{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:00:53Z","timestamp":1781514053959,"version":"3.54.1"},"reference-count":126,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Human lymphatic filariae have evolved numerous immune evasion strategies to secure their long-term survival in a host. These strategies include regulation of pattern recognition receptors, mimicry with host glycans and immune molecules, manipulation of innate and adaptive immune cells, induction of apoptosis in effector immune cells, and neutralization of free radicals. This creates an anti-inflammatory and immunoregulatory milieu in the host: a modified Th2 immune response. Therefore, targeting filarial immunomodulators and manipulating the filariae-driven immune system against the filariae can be a potential therapeutic and prophylactic strategy. Filariae-derived immunosuppression can also be exploited to treat other inflammatory diseases and immunopathologic states of parasitic diseases, such as cerebral malaria, and to prevent leishmaniasis. This paper reviews immunomodulatory mechanisms acquired by these filariae for their own survival and their potential application in the development of novel therapeutic approaches against parasitic and inflammatory diseases. Insight into the intricate network of host immune-parasite interactions would aid in the development of effective immune-therapeutic options for both infectious and immune-pathological diseases.<\/jats:p>","DOI":"10.3390\/vaccines10081235","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T23:49:27Z","timestamp":1659397767000},"page":"1235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-0021","authenticated-orcid":false,"given":"Priyanka","family":"Bhoj","sequence":"first","affiliation":[{"name":"Independent Researcher, El Paso, TX 79902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-6458","authenticated-orcid":false,"given":"Namdev","family":"Togre","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Texas, El Paso, TX 79968, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-6260","authenticated-orcid":false,"given":"Vishal","family":"Khatri","sequence":"additional","affiliation":[{"name":"Independent Researcher, Woburn, MA 01801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyan","family":"Goswami","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, Saguna, Kalyani 741245, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moreno, Y., and Geary, T.G. (2008). Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products. PLoS Negl. Trop. Dis., 2.","DOI":"10.1371\/journal.pntd.0000326"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0020-7519(00)00014-X","article-title":"The Filarial Genome Project: Analysis of the Nuclear, Mitochondrial and Endosymbiont Genomes of Brugia malayi","volume":"30","author":"Williams","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.parint.2008.09.003","article-title":"The Genome of Brugia malayi\u2014All Worms Are Not Created Equal","volume":"58","author":"Scott","year":"2009","journal-title":"Parasitol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"International Helminth Genomes Consortium (2019). Comparative genomics of the major parasitic worms. Nat. Genet., 51, 163\u2013174.","DOI":"10.1038\/s41588-018-0262-1"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.4049\/jimmunol.171.12.6723","article-title":"Proinflammatory Cytokines Dominate the Early Immune Response to Filarial Parasites","volume":"171","author":"Babu","year":"2003","journal-title":"J. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1128\/IAI.74.4.2366-2372.2006","article-title":"Inflammatory Responses to Migrating Brugia pahangi Third-Stage Larvae","volume":"74","author":"Porthouse","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri2992","article-title":"Diversity and Dialogue in Immunity to Helminths","volume":"11","author":"Allen","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Herbert, D., Douglas, B., and Zullo, K. (2019). Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092276"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1128\/IAI.01301-12","article-title":"Quiescent Innate Response to Infective Filariae by Human Langerhans Cells Suggests a Strategy of Immune Evasion","volume":"81","author":"Boyd","year":"2013","journal-title":"Infect. Immun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/pim.12169","article-title":"Brugia malayi Infective Larvae Fail to Activate Langerhans Cells and Dermal Dendritic Cells in Human Skin","volume":"37","author":"Cotton","year":"2015","journal-title":"Parasite Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e12442","DOI":"10.1111\/pim.12442","article-title":"Human Innate Lymphoid Cells (ILCs) in Filarial Infections","volume":"40","author":"Nutman","year":"2018","journal-title":"Parasite Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Boyd, A., Ribeiro, J.M.C., and Nutman, T.B. (2014). Human CD117 (CKit)+ Innate Lymphoid Cells Have a Discrete Transcriptional Profile at Homeostasis and Are Expanded during Filarial Infection. