{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:06:16Z","timestamp":1776909976830,"version":"3.51.2"},"reference-count":73,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Given the increasing anti-vaccine movements erroneously touting vaccine danger, this review has investigated the rare adverse events potentially associated with BNT162b2 (Pfizer-BioNTech), an mRNA vaccine against the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2). Only real-world surveillance studies with at least 0.1 million BNT162b2-vaccinated participants and one unvaccinated control group were selected for review. A total of 21 studies examining the potential association of BNT162b2 with cardiovascular, herpetic, thrombotic or thrombocytopenic, neurological, mortality, and other miscellaneous rare adverse events were described in this review. Only myocarditis is consistently associated with BNT162b2. An unclear direction of association was seen with stroke (hemorrhagic and ischemic), herpes zoster, and paresthesia from BNT162b2, which may require more studies to resolve. Fortunately, most surveillance studies detected no increased risks of the remaining rare adverse events reviewed herein, further reassuring the safety of BNT162b2. In conclusion, this review has concisely summarized the current rare adverse events related and unrelated to BNT162b2, arguably for the first time in sufficient depth, to better communicate vaccine safety to the public.<\/jats:p>","DOI":"10.3390\/vaccines10071067","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T23:38:55Z","timestamp":1656977935000},"page":"1067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies"],"prefix":"10.3390","volume":"10","author":[{"given":"Shin-Jie","family":"Yong","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Selangor 47500, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Halim","sequence":"additional","affiliation":[{"name":"Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Halim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, School of Science, Engineering and Environment, University of Salford, Greater Manchester, Salford M5 4WT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Al Mutair","sequence":"additional","affiliation":[{"name":"Research Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi Arabia"},{"name":"College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia"},{"name":"School of Nursing, Wollongong University, Wollongong 2522, Australia"},{"name":"Nursing Department, Prince Sultan Military College of Health Sciences, Dhahran 33048, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-4513","authenticated-orcid":false,"given":"Saad","family":"Alhumaid","sequence":"additional","affiliation":[{"name":"Administration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehad","family":"Al-Sihati","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Internal Medicine Department, King Fahad Specialist Hospital, Dammam 31311, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hawra","family":"Albayat","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, King Saud Medical City, Riyadh 7790, Saudi 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Ten Threats to Global Health in 2019. Available online: https:\/\/www.who.int\/news-room\/spotlight\/ten-threats-to-global-health-in-2019."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41562-021-01056-1","article-title":"Measuring the impact of COVID-19 vaccine misinformation on vaccination intent in the UK and USA","volume":"5","author":"Loomba","year":"2021","journal-title":"Nat. Hum. Behav."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0140-6736(20)31558-0","article-title":"Mapping global trends in vaccine confidence and investigating barriers to vaccine uptake: A large-scale retrospective temporal modelling study","volume":"396","author":"Simas","year":"2020","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e35552","DOI":"10.2196\/35552","article-title":"A Deadly Infodemic: Social Media and the Power of COVID-19 Misinformation","volume":"24","author":"Gisondi","year":"2022","journal-title":"J. Med. Internet Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1080\/21645515.2021.1926183","article-title":"COVID-19 vaccine hesitancy\u2014Reasons and solutions to achieve a successful global vaccination campaign to tackle the ongoing pandemic","volume":"17","author":"Dhama","year":"2021","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/j.ackd.2011.09.004","article-title":"Observational Studies Versus Randomized Controlled Trials: Avenues to Causal Inference in Nephrology","volume":"19","author":"Kovesdy","year":"2012","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1097\/PRS.0b013e31820da3eb","article-title":"Randomized controlled trials","volume":"127","author":"McCarthy","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa2101544","article-title":"Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against