{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:26:16Z","timestamp":1764350776774,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016175","name":"Chulabhorn Royal Academy","doi-asserted-by":"publisher","award":["11\/2564"],"award-info":[{"award-number":["11\/2564"]}],"id":[{"id":"10.13039\/100016175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Coronavirus disease 2019 affected child health and impacted learning because of the resulting onsite school closures. This prospective cohort study included children aged 10\u201317 who received two 4 \u00b5g doses of BBIBP-CorV administered intramuscularly 21\u201328 days apart. To assess vaccine safety, 36,808 participants were then followed with paper- and web-based online questionnaire surveys that captured local and systemic reactogenicities following vaccine administration on days 1, 7, and 30. Among participants, 76% (27,880) reported reactogenicity within the first 24 h and 7 days following the first dose. Half (51.41%) of participants experienced pain at the injection site; the majority of cases were mild in severity. Injection site tenderness (37.93%) was another common local reaction. Fatigue (37.89%), myalgia (33.56%), and headache (26.76%) were the most common systemic reactions. On days 2\u20137 after the first dose, 25.85% of participants experienced adverse reactions. Following the second dose, reactogenicity was 7.6% and 1.09% within 24 h and between days 2\u20137. The majority of reactions were of mild to moderate severity. We report that two doses of the BBIBP-CorV caused mild to moderate side effects in adolescents in Thailand. The findings confirm the vaccine\u2019s safety profile in this age group.<\/jats:p>","DOI":"10.3390\/vaccines10101765","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T11:53:55Z","timestamp":1666612435000},"page":"1765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety after BBIBP-CorV (Sinopharm) COVID-19 Vaccine in Adolescents Aged 10\u201317 Years in Thailand"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9082-289X","authenticated-orcid":false,"given":"Saraiorn","family":"Thonginnetra","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2862-948X","authenticated-orcid":false,"given":"Kriangkrai","family":"Tawinprai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krongkwan","family":"Niemsorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pathariya","family":"Promsena","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manunya","family":"Tandhansakul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruporn","family":"Kasemlawan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natthanan","family":"Ruangkijpaisal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narin","family":"Banomyong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanthida","family":"Phattraprayoon","sequence":"additional","affiliation":[{"name":"Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pisuttikan","family":"Rangkakulnuwat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeda","family":"Vanichsetakul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0140-9866","authenticated-orcid":false,"given":"Teerapat","family":"Ungtrakul","sequence":"additional","affiliation":[{"name":"Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasiruck","family":"Wittayasak","sequence":"additional","affiliation":[{"name":"Chulabhorn Learning and Research Centre, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawarat","family":"Thonwirak","sequence":"additional","affiliation":[{"name":"Chulabhorn Learning and Research Centre, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamonwan","family":"Soonklang","sequence":"additional","affiliation":[{"name":"Chulabhorn Learning and Research Centre, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithi","family":"Mahanonda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok 10210, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. 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