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108649"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.4049\/jimmunol.0904067","article-title":"At Homeostasis Filarial Infections Have Expanded Adaptive T Regulatory but Not Classical Th2 Cells","volume":"184","author":"Metenou","year":"2010","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern Recognition Receptors in Health and Diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1128\/IAI.72.1.398-407.2004","article-title":"Both Free-Living and Parasitic Nematodes Induce a Characteristic Th2 Response That Is Dependent on the Presence of Intact Glycans","volume":"72","author":"Tawill","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/glycob\/cwp140","article-title":"Glycan Gimmickry by Parasitic Helminths: A Strategy for Modulating the Host Immune Response?","volume":"20","author":"Cummings","year":"2010","journal-title":"Glycobiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.4049\/jimmunol.134.2.1172","article-title":"A Monoclonal Antibody-Based Immunoradiometric Assay for Detection of Circulating Antigen in Bancroftian Filariasis","volume":"134","author":"Forsyth","year":"1985","journal-title":"J. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-3024.1987.tb00488.x","article-title":"Phosphorylcholine-Bearing Antigens in Filarial Nematode Parasites: Analysis of Somatic Extracts, in-Vitro Secretions and Infection Sera from Brugia malayi and B. pahangi","volume":"9","author":"Maizels","year":"1987","journal-title":"Parasite Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1365-3024.1999.00267.x","article-title":"Immunomodulatory Properties of a Phosphorylcholine-Containing Secreted Filarial Glycoprotein","volume":"21","author":"Harnett","year":"1999","journal-title":"Parasite Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"807821","DOI":"10.3389\/fmolb.2021.807821","article-title":"Helminth Glycans at the Host-Parasite Interface and Their Potential for Developing Novel Therapeutics","volume":"8","author":"Bunte","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/nm1654","article-title":"Inhibition of Fc Epsilon RI-Mediated Mast Cell Responses by ES-62, a Product of Parasitic Filarial Nematodes","volume":"13","author":"Melendez","year":"2007","journal-title":"Nat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37276","DOI":"10.1038\/srep37276","article-title":"The Helminth Product, ES-62 Modulates Dendritic Cell Responses by Inducing the Selective Autophagolysosomal Degradation of TLR-Transducers, as Exemplified by PKC\u03b4","volume":"6","author":"Eason","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1182\/blood-2008-04-149856","article-title":"Inhibition of TLR3 and TLR4 Function and Expression in Human Dendritic Cells by Helminth Parasites","volume":"112","author":"Semnani","year":"2008","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s42003-019-0392-8","article-title":"Wuchereria bancrofti Filaria Activates Human Dendritic Cells and Polarizes T Helper 1 and Regulatory T Cells via Toll-like Receptor 4","volume":"2","author":"Mukherjee","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ijbiomac.2021.10.200","article-title":"Filarial Thioredoxin Reductase Exerts Anti-Inflammatory Effects upon Lipopolysaccharide Induced Inflammation in Macrophages","volume":"193","author":"Joardar","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ludin, P., Nilsson, D., and M\u00e4ser, P. (2011). Genome-Wide Identification of Molecular Mimicry Candidates in Parasites. