{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:50:49Z","timestamp":1760230249381,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>A considerable number of travelers receive multiple travel vaccinations before going on holiday. Here, we present a case report of a 56-year-old male traveler. On day 1, he received vaccinations against influenza, Tdab (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis), MMR (measles, mumps, and rubella), yellow fever, and cholera. On days 1,3, 5, and 7, he self-administered an oral vaccine against typhoid. Treatment comprised the combination of 220 mg naproxen and 180 mg fexofenadine (SJP-003), to be taken 4h before and 6h after the vaccinations on day 1, and every 12 h thereafter until the end of day 7. Side effects were noted daily, and their severity was scored on a scale ranging from 0 (absent) to 10 (severe). These reports revealed that, except from a slight bruising at the injection site, no side effects were experienced from day 1 to day 4. After the second dose on day 3, treatment was discontinued. Two hours after taking the typhoid vaccine on Day 5, various flu-like symptoms were reported of moderate to high severity, including fever, muscle aches (both with severity score of 8), headache (severity score 7), and nausea (severity score 6). Therefore, at 2 h after typhoid vaccination on day 5, naproxen and fexofenadine were self-administered. At 4 h thereafter, all symptoms were resolved. Treatment was continued at the 12 h schedule. On day 6 and 7, no side effects were reported. Taken together, this case study suggests that the combination of naproxen and fexofenadine was effective in preventing or reducing vaccination side effects. Therefore, more research is warranted to further evaluate the efficacy of SJP-003.<\/jats:p>","DOI":"10.3390\/vaccines10071128","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T01:53:22Z","timestamp":1658109202000},"page":"1128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Efficacy of the Combination of Naproxen and Fexofenadine (SJP-003) to Prevent or Reduce Side Effects of Receiving Multiple Travel Vaccines: A Case Report"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3073-9749","authenticated-orcid":false,"given":"Pantea","family":"Kiani","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Iversen","sequence":"additional","affiliation":[{"name":"Sen-Jam Pharmaceutical, 223 Wall St., #130, Huntington, NY 11743, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4484-5462","authenticated-orcid":false,"given":"Andrew","family":"Scholey","sequence":"additional","affiliation":[{"name":"Nutrition Dietetics and Food, School of Clinical Sciences, Monash University, Melbourne, VIC 3168, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-2096","authenticated-orcid":false,"given":"Joris C.","family":"Verster","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The Netherlands"},{"name":"Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"ref_1","first-page":"CD013717","article-title":"International travel-related control measures to contain the COVID-19 pandemic: A rapid review","volume":"3","author":"Burns","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jinf.2021.07.017","article-title":"Public health effects of travel-related policies on the COVID-19 pandemic: A mixed-methods systematic review","volume":"83","author":"Khabsa","year":"2021","journal-title":"J. Infect."},{"key":"ref_3","first-page":"191","article-title":"Has tourism gone on holiday? Analysis of the effects of the COVID-19 pandemic on tourism and post-pandemic tourism behavior","volume":"21","author":"Cretu","year":"2021","journal-title":"Sci. Pap. Ser. Manag. Econ. Eng. Agric. Rural Dev."},{"key":"ref_4","unstructured":"(2022, June 01). Number of Visitors to Africa from the U.S. from 2015 to 2019, by Month. Available online: https:\/\/www.statista.com\/statistics\/790448\/us-citizen-monthly-travel-to-africa\/."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102278","DOI":"10.1016\/j.tmaid.2022.102278","article-title":"Travel vaccines throughout history","volume":"46","author":"Pavli","year":"2022","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1073\/pnas.1704507114","article-title":"Simply put: Vaccination saves lives","volume":"114","author":"Orenstein","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","unstructured":"Centers for Disease Control and Prevention (2022, June 01). Need Travel Vaccines? Plan Ahead, Available online: https:\/\/wwwnc.cdc.gov\/travel\/page\/travel-vaccines."},{"key":"ref_8","unstructured":"Centers for Disease Control and Prevention (2022, June 01). 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Medical Management of Vaccine Reactions in Adults in a Community Setting. Available online: https:\/\/www.immunize.org\/catg.d\/p3082.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2165\/00003495-197918040-00001","article-title":"Naproxen up to date: A review of its pharmacological properties and therapeutic effcacy and use in rheumatic diseases and pain states","volume":"18","author":"Brogden","year":"1979","journal-title":"Drugs"},{"key":"ref_15","first-page":"207","article-title":"Fexofenadine hydrochloride\u2014A new anti-histaminic drug","volume":"3","author":"Amichai","year":"2001","journal-title":"IMAJ"},{"key":"ref_16","first-page":"20","article-title":"Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines","volume":"17","author":"Ashenager","year":"2007","journal-title":"J. Investig. Allergol. Clin. Immunol."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/7\/1128\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:50:59Z","timestamp":1760140259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/7\/1128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["vaccines10071128"],"URL":"https:\/\/doi.org\/10.3390\/vaccines10071128","relation":{},"ISSN":["2076-393X"],"issn-type":[{"type":"electronic","value":"2076-393X"}],"subject":[],"published":{"date-parts":[[2022,7,15]]}}}