additional","affiliation":[{"name":"Mayanei HaYeshuhai Medical Center, Bnei Brak 51544, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Mendelson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel"},{"name":"Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-2303","authenticated-orcid":false,"given":"Dani","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lital","family":"Keinan-Boker","sequence":"additional","affiliation":[{"name":"Israel Center for Disease Control, Ministry of Health, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"},{"name":"School of Public Health, University of Haifa, Haifa 3498838, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Indenbaum","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services, Ministry of Health, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"ref_1","unstructured":"(2022, June 18). The Division of Epidemiology, Public Health Services, Israel Ministry of Health. Vaccines Instructions, Available online: https:\/\/www.health.gov.il\/UnitsOffice\/HD\/PH\/epidemiology\/td\/docs\/tadrich_Chisunim.pdf."},{"key":"ref_2","unstructured":"Israel Center for Diseases Control (ICDC) and Division of Epidemiology, Public Health Services (2020). Notifiable Infectious Diseases in Israel: 65 Years of Surveillance 1951\u20132015."},{"key":"ref_3","unstructured":"Characterization and Classification of Local Authorities by the Socio-Economic Level of the Population in 2015. Local Councils and Municipalities\u2014Rank, Cluster Membership, Population, Variable Values, Standardized Values and Ranking for the Variables Used in the Computation of the Index, Available online:."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Bassal, R., Cohen, D., Green, M.S., and Keinan-Boker, L. (2021). The Israel National Sera Bank: Methods, Representativeness, and Challenges. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052280"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/0022-3859.173193","article-title":"Analysis of sparse data in logistic regression in medical research: A newer approach","volume":"62","author":"Devika","year":"2016","journal-title":"J. Postgrad. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1016\/j.vaccine.2015.08.088","article-title":"Seroprevalence of mumps in an epidemic period in Medell\u00edn, Colombia","volume":"33","author":"Ospina","year":"2015","journal-title":"Vaccine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s10096-006-0133-z","article-title":"Seroprevalence of measles, rubella, and mumps antibodies in Catalonia, Spain: Results of a cross-sectional study","volume":"25","author":"Plans","year":"2006","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.4161\/hv.25127","article-title":"Seroprevalence of antibodies against measles, rubella, mumps, varicella-zoster, and B. Pertussis in young adults of Madrid, Spain","volume":"9","year":"2013","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"ofv006","DOI":"10.1093\/ofid\/ofv006","article-title":"Seroprevalence of measles, mumps, rubella and varicella antibodies in the United States population, 2009\u20132010","volume":"2","author":"Lebo","year":"2015","journal-title":"Open Forum. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pang, H., Zhou, Y., Zhao, W., and Jiang, Q. (2018). Seroprevalence and Determinants Associated with Mumps Antibodies after 20 Years of MMR Vaccination in Urban Area of Shanghai, China. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15102089"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3329\/jhpn.v27i1.3320","article-title":"Seroprevalence of antibodies to measles, mumps, and rubella among Thai population: Evaluation of measles\/MMR immunization programme","volume":"27","author":"Tharmaphornpilas","year":"2009","journal-title":"J. Health Popul. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jmii.2017.09.001","article-title":"Humoral immunity to mumps in a highly vaccinated population in Taiwan","volume":"52","author":"Ho","year":"2019","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1080\/21645515.2017.1412021","article-title":"Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy","volume":"14","author":"Smetana","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0140-6736(90)90420-A","article-title":"Immunisation and herd immunity","volume":"335","author":"Anderson","year":"1990","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1017\/S0950268812001136","article-title":"Seroepidemiology of mumps in Europe (1996\u20132008): Why do outbreaks occur in highly vaccinated populations?","volume":"141","author":"Eriksen","year":"2013","journal-title":"Epidemiol. Infect."},{"key":"ref_16","unstructured":"World Health Organization (2022, June 18). WHO Vaccine-Preventable Diseases: Monitoring System. Available online: https:\/\/apps.who.int\/immunization_monitoring\/globalsummary\/timeseries\/tscoveragemcv2.html."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1017\/S0950268803001584","article-title":"Seroprevalence of measles, mumps and rubella antibodies in Luxembourg: Results from a national cross-sectional study","volume":"132","author":"Mossong","year":"2004","journal-title":"Epidemiol. Infect."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1017\/S0950268807008989","article-title":"Prevalence of mumps antibodies in the Israeli population in relation to mumps vaccination policy and incidence of disease","volume":"136","author":"Muhsen","year":"2008","journal-title":"Epidemiol. Infect."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.vaccine.2017.12.075","article-title":"Measles, mumps, and rubella antibody patterns of persistence and rate of decline following the second dose of the MMR vaccine","volume":"36","author":"Seagle","year":"2018","journal-title":"Vaccine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/21645515.2015.1021522","article-title":"Characteristics of a large mumps outbreak: Clinical severity, complications and association with vaccination status of mumps outbreak cases","volume":"11","author":"Zamir","year":"2015","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lam, E., Rosen, J.B., and Zucker, J.R. (2020). Mumps: An Update on Outbreaks, Vaccine Efficacy, and Genomic Diversity. Clin. Microbiol. Rev., 33.","DOI":"10.1128\/CMR.00151-19"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.vaccine.2014.01.066","article-title":"Seroprevalence of rubella antibodies in The Netherlands after 32 years of high vaccination coverage","volume":"32","author":"Smits","year":"2014","journal-title":"Vaccine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1016\/j.vaccine.2018.03.086","article-title":"Australian rubella serosurvey 2012\u20132013: On track for elimination?","volume":"36","author":"Edirisuriya","year":"2018","journal-title":"Vaccine"},{"key":"ref_24","unstructured":"World Health Organization (2022, June 18). The Immunological Basis for Immunization Series\u2014Module 11\u2014Rubella. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/43922\/9789241596848_eng.pdf;jsessionid=52CEB6A406A2ED553A762ABD35AFB08E?sequence=1."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Poethko-M\u00fcller, C., and Mankertz, A. (2012). Seroprevalence of measles-, mumps- and rubella-specific IgG antibodies in German children and adolescents and predictors for seronegativity. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042867"},{"key":"ref_26","first-page":"1700796","article-title":"Resurgence risk for measles, mumps and rubella in France in 2018 and 2020","volume":"23","author":"Abrams","year":"2018","journal-title":"Eurosurveillance"}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/7\/996\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:37:54Z","timestamp":1760139474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/7\/996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,22]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["vaccines10070996"],"URL":"https:\/\/doi.org\/10.3390\/vaccines10070996","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,22]]}}}