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017546"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1128\/IAI.68.11.6402-6410.2000","article-title":"Identification of Tgh-2, a Filarial Nematode Homolog of Caenorhabditis Elegans Daf-7 and Human Transforming Growth Factor \u03b2, Expressed in Microfilarial and Adult Stages of Brugia malayi","volume":"68","author":"Gregory","year":"2000","journal-title":"Infect. Immun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules","volume":"49","author":"Maizels","year":"2018","journal-title":"Immunity"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Dakshinamoorthy, G., Samykutty, A.K., Munirathinam, G., Shinde, G.B., Nutman, T., Reddy, M.V., and Kalyanasundaram, R. (2012). Biochemical Characterization and Evaluation of a Brugia malayi Small Heat Shock Protein as a Vaccine against Lymphatic Filariasis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034077"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1172\/JCI115691","article-title":"Intravascular Filarial Parasites Inhibit Platelet Aggregation. Role of Parasite-Derived Prostanoids","volume":"89","author":"Liu","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of Immune Responses by Prostaglandin E 2","volume":"188","author":"Kalinski","year":"2012","journal-title":"J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.4049\/jimmunol.175.3.1483","article-title":"Prostaglandin E 2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells","volume":"175","author":"Baratelli","year":"2005","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.4049\/jimmunol.181.9.6456","article-title":"Expansion of Foxp3+ Regulatory T Cells in Mice Infected with the Filarial Parasite Brugia malayi","volume":"181","author":"McSorley","year":"2008","journal-title":"J. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/eji.202048909","article-title":"Prostaglandin Regulation of Type 2 Inflammation: From Basic Biology to Therapeutic Interventions","volume":"51","author":"Oyesola","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"44261","DOI":"10.1074\/jbc.M204655200","article-title":"Homologues of Human Macrophage Migration Inhibitory Factor from a Parasitic Nematode","volume":"277","author":"Zang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1189\/jlb.0808459","article-title":"MIF Homologues from a Filarial Nematode Parasite Synergize with IL-4 to Induce Alternative Activation of Host Macrophages","volume":"85","author":"Gregory","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Koussa, J., Vitrinel, B., Whitney, P., Kasper, B.T., Mahal, L.K., Vogel, C., Lustigman, S., Salehi-Ashtiani, K., and Ghedin, E. (2021). Sex-Specific Glycosylation of Secreted Immunomodulatory Proteins in the Filarial Nematode Brugia malayi. bioRxiv.","DOI":"10.1101\/2021.02.24.432741"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ritter, M., Osei-Mensah, J., Debrah, L.B., Kwarteng, A., Mubarik, Y., Debrah, A.Y., Pfarr, K., Hoerauf, A., and Layland, L.E. (2019). Wuchereria Bancrofti-Infected Individuals Harbor Distinct IL-10-Producing Regulatory B and T Cell Subsets Which Are Affected by Anti-Filarial Treatment. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007436"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Gomez-Escobar, N., Bennett, C., Prieto-Lafuente, L., Aebischer, T., Blackburn, C.C., and Maizels, R.M. (2005). Heterologous Expression of the Filarial Nematode Alt Gene Products Reveals Their Potential to Inhibit Immune Function. BMC Biol., 3.","DOI":"10.1186\/1741-7007-3-8"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1096\/fj.14-251967","article-title":"Kv1.3 Channel-blocking Immunomodulatory Peptides from Parasitic Worms: Implications for Autoimmune Diseases","volume":"28","author":"Chhabra","year":"2014","journal-title":"FASEB J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.4049\/jimmunol.151.9.4829","article-title":"Inhibition of Murine B Cell Proliferation and Down-Regulation of Protein Kinase C Levels by a Phosphorylcholine-Containing Filarial Excretory-Secretory Product","volume":"151","author":"Harnett","year":"1993","journal-title":"J. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molbiopara.2008.02.007","article-title":"The Secretome of the Filarial Parasite, Brugia malayi: Proteomic Profile of Adult Excretory\u2013Secretory Products","volume":"160","author":"Hewitson","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1179\/136485910X12786389891407","article-title":"Induction of Immunoglobulin G4 in Human Filariasis: An Indicator of Immunoregulation","volume":"104","author":"Adjobimey","year":"2010","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Khatri, V., Chauhan, N., and Kalyanasundaram, R. (2020). Parasite Cystatin: Immunomodulatory Molecule with Therapeutic Activity against Immune Mediated Disorders. Pathogens, 9.","DOI":"10.3390\/pathogens9060431"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0960-9822(01)00118-X","article-title":"Bm-CPI-2, a Cystatin Homolog Secreted by the Filarial Parasite Brugia malayi, Inhibits Class II MHC-Restricted Antigen Processing","volume":"11","author":"Manoury","year":"2001","journal-title":"Curr. