{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:28:29Z","timestamp":1767706109794,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chung Shan Medical University Hospital","award":["CSH-2020-C-011"],"award-info":[{"award-number":["CSH-2020-C-011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>In recent years, during the ravages of COVID-19, a variety of vaccines have been developed and are now on the market. However, although these new vaccines have undergone various trials, there are still many unknown side effects. We report a case of a 30-year-old woman who presented with general weakness, sore throat, generalized skin rashes, symmetrical arthralgia, and persistent fever of up to 40 \u00b0C with onset 16 days after receiving the Moderna COVID-19 vaccine. Adult-onset Still\u2019s disease (AOSD) was diagnosed according to Yamaguchi\u2019s criteria after excluding the feasibility of infectious diseases, autoimmune diseases, and malignancies. In particular, her responses to glucocorticoids and naproxen were significant and inversely proportional to her use of empirical antibiotics in the initial stage of treatment. We studied some similar cases of AOSD, which also considered the adverse effects of COVID-19 vaccination and suggested the immunogenicity and possibility of inflammatory responses related to COVID-19 vaccination.<\/jats:p>","DOI":"10.3390\/vaccines10101687","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T06:13:27Z","timestamp":1665468807000},"page":"1687","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adult-Onset Still\u2019s Disease following Coronavirus 2 (SARS-CoV-2) Vaccination: A Case Report"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-2787","authenticated-orcid":false,"given":"Xiang-He","family":"Chua","sequence":"first","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung City 40201, Taiwan"},{"name":"Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wea-Lung","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung City 40201, Taiwan"},{"name":"Department of Pathology, Chung Shan Medical Hospital, Taichung City 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-4379","authenticated-orcid":false,"given":"Yuan-Ti","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medicine, Chung Shan Medical University, Taichung City 40201, Taiwan"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"ref_1","unstructured":"(2022, September 28). 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Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s10067-022-06106-1","article-title":"Flare of adult-onset Still\u2019s disease following mRNA COVID-19 vaccination: A case report and review of literature","volume":"41","author":"Kim","year":"2022","journal-title":"Clin. Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00296-021-05052-6","article-title":"A flare of Still\u2019s disease following COVID-19 vaccination in a 34-year-old patient","volume":"42","author":"Jeon","year":"2022","journal-title":"Rheumatol. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s10067-022-06124-z","article-title":"Two flares of Still\u2019s disease after two doses of the ChAdOx1 vaccine","volume":"41","author":"Roongta","year":"2022","journal-title":"Clin. Rheumatol."},{"key":"ref_21","unstructured":"European Medicines Agency (2022, September 08). 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Available online: https:\/\/www.ema.europa.eu\/en\/documents\/covid-19-vaccine-safety-update\/covid-19-vaccines-safety-update-8-september-2022_en.pdf."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/10\/1687\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:48:54Z","timestamp":1760143734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/10\/1687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,9]]},"references-count":21,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["vaccines10101687"],"URL":"https:\/\/doi.org\/10.3390\/vaccines10101687","relation":{},"ISSN":["2076-393X"],"issn-type":[{"type":"electronic","value":"2076-393X"}],"subject":[],"published":{"date-parts":[[2022,10,9]]}}}