{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:57:56Z","timestamp":1793408276508,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Maintenance hemodialysis (MHD) patients have impaired immunological responses to pathogens and vaccines. In this study, we compared the humoral response to HBV and COVID-19 vaccines in a cohort of MHD patients. Demographic and clinical characteristics of vaccine responders and non-responders were also compared, and the association between the humoral responses to both vaccines was evaluated. The cohort included 94 MHD patients who were vaccinated at least once for HBV and twice for COVID-19. Among the 94 patients, 28 (29.8%) did not develop protective titers to HBV. Hypertension, coronary heart disease, and heart failure were more common in non-responders. Among MHD patients, 85% had positive IgG anti-spike SARS-CoV-2 levels 6 months after two doses of BNT162b2 (Pfizer\/Biotech) vaccine. Age and immunosuppressive therapy were the main predictors of humoral response to COVID-19 vaccine. We did not find any association between non-responders to HBV and non-responders to COVID-19 vaccine. There was no difference in IgG anti-spike titers between HBV responders and non-responders (505 \u00b1 644 vs. 504 \u00b1 781, p = 0.9) Our results suggest that reduced humoral response to hepatitis B is not associated with reduced response to COVID-19 vaccine. Different risk-factors were associated with poor immune response to HBV and to COVID-19 vaccines.<\/jats:p>","DOI":"10.3390\/vaccines10101670","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T06:13:27Z","timestamp":1665468807000},"page":"1670","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Humoral Response to Hepatitis B and COVID-19 Vaccine among Maintenance Hemodialysis Patients"],"prefix":"10.3390","volume":"10","author":[{"given":"Naomi","family":"Nacasch","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba 4428163, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-6956","authenticated-orcid":false,"given":"Keren","family":"Cohen-Hagai","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba 4428163, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997543, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurit","family":"Tayar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba 4428163, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Levian","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba 4428163, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Rashid","sequence":"additional","affiliation":[{"name":"Clinical Laboratories, Meir Medical Center, Kfar Saba 4428163, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Benchetrit","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba 4428163, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997543, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Neumark","sequence":"additional","affiliation":[{"name":"Clinical Laboratories, Meir Medical Center, Kfar Saba 4428163, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7702-2967","authenticated-orcid":false,"given":"Ori","family":"Wand","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Barzilai Medical Center, Ashkelon 7830604, Israel"},{"name":"Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8499000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-7606","authenticated-orcid":false,"given":"Tammy","family":"Hod","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997543, Israel"},{"name":"Renal Transplant Center and Nephrology Department, Sheba Medical Center, Ramat Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossi","family":"Rosman","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997543, Israel"},{"name":"Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba 4428163, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Shashar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Laniado Hospital, Netanya 4244916, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Grupper","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997543, Israel"},{"name":"Department of Nephrology and Hypertension, Tel Aviv Sourasky Medical Center Tel Aviv, Tel Aviv 6423906, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pnina","family":"Shitrit","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997543, Israel"},{"name":"Infection Control Unit, Meir Medical Center, Kfar Saba 4428163, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","first-page":"1366","article-title":"Meta-Analysis: The Impact of Nutritional Status on the Immune Response to Hepatitis B Virus Vaccine in Chronic Kidney Disease","volume":"57","author":"Fabrizi","year":"2012","journal-title":"Am. 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