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.04.008","article-title":"Helminth Immunoregulation: The Role of Parasite Secreted Proteins in Modulating Host Immunity","volume":"167","author":"Hewitson","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1145697","article-title":"Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid","volume":"317","author":"Mucida","year":"2007","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4049\/jimmunol.179.4.2445","article-title":"Filarial Parasites Induce NK Cell Activation, Type 1 and Type 2 Cytokine Secretion, and Subsequent Apoptotic Cell Death","volume":"179","author":"Babu","year":"2007","journal-title":"J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.4049\/jimmunol.171.4.1950","article-title":"Brugia malayi Microfilariae Induce Cell Death in Human Dendritic Cells, Inhibit Their Ability to Make IL-12 and IL-10, and Reduce Their Capacity to Activate CD4 + T Cells","volume":"171","author":"Semnani","year":"2003","journal-title":"J. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1128\/IAI.00174-16","article-title":"Microfilariae of Brugia malayi Inhibit the MTOR Pathway and Induce Autophagy in Human Dendritic Cells","volume":"84","author":"Narasimhan","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ricciardi, A., Bennuru, S., Tariq, S., Kaur, S., Wu, W., Elkahloun, A.G., Arakelyan, A., Shaik, J., Dorward, D.W., and Nutman, T.B. (2021). Extracellular Vesicles Released from the Filarial Parasite Brugia malayi Downregulate the Host MTOR Pathway. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0008884"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e12421","DOI":"10.1111\/pim.12421","article-title":"Increased Fas Ligand Expression of Peripheral B-1 Cells Correlated with CD4 + T-Cell Apoptosis in Filarial-Infected Patients","volume":"39","author":"Mishra","year":"2017","journal-title":"Parasite Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-6851(97)00213-2","article-title":"Thioredoxin Peroxidases from Brugia malayi","volume":"91","author":"Ghosh","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-6851(02)00027-0","article-title":"Molecular Characterization of a Calcium Binding Translationally Controlled Tumor Protein Homologue from the Filarial Parasites Brugia malayi and Wuchereria bancrofti","volume":"121","author":"Gnanasekar","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.6026\/97320630001025","article-title":"Modeling Analysis of GST (Glutathione-S-Transferases) from Wuchereria bancrofti and Brugia malayi","volume":"1","author":"Bhargavi","year":"2005","journal-title":"Bioinformation"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Yadav, S., Gupta, S., Selvaraj, C., Doharey, P.K., Verma, A., Singh, S.K., and Saxena, J.K. (2014). In Silico and In Vitro Studies on the Protein-Protein Interactions between Brugia malayi Immunomodulatory Protein Calreticulin and Human C1q. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106413"},{"key":"ref_57","unstructured":"(2022, June 02). World Health Organization Lymphatic Filariasis. 2022. Lymphatic Filariasis. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/lymphatic-filariasis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13071-018-2649-3","article-title":"Human Infection with Sub-Periodic Brugia spp. in Gampaha District, Sri Lanka: A Threat to Filariasis Elimination Status?","volume":"11","author":"Mallawarachchi","year":"2018","journal-title":"Parasites Vectors"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10903-018-0767-9","article-title":"Prevalence of Neglected Tropical Diseases (Leishmaniasis and Lymphatic Filariasis) and Malaria among a Migrant Labour Settlement in Kerala, India","volume":"21","author":"George","year":"2019","journal-title":"J. Immigr. Minority Health"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.actatropica.2017.08.010","article-title":"Screening and Evaluation of Lymphatic Filariasis in Immigrants from Endemic Countries Residing in a Focus Where It Is Considered Eliminated in the Southern Region of Brazil: A Risk of Reemergence?","volume":"176","author":"Zuchi","year":"2017","journal-title":"Acta Trop."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1590\/0037-8682-0407-2016","article-title":"Wuchereria bancrofti Infection in Haitian Immigrants and the Risk of Re-Emergence of Lymphatic Filariasis in the Brazilian Amazon","volume":"50","author":"Fontes","year":"2017","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10136","DOI":"10.1038\/s41598-018-28081-x","article-title":"The Extensive Networks of Frequent Population Mobility in the Samoan Islands and Their Implications for Infectious Disease Transmission","volume":"8","author":"Xu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/trstmh\/trab004","article-title":"Delays in Lymphatic Filariasis Elimination Programmes Due to COVID-19, and Possible Mitigation Strategies","volume":"115","author":"Prada","year":"2021","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00436-020-06991-y","article-title":"Lymphatic Filariasis in Asia: A Systematic Review and Meta-Analysis","volume":"120","author":"Bizhani","year":"2021","journal-title":"Parasitol. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/2049-9957-3-31","article-title":"Mass Drug Administration for Lymphatic Filariasis Elimination in a Coastal State of India: A Study on Barriers to Coverage and Compliance","volume":"3","author":"Hussain","year":"2014","journal-title":"Infect. Dis. Poverty"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ahorlu, C.S.K., Koka, E., Adu-Amankwah, S., Otchere, J., and de Souza, D.K. (2018). Community Perspectives on Persistent Transmission of Lymphatic Filariasis in Three Hotspot Districts in Ghana after 15 Rounds of Mass Drug Administration: A Qualitative Assessment. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-5157-7"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Willis, G.A., Mayfield, H.J., Kearns, T., Naseri, T., Thomsen, R., Gass, K., Sheridan, S., Graves, P.M., and Lau, C.L. (2020). A Community Survey of Coverage and Adverse Events Following Country-Wide Triple-Drug Mass Drug Administration for Lymphatic Filariasis Elimination, Samoa 2018. PLOS Negl. Trop. Dis., 14.","DOI":"10.1101\/2020.04.21.20072363"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"de Souza, D.K., Gass, K., Otchere, J., Htet, Y.M., Asiedu, O., Marfo, B., Biritwum, N.-K., Boakye, D.A., and Ahorlu, C.S. (2020). Review of MDA Registers for Lymphatic Filariasis: Findings, and Potential Uses in Addressing the Endgame Elimination Challenges. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008306"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1090-0233(05)80005-X","article-title":"Modes of Action of Anthelmintic Drugs","volume":"154","author":"Martin","year":"1997","journal-title":"Vet. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"20120","DOI":"10.1073\/pnas.1011983107","article-title":"Ivermectin Disrupts the Function of the Excretory-Secretory Apparatus in Microfilariae of Brugia malayi","volume":"107","author":"Moreno","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1017\/pao.2019.1","article-title":"Effects of Diethylcarbamazine and Ivermectin Treatment on Brugia malayi Gene Expression in Infected Gerbils (Meriones unguiculatus)","volume":"5","author":"Maclean","year":"2019","journal-title":"Parasitol. Open"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1096\/fj.07-9268com","article-title":"Inhibitory Control of Endothelial Galectin-1 on in Vitro and in Vivo Lymphocyte Trafficking","volume":"22","author":"Norling","year":"2008","journal-title":"FASEB J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.4049\/jimmunol.180.4.2650","article-title":"Regulation of Alternative Macrophage Activation by Galectin-3","volume":"180","author":"MacKinnon","year":"2008","journal-title":"J. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/1756-3305-7-342","article-title":"Galectin Hco-Gal-m from Haemonchus Contortus Modulates Goat Monocytes and T Cell Function in Different Patterns","volume":"7","author":"Wang","year":"2014","journal-title":"Parasites Vectors"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejmech.2016.08.042","article-title":"Sulfonamide Chalcones: Synthesis and in Vitro Exploration for Therapeutic Potential against Brugia malayi","volume":"124","author":"Bahekar","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11686-020-00291-2","article-title":"Role of Glutathione in Chalcone Derivative Induced Apoptosis of Brugia malayi and Its Possible Therapeutic Implication","volume":"66","author":"Bhoj","year":"2021","journal-title":"Acta Parasitol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pt.2019.11.005","article-title":"Advances in Vaccine Development for Human Lymphatic Filariasis","volume":"36","author":"Kalyanasundaram","year":"2020","journal-title":"Trends Parasitol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.exppara.2007.02.017","article-title":"Brugia malayi: Comparison of Protective Immune Responses Induced by Bm-Alt-2 DNA, Recombinant Bm-ALT-2 Protein and Prime-Boost Vaccine Regimens in a Jird Model","volume":"116","author":"Thirugnanam","year":"2007","journal-title":"Exp. Parasitol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Dakshinamoorthy, G., Munirathinam, G., Stoicescu, K., Reddy, M.V., and