COVID-19","volume":"384","author":"Sadoff","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(20)32661-1","article-title":"Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: An interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK","volume":"397","author":"Voysey","year":"2021","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1056\/NEJMoa2107659","article-title":"Safety and Efficacy of NVX-CoV2373 COVID-19 Vaccine","volume":"385","author":"Heath","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"352","DOI":"10.7326\/M21-3256","article-title":"COVID-19 Vaccination Effectiveness Against Infection or Death in a National U.S. Health Care System: A Target Trial Emulation Study","volume":"175","author":"Ioannou","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2027160","DOI":"10.1080\/21645515.2022.2027160","article-title":"The efficacy and effectiveness of the COVID-19 vaccines in reducing infection, severity, hospitalization, and mortality: A systematic review","volume":"18","author":"Mohammed","year":"2022","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1056\/NEJMoa2115481","article-title":"Duration of Protection against Mild and Severe Disease by COVID-19 Vaccines","volume":"386","author":"Andrews","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/2229-3485.71852","article-title":"Phase IV of Drug Development","volume":"1","author":"Suvarna","year":"2010","journal-title":"Perspect. Clin. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.2020.19692","article-title":"Postapproval Vaccine Safety Surveillance for COVID-19 Vaccines in the US","volume":"324","author":"Lee","year":"2020","journal-title":"JAMA"},{"key":"ref_19","unstructured":"Billingsley, A. (2022, January 05). FDA COVID-19 Vaccine Approval: Live Updates on Pfizer, Moderna, and J&J Vaccines. Available online: https:\/\/www.goodrx.com\/conditions\/COVID-19\/fda-COVID-19-vaccine-approval-updates."},{"key":"ref_20","first-page":"1","article-title":"COVID-19 Vaccination Efficacy and Safety Literature Review","volume":"3","author":"Halim","year":"2021","journal-title":"J. Immunol. Allergy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"714170","DOI":"10.3389\/fimmu.2021.714170","article-title":"Efficacy, Immunogenicity and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis","volume":"12","author":"Sharif","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jaci.2015.07.048","article-title":"Risk of anaphylaxis after vaccination in children and adults","volume":"137","author":"McNeil","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13223-021-00613-7","article-title":"Anaphylactic and nonanaphylactic reactions to SARS-CoV-2 vaccines: A systematic review and meta-analysis","volume":"17","author":"Alhumaid","year":"2021","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"100260","DOI":"10.1016\/j.lanepe.2021.100260","article-title":"Risk of venous thrombotic events and thrombocytopenia in sequential time periods after ChAdOx1 and BNT162b2 COVID-19 vaccines: A national cohort study in England","volume":"13","author":"Andrews","year":"2022","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1056\/NEJMoa2110475","article-title":"Safety of the BNT162b2 mRNA COVID-19 Vaccine in a Nationwide Setting","volume":"385","author":"Barda","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Birabaharan, M., Kaelber, D.C., and Karris, M.Y. (2021). Risk of herpes zoster reactivation after messenger RNA COVID-19 vaccination: A cohort study. J. Am. Acad Dermatol.","DOI":"10.1016\/j.jaad.2021.11.025"},{"key":"ref_27","first-page":"n1931","article-title":"Risk of thrombocytopenia and thromboembolism after COVID-19 vaccination and SARS-CoV-2 positive testing: Self-controlled case series study","volume":"374","author":"Patone","year":"2021","journal-title":"BMJ"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e068665","DOI":"10.1136\/bmj-2021-068665","article-title":"SARS-CoV-2 vaccination and myocarditis or myopericarditis: Population based cohort study","volume":"375","author":"Husby","year":"2021","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7326\/M21-2452","article-title":"Association of AZD1222 and BNT162b2 COVID-19 Vaccination With Thromboembolic and Thrombocytopenic Events in Frontline Personnel: A Retrospective Cohort Study","volume":"175","author":"Hviid","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/jama.2021.21699","article-title":"Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine in People Aged 75 Years or Older","volume":"327","author":"Jabagi","year":"2022","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1001\/jamacardio.2022.0583","article-title":"SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents","volume":"7","author":"Karlstad","year":"2022","journal-title":"JAMA Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kerr, S., Joy, M., Torabi, F., Bedston, S., Akbari, A., Agrawal, U., Beggs, J., Bradley, D., Chuter, A., and Docherty, A.B. (2022). First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales. PLoS Med., 