{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:20:02Z","timestamp":1792002002354,"version":"4.4.0"},"reference-count":26,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Clinical and epidemiologic data on pustular psoriasis are scarce. To investigate the phenotypes of pustular psoriasis and the patients\u2019 characteristics observed in a real-life retrospective observational study. The number of incident cases of pustular psoriasis registered in the period 2005\u20132021 was retrieved from the electronic medical records of the University Hospital of Verona. One hundred and forty cases of pustular psoriasis were collected. Ninety-one out of 140 patients (65%) were females, with a median (IQR) age of 57 (43\u201366) years. According to the ERASPEN classification criteria, 116 patients (83%) had palmoplantar pustulosis (PPP), 13 (9%) generalized pustular psoriasis (GPP), and 11 (8%) acrodermatitis continua of Hallopeau (ACH). Gender distribution and median age were consistent among the three groups. The prevalence of psoriatic arthritis in GPP, ACH, and PPP was 8%, 36%, and 28%, respectively. During the same period, a total of 4718 cases of plaque psoriasis were retrieved, with a 1:34 ratio of pustular over plaque psoriasis. Pustular psoriasis is much rarer than plaque psoriasis, with PPP being the more common subtype.<\/jats:p>","DOI":"10.3390\/vaccines10081171","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T04:52:47Z","timestamp":1658724767000},"page":"1171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Characteristics of Patients with Pustular Psoriasis: A Single-Center Retrospective Observational Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9001","authenticated-orcid":false,"given":"Paolo","family":"Gisondi","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Dermatology and Venereology, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-6921","authenticated-orcid":false,"given":"Francesco","family":"Bellinato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology and Venereology, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-0493","authenticated-orcid":false,"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology and Venereology, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Genovese, G., Moltrasio, C., Cassano, N., Maronese, C.A., Vena, G.A., and Marzano, A.V. (2021). Pustular Psoriasis: From Pathophysiology to Treatment. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121746"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s13555-021-00677-8","article-title":"Role of Interleukin 36 in Generalised Pustular Psoriasis and Beyond","volume":"12","author":"Sugiura","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/bjd.16232","article-title":"Pustular psoriasis and related pustular skin diseases","volume":"178","author":"Bachelez","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1001\/archderm.1991.01680080075005","article-title":"Generalized pustular psoriasis. A review of 63 cases","volume":"127","author":"Zelickson","year":"1991","journal-title":"Arch. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1111\/jdv.14386","article-title":"European consensus statement on phenotypes of pustular psoriasis","volume":"31","author":"Navarini","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Assan, F., Husson, B., Hegazy, S., Seneschal, J., Aubin, F., Mah\u00e9, E., Jullien, D., Sbidian, E., D\u2019Incan, M., and Conrad, C. (2022). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: Demographic and clinical comparative study in a large multicentre cohort. J. Eur. Acad. Dermatol. Venereol.","DOI":"10.1111\/jdv.18127"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus, C.onference Committee. American College of Chest Physicians\/Society of Critical, Care Medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2165\/11586900-000000000-00000","article-title":"Clinical and laboratory features in acute generalized pustular psoriasis: A retrospective study of 34 patients","volume":"12","author":"Silva","year":"2011","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/1346-8138.12863","article-title":"Clinical features and course of generalized pustular psoriasis in Korea","volume":"42","author":"Jin","year":"2015","journal-title":"J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1365-4362.1997.00170.x","article-title":"The profile and outcome of pustular psoriasis in Singapore: A report of 28 cases","volume":"36","author":"Tay","year":"1997","journal-title":"Int. J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/ijd.12070","article-title":"Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis: Analysis of 102 cases seen in a tertiary hospital in Johor, Malaysia","volume":"53","author":"Choon","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/1346-8138.16164","article-title":"Epidemiology and clinical features of pustular psoriasis: A 15-year retrospective cohort","volume":"48","author":"Tosukhowong","year":"2021","journal-title":"J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/1346-8138.16022","article-title":"Patient characteristics and burden of disease in Japanese patients with generalized pustular psoriasis: Results from the Medical Data Vision claims database","volume":"48","author":"Morita","year":"2021","journal-title":"J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jdermsci.2019.04.002","article-title":"Cyto\/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon","volume":"94","author":"Furue","year":"2019","journal-title":"J. Dermatol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","article-title":"Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies","volume":"80","author":"Alinaghi","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/1346-8138.16217","article-title":"Western Japan Inflammatory, Disease Research Group. Clinical characteristics of Japanese pustular psoriasis: A multicenter observational study","volume":"49","author":"Ohata","year":"2022","journal-title":"J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jaci.2018.06.038","article-title":"Clinical and genetic differences between pustular psoriasis subtypes","volume":"143","author":"Twelves","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/bjd.20966","article-title":"Prevalence and incidence of generalised pustular psoriasis in Sweden\u2014A population-based register study","volume":"186","author":"Norlin","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41431-019-0508-0","article-title":"Estimating cumulative point prevalence of rare diseases: Analysis of the Orphanet database","volume":"28","author":"Lambert","year":"2020","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40257-021-00664-x","article-title":"The Prevalence and Disease, C.haracteristics of Generalized, P.ustular Psoriasis","volume":"23","author":"Zheng","year":"2022","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_21","first-page":"669","article-title":"Generalized pustular psoriasis (Zumbusch): A French epidemiological survey","volume":"16","author":"Augey","year":"2006","journal-title":"Eur. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2340\/00015555766871","article-title":"Generalized pustular psoriasis in Japan: Two distinct groups formed by differences in symptoms and genetic background","volume":"76","author":"Ohkawara","year":"1996","journal-title":"Acta Derm. Venereol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"761","DOI":"10.5021\/ad.2017.29.6.761","article-title":"Prevalence of psoriasis in Korea: A population-based epidemiological study using the Korean, N.ational Health, I.nsurance Database","volume":"29","author":"Lee","year":"2017","journal-title":"Ann. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.jaci.2021.09.035","article-title":"Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasis","volume":"149","author":"Baum","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa2111563","article-title":"Effisayil 1 Trial Investigators. Trial of Spesolimab for Generalized Pustular Psoriasis","volume":"385","author":"Bachelez","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40257-021-00655-y","article-title":"Pathophysiology of Generalized Pustular Psoriasis","volume":"23","author":"Marrakchi","year":"2022","journal-title":"Am. J. Clin. Dermatol."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/8\/1171\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:55:20Z","timestamp":1760140520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/8\/1171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,23]]},"references-count":26,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["vaccines10081171"],"URL":"https:\/\/doi.org\/10.3390\/vaccines10081171","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,23]]}}}