Kalyanasundaram, R. (2013). Large Extracellular Loop of Tetraspanin as a Potential Vaccine Candidate for Filariasis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0077394"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.vaccine.2013.10.083","article-title":"Evaluating the Efficacy of RBmHAT\u03b1c as a Multivalent Vaccine against Lymphatic Filariasis in Experimental Animals and Optimizing the Adjuvant Formulation","volume":"32","author":"Dakshinamoorthy","year":"2013","journal-title":"Vaccine"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Dakshinamoorthy, G., von Gegerfelt, A., Andersen, H., Lewis, M., and Kalyanasundaram, R. (2014). Evaluation of a Multivalent Vaccine against Lymphatic Filariasis in Rhesus Macaque Model. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112982"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"01520","DOI":"10.3389\/fimmu.2018.01520","article-title":"Evaluating the Vaccine Potential of a Tetravalent Fusion Protein (RBmHAXT) Vaccine Antigen Against Lymphatic Filariasis in a Mouse Model","volume":"9","author":"Chauhan","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ijpara.2018.04.002","article-title":"Prospects of Developing a Prophylactic Vaccine against Human Lymphatic Filariasis\u2014Evaluation of Protection in Non-Human Primates","volume":"48","author":"Khatri","year":"2018","journal-title":"Int. J. Parasitol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.4049\/jimmunol.165.9.5161","article-title":"The Serpin Secreted by Brugia malayi Microfilariae, Bm-SPN-2, Elicits Strong, but Short-Lived, Immune Responses in Mice and Humans","volume":"165","author":"Zang","year":"2000","journal-title":"J. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Veerapathran, A., Dakshinamoorthy, G., Gnanasekar, M., Reddy, M.V.R., and Kalyanasundaram, R. (2009). Evaluation of Wuchereria bancrofti GST as a Vaccine Candidate for Lymphatic Filariasis. PLoS Negl. Trop. Dis., 3.","DOI":"10.1371\/journal.pntd.0000457"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12291-016-0556-y","article-title":"Immunization with Wuchereria bancrofti Glutathione-S-Transferase Elicits a Mixed Th1\/Th2 Type of Protective Immune Response Against Filarial Infection in Mastomys","volume":"31","author":"Andure","year":"2016","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.vaccine.2012.09.055","article-title":"Multivalent Fusion Protein Vaccine for Lymphatic Filariasis","volume":"31","author":"Dakshinamoorthy","year":"2013","journal-title":"Vaccine"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Kushwaha, S., Singh, P.K., Rana, A.K., and Misra-Bhattacharya, S. (2013). Immunization of Mastomys Coucha with Brugia malayi Recombinant Trehalose-6-Phosphate Phosphatase Results in Significant Protection against Homologous Challenge Infection. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072585"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1017\/S0022149X13000333","article-title":"Tandem Antioxidant Enzymes Confer Synergistic Protective Responses in Experimental Filariasis","volume":"88","author":"Prince","year":"2014","journal-title":"J. Helminthol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ijpara.2014.05.003","article-title":"Vaccination with a Genetically Modified Brugia malayi Cysteine Protease Inhibitor-2 Reduces Adult Parasite Numbers and Affects the Fertility of Female Worms Following a Subcutaneous Challenge of Mongolian Gerbils (Meriones unguiculatus) with B. malayi Infective Larvae","volume":"44","author":"Arumugam","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e00092","DOI":"10.1016\/j.parepi.2019.e00092","article-title":"Immunological Evaluation of Fusion Protein of Brugia malayi Abundant Larval Protein Transcript-2 (BmALT-2) and Tuftsin in Experimental Mice Model","volume":"4","author":"Paul","year":"2019","journal-title":"Parasite Epidemiol. Control"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1021\/acsinfecdis.0c00565","article-title":"Immunization with Brugia malayi Calreticulin Protein Generates Robust Antiparasitic Immunity and Offers Protection during Experimental Lymphatic Filariasis","volume":"7","author":"Yadav","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"105487","DOI":"10.1016\/j.actatropica.2020.105487","article-title":"Fecundity of Adult Female Worms Were Affected When Brugia malayi Infected Mongolian Gerbils Were Immunized with a Multivalent Vaccine (RBmHAXT) against Human Lymphatic Filarial Parasite","volume":"208","author":"Khatri","year":"2020","journal-title":"Acta Trop."