{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:23:01Z","timestamp":1793013781006,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Seqirus Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>This US-based, prospective observational cohort study evaluated the safety of a quadrivalent inactivated influenza vaccine (IIV4; Afluria Quadrivalent) in pregnant persons immunized over four influenza seasons between 2017 and 2021. Pregnancy outcomes included live birth, stillbirth, spontaneous abortion, and elective termination. Infant events of interest were major congenital malformations (MCMs), preterm birth (&lt;37 weeks gestational age), and low birth weight (LBW). Data were descriptive; prevalence point estimates were reported with 95% confidence intervals (CI). A total of 483 pregnant persons were given IIV4 and evaluated; 477 (98.8%) reported a live birth, and there were 2 stillbirths, 4 spontaneous abortions, and no elective terminations or maternal deaths. The prevalence rates of infant events were as follows: preterm birth, 7.2% (upper 95% CI, 9.6%); LBW, 5.4% (upper 95% CI, 7.4%); and MCMs, 0.8% (upper 95% CI, 1.9%). Point estimates and upper 95% CIs of the observed prevalence rates were lower than or similar to background prevalence in the general US population. Our findings suggest no evidence of a safety concern with vaccinating this group at high risk of influenza complications and are consistent with published data from databases and surveillance systems that monitor the safety of influenza vaccines in pregnant persons.<\/jats:p>","DOI":"10.3390\/vaccines10101577","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T04:07:07Z","timestamp":1663906027000},"page":"1577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Prospective Cohort Study on Pregnancy Outcomes of Persons Immunized with a Seasonal Quadrivalent Inactivated Influenza Vaccine during Pregnancy"],"prefix":"10.3390","volume":"10","author":[{"given":"Christopher","family":"Robinson","sequence":"first","affiliation":[{"name":"Charleston Maternal Fetal Medicine, Summerville, SC 29485, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Oberye","sequence":"additional","affiliation":[{"name":"Seqirus Netherlands B.V., 1105 BJ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"van Boxmeer","sequence":"additional","affiliation":[{"name":"Seqirus Netherlands B.V., 1105 BJ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D.","family":"Albano","sequence":"additional","affiliation":[{"name":"Syneos Health, Wilmington, NC 28403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Tilson","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1351-4572","authenticated-orcid":false,"given":"Anthony","family":"Scialli","sequence":"additional","affiliation":[{"name":"Scialli Consulting LLC, Washington, DC 20008, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Vanchiere","sequence":"additional","affiliation":[{"name":"LSU Health Science Center, Shreveport, LA 71106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellis","family":"Ides","sequence":"additional","affiliation":[{"name":"Seqirus Netherlands B.V., 1105 BJ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Sawlwin","sequence":"additional","affiliation":[{"name":"Seqirus Australia Pty Ltd., Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hohenboken","sequence":"additional","affiliation":[{"name":"Seqirus USA Inc., Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Edelman","sequence":"additional","affiliation":[{"name":"Seqirus USA Inc., Summit, NJ 07901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1503\/cmaj.061435","article-title":"Impact of influenza exposure on rates of hospital admissions and physician visits because of respiratory illness among pregnant women","volume":"176","author":"Dodds","year":"2007","journal-title":"CMAJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.7326\/M21-3668","article-title":"Characteristics and outcomes of hospitalized pregnant women with influenza, 2010 to 2019: A repeated cross-sectional study","volume":"175","author":"Holstein","year":"2022","journal-title":"Ann. 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