19.","DOI":"10.1371\/journal.pmed.1003927"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1001\/jama.2021.15072","article-title":"Surveillance for Adverse Events After COVID-19 mRNA Vaccination","volume":"326","author":"Klein","year":"2021","journal-title":"JAMA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41467-022-28068-3","article-title":"Multimorbidity and adverse events of special interest associated with COVID-19 vaccines in Hong Kong","volume":"13","author":"Lai","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e068373","DOI":"10.1136\/bmj-2021-068373","article-title":"Association between COVID-19 vaccination, SARS-CoV-2 infection, and risk of immune mediated neurological events: Population based cohort and self-controlled case series analysis","volume":"376","author":"Li","year":"2022","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"McKeigue, P.M., Burgul, R., Bishop, J., Robertson, C., McMenamin, J., O\u2019Leary, M., McAllister, D.A., and Colhoun, H.M. (2021). Association of cerebral venous thrombosis with recent COVID-19 vaccination: Case-crossover study using ascertainment through neuroimaging in Scotland. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06960-5"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa2109730","article-title":"Myocarditis after BNT162b2 mRNA Vaccine against COVID-19 in Israel","volume":"385","author":"Mevorach","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1038\/s41591-021-01556-7","article-title":"Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection","volume":"27","author":"Patone","year":"2021","journal-title":"Nat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41591-021-01630-0","article-title":"Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection","volume":"28","author":"Patone","year":"2021","journal-title":"Nat. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cmi.2021.09.018","article-title":"Real-world safety data for the Pfizer BNT162b2 SARS-CoV-2 vaccine: Historical cohort study","volume":"28","author":"Shasha","year":"2022","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s41591-021-01408-4","article-title":"First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland","volume":"27","author":"Simpson","year":"2021","journal-title":"Nat. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1473-3099(21)00451-5","article-title":"Bell\u2019s palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: A case series and nested case-control study","volume":"22","author":"Wan","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_43","first-page":"100393","article-title":"Herpes zoster related hospitalization after inactivated (CoronaVac) and mRNA (BNT162b2) SARS-CoV-2 vaccination: A self-controlled case series and nested case-control study","volume":"21","author":"Wan","year":"2022","journal-title":"Lancet Reg. Health West Pac."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Whiteley, W.N., Ip, S., Cooper, J.A., Bolton, T., Keene, S., Walker, V., Denholm, R., Akbari, A., Omigie, E., and Hollings, S. (2022). Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England. PLoS Med., 19.","DOI":"10.1371\/journal.pmed.1003926"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-term cardiovascular outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-021-03553-9","article-title":"High-dimensional characterization of post-acute sequelae of COVID-19","volume":"594","author":"Xie","year":"2021","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1093\/cid\/ciab338","article-title":"Late Conditions Diagnosed 1\u20134 Months Following an Initial Coronavirus Disease 2019 (COVID-19) Encounter: A Matched-Cohort Study Using Inpatient and Outpatient Administrative Data-United States, 1 March-30 June 2020","volume":"73","author":"Chevinsky","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"n1098","DOI":"10.1136\/bmj.n1098","article-title":"Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: Retrospective cohort study","volume":"373","author":"Daugherty","year":"2021","journal-title":"BMJ"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"n693","DOI":"10.1136\/bmj.n693","article-title":"Post-covid syndrome in individuals admitted to hospital with COVID-19: Retrospective cohort study","volume":"372","author":"Ayoubkhani","year":"2021","journal-title":"BMJ"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Yong, S.J., and Liu, S. (2021). Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies. Rev. Med. Virol., e2315.","DOI":"10.1002\/rmv.2315"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0140-6736(99)00623-6","article-title":"Reactivation of herpesvirus infections after vaccinations?","volume":"353","author":"Walter","year":"1999","journal-title":"Lancet"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/bjo.2010.185983","article-title":"Reactivation of acute retinal necrosis after flu H1N1 vaccination","volume":"95","author":"Rothova","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Psichogiou, M., Samarkos, M., Mikos, N., and Hatzakis, A. (2021). Reactivation of Varicella Zoster Virus after Vaccination for SARS-CoV-2. Vaccines, 9.","DOI":"10.3390\/vaccines9060572"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Katsikas Triantafyllidis, K., Giannos, P., Mian, I.T., Kyrtsonis, G., and Kechagias, K.S. (2021). Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case Reports. Vaccines, 9.","DOI":"10.3390\/vaccines9091013"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Johnson, R.W., Bouhassira, D., Kassianos, G., Leplege, A., Schmader, K.E., and Weinke, T. (2010). The impact of herpes zoster and post-herpetic neuralgia on quality-of-life. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-37"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1161\/STROKEAHA.109.562017","article-title":"Increased risk of stroke after a herpes zoster attack: A population-based follow-up study","volume":"40","author":"Kang","year":"2009","journal-title":"Stroke"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/S2352-3026(21)00306-9","article-title":"Vaccine-induced immune thrombotic thrombocytopenia","volume":"9","author":"Klok","year":"2022","journal-title":"Lancet Haematol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1097\/CCM.0000000000005211","article-title":"Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia","volume":"50","author":"Iba","year":"2022","journal-title":"Crit. Care Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/thoraxjnl-2020-216243","article-title":"COVID-19, immunothrombosis and venous thromboembolism: Biological mechanisms","volume":"76","author":"Loo","year":"2021","journal-title":"Thorax"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.thromres.2020.06.029","article-title":"The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management","volume":"194","author":"Diamond","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.15585\/mmwr.mm7043e2","article-title":"COVID-19 Vaccination and Non-COVID-19 Mortality Risk\u2014Seven Integrated Health Care Organizations, United States, December 14, 2020\u2013July 31, 2021","volume":"70","author":"Xu","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jclinepi.2008.06.014","article-title":"New strategies are needed to improve the accuracy of influenza vaccine effectiveness estimates among seniors","volume":"62","author":"Nelson","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S1473-3099(07)70236-0","article-title":"Mortality benefits of influenza vaccination in elderly people: An ongoing controversy","volume":"7","author":"Simonsen","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41569-021-00662-w","article-title":"Myocarditis after COVID-19 mRNA vaccination: Clinical observations and potential mechanisms","volume":"19","author":"Heymans","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Puranik, A., Lenehan, P.J., Silvert, E., Niesen, M.J.M., Corchado-Garcia, J., O\u2019Horo, J.C., Virk, A., Swift, M.D., Halamka, J., and Badley, A.D. (2021). Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence. medRxiv.","DOI":"10.1101\/2021.08.06.21261707"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1001\/jama.2021.15125","article-title":"Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273","volume":"326","author":"Steensels","year":"2021","journal-title":"JAMA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1056\/NEJMoa2110737","article-title":"Myocarditis after COVID-19 Vaccination in a Large Health Care Organization","volume":"385","author":"Witberg","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.vaccine.2022.02.017","article-title":"Myocarditis following mRNA COVID-19 vaccination: A pooled analysis","volume":"40","author":"Bellos","year":"2022","journal-title":"Vaccine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/CIRCULATIONAHA.121.056135","article-title":"Myocarditis With COVID-19 mRNA Vaccines","volume":"144","author":"Bozkurt","year":"2021","journal-title":"Circulation"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1093\/cid\/ciab707","article-title":"Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model","volume":"74","author":"Li","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/cid\/ciab741","article-title":"Insights from a murine model of COVID-19 mRNA vaccination-induced myopericarditis: Could accidental intravenous vaccine injection induce myopericarditis?","volume":"74","author":"Knowlton","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Remschmidt, C., Wichmann, O., and Harder, T. (2015). Frequency and impact of confounding by indication and healthy vaccinee bias in observational studies assessing influenza vaccine effectiveness: A systematic review. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-1154-y"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cmi.2021.10.005","article-title":"Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: A narrative review","volume":"28","author":"Fiolet","year":"2022","journal-title":"Clin. Microbiol. 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