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/COH.0b013e3283522c3d","article-title":"Impact of Filarial Infections on Coincident Intracellular Pathogens","volume":"7","author":"Metenou","year":"2012","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1017\/S0031182096008566","article-title":"Down-Regulation of Murine Susceptibility to Cerebral Malaria by Inoculation with Third-Stage Larvae of the Filarial Nematode Brugia pahangi","volume":"114","author":"Yan","year":"1997","journal-title":"Parasitology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1086\/426871","article-title":"Malaria-Filaria Coinfection in Mice Makes Malarial Disease More Severe Unless Filarial Infection Achieves Patency","volume":"191","author":"Graham","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.micinf.2008.11.003","article-title":"Filarial Infection Induces Protection against P. berghei Liver Stages in Mice","volume":"11","author":"Dubben","year":"2009","journal-title":"Microbes Infect."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4049\/jimmunol.0900257","article-title":"Patent Filarial Infection Modulates Malaria-Specific Type 1 Cytokine Responses in an IL-10-Dependent Manner in a Filaria\/Malaria-Coinfected Population","volume":"183","author":"Metenou","year":"2009","journal-title":"J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.micinf.2010.04.006","article-title":"Filaria-Induced IL-10 Suppresses Murine Cerebral Malaria","volume":"12","author":"Specht","year":"2010","journal-title":"Microbes Infect."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1756-3305-6-203","article-title":"Decreased Prevalence of Sepsis but Not Mild or Severe P. falciparum Malaria Is Associated with Pre-Existing Filarial Infection","volume":"6","author":"Panda","year":"2013","journal-title":"Parasit Vectors"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/eji.201141955","article-title":"Nematode-Induced Interference with the Anti-Plasmodium CD8+ T-Cell Response Can Be Overcome by Optimizing Antigen Administration","volume":"42","author":"Kolbaum","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1016\/j.vaccine.2010.02.055","article-title":"Helminth Infection Impairs the Immunogenicity of a Plasmodium Falciparum DNA Vaccine, but Not Irradiated Sporozoites, in Mice","volume":"28","author":"Noland","year":"2010","journal-title":"Vaccine"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.actatropica.2015.08.018","article-title":"Cross Reactive Molecules of Human Lymphatic Filaria Brugia malayi Inhibit Leishmania Donovani Infection in Hamsters","volume":"152","author":"Verma","year":"2015","journal-title":"Acta Trop."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.actatropica.2008.01.007","article-title":"Influence of Brugia malayi Life Stages and BmAFII Fraction on Experimental Leishmania Donovani Infection in Hamsters","volume":"106","author":"Murthy","year":"2008","journal-title":"Acta Trop."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1016\/j.vaccine.2009.05.015","article-title":"Immunization with Inflammatory Proteome of Brugia malayi Adult Worm Induces a Th1\/Th2-Immune Response and Confers Protection against the Filarial Infection","volume":"27","author":"Sahoo","year":"2009","journal-title":"Vaccine"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biologicals.2021.06.001","article-title":"Cross-Protective Efficacy of Immuno-Stimulatory Recombinant Brugia malayi Protein HSP60 against the Leishmania Donovani in BALB\/c Mice","volume":"72","author":"Kushwaha","year":"2021","journal-title":"Biologicals"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s00436-018-5981-9","article-title":"Leishmania Donovani Molecules Recognized by Sera of Filaria Infected Host Facilitate Filarial Infection","volume":"117","author":"Verma","year":"2018","journal-title":"Parasitol. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13071-017-2531-8","article-title":"A Cross-Sectional Study of the Filarial and Leishmania Co-Endemicity in Two Ecologically Distinct Settings in Mali","volume":"11","author":"Sangare","year":"2018","journal-title":"Parasit Vectors"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-3024.2005.00779.x","article-title":"Co-Infected C57BL\/6 Mice Mount Appropriately Polarized and Compartmentalized Cytokine Responses to Litomosoides Sigmodontis and Leishmania Major but Disease Progression Is Altered","volume":"27","author":"Lamb","year":"2005","journal-title":"Parasite Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.trstmh.2007.05.014","article-title":"The Hygiene Hypothesis and the Increasing Prevalence of Chronic Inflammatory Disorders","volume":"101","author":"Rook","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/1744666X.2018.1424543","article-title":"The Tropics, Helminth Infections and Hygiene Hypotheses","volume":"14","author":"Caraballo","year":"2018","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"615192","DOI":"10.3389\/fimmu.2020.615192","article-title":"Revisiting the Hygiene Hypothesis in the Context of Autoimmunity","volume":"11","author":"Bach","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"00453","DOI":"10.3389\/fimmu.2017.00453","article-title":"Helminth Immunomodulation in Autoimmune Disease","volume":"8","author":"Smallwood","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2147\/JIR.S348079","article-title":"Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives","volume":"15","author":"Shi","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_115","first-page":"732","article-title":"Brugia malayi Abundant Larval Transcript 2 Protein Treatment Attenuates Experimentally-Induced Colitis in Mice","volume":"53","author":"Khatri","year":"2015","journal-title":"Indian J. Exp. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1017\/S0022149X1600064X","article-title":"Therapeutic Potential of the Immunomodulatory Proteins Wuchereria bancrofti L2 and Brugia malayi Abundant Larval Transcript 2 against Streptozotocin-Induced Type 1 Diabetes in Mice","volume":"91","author":"Amdare","year":"2017","journal-title":"J. Helminthol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.1007\/s00253-016-7829-5","article-title":"Genetic Engineering of Probiotic Escherichia Coli Nissle 1917 for Clinical Application","volume":"100","author":"Ou","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/1751-2980.12290","article-title":"Brugia malayi Cystatin Therapeutically Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice","volume":"16","author":"Khatri","year":"2015","journal-title":"J. Dig. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Bisht, N., Khatri, V., Chauhan, N., and Kalyanasundaram, R. (2019). Cystatin from Filarial Parasites Suppress the Clinical Symptoms and Pathology of Experimentally Induced Colitis in Mice by Inducing T-Regulatory Cells, B1-Cells, and Alternatively Activated Macrophages. Biomedicines, 7.","DOI":"10.3390\/biomedicines7040085"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12291-015-0515-z","article-title":"Immuno-Modulatory Effect and Therapeutic Potential of Brugia malayi Cystatin in Experimentally Induced Arthritis","volume":"31","author":"Yadav","year":"2016","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_121","first-page":"655","article-title":"Evaluation of Preventive Effect of Brugia malayi Recombinant Cystatin on MBSA-Induced Experimental Arthritis","volume":"55","author":"Khatri","year":"2017","journal-title":"Indian J. Exp. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"237.28","DOI":"10.4049\/jimmunol.204.Supp.237.28","article-title":"Peptide Fragments of Cystatin Protein from Filarial Parasite Has Potent Anti-Inflammatory Effect on DSS-Induced Colitis in Mouse","volume":"204","author":"Khatri","year":"2020","journal-title":"J. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/08923973.2018.1431925","article-title":"Immunomodulatory Potential of Recombinant Filarial Protein, RWbL2, and Its Therapeutic Implication in Experimental Ulcerative Colitis in Mouse","volume":"40","author":"Togre","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e12511","DOI":"10.1111\/pim.12511","article-title":"Human Filarial Proteins Attenuate Chronic Colitis in an Experimental Mouse Model","volume":"40","author":"Togre","year":"2018","journal-title":"Parasite Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/pim.12283","article-title":"Brugia malayi Soluble and Excretory-Secretory Proteins Attenuate Development of Streptozotocin-Induced Type 1 Diabetes in Mice","volume":"37","author":"Amdare","year":"2015","journal-title":"Parasite Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1128\/CVI.00594-12","article-title":"Nematode Asparaginyl-TRNA Synthetase Resolves Intestinal Inflammation in Mice with T-Cell Transfer Colitis","volume":"20","author":"Kron","year":"2013","journal-title":"Clin. Vaccine Immunol."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/8\/1235\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:58Z","timestamp":1760140858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/8\/1235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":126,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["vaccines10081235"],"URL":"https:\/\/doi.org\/10.3390\/vaccines10081235","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,1]]}}}